{"id":"https://openalex.org/W1597938007","doi":null,"title":"Thyroid Hormone Homeostasis in Adult Mammalian Brain: A Novel Mechanism for Functional Preservation of Cerebral T3 Content During Initial Peripheral Hypothyroidism","display_name":"Thyroid Hormone Homeostasis in Adult Mammalian Brain: A Novel Mechanism for Functional Preservation of Cerebral T3 Content During Initial Peripheral Hypothyroidism","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1597938007","mag":"1597938007"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:196b31b513014273869bf93ec10a5ac9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/196b31b513014273869bf93ec10a5ac9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Al Ameen Journal of Medical Sciences, Vol 03, Iss 01, Pp 5-20 (2010)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/196b31b513014273869bf93ec10a5ac9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108812281","display_name":"Samita Kundu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samita Kundu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Arun K Ray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arun K Ray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1942,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59564799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-hormone-homeostasis","display_name":"thyroid hormone homeostasis","score":0.9769999980926514},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.4050000011920929},{"id":"https://openalex.org/keywords/peripheral-hypothyroidism","display_name":"peripheral hypothyroidism","score":0.8700000047683716},{"id":"https://openalex.org/keywords/triiodothyronine","display_name":"triiodothyronine","score":0.9079999923706055},{"id":"https://openalex.org/keywords/deiodinases","display_name":"deiodinases","score":0.7369999885559082},{"id":"https://openalex.org/keywords/brain-barriers","display_name":"brain barriers","score":0.4490000009536743},{"id":"https://openalex.org/keywords/neuronal-glial-interactions","display_name":"neuron-glia interactions","score":0.7089999914169312},{"id":"https://openalex.org/keywords/neuropsychological-outcomes","display_name":"neuropsychological outcomes","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9226171374320984},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.7009111642837524},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6604149341583252},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.594438374042511},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.592566192150116},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5650153756141663},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45226991176605225},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44871360063552856},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.33794164657592773},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.32151931524276733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.04863154888153076},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:196b31b513014273869bf93ec10a5ac9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/196b31b513014273869bf93ec10a5ac9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Al Ameen Journal of Medical Sciences, Vol 03, Iss 01, Pp 5-20 (2010)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:196b31b513014273869bf93ec10a5ac9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/196b31b513014273869bf93ec10a5ac9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Al Ameen Journal of Medical Sciences, Vol 03, Iss 01, Pp 5-20 (2010)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W74306928","https://openalex.org/W134290761","https://openalex.org/W251106692","https://openalex.org/W1529727688","https://openalex.org/W1565281228","https://openalex.org/W1926332751","https://openalex.org/W1965462646","https://openalex.org/W1970656457","https://openalex.org/W1971263640","https://openalex.org/W1978102086","https://openalex.org/W1979153848","https://openalex.org/W1982946589","https://openalex.org/W1983804222","https://openalex.org/W1990031107","https://openalex.org/W1991665751","https://openalex.org/W1996820960","https://openalex.org/W1997539630","https://openalex.org/W1997873916","https://openalex.org/W1998356213","https://openalex.org/W2001316131","https://openalex.org/W2005364480","https://openalex.org/W2007734870","https://openalex.org/W2009051740","https://openalex.org/W2017578266","https://openalex.org/W2027368977","https://openalex.org/W2034321621","https://openalex.org/W2036030550","https://openalex.org/W2041329238","https://openalex.org/W2041717395","https://openalex.org/W2044162798","https://openalex.org/W2045155944","https://openalex.org/W2049982905","https://openalex.org/W2051723208","https://openalex.org/W2051866317","https://openalex.org/W2054474801","https