{"id":"https://openalex.org/W1600465483","doi":null,"title":"TrkB and Epileptogenesis","display_name":"TrkB and Epileptogenesis","publication_year":2008,"publication_date":"2008-04-09","ids":{"openalex":"https://openalex.org/W1600465483","mag":"1600465483"},"language":"en","primary_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/664","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/664","pdf_url":"http://hdl.handle.net/10161/664","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10161/664","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052162303","display_name":"Robert J. Kotloski","orcid":"https://orcid.org/0000-0003-0612-2255","observed_orcids":["https://orcid.org/0000-0003-0612-2255"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Robert J. Kotloski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0612-2255","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5052162303"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trkb","display_name":"TrkB","score":0.8650000095367432},{"id":"https://openalex.org/keywords/epileptogenesis","display_name":"epileptogenesis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.7580000162124634},{"id":"https://openalex.org/keywords/neurotrophins","display_name":"neurotrophins","score":0.9120000004768372},{"id":"https://openalex.org/keywords/kindling","display_name":"kindling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.953000009059906},{"id":"https://openalex.org/keywords/limbic-epilepsy","display_name":"limbic epilepsy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/hyperexcitability","display_name":"hyperexcitability","score":0.8190000057220459},{"id":"https://openalex.org/keywords/conditional-gene-deletion","display_name":"conditional gene deletion","score":0.5669999718666077},{"id":"https://openalex.org/keywords/pilocarpine","display_name":"pilocarpine","score":0.6980000138282776},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C57236427","wikidata":"https://www.wikidata.org/wiki/Q5382987","display_name":"Epileptogenesis","level":3,"score":0.8950678110122681},{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.4408303201198578},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3767527937889099},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.31391847133636475},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3138504922389984},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.12452870607376099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12436828017234802},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.057141512632369995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05255335569381714},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dukespace.lib.duke.edu:10161/664","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/664","pdf_url":"http://hdl.handle.net/10161/664","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:1600465483","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/handle/10161/664","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dukespace.lib.duke.edu:10161/664","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10161/664","pdf_url":"http://hdl.handle.net/10161/664","source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1600465483.pdf","grobid_xml":"https://content.openalex.org/works/W1600465483.grobid-xml"},"referenced_works_count":225,"referenced_works":["https://openalex.org/W170973748","https://openalex.org/W1517738240","https://openalex.org/W1527035699","https://openalex.org/W1561828919","https://openalex.org/W1573130913","https://openalex.org/W1574757902","https://openalex.org/W1575167357","https://openalex.org/W1625740378","https://openalex.org/W1648996761","https://openalex.org/W1742407721","https://openalex.org/W1768274470","https://openalex.org/W1850032865","https://openalex.org/W1910034899","https://openalex.org/W1921573595","https://openalex.org/W1942924653","https://openalex.org/W1963730891","https://openalex.org/W1966100684","https://openalex.org/W1966224996","https://openalex.org/W1967934002","https://openalex.org/W1969313300","https://openalex.org/W1969408505","https://openalex.org/W1970669095","https://openalex.org/W1971156703","https://openalex.org/W1971263143","https://openalex.org/W1971368098","https://openalex.org/W1972696506","https://openalex.org/W1973372962","https://openalex.org/W1973629131","https://openalex.org/W1973918689","https://openalex.org/W1974568737","https://openalex.org/W1975479827","https://openalex.org/W1975911537","https://openalex.org/W1976388593","https://openalex.org/W1979305117","https://openalex.org/W1979306444","https://openalex.org/W1979496428","https://openalex.org/W1984726790","https://openalex.org/W1984929819","https://openalex.org/W1987250310","https://openalex.org/W1987757645","https://openalex.org/W1987968465","https://openalex.org/W1989867719","https://openalex.org/W1990383598","https://openalex.org/W1990906839","https://openalex.org/W1991545156","https://openalex.org/W1993067806","https://openalex.org/W1995374378","https://openalex.org/W1995460856","https://openalex.org/W1996620432","https