{"id":"https://openalex.org/W159889187","doi":null,"title":"Lipids and progressive kidney disease.","display_name":"Lipids and progressive kidney disease.","publication_year":1991,"publication_date":"1991-04-01","ids":{"openalex":"https://openalex.org/W159889187","mag":"159889187","pmid":"https://pubmed.ncbi.nlm.nih.gov/2046269"},"language":"en","primary_location":{"id":"pmid:2046269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2046269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109140947","display_name":"J F Moorhead","orcid":"https://orcid.org/0000-0001-5933-0504","observed_orcids":["https://orcid.org/0000-0001-5933-0504"]},"institutions":[{"id":"https://openalex.org/I2801138448","display_name":"The Royal Free Hospital","ror":"https://ror.org/01ge67z96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I169248724","https://openalex.org/I2801138448"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J F Moorhead","raw_affiliation_strings":["Department of Nephrology, Royal Free Hospital, London, England, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, Royal Free Hospital, London, England, United Kingdom","institution_ids":["https://openalex.org/I2801138448"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109140947"],"corresponding_institution_ids":["https://openalex.org/I2801138448"],"apc_list":null,"apc_paid":null,"fwci":8.7091,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.98205272,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"31","issue":null,"first_page":"S35","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.8715999722480774,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.12370000034570694,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrotic-syndrome","display_name":"nephrotic syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/chronic-kidney-disease-progression","display_name":"chronic kidney disease progression","score":0.7590000033378601},{"id":"https://openalex.org/keywords/proteinuria","display_name":"proteinuria","score":0.8870000243186951},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.8090000152587891},{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.8199999928474426},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.9290000200271606},{"id":"https://openalex.org/keywords/albuminuria","display_name":"albuminuria","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C2778930706","wikidata":"https://www.wikidata.org/wiki/Q504790","display_name":"Nephrotic syndrome","level":2,"score":0.828719973564148},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.7337921857833862},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7192343473434448},{"id":"https://openalex.org/C2776174234","wikidata":"https://www.wikidata.org/wiki/Q974792","display_name":"Albuminuria","level":3,"score":0.6973408460617065},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6628431081771851},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4899088740348816},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.47959983348846436},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39556849002838135},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.36643433570861816},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3361240029335022},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32589399814605713}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001161","descriptor_name":"Arteriosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005920","descriptor_name":"Glomerular Mesangium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006949","descriptor_name":"Hyperlipidemias","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009404","descriptor_name":"Nephrotic Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011507","descriptor_name":"Proteinuria","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015777","descriptor_name":"Eicosanoids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:2046269","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2046269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney international. Supplement","raw_type":"Journal Article"},{"id":"mag:159889187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2046269","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W68072997","https://openalex.org/W90784699","https://openalex.org/W2325141633","https://openalex.org/W2086383516","https://openalex.org/W2029988322","https://openalex.org/W2399056528","https://openalex.org/W2419508306","https://openalex.org/W7135055102","https://openalex.org/W2077155600","https://openalex.org/W1975751137"],"abstract_inverted_index":{"The":[0],"nephrotic":[1,104],"syndrome":[2,105],"comprises":[3],"proteinuria,":[4,65,132],"oedema,":[5],"albuminuria,":[6],"hypoalbuminaemia,":[7],"and":[8,81,116,134,168],"hyperlipidaemia.":[9],"Some":[10],"of":[11,19,26,30,34,47,61,70,91,103,119,124,144,157],"its":[12],"manifestations":[13,33],"are":[14],"present":[15],"throughout":[16],"the":[17,27,31,35,45,58,76,92,97,122,139,155,164],"course":[18],"progressive":[20,79,135],"renal":[21,48,136],"disease.":[22,49],"Hyperlipidaemia":[23],"is":[24,109,159],"one":[25],"most":[28],"dramatic":[29],"clinical":[32],"syndrome,":[36],"but":[37],"has":[38,54],"not":[39],"been":[40,55],"seen":[41],"as":[42,67],"relevant":[43],"to":[44,111,163],"progression":[46],"Recently,":[50],"however,":[51],"increasing":[52],"interest":[53],"shown":[56],"in":[57,83,100,129,147,161,172],"lipid":[59,126],"abnormalities":[60],"patients":[62,130],"with":[63,131],"persistent":[64],"largely":[66],"a":[68],"result":[69],"experimental":[71],"data":[72],"which":[73,96],"have":[74],"emphasised":[75],"connection":[77],"between":[78,113],"disease":[80,115,137,166],"hyperlipidaemia":[82],"animal":[84,101],"models.":[85],"This":[86],"review":[87],"considers":[88],"some":[89],"aspects":[90],"metabolic":[93],"background":[94],"against":[95],"pathological":[98],"changes":[99],"models":[102],"take":[106],"place.":[107],"Attention":[108],"drawn":[110],"analogies":[112],"glomerular":[114],"atherosclerosis.":[117],"Lack":[118],"information":[120],"on":[121],"value":[123],"long-term":[125,142],"lowering":[127],"therapy":[128,146],"hyperlipidaemia,":[133],"emphasises":[138],"need":[140],"for":[141,153],"studies":[143],"lipid-lowering":[145],"these":[148],"individuals.":[149],"A":[150],"conceptual":[151],"framework":[152],"understanding":[154],"role":[156],"lipids":[158],"discussed":[160],"relation":[162],"underlying":[165],"processes":[167],"possible":[169],"therapeutic":[170],"approaches":[171],"man.":[173]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}