{"id":"https://openalex.org/W1600516138","doi":null,"title":"Effects of Endocrine Disrupting Chemicals on Human Endometrial Endothelial Cells In Vitro","display_name":"Effects of Endocrine Disrupting Chemicals on Human Endometrial Endothelial Cells In Vitro","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1600516138","mag":"1600516138"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-196730","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196730","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196730","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003754992","display_name":"Malin Helmestam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Malin Helmestam","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003754992"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.9890000224113464},{"id":"https://openalex.org/keywords/endometrial-angiogenesis","display_name":"endometrial angiogenesis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/endometrial-receptivity","display_name":"endometrial receptivity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/embryo-implantation","display_name":"embryo implantation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cadmium","display_name":"cadmium","score":0.8209999799728394},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":0.996999979019165},{"id":"https://openalex.org/keywords/mifepristone","display_name":"mifepristone","score":1.0},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":1.0},{"id":"https://openalex.org/keywords/endometrial-stromal-cells","display_name":"endometrial stromal cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.7179999947547913},{"id":"https://openalex.org/keywords/tube-formation","display_name":"tube formation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7820000052452087},{"id":"https://openalex.org/keywords/vegf-d","display_name":"VEGF-D","score":0.9629999995231628},{"id":"https://openalex.org/keywords/endometrial-vasculature","display_name":"endometrial vasculature","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.616092324256897},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.5817215442657471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4537113904953003},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39068877696990967},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.31192445755004883},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1945224106311798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17221415042877197}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-196730","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196730","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1600516138","doi":null,"is_oa":false,"landing_page_url":"https://uu.diva-portal.org/smash/get/diva2:616509/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-196730","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196730","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":120,"referenced_works":["https://openalex.org/W654928142","https://openalex.org/W1207573219","https://openalex.org/W1479965447","https://openalex.org/W1491459594","https://openalex.org/W1534980720","https://openalex.org/W1563659068","https://openalex.org/W1745112890","https://openalex.org/W1907235146","https://openalex.org/W1958574545","https://openalex.org/W1964945591","https://openalex.org/W1966414426","https://openalex.org/W1967211742","https://openalex.org/W1967777488","https://openalex.org/W1968108385","https://openalex.org/W1970760886","https://openalex.org/W1974562202","https://openalex.org/W1975965304","https://openalex.org/W1976184639","https://openalex.org/W1977296184","https://openalex.org/W1978506033","https://openalex.org/W1981552708","https://openalex.org/W1983141048","https://openalex.org/W1985289561","https://openalex.org/W1985990006","https://openalex.org/W1987668628","https://openalex.org/W1990860720","https://openalex.org/W1992112921","https://openalex.org/W1993281353","https://openalex.org/W1996020022","https://openalex.org/W1997168440","https://openalex.org/W1999023281","https://openalex.org/W2000292756","https://openalex.org/W2004918005","https://openalex.org/W2010965653","https://openalex.org/W2011246022","https://openalex.org/W2011827546","https://openalex.org/W2015186671","https://openalex.org/W2015307784","https://openalex.org/W2016906423","https://openalex.org/W2017184213","https://openalex.org/W2018994512","https://openalex.org/W2022121555","https://openalex.org/W2025562352","https://openalex.org/W2029300487","https://openalex.org/W2031688444","https://openalex.org/W2032141573","https://openalex.org/W2032303470","https://openalex.org/W2032395525","https://openalex.org/W2034024594","https://openalex.org/W2034759914","https://openalex.org/W2035410400","https://openalex.org/W2036674750","https://openalex.org/W2040047351","https://openalex.org/W2040883058","https://openalex.org/W2044060855","https://openalex.org/W2045945078","https://openalex.org/W2053380617","https://openalex.org/W2057598257","https://openalex.org/W2059612167","https://openalex.org/W2062146531","https://openalex.org/W2065337976","https://openalex.org/W2066546360","https://openalex.org/W2066611091","https://openalex.org/W2067058609","https://openalex.org/W2067980525","https://openalex.org/W2069514871","https://openalex.org/W2069612357","https://openalex.org/W2073797382","https://openalex.org/W2077801037","https://openalex.org/W2078275530","https://openalex.org/W2081746977","https://openalex.org/W2083835054","https://openalex.org/W2091127926","https://openalex.org/W2093189154","https://openalex.org/W2095148414","https://openalex.org/W2097327668","https://openalex.org/W2097881605","https://openalex.org/W2100560126","https://openalex.org/W2103549320","https://openalex.org/W2106876831","https://openalex.org/W2108244474","https://openalex.org/W2108884038","https://openalex.org/W2109160378","https://openalex.org/W2112983914","https://openalex.org/W2116041308","https://openalex.org/W2121605257","https://openalex.org/W2123476163","https://openalex.org/W2123962235","https://openalex.org/W2129486679","https://openalex.org/W2130196753","https://openalex.org/W2131868790","https://openalex.org/W2133413328","https://openalex.org/W2133700168","https://openalex.org/W2134564876","https://openalex.org/W2139659546","https://openalex.org/W2141349182","https://openalex.org/W2142331900","https://openalex.org/W2146479629","https://openalex.org/W2147407942","https://openalex.org/W2149275727","https://openalex.org/W2150386903","https://openalex.org/W2151762874","https://openalex.org/W2152806277","https://openalex.org/W2153355413","https://openalex.org/W2153497318","https://openalex.org/W2153812207","https://openalex.org/W2154434665","https://openalex.org/W2154968546","https://openalex.org/W2156181845","https://openalex.org/W2160337287","https://openalex.org/W2160882660","https://openalex.org/W2164398852","https://openalex.org/W2166212359","https://openalex.org/W2168420558","https://openalex.org/W2186393994","https://openalex.org/W2216094174","https://openalex.org/W2337821831","https://openalex.org/W2411716433","https://openalex.org/W2500614298","https://openalex.org/W2525954393"],"related_works":["https://openalex.org/W239327360","https://openalex.org/W2036461365","https://openalex.org/W2093324536","https://openalex.org/W4292372445","https://openalex.org/W6981357829","https://openalex.org/W2239511278","https://openalex.org/W3132104263","https://openalex.org/W3176347233","https://openalex.org/W7211886683","https://openalex.org/W2038523736"],"abstract_inverted_index":{"Evidence":[0],"from":[1],"an":[2,174,238],"abundant":[3],"number":[4],"of":[5,71,100,208,229,245,273,282,326],"studies":[6],"suggests":[7],"that":[8,22,289],"human":[9,102,123,329],"female":[10],"reproductive":[11,47],"functions":[12,48,309],"have":[13,291],"become":[14],"impaired":[15],"over":[16],"the":[17,77,206,227,271,292,324],"past":[18],"half":[19],"century":[20],"and":[21,33,55,64,73,93,126,136,147,154,176,189,193,201,211,232,303,313],"there":[23],"might":[24],"be":[25],"a":[26,113,339],"relationship":[27],"between":[28],"endocrine":[29,157],"disrupting":[30],"chemicals":[31],"(EDCs)":[32],"reduced":[34,233,243],"fertility.":[35],"It":[36],"is,":[37],"however,":[38],"not":[39,336],"known":[40],"by":[41,120,186],"what":[42],"mechanisms":[43],"EDCs":[44,121,290,327],"affect":[45],"different":[46,213],"such":[49],"as":[50,112,277,279,338],"endometrial":[51,90,97,103,124,130,137,298,308,330],"receptivity,":[52],"embryo":[53,86],"implantation":[54,87],"placentation.":[56],"The":[57,182],"endometrium":[58],"is":[59,173,335],"continuously":[60],"changing":[61],"its":[62],"morphological":[63],"functional":[65],"properties,":[66,166],"responding":[67],"to":[68,156,268,294,311],"cyclic":[69],"changes":[70,81,95,269,296],"oestrogen":[72],"progesterone":[74],"levels":[75],"during":[76],"menstrual":[78],"cycle.":[79],"These":[80,160],"include":[82],"monthly":[83],"preparation":[84],"for":[85,117],"through":[88],"changed":[89],"angiogenic":[91,299],"activity":[92,300],"consequent":[94],"in":[96,107,145,152,215,248,262,270,297,301,317],"vasculature.":[98],"Use":[99],"primary":[101],"endothelial":[104],"cells":[105,139,151],"(HEECs)":[106],"this":[108,133,333],"work":[109],"was":[110,266],"evaluated":[111,185],"possible":[114],"screening":[115,341],"tool":[116],"effects":[118,183,214,325],"caused":[119,212,242],"on":[122,128,323,328],"vasculature":[125],"subsequently":[127],"various":[129],"functions.":[131,331],"In":[132,285],"study":[134],"HEEC":[135,234],"stromal":[138,150,223,255],"were":[140,143,161,184],"isolated.":[141],"HEECs":[142,216,220,252,264,315],"grown":[144,316],"monocultures,":[146],"together":[148],"with":[149,168,179,222,254],"co-cultures,":[153],"exposed":[155],"active":[158],"substances.":[159],"cadmium,":[162],"which":[163,172,265],"has":[164],"oestrogenic":[165,180],"tamoxifen,":[167],"anti-oestrogenic":[169],"effects,":[170],"mifepristone,":[171],"anti-progestin,":[175],"bisphenol":[177],"A,":[178],"properties.":[181],"using":[187],"proliferation":[188],"viability":[190],"assays,":[191,196],"migration":[192],"tube":[194,260],"formation":[195,244,261],"quantitative":[197],"PCR":[198],"(qPCR),":[199],"immunohistochemistry":[200],"western":[202],"blot.":[203],"Cadmium":[204],"affected":[205],"expression":[207,228,272,281],"angiogenesis-related":[209,230,275],"genes,":[210],"cultured":[217],"alone":[218],"vs.":[219],"co-cultured":[221,253,263],"cells.":[224,256],"Tamoxifen":[225],"altered":[226],"genes":[231,276],"migration,":[235],"thus":[236,305],"having":[237],"anti-angiogenic":[239],"effect.":[240],"Mifepristone":[241],"tubular":[246],"structures":[247],"tube-formation":[249],"assays":[250],"involving":[251],"Bisphenol":[257],"A":[258],"promoted":[259],"related":[267,310],"several":[274],"well":[278],"up-regulated":[280],"VEGF-D":[283],"protein.":[284],"conclusion,":[286],"we":[287],"showed":[288],"ability":[293],"induce":[295],"vitro":[302,318],"may":[304,319],"disturb":[306],"normal":[307],"fertility":[312],"pregnancy.":[314],"provide":[320],"valuable":[321],"information":[322],"However,":[332],"model":[334],"suitable":[337],"large-scale":[340],"tool.":[342]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}
