{"id":"https://openalex.org/W159934013","doi":null,"title":"Proteomic analysis of plasma apolipoproteins in relation to atherosclerosis","display_name":"Proteomic analysis of plasma apolipoproteins in relation to atherosclerosis","publication_year":2012,"publication_date":"2012-02-21","ids":{"openalex":"https://openalex.org/W159934013","mag":"159934013"},"language":"en","primary_location":{"id":"pmh:oai:eprints.uniss.it:6734","doi":null,"is_oa":false,"landing_page_url":"http://eprints.uniss.it/6734/1/Zinellu_E_Proteomic_analysis_of_plasma.pdf","pdf_url":"http://eprints.uniss.it/6734/1/Zinellu_E_Proteomic_analysis_of_plasma.pdf","source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://iris.uniss.it/bitstream/11388/250956/1/Zinellu_E_Proteomic_analysis_of_plasma.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023892401","display_name":"Elisabetta Zinellu","orcid":"https://orcid.org/0000-0001-8707-2098","observed_orcids":["https://orcid.org/0000-0001-8707-2098"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zinellu, Elisabetta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023892401"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.4603999853134155,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.4603999853134155,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.4147999882698059,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.08860000222921371,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apolipoproteins","display_name":"apolipoproteins","score":0.9229999780654907},{"id":"https://openalex.org/keywords/plasma-lipoproteins","display_name":"serum lipoproteins","score":0.9940000176429749},{"id":"https://openalex.org/keywords/carotid-endarterectomy","display_name":"carotid endarterectomy","score":0.8999999761581421},{"id":"https://openalex.org/keywords/serum-amyloid-a","display_name":"serum amyloid A","score":0.8949999809265137},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9940000176429749},{"id":"https://openalex.org/keywords/very-low-density-lipoprotein","display_name":"VLDL","score":0.7889999747276306},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.9890000224113464},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":1.0},{"id":"https://openalex.org/keywords/lipoprotein-associated-proteins","display_name":"lipoprotein-associated proteins","score":0.7910000085830688},{"id":"https://openalex.org/keywords/atherogenesis","display_name":"atherogenesis","score":0.7170000076293945},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.69983971118927},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.6665024757385254},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.6215222477912903},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5960536599159241},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.530627965927124},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45148003101348877},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.42810195684432983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4210512340068817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3758031129837036},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.uniss.it:6734","doi":null,"is_oa":false,"landing_page_url":"http://eprints.uniss.it/6734/1/Zinellu_E_Proteomic_analysis_of_plasma.pdf","pdf_url":"http://eprints.uniss.it/6734/1/Zinellu_E_Proteomic_analysis_of_plasma.pdf","source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral Thesis"},{"id":"pmh:oai:iris.uniss.it:11388/250956","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11388/250956","pdf_url":"https://iris.uniss.it/bitstream/11388/250956/1/Zinellu_E_Proteomic_analysis_of_plasma.pdf","source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:iris.uniss.it:11388/250956","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11388/250956","pdf_url":"https://iris.uniss.it/bitstream/11388/250956/1/Zinellu_E_Proteomic_analysis_of_plasma.pdf","source":{"id":"https://openalex.org/S4306401147","display_name":"UnissResearch (Universit\u00e0 degli Studi di Sassari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I159650629","host_organization_name":"University of Sassari","host_organization_lineage":["https://openalex.org/I159650629"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W159934013.pdf","grobid_xml":"https://content.openalex.org/works/W159934013.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W121664585","https://openalex.org/W156678813","https://openalex.org/W1502098572","https://openalex.org/W1504285654","https://openalex.org/W1546262989","https://openalex.org/W1555157837","https://openalex.org/W1577502861","https://openalex.org/W1578820077","https://openalex.org/W1580333051","https://openalex.org/W1591191431","https://openalex.org/W1879810571","https://openalex.org/W1920171370","https://openalex.org/W1964388909","https://openalex.org/W1968171440","https://openalex.org/W1968196140","https://openalex.org/W1973309410","https://openalex.org/W1974082280","https://openalex.org/W1976428272","https://openalex.org/W1977084774","https://openalex.org/W1977765460","https://openalex.org/W1978856445","https://openalex.org/W1979258878","https://openalex.org/W1980644618","https://openalex.org/W1981540523","https://openalex.org/W1983089921","https://openalex.org/W1984669102","https://openalex.org/W1987430295","https://openalex.org/W1991347692","https://openalex.org/W1996945731","https://openalex.org/W1997040744","https://openalex.org/W1997090264","https://openalex.org/W2000011436","https://openalex.org/W2000789033","https://openalex.org/W2009978543","https://openalex.org/W2010588191","https://openalex.org/W2012494818","https://openalex.org/W2012861636","https://openalex.org/W2014409886","https://openalex.org/W2015230474","https://openalex.org/W2015816213","https://openalex.org/W2019825424","https://openalex.org/W2020686577","https://openalex.org/W2029638583","https://openalex.org/W2031850888","https://openalex.org/W2035996771","https://openalex.org/W2038117401","https://openalex.org/W2039307785","https://openalex.org/W2040551497","https://openalex.org/W2040748888","https://openalex.org/W2042299844","https://openalex.org/W2047927755","https://openalex.org/W2048333869","https://openalex.org/W2049314229","https://openalex.org/W2049444075","https://openalex.org/W2051444330","https://openalex.org/W2051702310","https://openalex.org/W2056892942","https://openalex.org/W2059256286","https://openalex.org/W2060490507","https://openalex.org/W2066644955","https://openalex.org/W2066963386","https://openalex.org/W2069141076","https://openalex.org/W2071064041","https://openalex.org/W2071945646","https://openalex.org/W2072567581","https://openalex.org/W2074374302","https://openalex.org/W2076752637","https://openalex.org/W2078554215","https://openalex.org/W2079926187","https://openalex.org/W2083154566","https://openalex.org/W2083315579","https://openalex.org/W2085159827","https://openalex.org/W2089940523","https://openalex.org/W2091814080","https://openalex.org/W2092635923","https://openalex.org/W2096432979","https://openalex.org/W2100709790","https://openalex.org/W2107611361","https://openalex.org/W2107940734","https://openalex.org/W2108554994","https://openalex.org/W2109457071","https://openalex.org/W2111498906","https://openalex.org/W2111570219","https://openalex.org/W2113382866","https://openalex.org/W2114063969","https://openalex.org/W2114918865","https://openalex.org/W2118476881","https://openalex.org/W2118568491","https://openalex.org/W2119288443","https://openalex.org/W2121101037","https://openalex.org/W2121799835","https://openalex.org/W2124324493","https://openalex.org/W2127025703","https://openalex.org/W2128633067","https://openalex.org/W2130696834","https://openalex.org/W2133272769","https://openalex.org/W2135302616","https://openalex.org/W2135503869","https://openalex.org/W2136127396","https://openalex.org/W2138758296","https://openalex.org/W2142584363","https://openalex.org/W2143340286","https://openalex.org/W2143975857","https://openalex.org/W2144473676","https://openalex.org/W2145410077","https://openalex.org/W2145642828","https://openalex.org/W2146321139","https://openalex.org/W2147990253","https://openalex.org/W2153245546","https://openalex.org/W2159406914","https://openalex.org/W2162547981","https://openalex.org/W2164576143","https://openalex.org/W2165184741","https://openalex.org/W2185031068","https://openalex.org/W2185157132","https://openalex.org/W2322317224","https://openalex.org/W2327887667","https://openalex.org/W2342524513","https://openalex.org/W2395862054","https://openalex.org/W4210821588"],"related_works":["https://openalex.org/W2152175870","https://openalex.org/W7216814221","https://openalex.org/W7095785170","https://openalex.org/W3198838278","https://openalex.org/W77941736","https://openalex.org/W2500579307","https://openalex.org/W7127571416","https://openalex.org/W3168909088","https://openalex.org/W2607134229","https://openalex.org/W2090614004"],"abstract_inverted_index":{"Introduction:":[0],"atherosclerosis":[1],"is":[2,20],"a":[3],"chronic":[4],"inflammatory":[5],"conditioncharacterized":[6],"by":[7,90,101],"the":[8,16,43,47,156,167,174,187,192],"accumulation":[9],"of":[10,25,31,39,42,50,124,169,176,194],"lipids":[11],"and":[12,28,60,68,82,93,110,143,145,153,161,184],"fibrous":[13],"elements":[14],"in":[15,129,140,151,165,171,182],"large":[17],"arteries.":[18],"It":[19],"known":[21],"that":[22],"high":[23],"levels":[24,30,137,148],"LDL":[26,142],"cholesterol":[27,33],"low":[29],"HDL":[32,107,144],"associate":[34],"with":[35],"an":[36],"increased":[37],"risk":[38],"developing":[40],"atherosclerosis.Aim":[41],"study:":[44],"to":[45,61,95,132],"characterize":[46],"apolipoprotein":[48,159],"component":[49],"plasma":[51,76],"lipoproteins":[52,170],"isolated":[53,89],"from":[54,78],"atherosclerotic":[55],"patients":[56,67,130],"undergoing":[57],"carotid":[58,85],"endarterectomy":[59],"identify":[62],"differentially":[63],"expressed":[64,128],"apolipoproteins":[65],"between":[66],"controls.Methods:":[69],"analyses":[70],"were":[71,88,121,126,138,149],"performed":[72],"on":[73,106,158],"4":[74],"pooled":[75],"samples":[77],"57":[79],"healthy":[80],"volunteers":[81],"79":[83],"patientsundergoing":[84],"endarterectomy.":[86],"Lipoproteins":[87],"isopycnic":[91],"ultracentrifugation":[92],"subjected":[94],"two":[96],"dimensional":[97],"electrophoresis":[98],"analysis":[99,114],"followed":[100],"peptide":[102],"mass":[103],"fingerprinting.":[104],"Moreover,":[105],"fraction":[108],"mono-":[109],"bi-dimensional":[111],"western":[112],"blotting":[113],"was":[115],"performed.Results:":[116],"several":[117],"lipoprotein":[118],"associated":[119],"proteins":[120],"identified.":[122],"Some":[123],"them":[125],"differently":[127],"compared":[131],"controls.":[133],"In":[134],"particular,":[135],"SAA":[136],"higher":[139,150],"VLDL,":[141],"apo":[146],"E":[147],"VLDL":[152],"LDL.Conclusions:":[154],"improving":[155],"knowledge":[157],"composition":[160],"structure":[162],"may":[163],"help":[164],"revealing":[166],"role":[168],"atherogenesis.":[172],"Moreover":[173],"identification":[175],"new":[177],"biomarkers":[178],"could":[179,185],"be":[180],"useful":[181],"diagnosis":[183],"improve":[186],"therapeutic":[188],"approaches":[189],"adopted":[190],"for":[191],"treatment":[193],"atherosclerosis.":[195]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}