{"id":"https://openalex.org/W1597007629","doi":null,"title":"Isolation and characterization of galectins in the mammalian retina.","display_name":"Isolation and characterization of galectins in the mammalian retina.","publication_year":2001,"publication_date":"2001-09-01","ids":{"openalex":"https://openalex.org/W1597007629","mag":"1597007629","pmid":"https://pubmed.ncbi.nlm.nih.gov/11527926"},"language":"en","primary_location":{"id":"pmid:11527926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11527926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058423158","display_name":"Fumiyuki Uehara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"F Uehara","raw_affiliation_strings":["Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan. fuehara@med5.kufm.kagoshima-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Kagoshima University Faculty of Medicine, Japan. fuehara@med5.kufm.kagoshima-u.ac.jp","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109036382","display_name":"Norio Ohba","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Ohba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068682184","display_name":"Masayuki Ozawa","orcid":"https://orcid.org/0000-0002-7887-8441","observed_orcids":["https://orcid.org/0000-0002-7887-8441"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ozawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4183,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.56901001,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"42","issue":"10","first_page":"2164","last_page":"72"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12387","display_name":"Galectins and Cancer Biology","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.020600000396370888,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galectins","display_name":"galectins","score":0.9580000042915344},{"id":"https://openalex.org/keywords/galectin-1","display_name":"galectin-1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/galectin-3","display_name":"galectin-3","score":1.0},{"id":"https://openalex.org/keywords/retinal-adhesion","display_name":"retinal adhesion","score":0.75},{"id":"https://openalex.org/keywords/photoreceptor-survival","display_name":"photoreceptor survival","score":0.949999988079071},{"id":"https://openalex.org/keywords/muller-cells","display_name":"M\u00fcller cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/retinal-detachment","display_name":"retinal detachment","score":0.847000002861023},{"id":"https://openalex.org/keywords/outer-plexiform-layer","display_name":"outer plexiform layer","score":0.8379999995231628},{"id":"https://openalex.org/keywords/retinal-pigment-epithelium","display_name":"retinal pigment epithelium","score":0.9620000123977661},{"id":"https://openalex.org/keywords/constant-light-exposure","display_name":"continuous light exposure","score":0.7400000095367432},{"id":"https://openalex.org/keywords/apoptosis-inhibition","display_name":"apoptosis inhibition","score":0.7049999833106995},{"id":"https://openalex.org/keywords/retinal-degeneration","display_name":"retinal degeneration","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C156293190","wikidata":"https://www.wikidata.org/wiki/Q83138026","display_name":"Galectin","level":2,"score":0.8015146851539612},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6543987989425659},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6379667520523071},{"id":"https://openalex.org/C2780758401","wikidata":"https://www.wikidata.org/wiki/Q408693","display_name":"Lectin","level":2,"score":0.5390427112579346},{"id":"https://openalex.org/C2778024200","wikidata":"https://www.wikidata.org/wiki/Q2346242","display_name":"Retinal pigment epithelium","level":3,"score":0.5266333222389221},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5233559012413025},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.5095791816711426},{"id":"https://openalex.org/C2777585161","wikidata":"https://www.wikidata.org/wiki/Q2357246","display_name":"Outer plexiform layer","level":3,"score":0.42754095792770386},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4081576466560364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2160787284374237},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D006388","descriptor_name":"Hemagglutinins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007267","descriptor_name":"Injections","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012163","descriptor_name":"Retinal Detachment","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012163","descriptor_name":"Retinal Detachment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012163","descriptor_name":"Retinal