{"id":"https://openalex.org/W159788574","doi":"https://doi.org/10.4049/jimmunol.190.supp.192.8","title":"Deep-sequencing reveals WHO class-specific urinary microRNAs in human lupus nephritis (P3245)","display_name":"Deep-sequencing reveals WHO class-specific urinary microRNAs in human lupus nephritis (P3245)","publication_year":2013,"publication_date":"2013-05-01","ids":{"openalex":"https://openalex.org/W159788574","doi":"https://doi.org/10.4049/jimmunol.190.supp.192.8","mag":"159788574"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.190.supp.192.8","doi":"https://doi.org/10.4049/jimmunol.190.supp.192.8","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.190.supp.192.8","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036519472","display_name":"B\u00e9atrice Goilav","orcid":"https://orcid.org/0000-0002-5204-7965","observed_orcids":["https://orcid.org/0000-0002-5204-7965"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatrice Goilav","raw_affiliation_strings":["Nephrology, Children\u2019s Hospital at Montefiore , Bronx, NY","Rheumatology, Albert Einstein College of Medicine , Bronx, NY","1Nephrology, Children's Hospital at Montefiore, Bronx, NY","2Rheumatology, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology, Children\u2019s Hospital at Montefiore , Bronx, NY","institution_ids":["https://openalex.org/I4210135976"]},{"raw_affiliation_string":"Rheumatology, Albert Einstein College of Medicine , Bronx, NY","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"1Nephrology, Children's Hospital at Montefiore, Bronx, NY","institution_ids":["https://openalex.org/I4210135976"]},{"raw_affiliation_string":"2Rheumatology, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025485690","display_name":"Iddo Z. Ben\u2010Dov","orcid":"https://orcid.org/0000-0002-9180-3604","observed_orcids":["https://orcid.org/0000-0002-9180-3604"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Iddo Ben-Dov","raw_affiliation_strings":["Nephrology and Hypertension, Hadassah Medical Center , Jerusalem,","5Nephrology and Hypertension, Hadassah Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nephrology and Hypertension, Hadassah Medical Center , Jerusalem,","institution_ids":["https://openalex.org/I2799899409"]},{"raw_affiliation_string":"5Nephrology and Hypertension, Hadassah Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007117107","display_name":"Olivier D. Loudig","orcid":"https://orcid.org/0000-0001-5677-4716","observed_orcids":["https://orcid.org/0000-0001-5677-4716"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivier Loudig","raw_affiliation_strings":["Epidemiology and Population Health, Albert Einstein College of Medicine , Bronx, NY","4Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epidemiology and Population Health, Albert Einstein College of Medicine , Bronx, NY","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"4Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058487371","display_name":"Irene Blanco","orcid":"https://orcid.org/0000-0002-8540-1289","observed_orcids":["https://orcid.org/0000-0002-8540-1289"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Blanco","raw_affiliation_strings":["Rheumatology, Albert Einstein College of Medicine , Bronx, NY","2Rheumatology, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Albert Einstein College of Medicine , Bronx, NY","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"2Rheumatology, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068037550","display_name":"Dawn M. Wahezi","orcid":"https://orcid.org/0000-0002-0543-7805","observed_orcids":["https://orcid.org/0000-0002-0543-7805"]},"institutions":[{"id":"https://openalex.org/I4210135976","display_name":"Children's Hospital at Montefiore","ror":"https://ror.org/03n0fp725","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135976"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn Wahezi","raw_affiliation_strings":["Rheumatology, Children\u2019s Hospital at Montefiore , Bronx, NY","6Rheumatology, Children's Hospital at Montefiore, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Children\u2019s Hospital at Montefiore , Bronx, NY","institution_ids":["https://openalex.org/I4210135976"]},{"raw_affiliation_string":"6Rheumatology, Children's Hospital at Montefiore, Bronx, NY","institution_ids":["https://openalex.org/I4210135976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088498253","display_name":"Chaim Putterman","orcid":"https://orcid.org/0000-0002-3204-6068","observed_orcids":["https://orcid.org/0000-0002-3204-6068"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chaim Putterman","raw_affiliation_strings":["Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY","Rheumatology, Albert Einstein College of Medicine , Bronx, NY","3Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"Rheumatology, Albert Einstein College of Medicine , Bronx, NY","institution_ids":["https://openalex.org/I129975664"]},{"raw_affiliation_string":"3Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"190","issue":"Supplement_1","first_page":"192.8","last_page":"192.8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/urinary-microrna","display_name":"urinary