{"id":"https://openalex.org/W1597525592","doi":"https://doi.org/10.1038/10754","title":"Co-translational domain folding as the structural basis for the rapid de novo folding of firefly luciferase.","display_name":"Co-translational domain folding as the structural basis for the rapid de novo folding of firefly luciferase.","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W1597525592","doi":"https://doi.org/10.1038/10754","mag":"1597525592","pmid":"https://pubmed.ncbi.nlm.nih.gov/10404229"},"language":"en","primary_location":{"id":"doi:10.1038/10754","doi":"https://doi.org/10.1038/10754","is_oa":false,"landing_page_url":"https://doi.org/10.1038/10754","pdf_url":null,"source":{"id":"https://openalex.org/S4394735520","display_name":"Nature Structural Biology","issn_l":"1072-8368","issn":["1072-8368","2331-365X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041204065","display_name":"Judith Frydman","orcid":"https://orcid.org/0000-0003-2302-6943","observed_orcids":["https://orcid.org/0000-0003-2302-6943"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Judith Frydman","raw_affiliation_strings":["Department of Biological Sciences, Stanford University, California 94305, USA. jfrydman@leland.stanford.edu","Department of Biological Sciences, Stanford University Stanford, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Stanford University, California 94305, USA. jfrydman@leland.stanford.edu","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Biological Sciences, Stanford University Stanford, USA","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082796663","display_name":"Hediye Erdjument\u2010Bromage","orcid":"https://orcid.org/0000-0003-0224-3594","observed_orcids":["https://orcid.org/0000-0003-0224-3594"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hediye Erdjument-Bromage","raw_affiliation_strings":["Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA","Molecular Biology Program; Memorial Sloan Kettering Cancer Center; New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Biology Program; Memorial Sloan Kettering Cancer Center; New York USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009347072","display_name":"Paul Tempst","orcid":"https://orcid.org/0000-0002-6680-3987","observed_orcids":["https://orcid.org/0000-0002-6680-3987"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Tempst","raw_affiliation_strings":["Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA","Molecular Biology Program; Memorial Sloan Kettering Cancer Center; New York USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, 10021, New York, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Molecular Biology Program; Memorial Sloan Kettering Cancer Center; New York USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086048712","display_name":"F. Ulrich Hartl","orcid":"https://orcid.org/0000-0002-7941-135X","observed_orcids":["https://orcid.org/0000-0002-7941-135X"]},"institutions":[{"id":"https://openalex.org/I4210150093","display_name":"Max Planck Institute of Biochemistry","ror":"https://ror.org/04py35477","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210150093"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"F. Ulrich Hartl","raw_affiliation_strings":["Department of Cellular Biochemistry, Max-Planck-Institut f\u00fcr Biochemie, Am Klopferspitz 18a, Martinsried, D-82152, Germany","Department of Cellular Biochemistry, Max-Planck-Institut f\u00fcr Biochemie, Martinsried, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biochemistry, Max-Planck-Institut f\u00fcr Biochemie, Am Klopferspitz 18a, Martinsried, D-82152, Germany","institution_ids":["https://openalex.org/I4210150093"]},{"raw_affiliation_string":"Department of Cellular Biochemistry, Max-Planck-Institut f\u00fcr Biochemie, Martinsried, Germany","institution_ids":["https://openalex.org/I4210150093"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041204065"],"corresponding_institution_ids":["https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":1.6283,"has_fulltext":false,"cited_by_count":194,"citation_normalized_percentile":{"value":0.82232947,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"6","issue":"7","first_page":"697","last_page":"705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.14309999346733093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/firefly-luciferase","display_name":"firefly luciferase","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cotranslational-folding","display_name":"co-translational folding","score":0.9599999785423279},{"id":"https://openalex.org/keywords/protein-folding-kinetics","display_name":"protein folding kinetics","score":0.7070000171661377},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.7070000171661377},{"id":"https://openalex.org/keywords/multidomain-proteins","display_name":"multidomain proteins","score":0.703000009059906},{"id":"https://openalex.org/keywords/denaturant-induced-unfolding","display_name":"denaturant-induced unfolding","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.7999694347381592},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.680801272392273},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6769707798957825},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.6622729897499084},{"id":"https://openalex.org/C88478588","wikidata":"https://www.wikidata.org/wiki/Q42244","display_name":"Ribosome","level":4,"score":0.6195741891860962},{"id":"https://openalex.org/C2776545253","wikidata":"https://www.wikidata.org/wiki/Q5464292","display_name":"Folding (DSP implementation)","level":2,"score":0.5744381546974182},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.5605350732803345},{"id":"https://openalex.org/C162203774","wikidata":"https://www.wikidata.org/wiki/Q7181581","display_name":"Phi value analysis","level":3,"score":0.49507299065589905},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.42119306325912476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39014700055122375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1872544288635254},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.17537358403205872},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.09125229716300964},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001517","descriptor_name":"Coleoptera","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019286","descriptor_name":"Endopeptidase K","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019791","descriptor_name":"Guanidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/10754","doi":"https://doi.org/10.1038/10754","is_oa":false,"landing_page_url":"https://doi.org/10.1038/10754","pdf_url":null,"source":{"id":"https://openalex.org/S4394735520","display_name":"Nature Structural Biology","issn_l":"1072-8368","issn":["1072-8368","2331-365X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Structural Biology","raw_type":"journal-article"},{"id":"pmid:10404229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10404229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature structural biology","raw_type":"Journal Article"},{"id":"mag:2467762188","doi":null,"is_oa":false,"landing_page_url":"http://ci.nii.ac.jp/naid/30013790805/en/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W294734509","https://openalex.org/W1497179297","https://openalex.org/W1593931811","https://openalex.org/W1602887917","https://openalex.org/W1854687733","https://openalex.org/W1963770237","https://openalex.org/W1984216534","https://openalex.org/W1987606713","https://openalex.org/W1999938778","https://openalex.org/W2009292400","https://openalex.org/W2014095962","https://openalex.org/W2018193494","https://openalex.org/W2023115041","https://openalex.org/W2044483297","https://openalex.org/W2045777307","https://openalex.org/W2051793369","https://openalex.org/W2061301953","https://openalex.org/W2061528889","https://openalex.org/W2082657939","https://openalex.org/W2087600266","https://openalex.org/W2089473305","https://openalex.org/W2097794242","https://openalex.org/W2119999468","https://openalex.org/W2139518648","https://openalex.org/W2163302928","https://openalex.org/W2164108483","https://openalex.org/W3107148387"],"related_works":["https://openalex.org/W2043113850","https://openalex.org/W2467762188","https://openalex.org/W2025025955","https://openalex.org/W2061672931","https://openalex.org/W2018193494","https://openalex.org/W2912906834","https://openalex.org/W2032492105","https://openalex.org/W294734509","https://openalex.org/W2084223019","https://openalex.org/W2038859375"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}