{"id":"https://openalex.org/W1599366995","doi":"https://doi.org/10.1016/s0021-9258(19)67758-6","title":"Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B.","display_name":"Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B.","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W1599366995","doi":"https://doi.org/10.1016/s0021-9258(19)67758-6","mag":"1599366995","pmid":"https://pubmed.ncbi.nlm.nih.gov/1848237"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)67758-6","doi":"https://doi.org/10.1016/s0021-9258(19)67758-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)67758-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)67758-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109998829","display_name":"Joseph L. Dixon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Dixon","raw_affiliation_strings":["Department of Medicine College of Physicians & Surgeons Columbia University New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine College of Physicians & Surgeons Columbia University New York, New York 10032","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108456723","display_name":"S Furukawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Furukawa","raw_affiliation_strings":["Department of Medicine College of Physicians & Surgeons Columbia University New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine College of Physicians & Surgeons Columbia University New York, New York 10032","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007048045","display_name":"Henry N. Ginsberg","orcid":"https://orcid.org/0000-0002-4103-3592","observed_orcids":["https://orcid.org/0000-0002-4103-3592"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H N Ginsberg","raw_affiliation_strings":["Department of Medicine College of Physicians & Surgeons Columbia University New York, New York 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine College of Physicians & Surgeons Columbia University New York, New York 10032","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":15.3192,"has_fulltext":false,"cited_by_count":418,"citation_normalized_percentile":{"value":0.99809362,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"266","issue":"8","first_page":"5080","last_page":"5086"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.8871999979019165,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.07509999722242355,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.03370000049471855,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oleate","display_name":"oleate","score":1.0},{"id":"https://openalex.org/keywords/apolipoprotein-b","display_name":"apolipoprotein B","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lipoprotein-secretion","display_name":"lipoprotein secretion","score":0.9279999732971191},{"id":"https://openalex.org/keywords/intracellular-degradation","display_name":"intracellular degradation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/secretory-pathway","display_name":"secretory pathway","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hepg2-cells","display_name":"HepG2 cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/fatty-acids","display_name":"fatty acids","score":0.6759999990463257},{"id":"https://openalex.org/keywords/lipoprotein-synthesis","display_name":"lipoprotein synthesis","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.9317281246185303},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.8300752639770508},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.618890643119812},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42898616194725037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4246934652328491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3719884157180786},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35203492641448975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34900975227355957},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.2728292644023895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08284461498260498}],"mesh":[{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001055","descriptor_name":"Apolipoproteins B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009829","descriptor_name":"Oleic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019301","descriptor_name":"Oleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)67758-6","doi":"https://doi.org/10.1016/s0021-9258(19)67758-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)67758-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1848237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1848237","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)67758-6","doi":"https://doi.org/10.1016/s0021-9258(19)67758-6","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)67758-6","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.766700029373169,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3206633817","display_name":"LIPOPROTEINS ATHEROGENESIS AND THE ARTERIAL WALL","funder_award_id":"P50HL021006","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G495104311","display_name":"REGULATION OF APOPROTEIN B METABOLISM IN HUMANS","funder_award_id":"R01HL036000","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W58132180","https://openalex.org/W1486210853","https://openalex.org/W1489766749","https://openalex.org/W1506096423","https://openalex.org/W1515368893","https://openalex.org/W1557907146","https://openalex.org/W1588762192","https://openalex.org/W1813690525","https://openalex.org/W1909180518","https://openalex.org/W1921601722","https://openalex.org/W1956183677","https://openalex.org/W1965588273","https://openalex.org/W1976981613","https://openalex.org/W1993666911","https://openalex.org/W2006246345","https://openalex.org/W2010923530","https://openalex.org/W2011347863","https://openalex.org/W2015776407","https://openalex.org/W2016092362","https://openalex.org/W2051248831","https://openalex.org/W2052008556","https://openalex.org/W2066145112","https://openalex.org/W2068556075","https://openalex.org/W2078198093","https://openalex.org/W2079897891","https://openalex.org/W2095272104","https://openalex.org/W2100837269","https://openalex.org/W2103658595","https://openalex.org/W2104720567","https://openalex.org/W2105732728","https://openalex.org/W2109377449","https://openalex.org/W2119987270","https://openalex.org/W2146409387","https://openalex.org/W2157680057","https://openalex.org/W2184394175","https://openalex.org/W2188563156","https://openalex.org/W2402354430","https://openalex.org/W2418359101"],"related_works":["https://openalex.org/W1493788388","https://openalex.org/W1541183759","https://openalex.org/W2189012619","https://openalex.org/W1599596785","https://openalex.org/W2068512714","https://openalex.org/W1972350612","https://openalex.org/W2066614296","https://openalex.org/W2092266450","https://openalex.org/W2005211484","https://openalex.org/W1979754520"],"abstract_inverted_index":{"Studies":[0],"were":[1,88],"conducted":[2],"to":[3,31,60,204],"explore":[4],"the":[5,11,34,53,55,61,77,81,112,121,134,163,175],"effects":[6,82],"of":[7,13,36,38,57,83,114,117,131,141,165,180,192,220],"oleate":[8,23,49,71,84,153,160,214],"addition":[9],"on":[10,85],"secretion":[12,37,58,74,87,130,164,182],"apolipoprotein":[14],"B":[15],"(apoB)-containing":[16],"lipoproteins":[17],"from":[18,52,171,194],"Hep":[19],"G2":[20],"cells.":[21],"Whether":[22],"was":[24,40,50,94,100,106,124,144,154,183],"added":[25,30],"simultaneously":[26],"with":[27],"[3H]-leucine":[28],"or":[29],"prelabeled":[32],"cells,":[33,54],"rate":[35,56,63],"apoB":[39,73,86,98,103,118,132,143,166,170,181,221],"stimulated":[41],"more":[42],"than":[43],"100%":[44],"within":[45,64,126],"40":[46,65],"min.":[47,66],"When":[48,80],"withdrawn":[51],"returned":[59],"prestimulated":[62],"These":[67],"observations":[68],"suggested":[69],"that":[70,96,159,188,212],"affects":[72],"early":[75,173],"in":[76,90,174],"secretory":[78,176],"pathway.":[79,177],"studied":[89],"pulse-chase":[91],"experiments,":[92],"it":[93,157],"observed":[95,184],"although":[97],"synthesis":[99],"not":[101],"affected,":[102],"intracellular":[104],"degradation":[105,172],"significant":[107],"inhibited":[108],"by":[109,167],"oleate.":[110],"In":[111],"absence":[113],"oleate,":[115,193],"58%":[116],"synthesized":[119],"during":[120,147],"labeling":[122],"period":[123,151],"degraded":[125,145],"20":[127],"min,":[128],"before":[129],"into":[133],"media":[135],"had":[136],"begun,":[137],"whereas":[138],"only":[139],"29%":[140],"labeled":[142],"intracellularly":[146],"this":[148],"same":[149],"time":[150],"when":[152],"present.":[155],"Thus,":[156],"appears":[158],"rapidly":[161],"stimulates":[162],"protecting":[168],"nascent":[169],"Furthermore,":[178],"stimulation":[179],"over":[185],"a":[186,217],"range":[187],"includes":[189],"physiological":[190,218],"concentrations":[191],"0.1":[195],"mM":[196,206],"(oleate:":[197,207],"bovine":[198],"serum":[199],"albumin":[200],"ratio":[201,208],"=":[202,209],"0.45)":[203],"0.8":[205],"3.6),":[210],"suggesting":[211],"exogenous":[213],"could":[215],"be":[216],"modulator":[219],"secretion.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}