{"id":"https://openalex.org/W1599323322","doi":null,"title":"Lowered plasma vitamin C, but not vitamin E, concentrations in dementia patients.","display_name":"Lowered plasma vitamin C, but not vitamin E, concentrations in dementia patients.","publication_year":2004,"publication_date":"2004-01-01","ids":{"openalex":"https://openalex.org/W1599323322","mag":"1599323322","pmid":"https://pubmed.ncbi.nlm.nih.gov/14978605"},"language":"en","primary_location":{"id":"pmid:14978605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14978605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009433771","display_name":"Karen Elizabeth Charlton","orcid":"https://orcid.org/0000-0002-8044-444X","observed_orcids":["https://orcid.org/0000-0002-8044-444X"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"K E Charlton","raw_affiliation_strings":["Nutrition and Dietetics Division, School of Health and Rehabilitation Sciences, University of Cape Town, South Africa. w.scott@iafrica.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition and Dietetics Division, School of Health and Rehabilitation Sciences, University of Cape Town, South Africa. w.scott@iafrica.com","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080997280","display_name":"Tracey L Rabinowitz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T L Rabinowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007314450","display_name":"Leon Geffen","orcid":"https://orcid.org/0000-0002-9546-5323","observed_orcids":["https://orcid.org/0000-0002-9546-5323"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L N Geffen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089288155","display_name":"Muhammad Ali Dhansay","orcid":"https://orcid.org/0000-0002-1448-4013","observed_orcids":["https://orcid.org/0000-0002-1448-4013"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M A Dhansay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6099,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.81619053,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"2","first_page":"99","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.6060000061988831,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.27810001373291016,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12554","display_name":"Vitamin C and Antioxidants Research","score":0.032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasma-vitamin-c","display_name":"plasma vitamin C","score":0.8360000252723694},{"id":"https://openalex.org/keywords/plasma-vitamin-e","display_name":"plasma vitamin E","score":0.902999997138977},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/senile-dementia","display_name":"senile dementia","score":0.8899999856948853},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.6420000195503235},{"id":"https://openalex.org/keywords/nutritional-status","display_name":"nutritional status","score":0.6970000267028809},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.6949999928474426},{"id":"https://openalex.org/keywords/dietary-vitamin-intake","display_name":"dietary vitamin intake","score":0.6420000195503235},{"id":"https://openalex.org/keywords/institutionalized-elderly","display_name":"institutionalized elderly","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8547368049621582},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8243060111999512},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.660300076007843},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.622717022895813},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5646213293075562},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.5269889235496521},{"id":"https://openalex.org/C2780022331","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Vitamin C","level":2,"score":0.522070586681366},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.5033156275749207},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.47891509532928467},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4376099109649658},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.4268532395362854},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4081721901893616},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3625122308731079},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3126128315925598},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13531574606895447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000203","descriptor_name":"Activities of Daily Living","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001206","descriptor_name":"Ascorbic Acid Deficiency","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009752","descriptor_name":"Nutritional Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011569","descriptor_name":"Psychiatric Status Rating Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015577","descriptor_name":"Geriatric Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:14978605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14978605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of nutrition, health & aging","raw_type":"Journal Article"},{"id":"pmh:oai:ro.uow.edu.au:smhpapers-1600","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/smhpapers/587","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Science, Medicine and Health - Papers: part