{"id":"https://openalex.org/W1600439587","doi":null,"title":"Non-transferrin-bound iron in hematopoietic stem cell transplantation","display_name":"Non-transferrin-bound iron in hematopoietic stem cell transplantation","publication_year":2015,"publication_date":"2015-05-22","ids":{"openalex":"https://openalex.org/W1600439587","mag":"1600439587"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/154444","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/154444","pdf_url":"http://hdl.handle.net/10138/154444","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/154444","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062176706","display_name":"Leila Sahlstedt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Leila Sahlstedt","raw_affiliation_strings":["Hematologian yksikk\u00f6"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematologian yksikk\u00f6","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5062176706"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9672999978065491,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-transferrin-bound-iron","display_name":"non-transferrin-bound iron","score":0.996999979019165},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/apotransferrin","display_name":"apotransferrin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/transferrin-saturation","display_name":"transferrin saturation","score":0.9459999799728394},{"id":"https://openalex.org/keywords/iron-overload","display_name":"iron overload","score":0.6240000128746033},{"id":"https://openalex.org/keywords/oxygen-free-radicals","display_name":"oxygen free radicals","score":0.6579999923706055},{"id":"https://openalex.org/keywords/allogeneic-transplantation","display_name":"allogeneic transplantation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/autologous-transplantation","display_name":"autologous transplantation","score":1.0},{"id":"https://openalex.org/keywords/conditioning-regimen","display_name":"conditioning regimen","score":0.5339999794960022},{"id":"https://openalex.org/keywords/bone-marrow-recovery","display_name":"bone marrow recovery","score":0.7590000033378601},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/iron-utilization","display_name":"iron utilization","score":0.5509999990463257},{"id":"https://openalex.org/keywords/iron-chelation","display_name":"iron chelation","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.6284474730491638},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5835429430007935},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5420374274253845},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5285704731941223},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.5102581977844238},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39609235525131226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3170297145843506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2934746742248535},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2598414421081543},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20274996757507324}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/154444","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/154444","pdf_url":"http://hdl.handle.net/10138/154444","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1600439587","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/handle/10138/154444/NONTRANSFE.pdf;sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/154444","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/154444","pdf_url":"http://hdl.handle.net/10138/154444","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1600439587.pdf","grobid_xml":"https://content.openalex.org/works/W1600439587.grobid-xml"},"referenced_works_count":235,"referenced_works":["https://openalex.org/W30458867","https://openalex.org/W78248770","https://openalex.org/W79989733","https://openalex.org/W100722149","https://openalex.org/W105261860","https://openalex.org/W114062130","https://openalex.org/W125730286","https://openalex.org/W129483669","https://openalex.org/W153121858","https://openalex.org/W158899810","https://openalex.org/W268116559","https://openalex.org/W294