{"id":"https://openalex.org/W1595742868","doi":"https://doi.org/10.4049/jimmunol.145.11.3855","title":"The mechanism of mediator release from human basophils induced by platelet-activating factor.","display_name":"The mechanism of mediator release from human basophils induced by platelet-activating factor.","publication_year":1990,"publication_date":"1990-12-01","ids":{"openalex":"https://openalex.org/W1595742868","doi":"https://doi.org/10.4049/jimmunol.145.11.3855","mag":"1595742868","pmid":"https://pubmed.ncbi.nlm.nih.gov/1700998"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.145.11.3855","doi":"https://doi.org/10.4049/jimmunol.145.11.3855","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.145.11.3855","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020323356","display_name":"Michele Columbo","orcid":"https://orcid.org/0000-0001-7874-1528","observed_orcids":["https://orcid.org/0000-0001-7874-1528"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Columbo","raw_affiliation_strings":["Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078306032","display_name":"Vincenzo Casolaro","orcid":"https://orcid.org/0000-0001-9810-0488","observed_orcids":["https://orcid.org/0000-0001-9810-0488"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Casolaro","raw_affiliation_strings":["Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088341329","display_name":"Jane A. Warner","orcid":"https://orcid.org/0000-0001-9345-4068","observed_orcids":["https://orcid.org/0000-0001-9345-4068"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A Warner","raw_affiliation_strings":["Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081046119","display_name":"Donald W. MacGlashan","orcid":"https://orcid.org/0000-0003-4525-0452","observed_orcids":["https://orcid.org/0000-0003-4525-0452"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D W MacGlashan","raw_affiliation_strings":["Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067592962","display_name":"Anne Kagey\u2010Sobotka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Kagey-Sobotka","raw_affiliation_strings":["Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111846072","display_name":"Lawrence M. Lichtenstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L M Lichtenstein","raw_affiliation_strings":["Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology, Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Asthma & Allergy Center , Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.1382,"has_fulltext":false,"cited_by_count":46,"citation_normalized_percentile":{"value":0.87821314,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"145","issue":"11","first_page":"3855","last_page":"3861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-activating-factor","display_name":"platelet-activating factor","score":0.9449999928474426},{"id":"https://openalex.org/keywords/basophils","display_name":"basophils","score":0.921999990940094},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9950000047683716},{"id":"https://openalex.org/keywords/leukotriene-c4","display_name":"leukotriene C4","score":0.8849999904632568},{"id":"https://openalex.org/keywords/paf-receptor","display_name":"PAF receptor","score":0.75},{"id":"https://openalex.org/keywords/desensitization","display_name":"desensitization","score":0.7149999737739563},{"id":"https://openalex.org/keywords/calcium-dependence","display_name":"calcium dependence","score":0.5709999799728394},{"id":"https://openalex.org/keywords/cytochalasin-b","display_name":"cytochalasin B","score":0.9079999923706055},{"id":"https://openalex.org/keywords/atopy","display_name":"atopy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/anti-ige-antibody","display_name":"anti-IgE","score":0.7450000047683716},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.6819999814033508},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8700000047683716},{"id":"https://openalex.org/keywords/allergic-inflammation","display_name":"allergic inflammation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/chemical-mediators","display_name":"chemical mediators","score":0.6039999723434448},{"id":"https://openalex.org/keywords/lyso-paf","display_name":"lyso-PAF","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.9253093600273132},{"id":"https://openalex.org/C2779020240","wikidata":"https://www.wikidata.org/wiki/Q420577","display_name":"Platelet-activating factor","level":2,"score":0.8740361332893372},{"id":"https://openalex.org/C2779012151","wikidata":"https://www.wikidata.org/wiki/Q26998028","display_name":"Cytochalasin B","level":3,"score":0.6946848630905151},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.6015892028808594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5843021869659424},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.47467470169067383},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45409104228019714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44196370244026184},{"id":"https://openalex.org/C2776711897","wikidata":"https://www.wikidata.org/wiki/Q5974727","display_name":"Liberation","level":3,"score":0.4263342022895813},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.41125935316085815},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3808012306690216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3609953224658966},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.24121436476707458},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21085801720619202},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17669937014579773},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000888","descriptor_name":"Antibodies, Anti-Idiotypic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001491","descriptor_name":"Basophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003571","descriptor_name":"Cytochalasin