://openalex.org/W2055465832","https://openalex.org/W2059428797","https://openalex.org/W2061658026","https://openalex.org/W2062347722","https://openalex.org/W2065565871","https://openalex.org/W2083145012","https://openalex.org/W2084798483","https://openalex.org/W2087489634","https://openalex.org/W2092300502","https://openalex.org/W2094704242","https://openalex.org/W2094888887","https://openalex.org/W2097440306","https://openalex.org/W2104878795","https://openalex.org/W2108671981","https://openalex.org/W2111897603","https://openalex.org/W2126215795","https://openalex.org/W2126991953","https://openalex.org/W2130538167","https://openalex.org/W2132457790","https://openalex.org/W2140822449","https://openalex.org/W2165735056","https://openalex.org/W2170028141","https://openalex.org/W2300509685","https://openalex.org/W2401442160","https://openalex.org/W2403882450","https://openalex.org/W2406126144","https://openalex.org/W2409891466","https://openalex.org/W2411897612","https://openalex.org/W2414402836","https://openalex.org/W2477235922","https://openalex.org/W2613229910","https://openalex.org/W2774656852","https://openalex.org/W3150353548"],"related_works":["https://openalex.org/W2059428797","https://openalex.org/W52206530","https://openalex.org/W2401442160","https://openalex.org/W2041717395","https://openalex.org/W2056824357","https://openalex.org/W2409891466","https://openalex.org/W2406126144","https://openalex.org/W1972911358","https://openalex.org/W2041566437","https://openalex.org/W3092512244"],"abstract_inverted_index":{"brain":[0,12,77,124,152,175],"is":[1,94],"well":[2],"known.":[3],"But":[4],"the":[5,10,71,86,103,123,139,145,172,183,200,205,222,242,256,271,281],"action":[6],"of":[7,18,25,50,54,63,68,74,83,99,120,142,158,166,207,244,261,270,278],"THs":[8,245],"in":[9,59,70,85,102,171,280],"adult":[11,75,87,173],"was":[13],"not":[14,38,212],"widely":[15,39],"a":[16,57,155,167,196,217,268],"focus":[17],"study":[19],"by":[20],"endocrinologists":[21],"based":[22],"on":[23,246,273],"lack":[24],"increased":[26],"energy":[27],"metabolism":[28],"and":[29,36,78,129,132,204,238,250,258,275],"oxygen":[30],"consumption":[31],"with":[32,96,110,189,231],"changing":[33],"thyroid":[34,92,179],"status":[35],"thus":[37],"acknowledged.":[40],"Extensive":[41],"research":[42],"has,":[43],"however,":[44],"revealed":[45],"interesting":[46],"findings":[47],"like":[48,236],"sequestration":[49],"T3,":[51],"possible":[52],"release":[53],"T3":[55,69,143],"as":[56],"neurotransmitter":[58],"nerve":[60],"terminals,":[61],"identification":[62],"specific":[64],"membrane":[65],"binding":[66],"sites":[67],"synaptosomal":[72],"fraction":[73],"rat":[76],"many":[79],"non-genomic":[80],"neurotransmitter-like":[81],"actions":[82],"TH":[84,121,159,274,279],"mammalian":[88,174],"brain.":[89],"Most":[90],"importantly,":[91],"dysfunction":[93],"associated":[95,188],"significant":[97],"disruption":[98],"psychobehavioural":[100],"system":[101],"adult,":[104],"which":[105],"can":[106,153],"however":[107],"be":[108,229],"reversed":[109],"therapeutic":[111],"hormonal":[112],"intervention.":[113],"A":[114],"complex":[115],"regulatory":[116],"network":[117],"involving":[118],"transfer":[119],"through":[122],"barriers,":[125],"interactions":[126],"between":[127],"neurons":[128],"glial":[130],"cells,":[131],"deiodinase":[133],"expression":[134],"works":[135],"synchronously":[136],"to":[137,144,161,181,220,228,253],"deliver":[138],"appropriate":[140],"amount":[141],"neurons.":[146],"Despite":[147],"peripheral":[148,190],"hypo-":[149],"or":[150],"hyper-thyroidism,":[151],"maintain":[154],"normal":[156],"level":[157],"up":[160],"certain":[162],"duration.":[163],"Thus,":[164],"presence":[165],"novel":[168],"homeostatic":[169,264],"mechanism":[170,206],"(\u2018central":[176],"homeostasis":[177,210],"for":[178,195],"hormone\u2019)":[180],"defend":[182],"adverse":[184],"neuropsychological":[185],"manifestations":[186],"commonly":[187],"hypothyroidism":[191],"has":[192],"been":[193],"known":[194],"long":[197],"time.":[198],"Unfortunately,":[199],"exact":[201],"time":[202],"course":[203],"such":[208],"central":[209,263],"were":[211],"determined,":[213],"till":[214],"we":[215],"made":[216],"pioneering":[218],"attempt":[219],"evaluate":[221],"same.":[223],"The":[224],"entire":[225],"phenomenon":[226,265],"appeared":[227],"coupled":[230],"nuclear":[232],"mediated":[233],"genomic":[234],"processes":[235],"mRNA":[237],"protein":[239],"synthesis.":[240],"Moreover,":[241],"effects":[243],"some":[247],"key":[248],"enzymes":[249,272],"ions":[251],"related":[252],"neurotransmission":[254],"during":[255],"start":[257],"end":[259],"days":[260],"this":[262],"point":[266],"towards":[267],"dependency":[269],"an":[276],"involvement":[277],"neurobiochemical":[282],"events":[283]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}