{"id":"https://openalex.org/W1597728543","doi":null,"title":"Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice.","display_name":"Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice.","publication_year":2003,"publication_date":"2003-08-15","ids":{"openalex":"https://openalex.org/W1597728543","mag":"1597728543","pmid":"https://pubmed.ncbi.nlm.nih.gov/12941805"},"language":"en","primary_location":{"id":"pmid:12941805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12941805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017785312","display_name":"Hiroki Nagase","orcid":"https://orcid.org/0000-0002-3992-5399","observed_orcids":["https://orcid.org/0000-0002-3992-5399"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroki Nagase","raw_affiliation_strings":["The Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. Hiroki.Nagase@RoswellPark.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. Hiroki.Nagase@RoswellPark.org","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032768695","display_name":"Jian\u2010Hua Mao","orcid":"https://orcid.org/0000-0001-9320-6021","observed_orcids":["https://orcid.org/0000-0001-9320-6021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jian-Hua Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050117160","display_name":"Allan Balmain","orcid":"https://orcid.org/0000-0001-6549-7861","observed_orcids":["https://orcid.org/0000-0001-6549-7861"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allan Balmain","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0789,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.73520126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"63","issue":"16","first_page":"4849","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.29170000553131104,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.29170000553131104,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.16359999775886536,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.07000000029802322,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/hras-mutation","display_name":"HRAS mutation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/somatic-alterations","display_name":"somatic alterations","score":0.7260000109672546},{"id":"https://openalex.org/keywords/allelic-imbalance","display_name":"allelic imbalance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/chromosome-7","display_name":"chromosome 7","score":0.6980000138282776},{"id":"https://openalex.org/keywords/mus-spretus","display_name":"Mus spretus","score":0.8080000281333923},{"id":"https://openalex.org/keywords/two-stage-carcinogenesis","display_name":"two-stage carcinogenesis","score":0.6449999809265137},{"id":"https://openalex.org/keywords/microsatellite-analysis","display_name":"microsatellite analysis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/skin-carcinoma","display_name":"skin carcinoma","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8032331466674805},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7250881791114807},{"id":"https://openalex.org/C1167327","wikidata":"https://www.wikidata.org/wiki/Q14884140","display_name":"HRAS","level":5,"score":0.6390354633331299},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6334425806999207},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.47700002789497375},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.42214471101760864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3807956278324127},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35539817810058594},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.33149561285972595},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.07984724640846252}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:12941805","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12941805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1597728543","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12941805","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000888465","display_name":"Roswell Park Cancer Center Support Grant","funder_award_id":"P30CA016056","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1523573638","https://openalex.org/W1606506184","https://openalex.org/W1770702054","https://openalex.org/W1785815924","https://openalex.org/W1985651419","https://openalex.org/W2000862549","https://openalex.org/W2002979338","https://openalex.org/W2070333386","https://openalex.org/W2077858999","https://openalex.org/W2083571813","https://openalex.org/W2093445801","https://openalex.org/W2110597562","https://openalex.org/W2119369274","https://openalex.org/W2124387047","https://openalex.org/W2146366952","https://openalex.org/W2151464048","https://openalex.org/W2163451864","https://openalex.org/W2169872133"],"related_works":["https://openalex.org/W2168412354","https://openalex.org/W1976241970","https://openalex.org/W2137934173","https://openalex.org/W2163451864","https://openalex.org/W2071664888","https://openalex.org/W2740742591","https://openalex.org/W1983751052","https://openalex.org/W3007797100","https://openalex.org/W2083534058","https://openalex.org/W7098877319"],"abstract_inverted_index":{"We":[0,194],"have":[1],"investigated":[2],"the":[3,15,60,72,92,118,121,178,182,188,191,207,223],"effects":[4],"of":[5,17,62,98,112,177,187,209,215,225],"germ-line":[6,227],"variants":[7,228],"that":[8,116,196,229],"influence":[9],"skin":[10,23,28,37,69],"tumor":[11,38,201,231],"susceptibility":[12,39],"loci":[13,41,67,154],"on":[14,84,155],"patterns":[16],"somatic":[18,210],"genetic":[19],"alterations":[20,64,211],"in":[21,42,68,91,96,198,206,212,219],"mouse":[22,77],"cancers.":[24],"Using":[25],"a":[26,43],"two-stage":[27],"carcinogenesis":[29],"model,":[30],"we":[31,58,174],"previously":[32],"identified":[33],"at":[34,65,150],"least":[35],"13":[36],"(Skts)":[40],"large":[44],"interspecific":[45],"F1":[46],"backcross":[47,74],"[(NIH/Ola":[48],"x":[49,52,139,142],"M.":[50,140],"spretus)":[51,141],"NIH/Ola]":[53],"study.":[54],"In":[55,101],"this":[56],"report,":[57],"describe":[59],"analysis":[61,127],"allele-specific":[63,217],"these":[66],"tumors":[70,104,220],"from":[71,134,137,181,190],"same":[73],"animals.":[75],"The":[76],"Hras":[78,106],"gene,":[79],"located":[80],"close":[81],"to":[82],"Skts2":[83],"chromosome":[85,113,119],"7,":[86,159],"had":[87],"specific":[88,110],"activating":[89],"mutations":[90,107],"Mus":[93],"musculus":[94],"allele":[95,179,189],"23":[97],"26":[99],"carcinomas.":[100],"all":[102,171],"cases,":[103],"with":[105],"also":[108,129],"showed":[109],"imbalance":[111,147],"7":[114],"markers":[115],"favored":[117],"carrying":[120],"mutant":[122],"allele.":[123],"Allele-specific":[124],"quantitative":[125],"microsatellite":[126],"was":[128,148],"carried":[130],"out,":[131],"using":[132],"DNA":[133],"62":[135],"carcinomas":[136],"(NIH/Ola":[138],"NIH/Ola":[143],"mice.":[144],"Frequent":[145],"allelic":[146],"detected":[149],"five":[151],"additional":[152],"tumor-susceptibility":[153],"chromosomes":[156],"4,":[157],"6,":[158],"9,":[160],"and":[161,167],"16":[162],"(Skts7,":[163],"Skts12,":[164],"Skts1,":[165],"Skts6,":[166],"Skts9,":[168],"respectively).":[169],"At":[170],"except":[172],"Skts7,":[173],"found":[175],"loss":[176],"inherited":[180],"resistant":[183],"strain":[184],"or":[185],"amplification":[186],"susceptible":[192],"strain.":[193],"conclude":[195],"polymorphisms":[197],"some":[199],"low-penetrance":[200],"modifier":[202],"genes":[203],"are":[204],"reflected":[205],"pattern":[208],"tumors.":[213],"Analysis":[214],"such":[216],"changes":[218],"may":[221],"facilitate":[222],"identification":[224],"functional":[226],"control":[230],"susceptibility.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}