{"id":"https://openalex.org/W1599007654","doi":"https://doi.org/10.1158/1538-7445.am2014-1982","title":"Abstract 1982: Invading cancer cells are mostly in G0/G1 and resist chemotherapy demonstrated by real-time FUCCI imaging of cell-cycle kinetics in Gelfoam\u00ae histoculture","display_name":"Abstract 1982: Invading cancer cells are mostly in G0/G1 and resist chemotherapy demonstrated by real-time FUCCI imaging of cell-cycle kinetics in Gelfoam\u00ae histoculture","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W1599007654","doi":"https://doi.org/10.1158/1538-7445.am2014-1982","mag":"1599007654"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-1982","doi":"https://doi.org/10.1158/1538-7445.am2014-1982","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1982","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062335013","display_name":"Shuya Yano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shuya Yano","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010692199","display_name":"Shinji Miwa","orcid":"https://orcid.org/0000-0002-5962-8287","observed_orcids":["https://orcid.org/0000-0002-5962-8287"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shinji Miwa","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018013081","display_name":"Sumiyuki Mii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sumiyuki Mii","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113917299","display_name":"Yukihiko Hiroshima","orcid":"https://orcid.org/0009-0005-7384-3513","observed_orcids":["https://orcid.org/0009-0005-7384-3513"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yukihiko Hiroshima","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019315942","display_name":"Fuminari Uehara","orcid":"https://orcid.org/0000-0001-6567-2113","observed_orcids":["https://orcid.org/0000-0001-6567-2113"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fuminari Uehara","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035456514","display_name":"Hiroyuki Kishimoto","orcid":"https://orcid.org/0000-0001-8174-3508","observed_orcids":["https://orcid.org/0000-0001-8174-3508"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Kishimoto","raw_affiliation_strings":["2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015421086","display_name":"Hiroshi Tazawa","orcid":"https://orcid.org/0000-0003-4658-1050","observed_orcids":["https://orcid.org/0000-0003-4658-1050"]},"institutions":[{"id":"https://openalex.org/I4210100185","display_name":"Okayama University Hospital","ror":"https://ror.org/019tepx80","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210100185"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Tazawa","raw_affiliation_strings":["3Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan","institution_ids":["https://openalex.org/I4210100185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083743508","display_name":"Ming Dan Zhao","orcid":"https://orcid.org/0000-0002-1025-8895","observed_orcids":["https://orcid.org/0000-0002-1025-8895"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ming Zhao","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009960666","display_name":"Michael Bouvet","orcid":"https://orcid.org/0000-0002-0086-2159","observed_orcids":["https://orcid.org/0000-0002-0086-2159"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Bouvet","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068717107","display_name":"Toshiyoshi Fujiwara","orcid":"https://orcid.org/0000-0002-5377-6051","observed_orcids":["https://orcid.org/0000-0002-5377-6051"]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyoshi Fujiwara","raw_affiliation_strings":["2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[{"id":"https://openalex.org/I4210121314","display_name":"AntiCancer (United States)","ror":"https://ror.org/02pp1v282","country_code":"US","type":"company","lineage":["https://openalex.org/I4210121314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":["1AntiCancer, Inc, San Diego, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1AntiCancer, Inc, San Diego, CA;","institution_ids":["https://openalex.org/I4210121314"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"1982","last_page":"1982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.42329999804496765,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.19679999351501465,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.13699999451637268,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cell-cycle-kinetics","display_name":"cell