{"id":"https://openalex.org/W1597906447","doi":null,"title":"Morin Attenuates Haloperidol Induced Tardive Dyskinesia and Oxidative Stress in Mice","display_name":"Morin Attenuates Haloperidol Induced Tardive Dyskinesia and Oxidative Stress in Mice","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1597906447","mag":"1597906447"},"language":"en","primary_location":{"id":"mag:1597906447","doi":null,"is_oa":false,"landing_page_url":"https://www.iiste.org/Journals/index.php/JNSR/article/download/3103/3144","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Natural Sciences Research","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009213906","display_name":"Govindhasamy Pushpavathi Selvakumar","orcid":"https://orcid.org/0000-0002-1053-2639","observed_orcids":["https://orcid.org/0000-0002-1053-2639"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Govindhasamy Pushpavathi Selvakumar","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1053-2639","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081387740","display_name":"Dhanraj Vijayraja","orcid":"https://orcid.org/0000-0002-4914-8482","observed_orcids":["https://orcid.org/0000-0002-4914-8482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dhanraj Vijayraja","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4914-8482","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108569634","display_name":"M. Krishnamoorthy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Krishnamoorthy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052925147","display_name":"Thamilarasan Manivasagam","orcid":"https://orcid.org/0000-0002-3948-8328","observed_orcids":["https://orcid.org/0000-0002-3948-8328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thamilarasan Manivasagam","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3948-8328","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1995,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.55897029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"2","issue":"8","first_page":"153","last_page":"165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.43070000410079956,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.43070000410079956,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.22709999978542328,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.15230000019073486,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morin","display_name":"morin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.9070000052452087},{"id":"https://openalex.org/keywords/tardive-dyskinesia","display_name":"tardive dyskinesia","score":1.0},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8730000257492065},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dopaminergic-neurons","display_name":"dopaminergic neurons","score":0.7770000100135803},{"id":"https://openalex.org/keywords/nigrostriatal-pathway","display_name":"nigrostriatal pathway","score":0.9100000262260437},{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.9620000123977661},{"id":"https://openalex.org/keywords/vmat2","display_name":"vesicular monoamine transporter 2","score":0.9100000262260437},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7319999933242798},{"id":"https://openalex.org/keywords/bradykinesia","display_name":"bradykinesia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/antipsychotic-side-effects","display_name":"antipsychotic adverse effects","score":0.7310000061988831},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C2779158372","wikidata":"https://www.wikidata.org/wiki/Q1546328","display_name":"Tardive dyskinesia","level":3,"score":0.761813759803772},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.7033156752586365},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6808239221572876},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.6563324332237244},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6370202302932739},{"id":"https://openalex.org/C2779968248","wikidata":"https://www.wikidata.org/wiki/Q418224","display_name":"Morin","level":2,"score":0.5712759494781494},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.5215680003166199},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5187723636627197},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.49796009063720703},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4811609983444214},{"id":"https://openalex.org/C2780405171","wikidata":"https://www.wikidata.org/wiki/Q629444","display_name":"Dyskinesia","level":4,"score":0.47508397698402405},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4281269311904907},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3869193196296692},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3635043501853943},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.1265813112258911},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.12509575486183167},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06494784355163574},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.05543181300163269},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1597906447","doi":null,"is_oa":false,"landing_page_url":"https://www.iiste.org/Journals/index.php/JNSR/article/download/3103/3144","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Natural