{"id":"https://openalex.org/W1600510649","doi":null,"title":"Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.","display_name":"Radiosensitization of human tumor cells by the phosphatidylinositol3-kinase inhibitors wortmannin and LY294002 correlates with inhibition of DNA-dependent protein kinase and prolonged G2-M delay.","publication_year":1997,"publication_date":"1997-07-01","ids":{"openalex":"https://openalex.org/W1600510649","mag":"1600510649","pmid":"https://pubmed.ncbi.nlm.nih.gov/9815794"},"language":"en","primary_location":{"id":"pmid:9815794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112384283","display_name":"K. Rosenzweig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K E Rosenzweig","raw_affiliation_strings":["Joint Center for Radiation Therapy, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Center for Radiation Therapy, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071320815","display_name":"M B Youmell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M B Youmell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111921913","display_name":"Sanjeewani T. Palayoor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S T Palayoor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044265138","display_name":"Brendan D. Price","orcid":"https://orcid.org/0000-0001-7075-4906","observed_orcids":["https://orcid.org/0000-0001-7075-4906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B D Price","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.641,"has_fulltext":false,"cited_by_count":210,"citation_normalized_percentile":{"value":0.97999682,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"3","issue":"7","first_page":"1149","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.2921999990940094,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.2921999990940094,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.23180000483989716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.19040000438690186,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.9769999980926514},{"id":"https://openalex.org/keywords/wortmannin","display_name":"wortmannin","score":1.0},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":1.0},{"id":"https://openalex.org/keywords/dna-dependent-protein-kinase","display_name":"DNA-dependent protein kinase","score":0.996999979019165},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.8330000042915344},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.7760000228881836},{"id":"https://openalex.org/keywords/sensitizer-enhancement-ratio","display_name":"sensitizer enhancement ratio","score":0.8140000104904175},{"id":"https://openalex.org/keywords/sw480-cells","display_name":"SW480 cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2778308172","wikidata":"https://www.wikidata.org/wiki/Q423565","display_name":"Wortmannin","level":4,"score":0.9911642074584961},{"id":"https://openalex.org/C2776912716","wikidata":"https://www.wikidata.org/wiki/Q4042503","display_name":"LY294002","level":4,"score":0.7600052356719971},{"id":"https://openalex.org/C68748289","wikidata":"https://www.wikidata.org/wiki/Q18030783","display_name":"DNA-PKcs","level":4,"score":0.6212097406387329},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6039003729820251},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5314216613769531},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5238202214241028},{"id":"https://openalex.org/C2779486608","wikidata":"https://www.wikidata.org/wiki/Q387082","display_name":"Ataxia-telangiectasia","level":4,"score":0.47509443759918213},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.46810150146484375},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4601041078567505},{"id":"https://openalex.org/C2780610907","wikidata":"https://www.wikidata.org/wiki/Q2273248","display_name":"Phosphatidylinositol","level":3,"score":0.4304943084716797},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39629632234573364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39183175563812256},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22997012734413147},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20288410782814026}],"mesh":[{"descriptor_ui":"D000077191","descriptor_name":"Wortmannin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081082","descriptor_name":"Phosphoinositide-3 Kinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000730","descriptor_name":"Androstadienes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004307","descriptor_name":"Dose-Response Relationship, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016195","descriptor_name":"G2 Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051747","descriptor_name":"DNA-Activated Protein Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9815794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:1600510649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9815794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3254607006","display_name":"Histone methylation controls activation of ATM and the radiation response","funder_award_id":"R01CA064585","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1481358348","https://openalex.org/W1516184246","https://openalex.org/W1528368632","https://openalex.org/W1583256888","https://openalex.org/W1969393623","https://openalex.org/W1977145510","https://openalex.org/W2036754489","https://openalex.org/W2038593531","https://openalex.org/W2044179656","https://openalex.org/W2048059265","https://openalex.org/W2100436127","https://openalex.org/W2102512189","https://openalex.org/W2168924996"],"related_works":["https://openalex.org/W2131660936","https://openalex.org/W7097530643","https://openalex.org/W2050878077","https://openalex.org/W2023797932","https://openalex.org/W1850501873","https://openalex.org/W2322000958","https://openalex.org/W2163066697","https://openalex.org/W2393281230","https://openalex.org/W2321041752","https://openalex.org/W2032261226"],"abstract_inverted_index":{"Members":[0],"of":[1,57,68,83,93,102,115,143,152,154,169,186,200,207,221,227],"the":[2,9,14,80,99,128,141,150,159,198,225],"phosphatidylinositol":[3],"(PI)":[4],"3-kinase":[5,32,49,209,214],"gene":[6,12],"family,":[7],"including":[8],"ataxia":[10,129],"telangiectasia":[11,130],"and":[13,35,43,52,70,77,86,107],"DNA-dependent":[15],"protein":[16,131,147],"kinase":[17,81,90,148],"(DNA-PK),":[18],"are":[19],"involved":[20],"in":[21,73,112,122,149,190],"regulating":[22],"cellular":[23,45,88,94],"radiosensitivity.":[24,46],"We":[25],"have":[26],"investigated":[27],"two":[28],"structurally":[29],"unrelated":[30],"PI":[31,48,208,213],"inhibitors,":[33],"wortmannin":[34,51,103],"LY294002,":[36],"to":[37,136],"determine":[38],"whether":[39],"they":[40],"inhibit":[41,224],"DNA-PK":[42,85,89,95,124],"increase":[44],"The":[47],"inhibitors":[50,215],"LY294002":[53,78],"were":[54,132,188],"effective":[55],"radiosensitizers":[56,222],"human":[58],"tumor":[59,116],"cells,":[60],"with":[61],"sensitizer":[62],"enhancement":[63],"ratios":[64],"(at":[65],"10%":[66],"survival)":[67],"2.8":[69],"1.9,":[71],"respectively,":[72],"SW480":[74,162,176],"cells.":[75],"Wortmannin":[76,156],"inhibited":[79],"activity":[82,96],"purified":[84],"inactivated":[87],"activity.":[91],"Inhibition":[92],"occurred":[97],"at":[98,192],"same":[100],"concentrations":[101],"that":[104,223],"caused":[105],"radiosensitization,":[106],"this":[108],"correlation":[109],"was":[110],"found":[111],"a":[113,165,179,218],"range":[114],"cell":[117],"lines.":[118],"However,":[119,174],"cells":[120,163,177,187],"deficient":[121],"either":[123],"(scid":[125],"cells)":[126],"or":[127],"also":[133,157],"partly":[134],"sensitized":[135],"radiation":[137],"by":[138],"wortmannin,":[139],"indicating":[140],"involvement":[142],"more":[144,183],"than":[145,184],"one":[146],"mechanism":[151],"action":[153],"wortmannin.":[155],"affected":[158],"G2-M":[160,167,181],"checkpoint.":[161],"had":[164,178],"reversible":[166],"delay":[168],"20":[170],"h":[171,194],"following":[172,205],"irradiation.":[173],"wortmannin-treated":[175],"prolonged":[180],"delay;":[182],"75%":[185],"arrested":[189],"G2":[191],"50":[193],"postirradiation.":[195],"This":[196],"suggests":[197],"accumulation":[199],"significant":[201],"unrepaired":[202],"DNA":[203,228],"damage":[204],"inhibition":[206],"family":[210],"members.":[211],"Therefore,":[212],"may":[216],"represent":[217],"new":[219],"class":[220],"repair":[226],"damage.":[229]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}