{"id":"https://openalex.org/W1598087732","doi":null,"title":"Interventions to Improve Patient Adherence to Hepatitis C Treatment: Comparative Effectiveness","display_name":"Interventions to Improve Patient Adherence to Hepatitis C Treatment: Comparative Effectiveness","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W1598087732","mag":"1598087732"},"language":"en","primary_location":{"id":"mag:1598087732","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/23346603","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100722008","display_name":"Xin Sun","orcid":"https://orcid.org/0000-0003-3845-4342","observed_orcids":["https://orcid.org/0000-0003-3845-4342"]},"institutions":[{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Sun","raw_affiliation_strings":["Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research"],"raw_orcid":"https://orcid.org/0000-0003-3845-4342","affiliations":[{"raw_affiliation_string":"Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research","institution_ids":["https://openalex.org/I4210114677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032552265","display_name":"Carrie D. Patnode","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carrie D. Patnode","raw_affiliation_strings":["Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research","institution_ids":["https://openalex.org/I4210114677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060609983","display_name":"Clara J. Williams","orcid":"https://orcid.org/0000-0003-1292-6313","observed_orcids":["https://orcid.org/0000-0003-1292-6313"]},"institutions":[{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara Williams","raw_affiliation_strings":["Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research"],"raw_orcid":"https://orcid.org/0000-0003-1292-6313","affiliations":[{"raw_affiliation_string":"Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research","institution_ids":["https://openalex.org/I4210114677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110649493","display_name":"Caitlyn A Senger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caitlyn A Senger","raw_affiliation_strings":["Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research","institution_ids":["https://openalex.org/I4210114677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048412000","display_name":"Tanya J. Kapka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanya Kapka","raw_affiliation_strings":["Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research","institution_ids":["https://openalex.org/I4210114677"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082093687","display_name":"Evelyn P Whitlock","orcid":"https://orcid.org/0000-0003-3581-0743","observed_orcids":["https://orcid.org/0000-0003-3581-0743"]},"institutions":[{"id":"https://openalex.org/I4210114677","display_name":"Kaiser Permanente Center for Health Research","ror":"https://ror.org/028gzjv13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4210114677"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelyn P Whitlock","raw_affiliation_strings":["Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research"],"raw_orcid":"https://orcid.org/0000-0003-3581-0743","affiliations":[{"raw_affiliation_string":"Oregon Evidence-based Practice Center, Kaiser Permanente Center for Health Research","institution_ids":["https://openalex.org/I4210114677"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210114677"],"apc_list":null,"apc_paid":null,"fwci":0.9219,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76532033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.07569999992847443,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.7910000085830688},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7770000100135803},{"id":"https://openalex.org/keywords/adherence-interventions","display_name":"adherence interventions","score":0.8220000267028809},{"id":"https://openalex.org/keywords/pegylated-interferon-alpha","display_name":"pegylated interferon-alpha","score":0.8220000267028809},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":1.0},{"id":"https://openalex.org/keywords/combination-antiviral-therapy","display_name":"combination antiviral therapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/sustained-virologic-response","display_name":"sustained virological response","score":0.9700000286102295},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8320000171661377},{"id":"https://openalex.org/keywords/harms-of-interventions","display_name":"harms of interventions","score":0.6100000143051147},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.4869999885559082},{"id":"https://openalex.org/keywords/comparative-effectiveness","display_name":"comparative effectiveness","score":0.4830000102519989},{"id":"https://openalex.org/keywords/patient-education","display_name":"patient