Sciences Research","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W7213480","https://openalex.org/W134606390","https://openalex.org/W1512211793","https://openalex.org/W1608114173","https://openalex.org/W1925938340","https://openalex.org/W1963623904","https://openalex.org/W1968835387","https://openalex.org/W1976749972","https://openalex.org/W1978091036","https://openalex.org/W1983922213","https://openalex.org/W1984061110","https://openalex.org/W1986475206","https://openalex.org/W1990207109","https://openalex.org/W1993734764","https://openalex.org/W1995827045","https://openalex.org/W2003020949","https://openalex.org/W2006827046","https://openalex.org/W2008081488","https://openalex.org/W2009740169","https://openalex.org/W2011818472","https://openalex.org/W2016293448","https://openalex.org/W2018047970","https://openalex.org/W2018556491","https://openalex.org/W2023576137","https://openalex.org/W2024539177","https://openalex.org/W2025697847","https://openalex.org/W2036082290","https://openalex.org/W2038360643","https://openalex.org/W2040638886","https://openalex.org/W2041172290","https://openalex.org/W2054087453","https://openalex.org/W2057526171","https://openalex.org/W2063984406","https://openalex.org/W2073092594","https://openalex.org/W2085728531","https://openalex.org/W2091249865","https://openalex.org/W2093628776","https://openalex.org/W2106770132","https://openalex.org/W2106840587","https://openalex.org/W2108610913","https://openalex.org/W2135506151","https://openalex.org/W2136912731","https://openalex.org/W2140295766","https://openalex.org/W2140674517","https://openalex.org/W2147114673","https://openalex.org/W2157175890","https://openalex.org/W2157577940","https://openalex.org/W2169238639","https://openalex.org/W2185193730","https://openalex.org/W2249779816","https://openalex.org/W2313229938","https://openalex.org/W2322226873","https://openalex.org/W2326728715","https://openalex.org/W2743736005"],"related_works":["https://openalex.org/W2183339829","https://openalex.org/W2050941602","https://openalex.org/W2546593550","https://openalex.org/W2084056738","https://openalex.org/W2074329504","https://openalex.org/W1985668748","https://openalex.org/W7120297841","https://openalex.org/W2027042551","https://openalex.org/W1988869202","https://openalex.org/W2681878784"],"abstract_inverted_index":{"Antipsychotic":[0],"treatment":[1,84],"with":[2,29,34,85,146],"classical":[3],"neuroleptics":[4],"in":[5,37,94,167,177],"humans":[6],"can":[7],"produce":[8],"a":[9],"serious":[10,21],"side":[11],"effect,":[12],"known":[13],"as":[14,76,78],"tardive":[15,198],"dyskinesia":[16],"(TD).":[17],"TD,":[18],"is":[19,44],"most":[20],"iatrogenic":[22],"movement":[23],"disorder,":[24],"has":[25],"been":[26],"tentatively":[27],"associated":[28],"nigrostriatal":[30,128],"dopaminergic":[31,182],"supersensitivity":[32],"and":[33,40,65,109,123,138,158,165,188],"oxidative":[35,103,150],"stress":[36],"brain":[38],"region":[39],"the":[41,48,53,79,140],"complete":[42],"pathophysiology":[43],"still":[45],"obscure.":[46],"In":[47],"present":[49],"study":[50],"we":[51],"investigated":[52],"effects":[54,80],"of":[55,57,81,88,97,161,181],"co-administration":[56],"morin":[58,89,147,173],"(30":[59],"mg/kg":[60,69],"b.w,":[61],"for":[62,73],"14":[63,74,82],"days)":[64],"haloperidol":[66],"(HP)":[67],"(1.0":[68],"i.p,":[70],"once":[71],"daily,":[72],"days),":[75],"well":[77],"days":[83],"this":[86],"dose":[87],"after":[90],"withdrawal":[91],"from":[92],"HP":[93,98],"mice.":[95],"Administration":[96],"led":[99],"to":[100],"significantly":[101,148],"increased":[102],"stress,":[104,151],"reduced":[105,127],"antioxidants,":[106],"dopamine":[107,129,153],"level":[108],"condensed":[110],"behavior":[111,157],"patterns":[112],"(vacuous":[113],"chewing":[114],"movements":[115],"(VCMs),":[116],"narrow":[117],"beam":[118],"walking,":[119],"akinesia,":[120],"hang":[121],"test":[122],"stride":[124],"length":[125],"measurement),":[126],"transporter":[130,134],"(DAT),":[131],"vesicular":[132],"monoamine":[133],"2":[135,164],"(VMAT":[136],"2)":[137],"increase":[139],"inflammatory":[141],"marker":[142],"?-actin\u00a0":[143],"expressions.":[144],"Pre-treatment":[145],"reduces":[149],"improves":[152],"level,":[154],"ameliorate":[155],"motor":[156],"reversed":[159],"expression":[160],"DAT,":[162],"VMAT":[163],"?-actin":[166],"striatum.":[168],"These":[169],"results":[170],"indicate":[171],"that":[172],"have":[174],"bene?cial":[175],"role":[176],"mitigating":[178],"HP-induced":[179],"damage":[180],"neurons,":[183],"possibly":[184],"via":[185],"its":[186,189],"neuroprotective":[187],"antioxidant":[190,203],"potential.":[191],"Key":[195],"words:":[196],"dyskinesia,":[199],"iatrogenic,":[200],"bradykinesia,":[201],"nigrostriatal,":[202]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
