{"id":"https://openalex.org/W159594237","doi":null,"title":"Hyaluronan distribution in the normal epithelium of esophagus, stomach, and colon and their cancers.","display_name":"Hyaluronan distribution in the normal epithelium of esophagus, stomach, and colon and their cancers.","publication_year":1996,"publication_date":"1996-06-01","ids":{"openalex":"https://openalex.org/W159594237","mag":"159594237","pmid":"https://pubmed.ncbi.nlm.nih.gov/8669472","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861659"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861659","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091499244","display_name":"C. Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"C Wang","raw_affiliation_strings":["Department of Anatomy, University of Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, University of Kuopio, Finland","institution_ids":["https://openalex.org/I175532246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088605616","display_name":"Markku Tammi","orcid":"https://orcid.org/0000-0001-8683-9525","observed_orcids":["https://orcid.org/0000-0001-8683-9525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tammi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101535856","display_name":"Haijian Guo","orcid":"https://orcid.org/0000-0002-9758-3374","observed_orcids":["https://orcid.org/0000-0002-9758-3374"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024772304","display_name":"Raija Tammi","orcid":"https://orcid.org/0000-0002-3819-9583","observed_orcids":["https://orcid.org/0000-0002-3819-9583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Tammi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1503,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.86127057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"148","issue":"6","first_page":"1861","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyaluronic-acid","display_name":"hyaluronic acid","score":0.9980000257492065},{"id":"https://openalex.org/keywords/esophageal-epithelium","display_name":"esophageal epithelium","score":0.7609999775886536},{"id":"https://openalex.org/keywords/gastric-epithelium","display_name":"gastric epithelium","score":0.9800000190734863},{"id":"https://openalex.org/keywords/colonic-epithelium","display_name":"colonic epithelium","score":0.9879999756813049},{"id":"https://openalex.org/keywords/squamous-cell-carcinoma","display_name":"squamous cell carcinoma","score":0.8640000224113464},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.7400000095367432},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.972000002861023},{"id":"https://openalex.org/keywords/colon-adenocarcinoma","display_name":"colon adenocarcinoma","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.9300000071525574},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7540000081062317},{"id":"https://openalex.org/keywords/stratified-squamous-epithelium","display_name":"stratified squamous epithelium","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.7563586235046387},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.7518861293792725},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.616214394569397},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.6011804342269897},{"id":"https://openalex.org/C2777819096","wikidata":"https://www.wikidata.org/wiki/Q173710","display_name":"Esophagus","level":2,"score":0.577409029006958},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5763121247291565},{"id":"https://openalex.org/C2777960253","wikidata":"https://www.wikidata.org/wiki/Q6133133","display_name":"Muscularis mucosae","level":2,"score":0.5382352471351624},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.522646427154541},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.5062245726585388},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.4682515561580658},{"id":"https://openalex.org/C2779636128","wikidata":"https://www.wikidata.org/wiki/Q1978278","display_name":"Stratified squamous epithelium","level":3,"score":0.4640952944755554},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4589596092700958},{"id":"https://openalex.org/C90378955","wikidata":"https://www.wikidata.org/wiki/Q5476344","display_name":"Foveolar cell","level":4,"score":0.450268030166626},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25541746616363525},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.2395641803741455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16171479225158691},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004064","descriptor_name":"Digestive System","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006820","descriptor_name":"Hyaluronic Acid","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:1533193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:8669472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8669472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1861659","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1861659/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"mag:159594237","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8669472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1861659","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1499793500","https://openalex.org/W1509620953","https://openalex.org/W1595631714","https://openalex.org/W1969245473","https://openalex.org/W1974348042","https://openalex.org/W1983020647","https://openalex.org/W1987597250","https://openalex.org/W1994496279","https://openalex.org/W2002793462","https://openalex.org/W2006585422","https://openalex.org/W2014862172","https://openalex.org/W2020032838","https://openalex.org/W2021287469","https://openalex.org/W2028542896","https://openalex.org/W2030408713","https://openalex.org/W2030752849","https://openalex.org/W2060348227","https://openalex.org/W2061820966","https://openalex.org/W2066800001","https://openalex.org/W2069762354","https://openalex.org/W2085369940","https://openalex.org/W2104124057","https://openalex.org/W2106906106","https://openalex.org/W2107237937","https://openalex.org/W2133580830","https://openalex.org/W2152797872","https://openalex.org/W2412195306","https://openalex.org/W2415286992","https://openalex.org/W2472537417"],"related_works":["https://openalex.org/W1978781408","https://openalex.org/W2028957277","https://openalex.org/W1995806216","https://openalex.org/W2157701137","https://openalex.org/W2108504660","https://openalex.org/W2077474313","https://openalex.org/W7099673340","https://openalex.org/W2425594625","https://openalex.org/W2027217545","https://openalex.org/W2014286535"],"abstract_inverted_index":{"The":[0,31,119],"distribution":[1],"of":[2,36,84,105,141,172],"hyaluronan":[3,28],"(HA)":[4],"in":[5,10,43,54,64,70,79,95,126,151,181],"normal":[6,32],"gastrointestinal":[7],"wall":[8],"and":[9,46,57,110],"tumors":[11,177],"originating":[12],"from":[13,23],"their":[14,91,173],"epithelium":[15,35],"was":[16,103,122,147],"studied":[17],"using":[18],"a":[19],"specific":[20],"probe":[21],"prepared":[22],"cartilage":[24],"proteoglycan":[25],"(bHABC,":[26],"biotinylated":[27],"binding":[29],"complex).":[30],"stratified":[33],"squamous":[34,87],"esophagus":[37],"showed":[38,116],"an":[39],"intense":[40],"HA":[41,61,68,92,124,152,169,179],"staining":[42],"the":[44,51,55,71,76,85,100,113,132,144,165,182],"basal":[45],"lower":[47],"intermediate":[48],"layers,":[49],"whereas":[50,143,176],"simple":[52],"epithelia":[53],"stomach":[56],"large":[58],"intestine":[59],"were":[60,136],"negative.":[62,82],"Esophageal":[63],"situ":[65],"carcinomas":[66,89],"expressed":[67],"also":[69],"cell":[72,88],"layers":[73],"close":[74],"to":[75],"luminal":[77],"surface,":[78],"regions":[80],"normally":[81],"Most":[83],"invasive":[86],"maintained":[90],"expression,":[93],"but":[94],"very":[96,149],"poorly":[97],"differentiated":[98,160],"types":[99],"tumor":[101,114],"parenchyma":[102,115],"devoid":[104],"HA.":[106,118],"In":[107],"both":[108],"gastric":[109],"colonic":[111],"adenocarcinomas":[112],"no":[117],"stromal":[120],"tissue":[121],"intensely":[123],"positive":[125],"all":[127],"tumors.":[128],"Cancer":[129],"cells":[130,162],"invading":[131],"intestinal":[133],"smooth":[134],"muscle":[135],"surrounded":[137],"by":[138],"copious":[139],"amounts":[140],"HA,":[142],"muscular":[145],"layer":[146],"otherwise":[148],"poor":[150],"staining.":[153],"These":[154],"results":[155],"show":[156],"that":[157],"relatively":[158],"well":[159],"carcinoma":[161],"themselves":[163],"retain":[164],"high":[166],"or":[167],"low":[168],"expression":[170],"pattern":[171],"original":[174],"epithelium,":[175],"stimulate":[178],"deposition":[180],"surrounding":[183],"stroma.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}