B","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013189","descriptor_name":"SRS-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.145.11.3855","doi":"https://doi.org/10.4049/jimmunol.145.11.3855","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.145.11.3855","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1700998","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1700998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4017219176","display_name":"Regulation of Secretion from Human Basophils","funder_award_id":"R01AI020253","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6303059242","display_name":null,"funder_award_id":"AI 7290","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1680578989","https://openalex.org/W2059423037","https://openalex.org/W2102621208","https://openalex.org/W3217440523","https://openalex.org/W2059783629","https://openalex.org/W2041956090","https://openalex.org/W2114023412","https://openalex.org/W1995453293","https://openalex.org/W2113997902","https://openalex.org/W2094590144"],"abstract_inverted_index":{"Platelet-activating":[0],"factor":[1],"(PAF)":[2],"is":[3,368,388],"a":[4,10,48,232,275,279,285,299,331,396],"lipid":[5],"mediator":[6],"able":[7,296,369],"to":[8,44,57,83,93,155,183,192,235,246,262,297,343,345,349,370],"induce":[9,298,371],"variety":[11],"of":[12,25,30,36,59,63,109,119,133,148,157,176,206,210,227,255,353,358,374,401],"inflammatory":[13,375],"processes":[14],"in":[15,61,129,163,252,288,309,311,328,398],"human":[16,34,321,337,378],"peripheral":[17],"blood":[18],"cells.":[19],"We":[20],"have":[21],"investigated":[22],"the":[23,28,117,126,146,161,164,172,218,238,253,258,271,324,354,372,399],"effect":[24],"PAF":[26,41,110,123,149,214,220,236,243,292,332,346,367],"on":[27],"release":[29,52,74,118,127,138,168,175,203,209,373],"chemical":[31],"mediators":[32,376],"from":[33,270,336,377],"basophils":[35,313,325],"allergic":[37,402],"and":[38,69,97,104,124,145,174,380],"normal":[39,143],"donors.":[40],"(10":[42,347],"nM":[43,191,245,348],"1":[45,182,247,350],"microM)":[46,248,294,351],"caused":[47],"concentration-dependent,":[49],"noncytotoxic":[50],"histamine":[51,120,141,187,211,290],"(greater":[53,151],"than":[54,142,152,306],"or":[55,86,153,196,278,340,356],"equal":[56,82,92,154],"10%":[58,156],"total)":[60,158],"27":[62],"44":[64],"subjects":[65],"tested":[66],"(24":[67],"atopic":[68],"20":[70],"nonatopic":[71],"donors).":[72],"The":[73,208],"process":[75,128],"was":[76,159,169,215,231,284,295],"either":[77],"very":[78,300],"rapid":[79],"(t1/2":[80],"approximately":[81,91],"10":[84,94,193,307],"s)":[85,308],"quite":[87],"slow":[88],"(t":[89],"1/2":[90],"min),":[95],"temperature-":[96],"Ca2(+)-dependent":[98],"(optimal":[99],"at":[100],"37":[101],"degrees":[102],"C":[103],"5":[105],"mM":[106],"Ca2+).":[107],"Coincubation":[108],"with":[111,198,224,242],"cytochalasin":[112,199,359],"B":[113,360],"(5":[114,361],"micrograms/ml)":[115],"enhanced":[116],"induced":[121],"by":[122,171,213,217,274,315],"activated":[125,212],"most":[130],"donors":[131],"(42":[132],"44).":[134],"Atopics":[135],"did":[136,201],"not":[137,202],"significantly":[139],"more":[140],"subjects,":[144],"percentage":[147],"responders":[150],"nearly":[160],"same":[162],"two":[165],"groups.":[166],"Histamine":[167],"accompanied":[170],"synthesis":[173],"leukotriene":[177],"C4,":[178],"although":[179],"this":[180,385],"lagged":[181],"2":[184,250],"min":[185,251],"behind":[186],"secretion.":[188],"Lyso-PAF":[189],"(100":[190,244],"microM),":[194],"alone":[195],"together":[197],"B,":[200],"significant":[204,286],"amounts":[205],"histamine.":[207],"inhibited":[216],"specific":[219],"receptor":[221],"antagonist,":[222],"L-652,731,":[223],"an":[225],"IC50":[226],"0.4":[228],"microM.":[229],"There":[230],"partial":[233],"desensitization":[234],"when":[237],"cells":[239,259,335],"were":[240,268],"preincubated":[241],"for":[249],"absence":[254,357],"Ca2+,":[256],"whereas":[257],"remained":[260],"responsive":[261],"anti-IgE":[263],"(0.1":[264],"micrograms/ml).":[265,362],"If":[266],"neutrophils":[267,382],"removed":[269],"basophil":[272,392],"preparation":[273],"Percoll":[276],"gradient":[277],"countercurrent":[280],"elutriation":[281],"technique,":[282],"there":[283],"decrease":[287],"PAF-induced":[289,391],"release.":[291],"(1":[293],"rapid,":[301],"transient":[302],"rise":[303],"(peak":[304],"less":[305],"[Ca2+]i":[310],"purified":[312],"analyzed":[314],"digital":[316],"video":[317],"microscopy.":[318],"Finally,":[319],"among":[320],"histamine-containing":[322],"cells,":[323],"are":[326],"unique":[327],"degranulating":[329],"following":[330],"challenge.":[333],"Mast":[334],"lung,":[338],"skin,":[339],"uterus":[341],"failed":[342],"respond":[344],"regardless":[352],"presence":[355],"Our":[363],"results":[364],"demonstrate":[365],"that":[366,381,390],"basophils,":[379],"can":[383,394],"influence":[384],"response.":[386],"It":[387],"suggested":[389],"activation":[393],"play":[395],"role":[397],"pathogenesis":[400],"disorders.":[403]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