430918","https://openalex.org/W626873401","https://openalex.org/W1489844805","https://openalex.org/W1500296017","https://openalex.org/W1501011194","https://openalex.org/W1509880727","https://openalex.org/W1510811131","https://openalex.org/W1518667052","https://openalex.org/W1575133603","https://openalex.org/W1595702568","https://openalex.org/W1734082729","https://openalex.org/W1761222131","https://openalex.org/W1827150386","https://openalex.org/W1832182760","https://openalex.org/W1837160055","https://openalex.org/W1859053864","https://openalex.org/W1896686116","https://openalex.org/W1899319059","https://openalex.org/W1917695900","https://openalex.org/W1928298896","https://openalex.org/W1935306343","https://openalex.org/W1952193752","https://openalex.org/W1963924913","https://openalex.org/W1964783819","https://openalex.org/W1965479004","https://openalex.org/W1966634667","https://openalex.org/W1967684793","https://openalex.org/W1967932437","https://openalex.org/W1969935717","https://openalex.org/W1970038366","https://openalex.org/W1970142391","https://openalex.org/W1972647898","https://openalex.org/W1972909206","https://openalex.org/W1973122898","https://openalex.org/W1973938903","https://openalex.org/W1976659843","https://openalex.org/W1977477477","https://openalex.org/W1979601721","https://openalex.org/W1979864553","https://openalex.org/W1980042430","https://openalex.org/W1981407334","https://openalex.org/W1981757167","https://openalex.org/W1983658905","https://openalex.org/W1984780486","https://openalex.org/W1985482871","https://openalex.org/W1988141641","https://openalex.org/W1992054309","https://openalex.org/W1992773264","https://openalex.org/W1992880469","https://openalex.org/W1993027982","https://openalex.org/W1993332017","https://openalex.org/W1995603249","https://openalex.org/W1996179075","https://openalex.org/W1996648139","https://openalex.org/W1997846723","https://openalex.org/W1998050599","https://openalex.org/W1999203566","https://openalex.org/W1999450971","https://openalex.org/W2001343095","https://openalex.org/W2003437918","https://openalex.org/W2005153221","https://openalex.org/W2005894414","https://openalex.org/W2006046265","https://openalex.org/W2006358233","https://openalex.org/W2006525603","https://openalex.org/W2007353459","https://openalex.org/W2007379541","https://openalex.org/W2007914124","https://openalex.org/W2009711648","https://openalex.org/W2011416297","https://openalex.org/W2012136328","https://openalex.org/W2012153513","https://openalex.org/W2012723575","https://openalex.org/W2013501828","https://openalex.org/W2014290287","https://openalex.org/W2014365717","https://openalex.org/W2014938358","https://openalex.org/W2015825307","https://openalex.org/W2016501571","https://openalex.org/W2017467835","https://openalex.org/W2017915278","https://openalex.org/W2018893405","https://openalex.org/W2019742598","https://openalex.org/W2021497905","https://openalex.org/W2021742570","https://openalex.org/W2023208774","https://openalex.org/W2025063713","https://openalex.org/W2025925747","https://openalex.org/W2026566972","https://openalex.org/W2027847278","https://openalex.org/W2027853843","https://openalex.org/W2028034405","https://openalex.org/W2028528508","https://openalex.org/W2029683748","https://openalex.org/W2029797310","https://openalex.org/W2032744416","https://openalex.org/W2032892073","https://openalex.org/W2033586673","https://openalex.org/W2034328820","https://openalex.org/W2035670156","https://openalex.org/W2036608644","https://openalex.org/W2037588183","https://openalex.org/W2038282096","https://openalex.org/W2038487176","https://openalex.org/W2039397645","https://openalex.org/W2040072456","https://openalex.org/W2040449770","https://openalex.org/W2042083701","https://openalex.org/W2044592505","https://openalex.org/W2048881932","https://openalex.org/W2048961365","https://openalex.org/W2049619475","https://openalex.org/W2051250762","https://openalex.org/W2051875442","https://openalex.org/W2052605694","https://openalex.org/W2054895606","https://openalex.org/W2055617596","https://openalex.org/W2056149198","https://openalex.org/W2056360848","https://openalex.org/W2