{"id":"https://openalex.org/W1595951835","doi":"https://doi.org/10.1038/90942","title":"Signaling through OX40 (CD134) breaks peripheral T-cell tolerance","display_name":"Signaling through OX40 (CD134) breaks peripheral T-cell tolerance","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W1595951835","doi":"https://doi.org/10.1038/90942","mag":"1595951835","pmid":"https://pubmed.ncbi.nlm.nih.gov/11479622"},"language":"en","primary_location":{"id":"doi:10.1038/90942","doi":"https://doi.org/10.1038/90942","is_oa":false,"landing_page_url":"https://doi.org/10.1038/90942","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031251681","display_name":"Pratima Bansal\u2010Pakala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratima Bansal-Pakala","raw_affiliation_strings":["Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, California, USA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058695420","display_name":"Amha Gebre-Hiwot Jember","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amha Gebre-Hiwot Jember","raw_affiliation_strings":["Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, California, USA","Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, California, USA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, USA","institution_ids":["https://openalex.org/I1311191458"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036973489","display_name":"Michael Croft","orcid":"https://orcid.org/0000-0002-6062-3635","observed_orcids":["https://orcid.org/0000-0002-6062-3635","https://orcid.org/0000-0002-6263-7256"]},"institutions":[{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Croft","raw_affiliation_strings":["Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, California, USA","Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, California, USA","institution_ids":["https://openalex.org/I1311191458"]},{"raw_affiliation_string":"Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, USA","institution_ids":["https://openalex.org/I1311191458"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5036973489"],"corresponding_institution_ids":["https://openalex.org/I1311191458"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":8.2317,"has_fulltext":false,"cited_by_count":230,"citation_normalized_percentile":{"value":0.98123898,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"7","issue":"8","first_page":"907","last_page":"912"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ox40","display_name":"OX40","score":1.0},{"id":"https://openalex.org/keywords/peripheral-t-cell-tolerance","display_name":"peripheral T cell tolerance","score":0.8629999756813049},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.628000020980835},{"id":"https://openalex.org/keywords/agonistic-antibodies","display_name":"agonistic antibodies","score":0.8700000047683716},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.703000009059906},{"id":"https://openalex.org/keywords/tnf-receptor-superfamily","display_name":"TNF receptor superfamily","score":0.7680000066757202},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2777016536","wikidata":"https://www.wikidata.org/wiki/Q7168713","display_name":"Peripheral tolerance","level":4,"score":0.7289961576461792},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.6055619120597839},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5255821347236633},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5112817287445068},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4992713928222656},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.4953716993331909},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.41950559616088867},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40817517042160034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3465747833251953},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32717037200927734},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.190161794424057}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018127","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018127","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018127","descriptor_name":"Tumor Necrosis Factor Receptor Superfamily, Member 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053262","descriptor_name":"Receptors, OX40","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053262","descriptor_name":"Receptors, OX40","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053262","descriptor_name":"Receptors, OX40","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/90942","doi":"https://doi.org/10.1038/90942","is_oa":false,"landing_page_url":"https://doi.org/10.1038/90942","pdf_url":null,"source":{"id":"https://openalex.org/S203256638","display_name":"Nature Medicine","issn_l":"1078-8956","issn":["1078-8956","1546-170X","1744-7933"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Medicine","raw_type":"journal-article"},{"id":"pmid:11479622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11479622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4548873109","display_name":null,"funder_award_id":"AI 42944","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5291716228","display_name":"The Role of 4-1BB in T Cell and APC Interactions","funder_award_id":"5r01ai042944-11","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1482598749","https://openalex.org/W1483682701","https://openalex.org/W1553714294","https://openalex.org/W1583246305","https://openalex.org/W1592534679","https://openalex.org/W1652473508","https://openalex.org/W1768650192","https://openalex.org/W1791922236","https://openalex.org/W1965786965","https://openalex.org/W1974381902","https://openalex.org/W2027929378","https://openalex.org/W2028809209","https://openalex.org/W2029060163","https://openalex.org/W2029896750","https://openalex.org/W2031869571","https://openalex.org/W2032856364","https://openalex.org/W2036510457","https://openalex.org/W2037626742","https://openalex.org/W2040572245","https://openalex.org/W2044163622","https://openalex.org/W2051803876","https://openalex.org/W2054419682","https://openalex.org/W2061014336","https://openalex.org/W2063480372","https://openalex.org/W2066331485","https://openalex.org/W2071442942","https://openalex.org/W2071483270","https://openalex.org/W2071969437","https://openalex.org/W2073391461","https://openalex.org/W2080435444","https://openalex.org/W2093542451","https://openalex.org/W2094366129","https://openalex.org/W2099748840","https://openalex.org/W2103767560","https://openalex.org/W2111185687","https://openalex.org/W2115112959","https://openalex.org/W2125224405","https://openalex.org/W2125504851","https://openalex.org/W2141842993","https://openalex.org/W2143488332","https://openalex.org/W2147051992","https://openalex.org/W2153268818","https://openalex.org/W2156253561","https://openalex.org/W2221926917"],"related_works":["https://openalex.org/W3032573347","https://openalex.org/W3208066950","https://openalex.org/W2746753481","https://openalex.org/W2091230248","https://openalex.org/W1990684941","https://openalex.org/W4211127938","https://openalex.org/W2630573111","https://openalex.org/W2158534453","https://openalex.org/W2115523852","https://openalex.org/W2019291297"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}