://openalex.org/W1997123576","https://openalex.org/W1999775510","https://openalex.org/W2000079550","https://openalex.org/W2000540402","https://openalex.org/W2002073425","https://openalex.org/W2004670058","https://openalex.org/W2005873273","https://openalex.org/W2006516773","https://openalex.org/W2009074935","https://openalex.org/W2009093172","https://openalex.org/W2011846968","https://openalex.org/W2011965698","https://openalex.org/W2012825989","https://openalex.org/W2013137971","https://openalex.org/W2013436215","https://openalex.org/W2015911535","https://openalex.org/W2016392763","https://openalex.org/W2017442183","https://openalex.org/W2017452733","https://openalex.org/W2019884656","https://openalex.org/W2021421941","https://openalex.org/W2021497853","https://openalex.org/W2023390598","https://openalex.org/W2023715580","https://openalex.org/W2024014699","https://openalex.org/W2024550853","https://openalex.org/W2027423193","https://openalex.org/W2028772150","https://openalex.org/W2029712849","https://openalex.org/W2029863311","https://openalex.org/W2031272200","https://openalex.org/W2032679087","https://openalex.org/W2033195474","https://openalex.org/W2033333756","https://openalex.org/W2033983053","https://openalex.org/W2036467957","https://openalex.org/W2038465691","https://openalex.org/W2038702076","https://openalex.org/W2040089579","https://openalex.org/W2040851668","https://openalex.org/W2041190857","https://openalex.org/W2042742511","https://openalex.org/W2043015557","https://openalex.org/W2045221948","https://openalex.org/W2046566670","https://openalex.org/W2048139403","https://openalex.org/W2050389368","https://openalex.org/W2050677374","https://openalex.org/W2051805503","https://openalex.org/W2052223075","https://openalex.org/W2052357631","https://openalex.org/W2053287079","https://openalex.org/W2054745107","https://openalex.org/W2056179104","https://openalex.org/W2056605466","https://openalex.org/W2056741090","https://openalex.org/W2058433936","https://openalex.org/W2058650902","https://openalex.org/W2058861807","https://openalex.org/W2060590276","https://openalex.org/W2061335061","https://openalex.org/W2062910236","https://openalex.org/W2063024365","https://openalex.org/W2063466487","https://openalex.org/W2063695629","https://openalex.org/W2063796705","https://openalex.org/W2064378491","https://openalex.org/W2065021869","https://openalex.org/W2065098417","https://openalex.org/W2065323876","https://openalex.org/W2068948696","https://openalex.org/W2069259673","https://openalex.org/W2069312841","https://openalex.org/W2069399898","https://openalex.org/W2069507189","https://openalex.org/W2070950696","https://openalex.org/W2073518596","https://openalex.org/W2073611916","https://openalex.org/W2074698464","https://openalex.org/W2075830803","https://openalex.org/W2076302671","https://openalex.org/W2076843536","https://openalex.org/W2077012261","https://openalex.org/W2077369265","https://openalex.org/W2077772823","https://openalex.org/W2078035790","https://openalex.org/W2078333644","https://openalex.org/W2079055832","https://openalex.org/W2079472132","https://openalex.org/W2081975691","https://openalex.org/W2082815510","https://openalex.org/W2083310100","https://openalex.org/W2083466698","https://openalex.org/W2084031564","https://openalex.org/W2084773215","https://openalex.org/W2085131134","https://openalex.org/W2087519172","https://openalex.org/W2090204265","https://openalex.org/W2091092254","https://openalex.org/W2092543304","https://openalex.org/W2092910148","https://openalex.org/W2093089884","https://openalex.org/W2093238337","https://openalex.org/W2093320992","https://openalex.org/W2093842873","https://openalex.org/W2096448639","https://openalex.org/W2096695182","https://openalex.org/W2097783529","https://openalex.org/W2098036830","https://openalex.org/W2099762599","https://openalex.org/W2100901337","https://openalex.org/W2102353290","https://openalex.org/W2102501457","https://openalex.org/W2102610315","https://openalex.org/W2103024352","https://openalex.org/W2103350456","https://openalex.org/W2103580807","https://openalex.org/W2103946141","https://openalex.org/W2107564230","https://openalex.org/W2108188100","https://openalex.org/W2108286207","https://openalex.org/W2111141909","https://openalex.org/W2113122815","https://openalex.org/W2113313348","https://openalex.org/W2114216374","https://openalex.org/W2118277088","https://openalex.org/W2119222668","https://openalex.org/W2122127855","https://openalex.org/W2122630126","https://openalex.org/W2123216119","https://openalex.org/W2124486647","https://openalex.org/W2128491503","https://openalex.org/W2128676313","https://openalex.org/W2128988164","https://openalex.org/W2129356204","https://openalex.org/W2129455633","https://openalex.org/W2130297832","https://openalex.org/W2130417276","https://openalex.org/W2130464434","https://openalex.org/W2131221732","https://openalex.org/W2131993276","https://openalex.org/W2133093591","https://openalex.org/W2133396632","https://openalex.org/W2138497185","https://openalex.org/W2138730880","https://openalex.org/W2139565721","https