education","score":0.3409999907016754},{"id":"https://openalex.org/keywords/medication-reminders","display_name":"medication reminders","score":0.3019999861717224},{"id":"https://openalex.org/keywords/behavioral-interventions","display_name":"behavioral interventions","score":0.3630000054836273},{"id":"https://openalex.org/keywords/psychosocial-interventions","display_name":"psychosocial interventions","score":0.4959999918937683},{"id":"https://openalex.org/keywords/self-monitoring","display_name":"self-monitoring","score":0.3569999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8545796275138855},{"id":"https://openalex.org/C2781145037","wikidata":"https://www.wikidata.org/wiki/Q5011772","display_name":"CINAHL","level":3,"score":0.7084675431251526},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.6882388591766357},{"id":"https://openalex.org/C2779549880","wikidata":"https://www.wikidata.org/wiki/Q5542226","display_name":"PsycINFO","level":3,"score":0.5960922241210938},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.569622814655304},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5280112624168396},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.43938133120536804},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.40034157037734985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2393995225429535},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15139231085777283},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1598087732","doi":null,"is_oa":false,"landing_page_url":"https://europepmc.org/article/MED/23346603","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W67796876","https://openalex.org/W138424127","https://openalex.org/W141102681","https://openalex.org/W1487959604","https://openalex.org/W1506255512","https://openalex.org/W1543074995","https://openalex.org/W1545238925","https://openalex.org/W1579958513","https://openalex.org/W1594567624","https://openalex.org/W1604838036","https://openalex.org/W1606007006","https://openalex.org/W1741567663","https://openalex.org/W1754449866","https://openalex.org/W1779164686","https://openalex.org/W1829380874","https://openalex.org/W1925910633","https://openalex.org/W1963967982","https://openalex.org/W1972107667","https://openalex.org/W1973760746","https://openalex.org/W1975620628","https://openalex.org/W1978088727","https://openalex.org/W1978339383","https://openalex.org/W1980027106","https://openalex.org/W1983553720","https://openalex.org/W1987972580","https://openalex.org/W1990845456","https://openalex.org/W1993575761","https://openalex.org/W1998364518","https://openalex.org/W2001048215","https://openalex.org/W2003300591","https://openalex.org/W2005543625","https://openalex.org/W2009468511","https://openalex.org/W2011472992","https://openalex.org/W2013679732","https://openalex.org/W2014740393","https://openalex.org/W2020989749","https://openalex.org/W2023153884","https://openalex.org/W2027540914","https://openalex.org/W2027545702","https://openalex.org/W2027792646","https://openalex.org/W2028918293","https://openalex.org/W2035422501","https://openalex.org/W2035745042","https://openalex.org/W2042701393","https://openalex.org/W2045555817","https://openalex.org/W2046853952","https://openalex.org/W2048820054","https://openalex.org/W2050261971","https://openalex.org/W2050440384","https://openalex.org/W2052151802","https://openalex.org/W2055155291","https://openalex.org/W2060338814","https://openalex.org/W2061365719","https://openalex.org/W2062374436","https://openalex.org/W2063285149","https://openalex.org/W2064910453","https://openalex.org/W2065986243","https://openalex.org/W2072951722","https://openalex.org/W2083304527","https://openalex.org/W2084428516","https://openalex.org/W2089884447","https://openalex.org/W2090284035","https://openalex.org/W2097522551","https://openalex.org/W2099244432","https://openalex.org/W2099646733","https://openalex.org/W2104010560","https://openalex.org/W2104563699","https://openalex.org/W2105286122","https://openalex.org/W2108276595","https://openalex.org/W2113864802","https://openalex.org/W2116998683","https://openalex.org/W2126529103","https://openalex.org/W2132290252","https://openalex.org/W2132492420","https://openalex.org/W2139062201","https://openalex.org/W2141559815","https://openalex.org/W2145735401","https://openalex.org/W2150052863","https://openalex.org/W2150684510","https://openalex.org/W2151512706","https://openalex.org/W2155441883","https://openalex.org/W2157961528","https://openalex.org/W2160304230","https://openalex.org/W2168911689","https://openalex.org/W2170628962","https://openalex.org/W2170956924","https://openalex.org/W2175805485","https://openalex.org/W2324308673","https://openalex.org/W2325353969","https://openalex.org/W2612891587"],"related_works":["https://openalex.org/W2172101034","https://openalex.org/W1968469883","https://openalex.org/W1604838036","https://openalex.org/W154688857","https://openalex.org