{"id":"https://openalex.org/W1600497872","doi":"https://doi.org/10.1016/s0021-9258(17)37899-7","title":"N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis.","display_name":"N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis.","publication_year":1979,"publication_date":"1979-02-01","ids":{"openalex":"https://openalex.org/W1600497872","doi":"https://doi.org/10.1016/s0021-9258(17)37899-7","mag":"1600497872","pmid":"https://pubmed.ncbi.nlm.nih.gov/762107"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(17)37899-7","doi":"https://doi.org/10.1016/s0021-9258(17)37899-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)37899-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(17)37899-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053933323","display_name":"Richard A. Padgett","orcid":"https://orcid.org/0000-0002-2910-1134","observed_orcids":["https://orcid.org/0000-0002-2910-1134"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.A. Padgett","raw_affiliation_strings":["From the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038885111","display_name":"Geoffrey M. Wahl","orcid":"https://orcid.org/0000-0003-3658-2279","observed_orcids":["https://orcid.org/0000-0003-3658-2279"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.M. Wahl","raw_affiliation_strings":["From the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031519850","display_name":"Patrick F. Coleman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P.F. Coleman","raw_affiliation_strings":["From the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080998429","display_name":"George Robert Stark","orcid":"https://orcid.org/0000-0002-8776-9597","observed_orcids":["https://orcid.org/0000-0002-8776-9597"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.R. Stark","raw_affiliation_strings":["From the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.5088,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.93933516,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"254","issue":"3","first_page":"974","last_page":"980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multifunctional-proteins","display_name":"multifunctional proteins","score":0.7250000238418579},{"id":"https://openalex.org/keywords/protein-overexpression","display_name":"protein overexpression","score":0.8240000009536743},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.4000000059604645},{"id":"https://openalex.org/keywords/polysomal-rna","display_name":"polysomal RNA","score":0.8339999914169312},{"id":"https://openalex.org/keywords/poly-a-rna","display_name":"polyadenylated RNA","score":0.75},{"id":"https://openalex.org/keywords/in-vitro-translation","display_name":"in vitro translation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/nucleotide-biosynthesis","display_name":"nucleotide synthesis","score":0.5730000138282776}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.7619094252586365},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.7553578019142151},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7041481733322144},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6837286949157715},{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.6704030632972717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5523647665977478},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5464597344398499},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5049734711647034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5044838190078735},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.47899338603019714},{"id":"https://openalex.org/C2779926675","wikidata":"https://www.wikidata.org/wiki/Q6943700","display_name":"Mutant protein","level":4,"score":0.4138951301574707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32875144481658936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19108504056930542},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.053563445806503296}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009943","descriptor_name":"Organophosphorus Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014500","descriptor_name":"Uracil Nucleotides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014542","descriptor_name":"Uridine Monophosphate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(17)37899-7","doi":"https://doi.org/10.1016/s0021-9258(17)37899-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)37899-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:762107","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/762107","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(17)37899-7","doi":"https://doi.org/10.1016/s0021-9258(17)37899-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(17)37899-7","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1480437404","https://openalex.org/W1507212424","https://openalex.org/W1555545406","https://openalex.org/W1561167748","https://openalex.org/W1563426329","https://openalex.org/W1567844991","https://openalex.org/W1573543146","https://openalex.org/W1580814042","https://openalex.org/W1588885776","https://openalex.org/W1605140772","https://openalex.org/W1625660792","https://openalex.org/W1967163539","https://openalex.org/W1970403529","https://openalex.org/W1990338613","https://openalex.org/W1997516806","https://openalex.org/W2000209787","https://openalex.org/W2011447940","https://openalex.org/W2025105171","https://openalex.org/W2025675183","https://openalex.org/W2034627702","https://openalex.org/W2037957091","https://openalex.org/W2038961110","https://openalex.org/W2044519554","https://openalex.org/W2049510742","https://openalex.org/W2050528548","https://openalex.org/W2053377706","https://openalex.org/W2056072167","https://openalex.org/W2061802290","https://openalex.org/W2076300996","https://openalex.org/W2081877434","https://openalex.org/W2118744932","https://openalex.org/W2128635872","https://openalex.org/W2156502713","https://openalex.org/W2180080905","https://openalex.org/W4293021319"],"related_works":["https://openalex.org/W1487534034","https://openalex.org/W1982618223","https://openalex.org/W1546760200","https://openalex.org/W2045780967","https://openalex.org/W7073743252","https://openalex.org/W1654081566","https://openalex.org/W1527912425","https://openalex.org/W2000931697","https://openalex.org/W1557105861","https://openalex.org/W2090472241"],"abstract_inverted_index":{"We":[0],"have":[1],"investigated":[2],"the":[3,8,12,51,54,64,86,97,100,141,145,148],"mechanism":[4],"of":[5,7,16,22,30,32,56,58,80,88,99,113,147],"overproduction":[6],"multifunctional":[9,149],"protein":[10,34,60,82,101,150],"catalyzing":[11],"first":[13],"three":[14],"steps":[15],"UMP":[17],"biosynthesis":[18],"in":[19,26,37,53,66,83,102,129,137,151],"stable":[20],"mutants":[21,49],"Syrian":[23],"hamster":[24],"cells":[25,94],"culture.":[27],"The":[28,104],"rate":[29,55],"degradation":[31],"this":[33,59,81],"is":[35,61,72,126],"unaltered":[36],"one":[38,105],"mutant":[39,106],"cell":[40,107],"line":[41,108],"which":[42],"overproduces":[43],"it":[44],"by":[45],"118-fold.":[46],"In":[47],"all":[48],"tested,":[50],"increase":[52,65],"synthesis":[57,98,146],"equal":[62],"to":[63,95,143],"its":[67],"steady":[68,77],"state":[69,78],"concentration.":[70],"There":[71],"a":[73,114],"similar":[74],"correlation":[75],"between":[76],"levels":[79],"vivo":[84],"and":[85],"capacity":[87,142],"polysomal":[89,115],"RNA":[90,117,135],"isolated":[91],"from":[92],"these":[93],"direct":[96,144],"vitro.":[103,152],"studied":[109],"contains":[110],"large":[111,134],"amounts":[112],"poly(A)-containing":[116],"(Mr":[118],"=":[119],"2.7":[120],"+/-":[121],"0.2":[122],"times":[123],"10(6))":[124],"that":[125],"not":[127],"detected":[128],"wild":[130],"type":[131],"cells.":[132],"This":[133],"co-sediments":[136],"sucrose":[138],"gradients":[139],"with":[140]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