058106195","https://openalex.org/W2060112237","https://openalex.org/W2060222877","https://openalex.org/W2062163666","https://openalex.org/W2062742764","https://openalex.org/W2063540908","https://openalex.org/W2065902356","https://openalex.org/W2066350453","https://openalex.org/W2066875574","https://openalex.org/W2068337287","https://openalex.org/W2069968835","https://openalex.org/W2070299813","https://openalex.org/W2070853296","https://openalex.org/W2071068942","https://openalex.org/W2075604428","https://openalex.org/W2076614074","https://openalex.org/W2078062413","https://openalex.org/W2079308680","https://openalex.org/W2079334618","https://openalex.org/W2081087037","https://openalex.org/W2081945798","https://openalex.org/W2082318444","https://openalex.org/W2083017360","https://openalex.org/W2085831946","https://openalex.org/W2086224778","https://openalex.org/W2086531744","https://openalex.org/W2087450601","https://openalex.org/W2087503863","https://openalex.org/W2087666407","https://openalex.org/W2090768410","https://openalex.org/W2090897211","https://openalex.org/W2092225509","https://openalex.org/W2094683614","https://openalex.org/W2095232221","https://openalex.org/W2095979534","https://openalex.org/W2096580066","https://openalex.org/W2097534024","https://openalex.org/W2100686679","https://openalex.org/W2107423980","https://openalex.org/W2107623076","https://openalex.org/W2107663968","https://openalex.org/W2107894900","https://openalex.org/W2107925558","https://openalex.org/W2108344872","https://openalex.org/W2111004784","https://openalex.org/W2111426991","https://openalex.org/W2112225163","https://openalex.org/W2112756201","https://openalex.org/W2113462770","https://openalex.org/W2115464590","https://openalex.org/W2117997453","https://openalex.org/W2121844342","https://openalex.org/W2123479244","https://openalex.org/W2124170472","https://openalex.org/W2127855419","https://openalex.org/W2127975197","https://openalex.org/W2129422969","https://openalex.org/W2129961000","https://openalex.org/W2132155262","https://openalex.org/W2132899947","https://openalex.org/W2136575529","https://openalex.org/W2138213276","https://openalex.org/W2140582054","https://openalex.org/W2142493118","https://openalex.org/W2143105570","https://openalex.org/W2143598267","https://openalex.org/W2148254919","https://openalex.org/W2150965624","https://openalex.org/W2151091220","https://openalex.org/W2151795682","https://openalex.org/W2152599602","https://openalex.org/W2153215336","https://openalex.org/W2154037033","https://openalex.org/W2158670179","https://openalex.org/W2159817884","https://openalex.org/W2160125069","https://openalex.org/W2161998284","https://openalex.org/W2162587350","https://openalex.org/W2162635058","https://openalex.org/W2163235960","https://openalex.org/W2164273932","https://openalex.org/W2168302119","https://openalex.org/W2169983938","https://openalex.org/W2170885365","https://openalex.org/W2171369601","https://openalex.org/W2172182806","https://openalex.org/W2176262851","https://openalex.org/W2186107572","https://openalex.org/W2234963596","https://openalex.org/W2267695900","https://openalex.org/W2268395224","https://openalex.org/W2270579673","https://openalex.org/W2315616170","https://openalex.org/W2315811017","https://openalex.org/W2318456157","https://openalex.org/W2328568398","https://openalex.org/W2329706435","https://openalex.org/W2335701371","https://openalex.org/W2336969242","https://openalex.org/W2339394139","https://openalex.org/W2399378246","https://openalex.org/W2460460879","https://openalex.org/W2600913486","https://openalex.org/W3148765499","https://openalex.org/W3191023531"],"related_works":["https://openalex.org/W1978449294","https://openalex.org/W2036798182","https://openalex.org/W2980084694","https://openalex.org/W2086224778","https://openalex.org/W2089049808","https://openalex.org/W4386024620","https://openalex.org/W2024847667","https://openalex.org/W2562704554","https://openalex.org/W2624368313","https://openalex.org/W7099384152"],"abstract_inverted_index":{"Hematopoietic":[0],"stem":[1],"cell":[2],"transplantation":[3,242,426],"(HSCT)":[4],"is":[5,24,222],"an":[6,18,188