{"id":"https://openalex.org/W1598202087","doi":"https://doi.org/10.1016/s0021-9258(18)54472-0","title":"Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.","display_name":"Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis, and receptor binding activities.","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W1598202087","doi":"https://doi.org/10.1016/s0021-9258(18)54472-0","mag":"1598202087","pmid":"https://pubmed.ncbi.nlm.nih.gov/1744111"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)54472-0","doi":"https://doi.org/10.1016/s0021-9258(18)54472-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)54472-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)54472-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091242881","display_name":"Ian Clark\u2010Lewis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"I. Clark-Lewis","raw_affiliation_strings":["Biomedical Research Centre; University of British Columbia; Vancouver Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre; University of British Columbia; Vancouver Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111736432","display_name":"Christoph Schumacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"C. Schumacher","raw_affiliation_strings":["Biomedical Research Centre; University of British Columbia; Vancouver Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre; University of British Columbia; Vancouver Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004188962","display_name":"Marco Baggiolini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Baggiolini","raw_affiliation_strings":["Biomedical Research Centre; University of British Columbia; Vancouver Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre; University of British Columbia; Vancouver Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019701092","display_name":"Bernhard Moser","orcid":"https://orcid.org/0000-0002-4354-4572","observed_orcids":["https://orcid.org/0000-0002-4354-4572"]},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B. Moser","raw_affiliation_strings":["Biomedical Research Centre; University of British Columbia; Vancouver Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Centre; University of British Columbia; Vancouver Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":11.0163,"has_fulltext":false,"cited_by_count":423,"citation_normalized_percentile":{"value":0.98655157,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"266","issue":"34","first_page":"23128","last_page":"23134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":1.0},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neutrophil-chemotaxis","display_name":"neutrophil chemotaxis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/elastase-release","display_name":"elastase release","score":0.8629999756813049},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.906000018119812},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.8960000276565552},{"id":"https://openalex.org/keywords/peptide-analogs","display_name":"peptide analogues","score":0.3449999988079071},{"id":"https://openalex.org/keywords/cytokine-structure","display_name":"cytokine structure","score":0.42399999499320984},{"id":"https://openalex.org/keywords/inflammatory-mediators","display_name":"inflammatory mediators","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.8484799861907959},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6406751275062561},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5641929507255554},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5504100918769836},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.5225407481193542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5043884515762329},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.47359564900398254},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.41553473472595215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3315433859825134},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2659015357494354},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.20518136024475098}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019272","descriptor_name":"Leukocyte