://openalex.org/W2145079470","https://openalex.org/W2145564483","https://openalex.org/W2145926386","https://openalex.org/W2146252992","https://openalex.org/W2146909965","https://openalex.org/W2151260972","https://openalex.org/W2152099367","https://openalex.org/W2153279852","https://openalex.org/W2154380548","https://openalex.org/W2154409965","https://openalex.org/W2154684087","https://openalex.org/W2155585976","https://openalex.org/W2157616236","https://openalex.org/W2157784361","https://openalex.org/W2158436381","https://openalex.org/W2160789742","https://openalex.org/W2164658118","https://openalex.org/W2164730488","https://openalex.org/W2165418107","https://openalex.org/W2166447911","https://openalex.org/W2171661590","https://openalex.org/W2173317214","https://openalex.org/W2395178461","https://openalex.org/W2417584253","https://openalex.org/W2476906586","https://openalex.org/W2488179669","https://openalex.org/W2698750706","https://openalex.org/W2908594935","https://openalex.org/W3133772728","https://openalex.org/W7097093313"],"related_works":["https://openalex.org/W2052223075","https://openalex.org/W2082337120","https://openalex.org/W2078385314","https://openalex.org/W2137782013","https://openalex.org/W4401032287","https://openalex.org/W2928040144","https://openalex.org/W4408596399","https://openalex.org/W2966449460","https://openalex.org/W2080576899","https://openalex.org/W2973490751"],"abstract_inverted_index":{"Discovering":[0],"the":[1,7,10,17,39,53,57,78,87,91,112,126,150,165,185,205,222,264,281,289,305,319],"cellular":[2],"and":[3,24,30,118,172,315],"molecular":[4,274],"mechanisms":[5],"underlying":[6,9],"pathophysiology":[8],"development":[11],"of":[12,19,71,75,99,125,139,145,176,180,184,202,243,259,286,294,318,330,340],"epilepsy":[13,321,332],"is":[14,61,190,255],"key":[15],"to":[16,35,93,160,231,271,312,333],"creation":[18],"improved":[20],"treatments.":[21],"The":[22,49,153],"neurotrophins":[23],"their":[25],"receptors,":[26],"in":[27,38,52,65,67,77,86,103,111,204,214,266,280,288,298,322],"particular":[28],"BDNF":[29],"TrkB,":[31],"are":[32],"likely":[33],"candidates":[34],"be":[36,272],"involved":[37],"process":[40],"by":[41,195],"which":[42],"a":[43,62,95,191,273,299,334],"normal":[44],"brain":[45],"becomes":[46],"epileptic":[47],"(epileptogenesis).":[48],"work":[50],"presented":[51],"dissertation":[54,268],"has":[55],"investigated":[56],"hypothesis":[58],"that":[59,174,252],"TrkB":[60,76,100,140,162,177,203,244,253,270],"central":[63],"factor":[64],"epileptogenesis":[66,85,110,279],"multiple":[68],"animal":[69],"models":[70],"epilepsy.":[72],"Conditional":[73,200],"deletion":[74,201],"Syn-Cre":[79,116,206,223],"TrkB-/-":[80,106,120,207,224],"mouse":[81],"prevented":[82],"nearly":[83],"all":[84],"kindling":[88,113,146,181,282,290],"model,":[89],"despite":[90],"ability":[92],"have":[94],"tonic-clonic":[96],"seizure.":[97],"Reduction":[98],"de":[101],"novo":[102],"mature":[104],"Act-CreER":[105,119,155],"mice":[107,121,157,208,217,225],"also":[108,227],"delayed":[109],"model.":[114,301],"Additionally,":[115],"TrkB+/-":[117],"had":[122,169],"impaired":[123,151],"persistence":[124,183,258,285,293],"hyperexcitable":[127,186],"state":[128,168],"following":[129,143,218,233],"kindling.":[130],"It":[131],"remained":[132],"unclear":[133],"from":[134],"these":[135,249],"findings":[136,250,265],"whether":[137],"reduction":[138],"during":[141,246],"and/or":[142],"induction":[144],"was":[147],"responsible":[148],"for":[149,257,307],"persistence.":[152],"inducible":[154],"TrkBflox/flox":[156],"were":[158],"used":[159],"reduce":[161],"only":[163],"after":[164,178],"fully":[166],"kindled":[167],"been":[170],"reached":[171],"demonstrated":[173],"loss":[175],"completion":[179],"impairs":[182],"state.":[187],"Status":[188],"epilepticus":[189,235,297],"medical":[192],"emergency":[193],"defined":[194],"prolonged":[196],"continuous":[197],"seizure":[198,211],"activity.":[199],"prevents":[209],"sustained":[210],"activity":[212],"evident":[213],"wild":[215],"type":[216],"pilocarpine":[219],"injection.":[220],"Furthermore,":[221],"may":[226],"retain":[228],"greater":[229],"sensitivity":[230],"diazepam":[232],"status":[234,247,260,296,348],"than":[236],"control":[237],"mice.":[238],"Together":[239],"with":[240],"biochemical":[241],"evidence":[242],"activation":[245,254],"epilepticus,":[248],"suggest":[251],"required":[256],"epilepticus.":[261,349],"In":[262],"conclusion,":[263],"this":[267],"demonstrate":[269],"mechanism":[275],"critical":[276],"for:":[277],"1)":[278,327],"model;":[283,291],"2)":[284,338],"hyperexcitability":[287],"3)":[292,345],"limbic":[295,320,331,343],"chemoconvulsant":[300],"These":[302,324],"discoveries":[303],"provide":[304],"basis":[306],"developing":[308],"novel":[309],"therapeutic":[310],"approaches":[311],"three":[313],"distinct":[314],"devastating":[316],"aspects":[317,325],"humans.":[323],"are:":[326],"preventing":[328],"progression":[329],"medically":[335,341,346],"refractory":[336,342,347],"state;":[337],"reversal":[339],"epilepsy;":[344]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
