{"id":"https://openalex.org/W1595564022","doi":null,"title":"The integrin equilibrium: Balancing protein-protein and protein-lipid interactions","display_name":"The integrin equilibrium: Balancing protein-protein and protein-lipid interactions","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1595564022","mag":"1595564022"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-1711","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1711&context=edissertations","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1711&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1711&context=edissertations","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"David T. Moore","orcid":"https://orcid.org/0000-0003-3538-7586","observed_orcids":["https://orcid.org/0000-0003-3538-7586"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David T. Moore","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3538-7586","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.8159999847412109},{"id":"https://openalex.org/keywords/fibrinogen-receptor","display_name":"fibrinogen receptor","score":0.8629999756813049},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/talin-1","display_name":"talin-1","score":0.8830000162124634},{"id":"https://openalex.org/keywords/kindlin-3","display_name":"kindlin-3","score":1.0},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.8209999799728394},{"id":"https://openalex.org/keywords/integrin-cytoplasmic-domain","display_name":"integrin cytoplasmic domain","score":0.9259999990463257},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.699999988079071},{"id":"https://openalex.org/keywords/protein-lipid-interactions","display_name":"protein-lipid interactions","score":0.8199999928474426},{"id":"https://openalex.org/keywords/membrane-environment","display_name":"membrane environment","score":0.6710000038146973},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7559999823570251},{"id":"https://openalex.org/keywords/integrin-activation","display_name":"integrin activation","score":0.578000009059906},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.699999988079071},{"id":"https://openalex.org/keywords/thermodynamic-coupling","display_name":"thermodynamic coupling","score":0.5830000042915344},{"id":"https://openalex.org/keywords/disordered-proteins","display_name":"disordered proteins","score":0.32199999690055847}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5049141049385071},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.43083709478378296},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3425876498222351}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:edissertations-1711","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1711&context=edissertations","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1711&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:20.500.14332/32200","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/32200","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-10881","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3509289","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:1595564022","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=10881&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-1711","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1711&context=edissertations","pdf_url":"https://repository.upenn.edu/cgi/viewcontent.cgi?article=1711&context=edissertations","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1595564022.pdf","grobid_xml":"https://content.openalex.org/works/W1595564022.grobid-xml"},"referenced_works_count":167,"referenced_works":["https://openalex.org/W35241519","https://openalex.org/W45634013","https://openalex.org/W111116455","https://openalex.org/W1500795239","https://openalex.org/W1506821897","https://openalex.org/W1522028852","https://openalex.org/W1576773659","https://openalex.org/W1589295940","https://openalex.org/W1900495018","https://openalex.org/W1925800905","https://openalex.org/W1938388466","https://openalex.org/W1964442771","https://openalex.org/W1964951230","https://openalex.org/W1965526605","https://openalex.org/W1966022051","https://openalex.org/W1966998035","https://openalex.org/W1967448808","https://openalex.org/W1968260093","https://openalex.org/W1968339091","https://openalex.org/W1968710931","https://openalex.org/W1969129798","https://openalex.org/W1970213932","https://openalex.org/W1970481482","https://openalex.org/W1971103240","https://openalex.org/W1973204293","https://openalex.org/W1974058127","https://openalex.org/W1975459052","https://openalex.org/W1980318325","https://openalex.org/W1982330320","https://openalex.org/W1982536372","https://openalex.org/W1985337611","https://openalex.org/W1986225743","https://openalex.org/W1989262163","https://openalex.org/W1991683855","https://openalex.org/W1994057597","https://