microRNA","score":0.9660000205039978},{"id":"https://openalex.org/keywords/who-classification","display_name":"WHO classification","score":0.6439999938011169},{"id":"https://openalex.org/keywords/class-iv-lupus-nephritis","display_name":"class IV lupus nephritis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/class-v-lupus-nephritis","display_name":"class V lupus nephritis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mir-193a-5p","display_name":"miR-193a-5p","score":0.9240000247955322},{"id":"https://openalex.org/keywords/mir-423","display_name":"miR-423","score":0.968999981880188},{"id":"https://openalex.org/keywords/mir-501-3p","display_name":"miR-501-3p","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mir-874","display_name":"miR-874","score":1.0},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.6470000147819519},{"id":"https://openalex.org/keywords/pediatric-lupus-nephritis","display_name":"pediatric lupus nephritis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/disease-activity","display_name":"disease activity","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.7271764278411865},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5877277851104736},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5857663750648499},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5725178718566895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4779108464717865},{"id":"https://openalex.org/C112190416","wikidata":"https://www.wikidata.org/wiki/Q2124450","display_name":"RNA extraction","level":4,"score":0.45999181270599365},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.4587782323360443},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3770672678947449},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36417651176452637},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3603980541229248},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35736843943595886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32574066519737244},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2097058892250061}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.190.supp.192.8","doi":"https://doi.org/10.4049/jimmunol.190.supp.192.8","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.190.supp.192.8","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2735676906","https://openalex.org/W2239166040","https://openalex.org/W2771012692","https://openalex.org/W2620877772","https://openalex.org/W2069954171","https://openalex.org/W4403049281","https://openalex.org/W2316549902","https://openalex.org/W2024018562","https://openalex.org/W2313221724","https://openalex.org/W4206026575"],"abstract_inverted_index":{"Abstract":[0],"Lupus":[1],"nephritis":[2],"(LN)":[3],"is":[4,220],"associated":[5,215],"with":[6,35,64,77,152,198,216],"significant":[7,162],"morbidity":[8],"and":[9,31,61,72,81,91,121,149,173,195],"mortality.":[10],"microRNAs":[11],"(miRs)":[12],"are":[13],"small,":[14],"non-coding":[15],"RNAs":[16],"that":[17,33],"regulate":[18],"translation.":[19],"Previous,":[20],"studies":[21],"report":[22],"changes":[23,163],"in":[24,27,57,145,164,177,191,224],"miR":[25,143],"expression":[26],"kidney":[28],"tissue,":[29],"urine":[30,58,68,146,192],"PBMC":[32],"correlate":[34],"LN":[36,40,83,199,212,218],"disease":[37,90],"activity.":[38],"However,":[39],"WHO":[41,54,78,178],"class-specific":[42,55],"miRs":[43,56,125,190,214],"have":[44],"not":[45],"been":[46],"described.":[47],"Using":[48],"deep-sequencing,":[49],"we":[50,160,184],"aimed":[51],"to":[52,98,117],"identify":[53],"from":[59,69],"adult":[60,70,148,194],"pediatric":[62,73,150,196],"patients":[63,76,151,197],"biopsy-proven":[65],"LN.":[66,181],"Cell-free":[67],"(n=25)":[71],"(n=8)":[74],"female":[75],"class":[79,154,157,179,200,203,210,219],"IV":[80,155,180,211],"V":[82,158],"were":[84,115,126],"obtained":[85,133],"at":[86],"time":[87],"of":[88,136,147,169,188,193,209,227],"active":[89,153],"during":[92],"remission.":[93],"Total":[94],"RNA":[95,101,123],"was":[96,111],"used":[97],"prepare":[99],"small":[100,122],"cDNA":[102],"libraries":[103],"for":[104],"sequencing.":[105],"Multiplexing":[106],"through":[107],"sample-specific":[108],"3'":[109],"adapters":[110],"applied.":[112],"Sequence":[113],"reads":[114],"mapped":[116],"the":[118,206],"human":[119],"genome":[120],"databases.":[124],"quantified":[127],"by":[128,175],"relative":[129],"read":[130],"abundance.":[131],"We":[132],"reproducible":[134],"profiles":[135],"miRs.":[137],"In":[138,182],"a":[139],"paired-sample":[140],"analysis":[141],"comparing":[142],"abundance":[144],"versus":[156,202],"LN,":[159],"found":[161],"6":[165],"miRs,":[166],"including":[167],"up-regulation":[168],"miR-193a-5p,":[170],"-423,":[171],"501-3p,":[172],"-874":[174],"400-1,000x":[176],"conclusion,":[183],"detected":[185],"higher":[186],"counts":[187],"specific":[189],"IV,":[201],"V.":[204],"Given":[205],"worse":[207],"prognosis":[208],"identifying":[213],"this":[217,228],"an":[221],"important":[222],"step":[223],"biomarker":[225],"discovery":[226],"particulary":[229],"aggressive":[230],"disease.":[231]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}