cycle kinetics","score":0.675000011920929},{"id":"https://openalex.org/keywords/g0-g1-phase","display_name":"G0/G1 phase","score":0.8289999961853027},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7699999809265137},{"id":"https://openalex.org/keywords/metastasis-prevention","display_name":"metastasis prevention","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6989486813545227},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6413271427154541},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.639569878578186},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6302429437637329},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6121400594711304},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5693429708480835},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4886660873889923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4497596025466919},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3648553490638733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3265668749809265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23044398427009583},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14957782626152039}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-1982","doi":"https://doi.org/10.1158/1538-7445.am2014-1982","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-1982","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2012091159","https://openalex.org/W2207214542","https://openalex.org/W2027079605","https://openalex.org/W2047515867","https://openalex.org/W1571918456","https://openalex.org/W2004295263","https://openalex.org/W2790576209","https://openalex.org/W3086088575","https://openalex.org/W2012873903","https://openalex.org/W3127202769"],"abstract_inverted_index":{"Abstract":[0],"Invasive":[1],"cancer":[2,28,65,80,104,137,170],"cells":[3,45,53,66,81,86,105,121,138,171],"are":[4,172],"a":[5,47,55],"critical":[6],"target":[7],"for":[8,202],"chemotherapy":[9,110,119,178],"in":[10,29,67,70,82,115,122,174,187],"order":[11],"to":[12,109,141],"prevent":[13,142],"metastasis.":[14,143],"In":[15],"the":[16,79,128,194,199],"present":[17,129],"report,":[18],"we":[19,62],"demonstrate":[20],"real-time":[21,181],"visualization":[22],"of":[23,26,127,184,193,198],"cell-cycle":[24,185],"kinetics":[25,186],"invading":[27],"three-dimensional":[30],"(3D)":[31],"Gelfoam\u00ae":[32,71,188],"histoculture.":[33,189],"A":[34],"fluorescence":[35],"ubiquitination":[36],"cell":[37],"cycle":[38],"indicator":[39],"(FUCCI)":[40],"was":[41],"used":[42],"whereby":[43],"G1/G0":[44],"express":[46,54],"red":[48],"fluorescent":[49,57],"protein":[50],"and":[51,76,94,99,117,176],"S/G2/M":[52,83,92,123],"green":[56],"protein.":[58],"With":[59],"FUCCI":[60,182],"imaging,":[61],"observed":[63],"that":[64,132],"G0/G1":[68,175],"phase":[69],"histoculture":[72],"migrated":[73],"more":[74],"rapidly":[75],"further":[77],"than":[78],"phase.":[84,124],"Cancer":[85,203,214],"ceased":[87],"migrating":[88,96],"when":[89],"they":[90,112],"entered":[91],"phases":[93],"restarted":[95],"after":[97],"division":[98],"re-entry":[100],"into":[101],"G1/G0.":[102],"Migrating":[103],"also":[106],"were":[107,113],"resistant":[108],"since":[111],"preponderantly":[114],"G1/G2":[116,136],"cytotoxic":[118],"targets":[120],"The":[125],"results":[126],"report":[130],"suggest":[131],"novel":[133],"therapy":[134],"targeting":[135],"is":[139],"necessary":[140],"Citation":[144],"Format:":[145],"Shuya":[146],"Yano,":[147],"Shinji":[148],"Miwa,":[149],"Sumiyuki":[150],"Mii,":[151],"Yukihiko":[152],"Hiroshima,":[153],"Fuminari":[154],"Uehara,":[155],"Hiroyuki":[156],"Kishimoto,":[157],"Hiroshi":[158],"Tazawa,":[159],"Ming":[160],"Zhao,":[161],"Michael":[162],"Bouvet,":[163],"Toshiyoshi":[164],"Fujiwara,":[165],"Robert":[166],"M.":[167],"Hoffman.":[168],"Invading":[169],"mostly":[173],"resist":[177],"demonstrated":[179],"by":[180],"imaging":[183],"[abstract].":[190],"In:":[191],"Proceedings":[192],"105th":[195],"Annual":[196],"Meeting":[197],"American":[200],"Association":[201],"Research;":[204],"2014":[205],"Apr":[206],"5-9;":[207],"San":[208],"Diego,":[209],"CA.":[210],"Philadelphia":[211],"(PA):":[212],"AACR;":[213],"Res":[215],"2014;74(19":[216],"Suppl):Abstract":[217],"nr":[218],"1982.":[219],"doi:10.1158/1538-7445.AM2014-1982":[220]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}
