{"id":"https://openalex.org/W1596658387","doi":null,"title":"Identifying Genetic Risk Factors in Canine Autoimmune Disorders","display_name":"Identifying Genetic Risk Factors in Canine Autoimmune Disorders","publication_year":2011,"publication_date":"2011-01-28","ids":{"openalex":"https://openalex.org/W1596658387","mag":"1596658387"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/24488","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/24488","pdf_url":"http://hdl.handle.net/10138/24488","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/24488","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078718639","display_name":"P\u00e4ivi Jokinen","orcid":"https://orcid.org/0000-0002-9776-9558","observed_orcids":["https://orcid.org/0000-0002-9776-9558"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"P\u00e4ivi Jokinen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5078718639"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.3621000051498413,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies","score":0.29760000109672546,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.133200004696846,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canine-autoimmune-disease","display_name":"canine autoimmune disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.9269999861717224},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.9309999942779541},{"id":"https://openalex.org/keywords/dog-leukocyte-antigen","display_name":"dog leukocyte antigen","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.8050000071525574},{"id":"https://openalex.org/keywords/immune-mediated-rheumatic-diseases","display_name":"immune-mediated rheumatic diseases","score":0.9259999990463257},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.8830000162124634},{"id":"https://openalex.org/keywords/steroid-responsive-meningitis-arteritis","display_name":"steroid-responsive meningitis-arteritis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/addison-s-disease","display_name":"Addison's disease","score":0.8569999933242798},{"id":"https://openalex.org/keywords/chronic-superficial-keratitis","display_name":"chronic superficial keratitis","score":0.9319999814033508},{"id":"https://openalex.org/keywords/german-shepherd-dog","display_name":"German Shepherd","score":0.8999999761581421},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.6880000233650208},{"id":"https://openalex.org/keywords/candidate-gene-studies","display_name":"candidate gene association","score":0.593999981880188},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46287301182746887},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34898069500923157}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/24488","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/24488","pdf_url":"http://hdl.handle.net/10138/24488","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"mag:1596658387","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/handle/10138/24488/identify.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/24488","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/24488","pdf_url":"http://hdl.handle.net/10138/24488","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1596658387.pdf","grobid_xml":"https://content.openalex.org/works/W1596658387.grobid-xml"},"referenced_works_count":123,"referenced_works":["https://openalex.org/W48978471","https://openalex.org/W52127274","https://openalex.org/W85617918","https://openalex.org/W96553600","https://openalex.org/W135424838","https://openalex.org/W199597446","https://openalex.org/W1510081630","https://openalex.org/W1540572808","https://openalex.org/W1552053778","https://openalex.org/W1564416982","https://openalex.org/W1652383174","https://openalex.org/W1809561724","https://openalex.org/W1847245720","https://openalex.org/W1871753264","https://openalex.org/W1965727970","https://openalex.org/W1966248453","https://openalex.org/W1967491345","https://openalex.org/W1967817189","https://openalex.org/W1968868444","https://openalex.org/W1971412090","https://openalex.org/W1974450480","https://openalex.org/W1975718646","https://openalex.org/W1976346108","https://openalex.org/W1979325642","https://openalex.org/W1979560492","https://openalex.org/W1981444017","https://openalex.org/W1986390617","https://openalex.org/W1987680648","https://openalex.org/W1988589573","https://openalex.org/W1989848313","https://openalex.org/W1993771802","https://openalex.org/W1993927094","https://openalex.org/W2003364062","https://openalex.org/W2003773439","https://openalex.org/W2005279553","https://openalex.org/W2007709653","https://openalex.org/W2008439087","https://openalex.org/W2009171929","https://openalex.org/W2009319643","https://openalex.org/W2009338370","https://openalex.org/W2009570821","https://openalex.org/W2015638404","https://openalex.org/W2016265097","https://openalex.org/W2019169142","https://openalex.org/W2022719025","https://openalex.org/W2026411672","https://openalex.org/W2027774380","https://openalex.org/W2031941175","https://openalex.org/W2034458200","https://openalex.org/W2047213526","https://openalex.org/W2047548224","https://openalex.org/W2048131372","https://openalex.org/W2049422399","https://openalex.org/W2052425512","https://openalex.org/W2053980253","https://openalex.org/W2054599718","https://openalex.org/W2057097356","https://openalex.org/W2060311755","https://openalex.org/W2060427517","https://openalex.org/W2064090282","https://openalex.org/W2064981157","https://openalex.org/W2065024904","https://openalex.org/W2065046877","https://openalex.org/W2065480446","https://openalex.org/W2070527591","https://openalex.org/W2074609366","https://openalex.org/W2075366117","https://openalex.org/W2076480738","https://openalex.org/W2077484968","https://openalex.org/W2077617852","https://openalex.org/W2077797960","https://openalex.org/W2079490247","https://openalex.org/W2080105198","https://openalex.org/W2081302492","https://openalex.org/W2081885755","https://openalex.org/W2082829053","https://openalex.org/W2083527838","https://openalex.org/W2085024301","https://openalex.org/W2087260514","https://openalex.org/W2087785715","https://openalex.org/W2089844380","https://openalex.org/W2090743469","https://openalex.org/W2092071745","https://openalex.org/W2099390252","https://openalex.org/W2104651501","https://openalex.org/W2108816348","https://openalex.org/W2111536363","https://openalex.org/W2113368564","https://openalex.org/W2114611642","https://openalex.org/W2114857255","https://openalex.org/W2119004823","https://openalex.org/W2120269073","https://openalex.org/W2124308998","https://openalex.org/W2125109373","https://openalex.org/W2128310039","https://openalex.org/W2135458863","https://openalex.org/W2139900172","https://openalex.org/W2140107142","https://openalex.org/W2140548491","https://openalex.org/W2140960450","https://openalex.org/W2146293362","https://openalex.org/W2147149106","https://openalex.org/W2150000105","https://openalex.org/W2152006276","https://openalex.org/W2152144272","https://openalex.org/W2153170915","https://openalex.org/W2153389047","https://openalex.org/W2155712490","https://openalex.org/W2155769512","https://openalex.org/W2157229204","https://openalex.org/W2157816493","https://openalex.org/W2160377169","https://openalex.org/W2161633633","https://openalex.org/W2162086966","https://openalex.org/W2162212014","https://openalex.org/W2163811257","https://openalex.org/W2171547066","https://openalex.org/W2172466148","https://openalex.org/W2234274994","https://openalex.org/W2331919277","https://openalex.org/W2333707811","https://openalex.org/W2938814701","https://openalex.org/W4390312217"],"related_works":["https://openalex.org/W767103321","https://openalex.org/W1912129566","https://openalex.org/W2047548224","https://openalex.org/W2902544433","https://openalex.org/W2146341309","https://openalex.org/W2911947398","https://openalex.org/W2330365264","https://openalex.org/W2807119213","https://openalex.org/W4376460493","https://openalex.org/W1965451930"],"abstract_inverted_index":{"Autoimmune":[0],"diseases":[1,25,61],"are":[2,11],"more":[3],"common":[4,62,157],"in":[5,8,99,126,175,202,214,253,274,293,310,321,363,381,452,478],"dogs":[6,217,322,342],"than":[7,456],"humans":[9],"and":[10,30,48,83,139,160,164,190,209,272,289,295,338,374,404,416,459,470,472,512,520],"already":[12],"threatening":[13],"the":[14,34,80,114,146,165,238,298,325,375,379,394,398,410,422,433,444,509,523],"future":[15],"of":[16,69,79,86,116,118,131,241,285,424,435,497,522,525],"some":[17],"highly":[18],"predisposed":[19],"dog":[20,81,249,489],"breeds.":[21,101],"Susceptibility":[22],"to":[23,63,94,170,224,236,264,414,427,507,516],"autoimmune":[24,60,71,97,103,128,177,312],"is":[26,73,304],"controlled":[27],"by":[28,431],"environmental":[29],"genetic":[31,67,111,121,172,226,307,425,502],"factors,":[32,494],"especially":[33],"major":[35,306],"histocompatibility":[36],"complex":[37,127,450],"(MHC)":[38],"gene":[39,124,232,302],"region.":[40],"Dogs":[41],"show":[42,105,296