/W2059588589","https://openalex.org/W2035458181","https://openalex.org/W7052700793","https://openalex.org/W2912700700","https://openalex.org/W2319681844","https://openalex.org/W7099190036"],"abstract_inverted_index":{"Objectives":[0],"Patients":[2],"with":[3,96,265,296,338,355],"chronic":[4,49,356],"hepatitis":[5,50,243,357],"C":[6,244],"often":[7],"have":[8],"difficulties":[9],"adhering":[10],"to":[11,15,200,263,378],"antiviral":[12,46],"therapy":[13,47,182],"due":[14],"the":[16,21,33,86,90,176,216,229,276,302,315,339,405],"complexities":[17],"of":[18,38,76,183,191,211,228,260,291,301,314,361,415],"treatment":[19,39],"and":[20,36,63,93,101,109,122,171,185,194,214,223,242,250,299,326,350,372,385,408],"adverse":[22],"events":[23],"commonly":[24],"experienced.":[25],"This":[26],"Comparative":[27],"Effectiveness":[28],"Review":[29,81],"(CER)":[30],"systematically":[31],"assesses":[32],"comparative":[34],"benefits":[35],"harms":[37,336],"adherence":[40,319,349,381],"interventions":[41,249,266,345,382],"for":[42,48,111,253],"adults":[43],"receiving":[44,180,395],"combination":[45,181],"C.":[51,358],"Data":[53],"sources":[54],"We":[56,84,144,155],"searched":[57],"MEDLINE\u00ae,":[58],"PubMed\u00ae,":[59],"CENTRAL,":[60],"PsycInfo,":[61],"Embase,":[62],"CINAHL":[64],"from":[65,98,133,159,363],"2001":[66],"through":[67],"June":[68],"20,":[69],"2012,":[70],"as":[71,73,238,388,390],"well":[72,389],"reference":[74],"lists":[75],"relevant":[77],"review":[78,87],"articles.":[79],"methods":[82],"developed":[85],"protocol,":[88],"including":[89,410],"analytic":[91],"framework":[92],"Key":[94,99],"Questions,":[95],"input":[97],"Informants":[100],"technical":[102],"experts.":[103],"Two":[104,117,332],"investigators":[105,118],"independently":[106,123],"assessed":[107],"titles":[108],"abstracts":[110],"eligibility":[112],"against":[113],"predefined":[114],"inclusion/exclusion":[115],"criteria.":[116,128],"reviewed":[119],"full-text":[120],"articles":[121],"quality-rated":[124],"those":[125],"meeting":[126],"inclusion":[127],"One":[129],"reviewer":[130],"abstracted":[131],"data":[132,138,146,232],"all":[134],"included":[135,156,165,207],"studies;":[136],"these":[137,254,364],"were":[139,189],"verified":[140],"by":[141,149],"another":[142],"reviewer.":[143],"summarized":[145],"qualitatively":[147],"grouped":[148],"intervention":[150],"type.":[151],"Results":[153],"12":[157],"studies":[158,164,177,206,218,230,255,278,317,333],"1,629":[160],"identified":[161],"reports.":[162],"These":[163],"six":[166,172,304],"randomized":[167],"controlled":[168],"trials":[169],"(RCTs)":[170],"cohort":[173,205],"studies.":[174],"All":[175],"enrolled":[178],"patients":[179,212,292,354,394],"peginterferon-\u03b1":[184],"ribavirin.":[186],"The":[187,248,359],"RCTs":[188,375],"generally":[190],"poor":[192],"quality":[193,259],"had":[195,219],"small":[196,224],"sample":[197,225],"sizes":[198],"(21":[199],"250).":[201],"While":[202],"two":[203,268,284,327],"good-quality":[204],"relatively":[208],"large":[209],"numbers":[210],"(674":[213],"1,560),":[215],"remaining":[217],"serious":[220],"methodological":[221],"limitations":[222],"sizes.":[226],"None":[227],"reported":[231,334],"on":[233,383],"important":[234],"health":[235,386],"outcomes,":[236,387],"such":[237],"liver":[239],"complications,":[240],"mortality,":[241],"virus":[245],"(HCV)":[246],"transmission.":[247],"patient":[251,348],"populations":[252],"differed":[256],"substantially.":[257],"Although":[258],"life":[261],"appeared":[262],"improve":[264,347],"in":[267,311,324,353,391],"studies,":[269],"no":[270,335],"statistical":[271],"significance":[272],"was":[273],"reported.":[274],"In":[275],"eight":[277,316],"reporting":[279,318],"sustained":[280],"viral":[281,351],"response":[282,352],"(SVR),":[283],"showed":[285,305,320],"a":[286,306,412],"statistically":[287,321],"significantly":[288],"higher":[289],"proportion":[290],"achieving":[293],"SVR":[294],"compared":[295],"usual":[297],"care,":[298],"three":[300],"other":[303],"tendency":[307],"toward":[308],"an":[309],"improvement":[310,323],"SVR.":[312],"Four":[313],"significant":[322],"adherence,":[325],"others":[328],"achieved":[329],"nonsignificant":[330],"improvement.":[331],"associated":[337],"interventions.":[340],"Conclusions":[342],"Adherence":[344],"might":[346],"strength":[360],"evidence":[362],"interventions,":[365],"however,":[366],"is":[367],"low.":[368],"More":[369],"adequately":[370,401],"powered":[371],"rigorously":[373],"conducted":[374],"are":[376],"needed":[377],"test":[379],"HCV":[380],"intermediate":[384],"genotype":[392],"1":[393],"triple":[396],"therapy.":[397],"Researchers":[398],"must":[399],"also":[400],"report":[402],"details":[403],"about":[404],"study\u2019s":[406],"design":[407],"conduct,":[409],"adopting":[411],"standard":[413],"definition":[414],"adherence.":[416]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}