A","raw_type":"article"},{"id":"mag:1599323322","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14978605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W39805860","https://openalex.org/W84374928","https://openalex.org/W135043664","https://openalex.org/W186062299","https://openalex.org/W572517404","https://openalex.org/W944673322","https://openalex.org/W1576404822","https://openalex.org/W1585634979","https://openalex.org/W1587863760","https://openalex.org/W1847168837","https://openalex.org/W1897258672","https://openalex.org/W1922689867","https://openalex.org/W1953528800","https://openalex.org/W1965965293","https://openalex.org/W1974380679","https://openalex.org/W1981883193","https://openalex.org/W1990427131","https://openalex.org/W1990557557","https://openalex.org/W1996126201","https://openalex.org/W1999108861","https://openalex.org/W2001928135","https://openalex.org/W2003471941","https://openalex.org/W2006588849","https://openalex.org/W2014135612","https://openalex.org/W2016293448","https://openalex.org/W2016787732","https://openalex.org/W2019275855","https://openalex.org/W2035563772","https://openalex.org/W2040923416","https://openalex.org/W2053227808","https://openalex.org/W2063928073","https://openalex.org/W2072683060","https://openalex.org/W2075482140","https://openalex.org/W2075538515","https://openalex.org/W2079429376","https://openalex.org/W2085385091","https://openalex.org/W2108563688","https://openalex.org/W2109140840","https://openalex.org/W2116404316","https://openalex.org/W2118206405","https://openalex.org/W2130912131","https://openalex.org/W2139931759","https://openalex.org/W2146141276","https://openalex.org/W2156220037","https://openalex.org/W2166450294","https://openalex.org/W2169742106","https://openalex.org/W2234287987","https://openalex.org/W2326200998","https://openalex.org/W2340238760","https://openalex.org/W2412868372","https://openalex.org/W2414167269","https://openalex.org/W3100475845"],"related_works":["https://openalex.org/W1981883193","https://openalex.org/W2085385091","https://openalex.org/W2321934516","https://openalex.org/W2137290134","https://openalex.org/W1567351354","https://openalex.org/W2139931759","https://openalex.org/W84838632","https://openalex.org/W3024923583","https://openalex.org/W2067460377","https://openalex.org/W2144127904"],"abstract_inverted_index":{"BACKGROUND:":[0],"Alzheimer":[1,71],"s":[2,72],"disease":[3],"(AD),":[4],"according":[5],"to":[6,23,202,271],"the":[7,82,101,111,115,136,143,158,168,250,286,306],"free":[8,15,287],"radical":[9,16,288],"hypothesis,":[10],"affects":[11],"brain":[12,26],"regions":[13],"where":[14],"damage":[17],"occurs.":[18],"Antioxidant":[19],"nutrients":[20],"may":[21,302],"help":[22],"protect":[24],"these":[25],"regions.":[27],"OBJECTIVE:":[28],"To":[29],"investigate":[30],"whether":[31,297],"plasma":[32,176,205,254],"vitamin":[33,104,177,206,229,233,257,261,280,301],"C":[34,105,178,207,230,234,262,281],"and":[35,44,75,106,114,138,161,190,315],"E":[36,107],"status":[37,140],"is":[38],"lowered":[39],"in":[40,53,266,311],"subjects":[41,56,69,77,87,214,267],"with":[42,70,78,88,93,167,238,268,299,313],"AD":[43,314],"dementia.":[45],"DESIGN:":[46],"A":[47],"case":[48],"control":[49,83,151,213],"study":[50],"was":[51,108,124,133,235,247,274],"conducted":[52],"93":[54],"institutionalized":[55],"aged":[57],"65":[58],"+":[59],"yrs.":[60],"The":[61,150,196],"dementia":[62,169,181,197,269,317],"group":[63,84,152,198],"(N":[64],"=":[65,184,187,216,221,242],"43)":[66],"included":[67,85],"15":[68],"Disease":[73],"(AD)":[74],"28":[76],"senile":[79,316],"dementia,":[80],"while":[81],"50":[86],"no":[89],"cognitive":[90,309],"impairment.":[91],"Subjects":[92],"uncontrolled":[94],"hypertension":[95],"and/or":[96],"diabetes":[97],"were":[98,199,264],"excluded":[99],"from":[100],"study.":[102],"Plasma":[103,232,260],"determined":[109],"using":[110,126,135,142],"2,6-":[112],"dichlorophenolindophenol":[113],"HPLC":[116],"methods,":[117],"respectively.":[118],"Dietary":[119],"intake,":[120],"including":[121],"dietary":[122,228,256,279],"supplements,":[123],"assessed":[125,141],"a":[127,173],"2-day":[128],"plate-waste":[129],"method.":[130],"Cognitive":[131],"function":[132],"measured":[134],"MMSE":[137,160,239],"nutritional":[139],"Mini":[144],"Nutritional":[145],"Assessment":[146],"(MNA)":[147],"tool.":[148],"RESULTS:":[149],"had":[153,172],"significantly":[154,174],"higher":[155,175],"scores":[156],"for":[157,252],"MNA,":[159],"Activities":[162],"of":[163,290,296,308],"Daily":[164],"Living,":[165],"compared":[166,270],"group.":[170],"Controls":[171],"concentration":[179],"than":[180,212],"patients":[182,312],"(median":[183],"0.84":[185],"(IQR":[186],"0.54)":[188],"mg/dl":[189],"0.56":[191],"(0.80)":[192],"mg/dl,":[193],"respectively;":[194],"P<0.05).":[195,244],"more":[200],"likely":[201],"have":[203],"sub-optimal":[204],"levels":[208,263],"(<":[209],"0.6":[210],"mg/dl)":[211],"(OR":[215],"2.99;":[217],"95":[218],"%":[219],"CI":[220],"0.95":[222],"9.79;":[223],"P<0.05),":[224],"despite":[225],"having":[226],"similar":[227],"intakes.":[231,282],"positively":[236],"associated":[237],"score":[240],"(r":[241],"0.21;":[243],"No":[245],"difference":[246],"found":[248],"between":[249],"groups":[251],"either":[253],"or":[255,304],"E.":[258],"CONCLUSION:":[259],"lower":[265],"controls,":[272],"which":[273],"not":[275],"explained":[276],"by":[277],"their":[278],"This":[283],"data":[284],"supports":[285],"theory":[289],"oxidative":[291],"neuronal":[292],"damage.":[293],"Further":[294],"investigations":[295],"supplementation":[298],"this":[300],"prevent":[303],"delay":[305],"progression":[307],"decline":[310],"appear":[318],"warranted.":[319]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}