{"id":"https://openalex.org/W1596765859","doi":"https://doi.org/10.4049/jimmunol.149.5.1619","title":"T cell receptor expression can switch on and off at a posttranslational level","display_name":"T cell receptor expression can switch on and off at a posttranslational level","publication_year":1992,"publication_date":"1992-09-01","ids":{"openalex":"https://openalex.org/W1596765859","doi":"https://doi.org/10.4049/jimmunol.149.5.1619","mag":"1596765859","pmid":"https://pubmed.ncbi.nlm.nih.gov/1387145"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.149.5.1619","doi":"https://doi.org/10.4049/jimmunol.149.5.1619","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.149.5.1619","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068399737","display_name":"Holden Terry Maecker","orcid":"https://orcid.org/0000-0003-0795-9946","observed_orcids":["https://orcid.org/0000-0003-0795-9946","https://orcid.org/0000-0001-5389-0906"]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H T Maecker","raw_affiliation_strings":["Department of Biology, Loyola University of Chicago, IL 60626"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Loyola University of Chicago, IL 60626","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030125647","display_name":"Diane M. Jokinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D M Jokinen","raw_affiliation_strings":["Department of Biology, Loyola University of Chicago, IL 60626"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Loyola University of Chicago, IL 60626","institution_ids":["https://openalex.org/I1925986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111441938","display_name":"Richard I. Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R I Fisher","raw_affiliation_strings":["Department of Biology, Loyola University of Chicago, IL 60626"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Loyola University of Chicago, IL 60626","institution_ids":["https://openalex.org/I1925986"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1925986"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06111416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"149","issue":"5","first_page":"1619","last_page":"1625"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T cell receptor","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cd3","display_name":"CD3","score":0.777999997138977},{"id":"https://openalex.org/keywords/post-translational-regulation","display_name":"post-translational regulation","score":0.9700000286102295}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.8849994540214539},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.8396384716033936},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5423626899719238},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4831359088420868},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4754978120326996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4697335660457611},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.2485227882862091},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.225346177816391},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1469239890575409},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.12930896878242493}],"mesh":[{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015458","descriptor_name":"Leukemia, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.149.5.1619","doi":"https://doi.org/10.4049/jimmunol.149.5.1619","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.149.5.1619","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1387145","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1387145","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2398881750","https://openalex.org/W1973507386","https://openalex.org/W1495986758","https://openalex.org/W7100297041","https://openalex.org/W7095537725","https://openalex.org/W1591654788","https://openalex.org/W2122959032","https://openalex.org/W2033600893","https://openalex.org/W1983539379","https://openalex.org/W1545567903"],"abstract_inverted_index":{"The":[0,46],"human":[1],"T":[2,213],"acute":[3],"lymphocytic":[4],"leukemia":[5],"cell":[6,39,166,214],"line,":[7],"SUP-T13,":[8],"is":[9,50,59,93,151,170],"a":[10,66,90,176],"mosaic":[11],"of":[12,37,48,99,125,172,187,201,209],"TCR/CD3+":[13,43,119],"and":[14,24,35,83,111],"TCR/CD3-":[15,109,133,180],"cells.":[16,120],"Individual":[17],"SUP-T13":[18],"cells":[19,72,134,181],"can":[20,73,129],"spontaneously":[21],"switch":[22],"on":[23,164],"off":[25],"surface":[26],"TCR/CD3":[27,103,127,155,197,202],"expression.":[28],"This":[29,58,85,149],"switching":[30,49],"was":[31],"demonstrated":[32,79],"by":[33,80],"culturing":[34],"analysis":[36],"single":[38],"clones":[40],"that":[41,89],"were":[42],"or":[44,194],"TCR/CD3-.":[45],"rate":[47],"about":[51],"10(-2)/cell":[52],"per":[53],"generation":[54],"in":[55,108,118,132,139,145,191],"either":[56],"direction.":[57],"too":[60],"high":[61],"to":[62,65,153,184],"be":[63,130],"due":[64],"spontaneous":[67],"mutation":[68],"event.":[69],"Furthermore,":[70,121],"switched":[71],"revert":[74],"at":[75,175],"similar":[76],"rates,":[77],"as":[78,117,157],"repeated":[81],"cloning":[82],"reanalysis.":[84],"makes":[86],"it":[87],"likely":[88],"regulatory":[91],"change":[92],"responsible":[94],"for":[95,212],"switching.":[96],"In":[97],"support":[98],"this,":[100],"all":[101],"known":[102],"proteins":[104],"are":[105,160],"found":[106],"intracellularly":[107],"cells,":[110,141],"they":[112],"associate":[113],"with":[114],"each":[115],"other":[116,158],"no":[122],"structural":[123],"abnormalities":[124],"the":[126,142,154,165,185,196,207],"chains":[128,143],"seen":[131],"using":[135],"two-dimensional":[136],"electrophoresis.":[137],"However,":[138],"these":[140],"accumulate":[144],"great":[146],"excess":[147],"intracellularly.":[148],"accumulation":[150],"specific":[152],"complex,":[156],"glycoproteins":[159],"still":[161],"expressed":[162],"normally":[163],"surface.":[167],"Thus,":[168],"there":[169],"regulation":[171],"TCR":[173],"expression":[174,203],"posttranslational":[177],"level.":[178],"These":[179],"may":[182,204],"lead":[183],"identification":[186],"novel":[188],"protein(s)":[189],"involved":[190],"glycosylating,":[192],"processing,":[193],"transporting":[195],"complex.":[198],"Potential":[199],"loss":[200],"also":[205],"limit":[206],"feasibility":[208],"TCR-based":[210],"therapies":[211],"leukemias.":[215]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
