{"id":"https://openalex.org/W1600433572","doi":"https://doi.org/10.1046/j.1365-313x.2001.01058.x","title":"A deficiency of coproporphyrinogen III oxidase causes lesion formation in Arabidopsis","display_name":"A deficiency of coproporphyrinogen III oxidase causes lesion formation in Arabidopsis","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W1600433572","doi":"https://doi.org/10.1046/j.1365-313x.2001.01058.x","mag":"1600433572","pmid":"https://pubmed.ncbi.nlm.nih.gov/11489187"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-313x.2001.01058.x","doi":"https://doi.org/10.1046/j.1365-313x.2001.01058.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2001.01058.x","pdf_url":null,"source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Atsushi Ishikawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94422183","display_name":"Fukui Prefectural University","ror":"https://ror.org/02c3vg160","country_code":"JP","type":"education","lineage":["https://openalex.org/I94422183"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Atsushi Ishikawa","raw_affiliation_strings":["Department of Bioscience, Fukui Prefectural University, Fukui 910-1195, Japan. ishikawa@fpu.ac.jp","Department of Bioscience, Fukui Prefectural University, Fukui 910-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience, Fukui Prefectural University, Fukui 910-1195, Japan. ishikawa@fpu.ac.jp","institution_ids":["https://openalex.org/I94422183"]},{"raw_affiliation_string":"Department of Bioscience, Fukui Prefectural University, Fukui 910-1195, Japan","institution_ids":["https://openalex.org/I94422183"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hiroki Okamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94422183","display_name":"Fukui Prefectural University","ror":"https://ror.org/02c3vg160","country_code":"JP","type":"education","lineage":["https://openalex.org/I94422183"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Okamoto","raw_affiliation_strings":["Department of Bioscience, Fukui Prefectural University, Fukui 910\u20131195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience, Fukui Prefectural University, Fukui 910\u20131195, Japan","institution_ids":["https://openalex.org/I94422183"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109211004","display_name":"Yukimoto Iwasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94422183","display_name":"Fukui Prefectural University","ror":"https://ror.org/02c3vg160","country_code":"JP","type":"education","lineage":["https://openalex.org/I94422183"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukimoto Iwasaki","raw_affiliation_strings":["Department of Bioscience, Fukui Prefectural University, Fukui 910\u20131195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience, Fukui Prefectural University, Fukui 910\u20131195, Japan","institution_ids":["https://openalex.org/I94422183"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076564955","display_name":"Tadashi Asahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I94422183","display_name":"Fukui Prefectural University","ror":"https://ror.org/02c3vg160","country_code":"JP","type":"education","lineage":["https://openalex.org/I94422183"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Asahi","raw_affiliation_strings":["Department of Bioscience, Fukui Prefectural University, Fukui 910\u20131195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience, Fukui Prefectural University, Fukui 910\u20131195, Japan","institution_ids":["https://openalex.org/I94422183"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I94422183"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":8.0798,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.97165454,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"27","issue":"2","first_page":"89","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.08110000193119049,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12441","display_name":"Porphyrin Metabolism and Disorders","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coproporphyrinogen-iii-oxidase","display_name":"coproporphyrinogen III oxidase","score":0.996999979019165},{"id":"https://openalex.org/keywords/lesion-formation","display_name":"lesion formation","score":0.675000011920929},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tetrapyrrole-biosynthesis","display_name":"tetrapyrrole biosynthesis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/chlorophyll-biosynthesis","display_name":"chlorophyll biosynthesis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/heme-biosynthesis","display_name":"heme biosynthesis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/plant-defense-response","display_name":"plant defense response","score":0.7680000066757202},{"id":"https://openalex.org/keywords/salicylic-acid","display_name":"salicylic acid","score":0.9760000109672546},{"id":"https://openalex.org/keywords/salicylate-hydroxylase","display_name":"salicylate hydroxylase","score":0.890999972820282},{"id":"https://openalex.org/keywords/t-dna-tagging","display_name":"T-DNA tagging","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C2779491563","wikidata":"https://www.wikidata.org/wiki/Q157892","display_name":"Arabidopsis","level":4,"score":0.9330581426620483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.693002462387085},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6914883852005005},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.6001540422439575},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.575867772102356},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4767652153968811},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.4760589301586151},{"id":"https://openalex.org/C38485361","wikidata":"https://www.wikidata.org/wiki/Q576379","display_name":"Oxidase