{"id":"https://openalex.org/W1595874320","doi":null,"title":"THE HNRNP F AND HNRNP H' AREMAMMALIAN 3' MRNA PROCESSING FACTORS ACTING THROUGH GUANINE RICH SEQUENCES","display_name":"THE HNRNP F AND HNRNP H' AREMAMMALIAN 3' MRNA PROCESSING FACTORS ACTING THROUGH GUANINE RICH SEQUENCES","publication_year":2004,"publication_date":"2004-12-10","ids":{"openalex":"https://openalex.org/W1595874320","mag":"1595874320"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10175","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10175/1/AlkanSerkanPhD03.pdf","pdf_url":"http://d-scholarship.pitt.edu/10175/1/AlkanSerkanPhD03.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/10175/1/AlkanSerkanPhD03.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046758213","display_name":"Serkan Alkan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Serkan Alkan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5046758213"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12610","display_name":"RNA regulation and disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hnrnp-f","display_name":"hnRNP F","score":0.9350000023841858},{"id":"https://openalex.org/keywords/hnrnp-h","display_name":"hnRNP H","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hnrnp","display_name":"heterogeneous nuclear ribonucleoproteins","score":0.949999988079071},{"id":"https://openalex.org/keywords/polyadenylation","display_name":"polyadenylation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/alternative-polyadenylation","display_name":"alternative polyadenylation","score":0.968999981880188},{"id":"https://openalex.org/keywords/ell2","display_name":"ELL2","score":0.9359999895095825},{"id":"https://openalex.org/keywords/transcription-elongation","display_name":"transcription elongation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C159194896","wikidata":"https://www.wikidata.org/wiki/Q417662","display_name":"Heterogeneous ribonucleoprotein particle","level":5,"score":0.7643033266067505},{"id":"https://openalex.org/C142575336","wikidata":"https://www.wikidata.org/wiki/Q412148","display_name":"Polyadenylation","level":4,"score":0.7562379837036133},{"id":"https://openalex.org/C2909472194","wikidata":"https://www.wikidata.org/wiki/Q417662","display_name":"Heterogeneous nuclear ribonucleoprotein","level":5,"score":0.6838154792785645},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6105716228485107},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6008332967758179},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.4822133779525757},{"id":"https://openalex.org/C41282012","wikidata":"https://www.wikidata.org/wiki/Q3928341","display_name":"RNA-binding protein","level":4,"score":0.4629232883453369},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4441242218017578},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4421733021736145},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.4315774142742157},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.43068674206733704},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3944171071052551},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3359922766685486},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26447543501853943}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:10175","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10175/1/AlkanSerkanPhD03.pdf","pdf_url":"http://d-scholarship.pitt.edu/10175/1/AlkanSerkanPhD03.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:1595874320","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/10175/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:10175","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/10175/1/AlkanSerkanPhD03.pdf","pdf_url":"http://d-scholarship.pitt.edu/10175/1/AlkanSerkanPhD03.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1595874320.pdf","grobid_xml":"https://content.openalex.org/works/W1595874320.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W119767403","https://openalex.org/W1529739927","https://openalex.org/W1534833050","https://openalex.org/W1585782442","https://openalex.org/W1767139161","https://openalex.org/W1790299687","https://openalex.org/W1813910892","https://openalex.org/W1875884436","https://openalex.org/W1973697733","https://openalex.org/W1974220691","https://openalex.org/W1995477021","https://openalex.org/W1995896415","https://openalex.org/W2003083382","https://openalex.org/W2004509913","https://openalex.org/W2005788509","https://openalex.org/W2015249201","https://openalex.org/W2019773602","https://openalex.org/W2022074355","https://openalex.org/W2025214296","https://openalex.org/W2029309165","https://openalex.org/W2030209301","https://openalex.org/W2043957477","https://openalex.org/W2045010509","https://openalex.org/W2049525485","https://openalex.org/W2052433275","https://openalex.org/W2058004132","https://openalex.org/W2058737848","https