Detachment","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014822","descriptor_name":"Vitreous Body","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037483","descriptor_name":"Galectin 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037502","descriptor_name":"Galectin 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11527926","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11527926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:1597007629","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11527926","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W45837274","https://openalex.org/W139331214","https://openalex.org/W148500261","https://openalex.org/W175108226","https://openalex.org/W198037453","https://openalex.org/W250440749","https://openalex.org/W611106571","https://openalex.org/W659087181","https://openalex.org/W1498536727","https://openalex.org/W1537476598","https://openalex.org/W1549447766","https://openalex.org/W1576305569","https://openalex.org/W1638424324","https://openalex.org/W2002108286","https://openalex.org/W2007966350","https://openalex.org/W2023028683","https://openalex.org/W2033325512","https://openalex.org/W2045458224","https://openalex.org/W2054862233","https://openalex.org/W2060490044","https://openalex.org/W2068153867","https://openalex.org/W2075413987","https://openalex.org/W2080326808","https://openalex.org/W2100837269","https://openalex.org/W2117832286","https://openalex.org/W2128073497","https://openalex.org/W2240884576","https://openalex.org/W2419163848","https://openalex.org/W2420123422"],"related_works":["https://openalex.org/W1576305569","https://openalex.org/W2129617891","https://openalex.org/W7065770863","https://openalex.org/W2469947272","https://openalex.org/W2621259244","https://openalex.org/W2087551001","https://openalex.org/W2012689651","https://openalex.org/W4281779632","https://openalex.org/W2063580158","https://openalex.org/W3048243409"],"abstract_inverted_index":{"PURPOSE:":[0],"Previous":[1],"studies":[2],"have":[3],"suggested":[4],"that":[5,52],"galectins":[6,87,116,135],"may":[7,219,247],"be":[8,220],"involved":[9,221],"in":[10,117,136,156,171,180,193,207,222,238,249],"retinal":[11,25,50,72,86,161],"adhesion":[12,223],"and":[13,30,32,78,97,119,131,148,167,173,198,227,242],"photoreceptor":[14,226],"cell":[15],"survival.":[16],"To":[17],"elucidate":[18],"the":[19,22,34,37,63,76,107,110,113,129,160,181,201,214,225,239],"underlying":[20],"mechanisms,":[21],"authors":[23,111],"isolated":[24,54,66,90],"galectins,":[26],"determined":[27],"their":[28],"types":[29],"distributions,":[31],"investigated":[33],"validity":[35],"of":[36,57,62,69,84,93,115,124,134,143,183,200,213,224,252],"hypothesis,":[38],"using":[39,75],"rat":[40,85,120,125,138,146,149,174,208,255],"models.":[41],"METHODS:":[42],"An":[43],"antibody":[44,102],"was":[45,53,65,80,154,177],"prepared":[46],"against":[47,103],"a":[48,58,70,253],"bovine":[49,71,118,144,172],"lectin":[51,64],"by":[55,67,91,128,210,231],"use":[56],"lactose-agarose":[59],"column.":[60],"cDNA":[61,73],"screening":[68],"library,":[74],"antibody,":[77],"then":[79],"sequenced.":[81],"The":[82,141],"cDNAs":[83,142],"were":[88,151,205],"also":[89],"means":[92],"polymerase":[94],"chain":[95],"reaction":[96],"used":[98],"to":[99],"produce":[100],"an":[101,191],"recombinant":[104],"galectin-3.":[105],"Using":[106],"described":[108],"antibodies,":[109,130],"examined":[112],"distributions":[114],"retinas,":[121],"morphologic":[122],"changes":[123,133],"retinas":[126],"induced":[127,206],"distributional":[132],"constant-light-exposed":[137],"retinas.":[139,175],"RESULTS:":[140],"galectin-1,":[145,147],"galectin-3":[150],"isolated.":[152],"Galectin-1":[153,218],"found":[155],"various":[157],"regions,":[158],"including":[159],"pigment":[162],"epithelium,":[163],"outer":[164,168,202,228],"limiting":[165],"membrane,":[166],"plexiform":[169,203,229],"layer":[170,204],"Galectin-3":[176,246],"increasingly":[178],"detected":[179],"cytoplasm":[182],"M\u00fcller":[184,250],"cells":[185,251],"after":[186,190],"constant":[187],"light":[188],"exposure":[189],"increase":[192,248],"its":[194],"transcript.":[195],"Retinal":[196],"detachment":[197],"vacuolation":[199],"eyes":[209],"intravitreous":[211],"injection":[212],"anti-galectin-1":[215],"antibody.":[216],"CONCLUSIONS:":[217],"layers":[230],"interacting":[232],"with":[233,235],"glycoconjugates":[234],"beta-galactoside":[236],"residues":[237],"interphotoreceptor":[240],"matrix":[241],"synaptic":[243],"cleft":[244],"matrix.":[245],"degenerative":[254],"retina,":[256],"probably":[257],"through":[258],"endogenous":[259],"anti-apoptosis.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}