test","level":3,"score":0.4688348174095154},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38771161437034607},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38090333342552185},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2520751953125},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2249646782875061},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0873032808303833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05765339732170105}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003304","descriptor_name":"Coproporphyrinogen Oxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003304","descriptor_name":"Coproporphyrinogen Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006899","descriptor_name":"Mixed Function Oxygenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020156","descriptor_name":"Salicylic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-313x.2001.01058.x","doi":"https://doi.org/10.1046/j.1365-313x.2001.01058.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-313x.2001.01058.x","pdf_url":null,"source":{"id":"https://openalex.org/S67862205","display_name":"The Plant Journal","issn_l":"0960-7412","issn":["0960-7412","1365-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Journal","raw_type":"journal-article"},{"id":"pmid:11489187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11489187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant journal : for cell and molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W209234419","https://openalex.org/W647314868","https://openalex.org/W1500849587","https://openalex.org/W1501460217","https://openalex.org/W1505415013","https://openalex.org/W1533664250","https://openalex.org/W1550007121","https://openalex.org/W1591755907","https://openalex.org/W1768641177","https://openalex.org/W1904968063","https://openalex.org/W1968376538","https://openalex.org/W1969676666","https://openalex.org/W1973157170","https://openalex.org/W1974954117","https://openalex.org/W1974980101","https://openalex.org/W1980665099","https://openalex.org/W1984100427","https://openalex.org/W1985014052","https://openalex.org/W1987003587","https://openalex.org/W1989046023","https://openalex.org/W1995554288","https://openalex.org/W1995764868","https://openalex.org/W2005653200","https://openalex.org/W2015093208","https://openalex.org/W2016657576","https://openalex.org/W2022738681","https://openalex.org/W2034125381","https://openalex.org/W2047386729","https://openalex.org/W2052602128","https://openalex.org/W2060298898","https://openalex.org/W2061370033","https://openalex.org/W2066658921","https://openalex.org/W2070038134","https://openalex.org/W2071504725","https://openalex.org/W2075370277","https://openalex.org/W2075666993","https://openalex.org/W2090083319","https://openalex.org/W2107965229","https://openalex.org/W2108931188","https://openalex.org/W2110012461","https://openalex.org/W2116122104","https://openalex.org/W2119735766","https://openalex.org/W2120786757","https://openalex.org/W2124076710","https://openalex.org/W2127375043","https://openalex.org/W2130819115","https://openalex.org/W2140554168","https://openalex.org/W2144103371","https://openalex.org/W2154103687","https://openalex.org/W2154606961","https://openalex.org/W2154990138","https://openalex.org/W2159839606","https://openalex.org/W2164671653","https://openalex.org/W2165462764","https://openalex.org/W2166717297","https://openalex.org/W2166930316","https://openalex.org/W2247660488","https://openalex.org/W2415245373","https://openalex.org/W2499457821","https://openalex.org/W4230572931","https://openalex.org/W4247934961","https://openalex.org/W4251065958"],"related_works":["https://openalex.org/W2142311222","https://openalex.org/W2024350731","https://openalex.org/W2159839606","https://openalex.org/W7096492081","https://openalex.org/W2140554168","https://openalex.org/W4214639410","https://openalex.org/W7128775907","https://openalex.org/W2165027342","https://openalex.org/W1973157170","https://openalex.org/W2972914540"],"abstract_inverted_index":{"We":[0],"isolated":[1,40],"an":[2,134],"Arabidopsis":[3],"lesion":[4,11,97,144],"initiation":[5,98],"2":[6],"(lin2)":[7],"mutant,":[8],"which":[9,100],"develops":[10],"formation":[12,111,145],"on":[13],"leaves":[14],"and":[15,21,37,60,72,115],"siliques":[16],"in":[17,54,65,108,127,147,173],"a":[18,32,42,51,62,89],"developmentally":[19],"regulated":[20],"light-dependent":[22],"manner.":[23],"The":[24,67],"phenotype":[25],"of":[26,58,105,121,133,156,159,171],"the":[27,55,77,96,103,131,143,157,163,169],"lin2":[28,68,128,148,174],"plants":[29,69,129,149],"resulted":[30],"from":[31],"single":[33],"nuclear":[34],"recessive":[35],"mutation,":[36],"LIN2":[38,46],"was":[39,112,116,125],"by":[41,82,130],"T-DNA":[43],"tagging":[44],"approach.":[45],"encodes":[47],"coproporphyrinogen":[48],"III":[49],"oxidase,":[50],"key":[52],"enzyme":[53],"biosynthetic":[56],"pathway":[57,91],"chlorophyll":[59],"heme,":[61],"tetrapyrrole":[63],"pathway,":[64],"Arabidopsis.":[66,109],"express":[70],"cytological":[71],"molecular":[73],"markers":[74],"associated":[75],"with":[76],"defense":[78,106],"responses,":[79,107],"usually":[80],"activated":[81],"pathogen":[83],"infection.":[84],"These":[85],"results":[86],"demonstrate":[87],"that":[88,142,162],"porphyrin":[90],"impairment":[92],"is":[93,150,165],"responsible":[94],"for":[95],"phenotype,":[99],"leads":[101],"to":[102,153,167],"activation":[104],"Lesion":[110],"not":[113],"suppressed,":[114],"even":[117],"enhanced":[118],"when":[119],"accumulation":[120,158,164],"salicylic":[122],"acid":[123],"(SA)":[124],"prevented":[126],"expression":[132],"SA-degrading":[135],"salicylate":[136],"hydroxylase":[137],"(nahG)":[138],"gene.":[139],"This":[140],"suggests":[141],"triggered":[146],"determined":[151],"prior":[152],"or":[154],"independently":[155],"SA":[160],"but":[161],"required":[166],"limit":[168],"spread":[170],"lesions":[172],"plants.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}