{"id":"https://openalex.org/W1597852608","doi":null,"title":"Platelet-Leukocyte Interaction in Atherosclerosis and Atherothrombosis: What We Have Learnt From Human Studies and Animal Models","display_name":"Platelet-Leukocyte Interaction in Atherosclerosis and Atherothrombosis: What We Have Learnt From Human Studies and Animal Models","publication_year":2014,"publication_date":"2014-06-10","ids":{"openalex":"https://openalex.org/W1597852608","mag":"1597852608"},"language":"en","primary_location":{"id":"mag:1597852608","doi":null,"is_oa":false,"landing_page_url":"http://www.ghrnet.org/index.php/jct/article/download/710/820","pdf_url":null,"source":{"id":"https://openalex.org/S2764742042","display_name":"Journal of Cardiology and Therapy","issn_l":"2309-6861","issn":["2309-6861","2312-122X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cardiology and Therapy","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100347048","display_name":"Ying Wang","orcid":"https://orcid.org/0000-0002-0429-9551","observed_orcids":["https://orcid.org/0000-0002-0429-9551"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Departments of Medicine, Division of Molecular Medicine, Columbia University, New York, the United States"],"raw_orcid":"https://orcid.org/0000-0002-0429-9551","affiliations":[{"raw_affiliation_string":"Departments of Medicine, Division of Molecular Medicine, Columbia University, New York, the United States","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhen Yuan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Yuan Li","raw_affiliation_strings":["Renal Division, Renji Hospital , Shanghai Jiaotong University School of Medicine , Shanghai , China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Division, Renji Hospital , Shanghai Jiaotong University School of Medicine , Shanghai , China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007"]}]},{"author_position":"last","author":{"id":null,"display_name":"Wei Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Wang","raw_affiliation_strings":["Departments of Medicine, Division of Molecular Medicine, Columbia University, New York, the United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Division of Molecular Medicine, Columbia University, New York, the United States","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6364,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70575926,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"1","issue":"5","first_page":"92","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.3012999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.028200000524520874,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-leukocyte-interaction","display_name":"platelet-leukocyte interaction","score":0.9940000176429749},{"id":"https://openalex.org/keywords/platelet-leukocyte-aggregates","display_name":"platelet-leukocyte aggregates","score":0.9679999947547913},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/atherothrombosis","display_name":"atherothrombosis","score":1.0},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.968999981880188},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7960000038146973},{"id":"https://openalex.org/keywords/megakaryocytes","display_name":"megakaryocytes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.6579999923706055},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.4699999988079071},{"id":"https://openalex.org/keywords/animal-models","display_name":"animal models","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.8893650770187378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7167021632194519},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.6521317362785339},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.6186503767967224},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.4857966899871826},{"id":"https://openalex.org/C2993802102","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet aggregation","level":3,"score":0.4520523250102997},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4430694580078125},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.4291534423828125},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2163906693458557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18435201048851013}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1597852608","doi":null,"is_oa":false,"landing_page_url":"http://www.ghrnet.org/index.php/jct/article/download/710/820","pdf_url":null,"source":{"id":"https://openalex.org/S2764742042","display_name":"Journal of Cardiology and Therapy","issn_l":"2309-6861","issn":["2309-6861","2312-122X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cardiology and Therapy","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W229396605","https://openalex.org/W1967376890","https://openalex.org/W1979346097","https://openalex.org/W1982958883","https://openalex.org/W1984464853","https://openalex.org/W1984514918","https://openalex.org/W1988098053","https://openalex.org/W1989605865","https://openalex.org/W1993981546","https://openalex.org/W2009814597","https://openalex.org/W2011854883","https://openalex.org/W2019314531","https://openalex.org/W2023429077","https://openalex.org/W2026287488","https://openalex.org/W2030281077","https://openalex.org/W2034551997","https://openalex.org/W2037844800","https://openalex.org/W2038579255","https://openalex.org/W2048674513","https://openalex.org/W2052863327","https://openalex.org/W2055998280","https://openalex.org/W2057016253","https://openalex.org/W2058217708","https://openalex.org/W2062924915","https://openalex.org/W2068153038","https://openalex.org/W2072190804","https://openalex.org/W2080455788","https://openalex.org/W2082264161","https://openalex.org/W2084158483","https://openalex.org/W2092557265","https://openalex.org/W2097097037","https://openalex.org/W2097393755","https://openalex.org/W2116187812","https://openalex.org/W2120047761","https://openalex.org/W2120645566","https://openalex.org/W2124989653","https://openalex.org/W2127617190","https://openalex.org/W2136650071","https://openalex.org/W2143900848","https://openalex.org/W2152962086","https://openalex.org/W2158062242","https://openalex.org/W2158369873","https://openalex.org/W2160309383","https://openalex.org/W2164129667","https://openalex.org/W2169304723","https://openalex.org/W2272630110","https://openalex.org/W2276235167","https://openalex.org/W2319834083","https://openalex.org/W2419317687","https://openalex.org/W2586950898"],"related_works":["https://openalex.org/W2489819842","https://openalex.org/W2114381479","https://openalex.org/W2073037837","https://openalex.org/W1993630854","https://openalex.org/W2141015143","https://openalex.org/W2373557981","https://openalex.org/W1038654382","https://openalex.org/W2307247696","https://openalex.org/W2103363585","https://openalex.org/W2360685554"],"abstract_inverted_index":{"Platelets,":[0],"the":[1,33,42,46,72,76,83,106,110],"cellular":[2],"fragments":[3],"of":[4,52,95,98],"their":[5],"precursor":[6],"megakaryocytes,":[7],"play":[8],"an":[9],"important":[10],"role":[11],"in":[12,41,57,87,114],"hemostasis":[13],"and":[14,20,63,89],"other":[15,30],"pathophysiological":[16],"circumstances":[17],"including":[18],"atherothrombosis":[19,90],"atherosclerosis.":[21,117],"Activated":[22],"platelet":[23,77,84,99,111],"not":[24],"only":[25],"can":[26,37],"aggregate":[27],"with":[28,39,59,105,116],"each":[29],"to":[31,44],"form":[32,45],"thrombi,":[34],"but":[35],"also":[36],"interact":[38],"leukocytes":[40],"circulation":[43],"platelet-leukocyte":[47],"aggregates":[48],"(PLAs).":[49],"Increased":[50],"number":[51],"PLAs":[53],"has":[54],"been":[55],"reported":[56],"patients":[58,115],"atherosclerosis":[60,88],"or":[61],"atherothrombosis,":[62],"animal":[64,103],"models":[65],"using":[66],"different":[67],"knock-out":[68],"mice":[69],"have":[70],"unraveled":[71],"molecular":[73],"mechanisms":[74,97],"underlying":[75],"leukocyte":[78,85,100,112],"interaction.":[79],"This":[80],"review":[81],"describes":[82],"interaction":[86,101,113],"by":[91],"integrating":[92],"our":[93],"knowledge":[94],"basic":[96],"from":[102],"studies":[104,108],"clinical":[107],"illustrating":[109]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}