://openalex.org/W2058785362","https://openalex.org/W2059368312","https://openalex.org/W2070920231","https://openalex.org/W2076794781","https://openalex.org/W2076849957","https://openalex.org/W2079932405","https://openalex.org/W2080489609","https://openalex.org/W2082805027","https://openalex.org/W2085272777","https://openalex.org/W2089732199","https://openalex.org/W2100998712","https://openalex.org/W2103065204","https://openalex.org/W2104062576","https://openalex.org/W2104844714","https://openalex.org/W2110413885","https://openalex.org/W2112441454","https://openalex.org/W2116965031","https://openalex.org/W2117784725","https://openalex.org/W2120049843","https://openalex.org/W2122475046","https://openalex.org/W2134281471","https://openalex.org/W2136471718","https://openalex.org/W2136898333","https://openalex.org/W2141157874","https://openalex.org/W2149242389","https://openalex.org/W2149813201","https://openalex.org/W2150449890","https://openalex.org/W2157795344","https://openalex.org/W2167931447","https://openalex.org/W2167968442","https://openalex.org/W2405803481"],"related_works":["https://openalex.org/W1972116340","https://openalex.org/W2151199680","https://openalex.org/W2122475046","https://openalex.org/W1995477021","https://openalex.org/W2030209301","https://openalex.org/W2136471718","https://openalex.org/W2075512660","https://openalex.org/W2022074355","https://openalex.org/W7099777176","https://openalex.org/W2118627132"],"abstract_inverted_index":{"Heterogenous":[0],"nuclear":[1,6],"ribonucleoproteins":[2],"(hnRNPs)":[3],"are":[4,19,187,280],"predominantly":[5],"and":[7,28,60,111,159,199,219,266,328],"have":[8,45],"been":[9],"shown":[10,43,228],"to":[11,44,79,89,116,169,239,248,324],"be":[12,170],"involved":[13],"in":[14,38,109,120,123,173,212,233,300],"multiple":[15],"cellular":[16],"processes.":[17],"There":[18,279],"more":[20],"than":[21,164],"20":[22],"members":[23],"of":[24,67,94,149,224,275,289],"hnRNP":[25,39,51,56,68,95,225,260,290,301],"protein":[26],"family":[27,41,54],"they":[29],"all":[30],"bind":[31],"RNA.":[32],"Some":[33],"hnRNPs":[34],"like":[35],"the":[36,65,73,80,100,230,250,268,273,322],"ones":[37],"H":[40,52],"was":[42,131,227],"sequence":[46],"specific":[47,184,295],"RNA":[48,205],"binding":[49,70,84,97],"activity.":[50],"potein":[53],"includes":[55,179,196],"H1,":[57],"H2.":[58],"H3":[59],"F.":[61,291],"This":[62],"study":[63,151],"mapped":[64],"location":[66],"H/F":[69,96],"site":[71,85,98],"on":[72,99,107,143],"SV40":[74],"Late":[75],"(SVL)":[76],"pre-mRNA":[77,102],"relative":[78],"polyA":[81,137],"signal.":[82],"The":[83,126,146,194,222],"is":[86,114,210,243,307,312,331],"characterized":[87],"down":[88],"five":[90],"consecutive":[91],"Guanines.":[92],"Disruption":[93],"SVL":[101],"had":[103],"a":[104,140,313],"negative":[105],"effect":[106,113,130,142],"polyadenylation":[108,200],"vitro":[110],"this":[112,129,150,177,253],"translated":[115],"downregulated":[117],"gene":[118,269],"expression":[119,270,288],"Gfp":[121],"based":[122],"vivo":[124],"assays.":[125],"fact":[127],"that":[128],"seen":[132],"with":[133,155,259,272],"constructs":[134],"having":[135],"single":[136],"sites":[138],"implicates":[139],"pronounced":[141],"alternative":[144],"polyadenylation.":[145],"second":[147],"part":[148],"involves":[152],"microarray":[153,218,255],"experiments":[154,256],"A20":[156],"B-cell":[157,182,231,293],"lymphoma":[158],"AxJ":[160,174,213,263,304],"Plasmacytoma":[161],"cells.":[162,175,278,305],"More":[163],"400":[165],"genes":[166,251,296],"were":[167,257,297],"found":[168],"differentially":[171,191,283,298],"expressed":[172,192,284,299],"While":[176],"group":[178],"many":[180],"known":[181,314],"stage":[183,294],"genes,":[185],"there":[186],"also":[188],"numerous":[189],"novel":[190,319],"transcripts.":[193],"list":[195],"transcription,":[197],"splicing":[198],"factors,":[201],"too.":[202],"Elongation":[203],"factor":[204],"polymerase":[206],"II":[207],"2":[208],"(ELL2)":[209],"induced":[211],"cells":[214,265],"as":[215,235,237],"assayed":[216],"by":[217],"RT-PCR":[220],"experiments.":[221],"overexpression":[223],"F":[226,261,302],"revert":[229],"clock,":[232],"so":[234],"far":[236],"secretory":[238,323],"membrane":[240,325],"Immunoglobulin":[241,326],"ratio":[242],"concerned.":[244],"In":[245],"an":[246],"attempt":[247],"identify":[249],"underlying":[252],"mechanism,":[254],"preformed":[258],"overexpressing":[262,303],"plasmacytoma":[264],"compared":[267],"profile":[271],"one":[274],"mock":[276],"transfected":[277],"about":[281],"30":[282],"transcripts":[285],"upon":[286],"forced":[287],"Three":[292],"ELL2":[306,311,330],"among":[308],"these":[309],"genes.":[310],"transcriptional":[315],"elongation":[316],"enhancer.":[317],"A":[318],"model":[320],"regarding":[321],"switch":[327],"involving":[329],"proposed.":[332]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