,485],"a":[43,91,109,230,248,257,305,449,479,500],"similar":[44],"physiology,":[45],"disease":[46,57,188,200,271,402,451,469],"presentation":[47],"clinical":[49],"response":[50],"as":[51,120,137,195,197,247],"humans,":[52],"making":[53],"them":[54,498],"an":[55,282,406,487],"excellent":[56],"model":[58],"for":[59,145,269,281,319,339,393,400,409,438,448,467],"both":[64],"species.":[65,255],"The":[66],"background":[68],"canine":[70,254,311],"disorders":[72,104],"largely":[74],"unknown,":[75],"but":[76,291,495],"recent":[77],"annotation":[78],"genome":[82],"subsequent":[84],"development":[85,423],"new":[87,514],"genomic":[88],"tools":[89],"offer":[90],"unique":[92],"opportunity":[93],"map":[95],"novel":[96,132,142,266,480],"genes":[98,134,144,163,476],"various":[100,176],"Many":[102],"breed-specific":[106],"enrichment,":[107],"supporting":[108],"strong":[110,474],"background.":[112],"Furthermore,":[113],"presence":[115],"hundreds":[117],"breeds":[119,136],"isolates":[122],"facilitates":[123],"mapping":[125],"disorders.":[129,149],"Identification":[130],"predisposing":[133],"establishes":[135],"models":[138],"may":[140],"reveal":[141],"candidate":[143,231,475],"corresponding":[147],"human":[148],"Genetic":[150],"studies":[151,505],"will":[152],"eventually":[153],"shed":[154],"light":[155],"on":[156],"biological":[158],"functions":[159],"interactions":[161],"between":[162],"environment.":[166],"This":[167],"study":[168,260],"aimed":[169],"identify":[171,225,265,508],"risk":[173,227,267,279,308,316,395,399,439,465,493],"factors":[174],"disorders,":[178],"including":[179],"systemic":[180],"lupus":[181],"erythematosus":[182],"(SLE)-related":[183],"diseases,":[184],"comprising":[185],"immune-mediated":[186],"rheumatic":[187],"(IMRD)":[189],"steroid-responsive":[191],"meningitis":[192],"arteritis":[193],"(SMRA)":[194],"well":[196],"Addison":[198],"s":[199],"(AD)":[201],"Nova":[203],"Scotia":[204],"Duck":[205],"Tolling":[206],"Retrievers":[207],"(NSDTRs)":[208],"chronic":[210],"superficial":[211],"keratitis":[212],"(CSK)":[213],"German":[215],"Shepherd":[216],"(GSDs).":[218],"We":[219,276,352,441,484],"used":[220],"two":[221],"different":[222],"approaches":[223],"factors.":[228],"Firstly,":[229],"approach":[233],"was":[234,262,317,358],"applied":[235],"test":[237],"potential":[239],"association":[240,259],"MHC":[242,299],"class":[243,300],"II,":[244],"also":[245,353,442],"known":[246],"leukocyte":[250],"antigen":[251],"(DLA)":[252],"Secondly,":[256],"genome-wide":[258],"(GWAS)":[261],"performed":[263,443],"loci":[268,466],"SLE-related":[270,286,468,526],"AD":[273,288,362,471],"NSDTRs.":[275],"identified":[277,463],"DLA":[278,411],"haplotypes":[280],"IMRD":[283,320,341],"subphenotype":[284],"disease,":[287],"CSK,":[290],"not":[292],"SMRA,":[294],"that":[297,323,355,391,405,486],"II":[301],"region":[303,412],"factor":[309],"diseases.":[313,527],"An":[314],"elevated":[315],"found":[318,354,390,473],"carried":[324],"DLA-DRB1*00601/DQA1*005011/DQB1*02001":[326],"haplotype":[327,357,377,396],"(OR":[328,343,365],"=":[329,333,336,344,348,366,369,372],"2.0,":[330],"99%":[331,346],"CI":[332,347,368],"1.03-3.95,":[334],"p":[335],"0.01)":[337],"ANA-positive":[340],"2.3,":[345],"1.07-5.04,":[349],"p-value":[350],"0.007).":[351],"DLA-DRB1*01502/DQA*00601/DQB1*02301":[356],"significantly":[359],"associated":[360],"with":[361,378],"NSDTRs":[364],"2.1,":[367],"1.0-4.4,":[370],"P":[371],"0.044)":[373],"DLA-DRB1*01501/DQA1*00601/DQB1*00301":[376],"CSK":[380,415],"GSDs":[382],"(OR=2.67,":[383],"CI=1.17-6.44,":[384],"p=":[385],"0.02).":[386],"In":[387],"addition,":[388],"we":[389,462],"homozygosity":[392,408],"increases":[397],"each":[401,496],"phenotype":[403],"overall":[407],"predisposes":[413],"AD.":[417],"Our":[418],"results":[419],"have":[420],"enabled":[421],"tests":[426],"improve":[428],"breeding":[429],"practices":[430],"avoiding":[432],"production":[434],"puppies":[436],"homozygous":[437],"haplotypes.":[440],"first":[445],"successful":[446],"GWAS":[447],"dogs.":[453],"With":[454],"less":[455],"100":[457,460],"cases":[458],"controls,":[461],"five":[464],"involved":[477],"T-cell":[481],"activation":[482],"pathway.":[483],"inbred":[488],"population":[490],"has":[491,499],"fewer":[492],"stronger":[501],"risk.":[503],"Ongoing":[504],"aim":[506],"causative":[510],"mutations":[511],"bring":[513],"knowledge":[515],"help":[517],"diagnostics,":[518],"treatment":[519],"understanding":[521],"aetiology":[524]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