],"intensive":[7],"treatment":[8],"often":[9],"complicated":[10],"by":[11,54,138,230,240,315,413],"organ":[12],"injuries.":[13],"Non-transferrin-bound":[14],"iron":[15,229],"(NTBI),":[16],"as":[17],"inducer":[19],"of":[20,31,40,52,90,102,105,116,134,182,193,200,209,220,228,235,251,281,297,312,329,366,375,388,406,419],"free":[21],"oxygen":[22],"radicals,":[23],"a":[25,120,156,268,349],"potential":[26],"factor":[27],"in":[28,42,70,73,93,162,359,432],"the":[29,36,46,50,67,82,85,91,97,100,103,113,132,163,170,173,180,183,191,201,207,210,218,233,241,249,255,261,279,283,310,330,334,341,363,372,384,404,416,423],"pathogenesis":[30],"these":[32],"complications.":[33],"We":[34,60,78,107],"studied":[35],"appearance":[37,98,133,192,405],"and":[38,45,75,88,96,99,111,131,232,371,422],"timing":[39,87],"NTBI":[41,53,63,135,145,202,221,245,259,276,338,367,377,389,407],"transplant":[43],"patients":[44,292,332],"possibility":[47,256,385],"to":[48,118,172,186,225,248,257,325,396,429],"prevent":[49],"occurrence":[51],"binding":[55,376,387],"it":[56],"with":[57,206,264,355,378,390],"apotransferrin":[58,265,270,298,379,392,420],"administration.":[59],"showed":[61,402],"that":[62,217,386,403],"appears":[64],"regularly":[65],"during":[66,260],"peritransplantation":[68],"period":[69,263],"HSCT,":[71,252],"both":[72],"allogeneic":[74,126],"autologous":[76,154],"transplantation.":[77],"could":[79,108,408],"demonstrate,":[80],"for":[81,123,150,169],"first":[83,171],"time,":[84],"exact":[86],"duration":[89],"changes":[92],"transferrin":[94,117,130,164,237],"saturation":[95,115],"length":[101],"presence":[104,219],"NTBI.":[106,124,194,357],"also":[109],"show":[110],"confirm":[112],"80%":[114],"be":[119,397,409,430],"reliable":[121],"threshold":[122],"In":[125,153],"HSCT":[127,142,155],"fully":[128],"saturated":[129],"was":[136,146,160,177,348],"observed":[137],"day":[139,274,320,323,326],"-4":[140],"before":[141],"(day":[143],"0).":[144],"detectable":[147],"on":[148,190,273,368,380,425],"average":[149],"14":[151],"days.":[152],"similar":[157],"steep":[158],"rise":[159],"found":[161],"saturation.":[165],"The":[166,195,303],"mean":[167],"time":[168],"last":[174],"NTBI-positive":[175],"samples":[176,204],"6.1":[178],"days,":[179],"intensity":[181],"conditioning":[184],"seemed":[185],"have":[187],"effect":[189,365,374],"disappearance":[196],"or":[197,411],"marked":[198],"reduction":[199,234],"positive":[203],"coincided":[205],"recovery":[208],"bone":[211],"marrow":[212],"function.":[213],"Our":[214,358,400],"studies":[215,401],"indicate":[216],"largely":[223],"due":[224],"reduced":[226,412],"utilization":[227],"erythropoiesis":[231],"serum":[236],"levels":[238],"caused":[239],"process.":[243],"As":[244],"might":[246],"contribute":[247],"complications":[250],"we":[253],"assessed":[254],"bind":[258],"peritransplant":[262],"infusions.":[266],"With":[267,344],"single":[269],"dose":[271,301,336],"given":[272,294,308,321,333],"+3":[275],"disappeared":[277],"from":[278],"sera":[280],"all":[282],"six":[284],"patients,":[285],"but":[286],"reappeared":[287],"12-24":[288],"hours":[289],"later.":[290],"Twenty":[291],"were":[293,307,337],"repeated":[295],"doses":[296,306,317,346],"at":[299,309],"three":[300],"levels.":[302],"daily":[304],"loading":[305],"start":[311],"conditioning,":[313],"followed":[314],"maintenance":[316],"every":[318],"other":[319],"until":[322],"+7":[324],"+13.":[327],"Five":[328],"eight":[331],"highest":[335],"negative":[339],"through":[340],"study":[342,361],"period.":[343],"lower":[345],"there":[347],"nonsignificant":[350],"trend":[351],"towards":[352],"fewer":[353],"days":[354],"demonstrable":[356],"vitro":[360],"demonstrating":[362],"toxic":[364],"hematopoietic":[369],"progenitors":[370],"beneficial":[373],"colony":[381],"growth":[382],"supports":[383],"exogenous":[391],"may":[393],"turn":[394],"out":[395],"clinically":[398],"useful.":[399],"prevented":[410],"apotransferrin.":[414],"However,":[415],"clinical":[417],"utility":[418],"administration":[421],"effects":[424],"outcomes":[427],"remain":[428],"investigated":[431],"further":[433],"studies.":[434]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}