Elastase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)54472-0","doi":"https://doi.org/10.1016/s0021-9258(18)54472-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)54472-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1744111","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1744111","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)54472-0","doi":"https://doi.org/10.1016/s0021-9258(18)54472-0","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)54472-0","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W566987316","https://openalex.org/W1486569222","https://openalex.org/W1510258932","https://openalex.org/W1524903400","https://openalex.org/W1543948010","https://openalex.org/W1565106068","https://openalex.org/W1565707529","https://openalex.org/W1567011032","https://openalex.org/W1969904510","https://openalex.org/W1972229214","https://openalex.org/W1973195685","https://openalex.org/W1973894971","https://openalex.org/W1975742983","https://openalex.org/W1976482662","https://openalex.org/W1994539063","https://openalex.org/W2002942416","https://openalex.org/W2003570488","https://openalex.org/W2004769764","https://openalex.org/W2006299985","https://openalex.org/W2007078473","https://openalex.org/W2010258932","https://openalex.org/W2020745281","https://openalex.org/W2026835141","https://openalex.org/W2042383304","https://openalex.org/W2045968396","https://openalex.org/W2053902929","https://openalex.org/W2057350048","https://openalex.org/W2058757949","https://openalex.org/W2073460964","https://openalex.org/W2083430194","https://openalex.org/W2085264314","https://openalex.org/W2092340684","https://openalex.org/W2102084025","https://openalex.org/W2122794487","https://openalex.org/W2123797864","https://openalex.org/W2123884323","https://openalex.org/W2142090875","https://openalex.org/W2152762475","https://openalex.org/W2320556745","https://openalex.org/W2405884584"],"related_works":["https://openalex.org/W1595430911","https://openalex.org/W2094070917","https://openalex.org/W1666643260","https://openalex.org/W2028374346","https://openalex.org/W2071810692","https://openalex.org/W4214871602","https://openalex.org/W1559059912","https://openalex.org/W1553611715","https://openalex.org/W2070044854","https://openalex.org/W1570387161"],"abstract_inverted_index":{"Interleukin-8":[0],"(IL-8)":[1],"is":[2,171,264],"an":[3,201],"inflammatory":[4],"mediator":[5],"that":[6,93,166,185,237],"stimulates":[7],"neutrophil":[8,34],"migration":[9],"and":[10,21,36,67,72,75,98,106,114,162,210,243],"functional":[11],"activation.":[12],"Analogs":[13,57],"of":[14,44,111,177],"human":[15],"IL-8":[16,28,84,104,142,250],"were":[17,70,100,194],"chemically":[18],"synthesized,":[19],"purified,":[20],"compared":[22,122],"with":[23,119,123,204,226],"the":[24,60,73,82,130,146,167,181,191,205,218,227,238,249,260,269],"full-length":[25],"72-residue":[26],"synthetic":[27],"for":[29,42,103,174,267],"their":[30,49],"ability":[31],"to":[32,51,59,217],"stimulate":[33],"chemotaxis":[35,115],"exocytosis":[37],"as":[38,46,48,190],"measured":[39],"by":[40],"assaying":[41],"release":[43,113],"elastase,":[45],"well":[47],"binding":[50,154],"specific":[52],"receptors":[53],"in":[54,129,139,200,230,248,256],"competition":[55],"assays.":[56],"corresponding":[58,216],"less":[61,87,127,137],"abundant":[62],"natural":[63],"forms,":[64],"3-72,":[65],"4-72,":[66],"77-residue":[68,83],"IL-8,":[69],"evaluated":[71],"3-72":[74],"4-72":[76],"had":[77,151],"2-5-fold":[78],"higher":[79],"potencies,":[80],"whereas":[81],"was":[85,92,117,125,134,187,198],"2-fold":[86],"potent.":[88],"A":[89,214],"major":[90],"finding":[91],"NH2-terminal":[94,157,168,239],"residues":[95,193,240,275],"4,":[96,241],"5,":[97,242],"6":[99],"absolutely":[101],"essential":[102],"activity":[105,116,161,197],"receptor":[107,153,163,257],"binding.":[108],"Quantitative":[109],"dissociation":[110],"elastase":[112,131,232],"detected":[118],"5-72,":[120],"which":[121,245],"1-72,":[124],"80-fold":[126],"potent":[128,138],"assay,":[132],"but":[133,150,259],"only":[135],"slightly":[136],"stimulating":[140,231],"chemotaxis.":[141],"6-72":[143],"lacked":[144,160],"all":[145],"biological":[147],"activities":[148],"tested":[149],"detectable":[152],"activity.":[155],"The":[156,234],"peptide,":[158],"AVLPRSAKEL,":[159],"binding,":[164,258],"suggesting":[165],"region":[169],"alone":[170],"not":[172],"sufficient":[173],"function.":[175],"Comparison":[176],"analogs":[178],"shortened":[179],"at":[180],"COOH":[182],"terminus":[183],"showed":[184],"potency":[186],"progressively":[188],"reduced":[189],"COOH-terminal":[192,207,219,261],"excluded.":[195],"However":[196],"retained":[199],"analog":[202,229],"(1-51)":[203],"entire":[206],"alpha":[208,262],"helix":[209,263],"beta":[211],"turn":[212],"missing.":[213],"peptide":[215],"22":[220],"residues,":[221],"although":[222],"inactive":[223],"alone,":[224],"synergized":[225],"1-51":[228],"release.":[233],"results":[235],"suggest":[236],"6,":[244],"are":[246,253,277],"disordered":[247],"solution":[251],"structure,":[252],"directly":[254],"involved":[255],"probably":[265],"important":[266],"stabilizing":[268],"three-dimensional":[270],"structure.":[271],"Other":[272],"regions":[273],"within":[274],"7-51":[276],"also":[278],"functionally":[279],"important.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