openalex.org/W1994240328","https://openalex.org/W1997784032","https://openalex.org/W1998077493","https://openalex.org/W1998093640","https://openalex.org/W1998539678","https://openalex.org/W1999825321","https://openalex.org/W2000948557","https://openalex.org/W2004063139","https://openalex.org/W2004771750","https://openalex.org/W2005392755","https://openalex.org/W2010211761","https://openalex.org/W2013002982","https://openalex.org/W2013672653","https://openalex.org/W2016109033","https://openalex.org/W2016742702","https://openalex.org/W2019466328","https://openalex.org/W2019806947","https://openalex.org/W2020898985","https://openalex.org/W2021053981","https://openalex.org/W2022007365","https://openalex.org/W2022309859","https://openalex.org/W2022495919","https://openalex.org/W2022496873","https://openalex.org/W2025929177","https://openalex.org/W2026804025","https://openalex.org/W2027094692","https://openalex.org/W2028803516","https://openalex.org/W2031261181","https://openalex.org/W2032348507","https://openalex.org/W2033277970","https://openalex.org/W2033728878","https://openalex.org/W2036286128","https://openalex.org/W2036988959","https://openalex.org/W2037419242","https://openalex.org/W2037831301","https://openalex.org/W2038126024","https://openalex.org/W2040379229","https://openalex.org/W2041256732","https://openalex.org/W2042015318","https://openalex.org/W2042341077","https://openalex.org/W2042371636","https://openalex.org/W2043172297","https://openalex.org/W2043312574","https://openalex.org/W2043555344","https://openalex.org/W2043761739","https://openalex.org/W2044441652","https://openalex.org/W2044802861","https://openalex.org/W2044882848","https://openalex.org/W2050701385","https://openalex.org/W2051903847","https://openalex.org/W2053202752","https://openalex.org/W2054799935","https://openalex.org/W2058624823","https://openalex.org/W2061144516","https://openalex.org/W2061636592","https://openalex.org/W2063559096","https://openalex.org/W2065921660","https://openalex.org/W2066962978","https://openalex.org/W2067834210","https://openalex.org/W2067836657","https://openalex.org/W2070373300","https://openalex.org/W2070504376","https://openalex.org/W2071552704","https://openalex.org/W2074070818","https://openalex.org/W2074792365","https://openalex.org/W2077277541","https://openalex.org/W2078394309","https://openalex.org/W2079961202","https://openalex.org/W2081359387","https://openalex.org/W2082019380","https://openalex.org/W2082364599","https://openalex.org/W2083012496","https://openalex.org/W2083100745","https://openalex.org/W2084777518","https://openalex.org/W2085281184","https://openalex.org/W2085979652","https://openalex.org/W2086862822","https://openalex.org/W2089103592","https://openalex.org/W2090429239","https://openalex.org/W2090659127","https://openalex.org/W2094469836","https://openalex.org/W2096929343","https://openalex.org/W2098438673","https://openalex.org/W2098613471","https://openalex.org/W2105183595","https://openalex.org/W2109385815","https://openalex.org/W2110785919","https://openalex.org/W2111803487","https://openalex.org/W2112418305","https://openalex.org/W2112611026","https://openalex.org/W2114319047","https://openalex.org/W2114320763","https://openalex.org/W2114449882","https://openalex.org/W2117905361","https://openalex.org/W2118758577","https://openalex.org/W2121781131","https://openalex.org/W2121861656","https://openalex.org/W2123122700","https://openalex.org/W2124903948","https://openalex.org/W2125159941","https://openalex.org/W2126947308","https://openalex.org/W2130479394","https://openalex.org/W2134572302","https://openalex.org/W2135187069","https://openalex.org/W2135577930","https://openalex.org/W2137326912","https://openalex.org/W2141643986","https://openalex.org/W2143554526","https://openalex.org/W2143632667","https://openalex.org/W2146044001","https://openalex.org/W2147979587","https://openalex.org/W2148377692","https://openalex.org/W2152824691","https://openalex.org/W2154909249","https://openalex.org/W2156293127","https://openalex.org/W2156393136","https://openalex.org/W2157012084","https://openalex.org/W2157330541","https://openalex.org/W2159018836","https://openalex.org/W2162005182","https://openalex.org/W2164689526","https://openalex.org/W2165546199","https://openalex.org/W2169481463","https://openalex.org/W2170285690","https://openalex.org/W2170671445","https://openalex.org/W2172286296","https://openalex.org/W2302725631","https://openalex.org/W2334239634","https://openalex.org/W2427875153","https://openalex.org/W2586256972","https://openalex.org/W3085129072","https://openalex.org/W3139752542"],"related_works":["https://openalex.org/W7099442932","https://openalex.org/W2577808840","https://openalex.org/W2397543737","https://openalex.org/W2092964767","https://openalex.org/W2510854979","https://openalex.org/W1978430499","https://openalex.org/W2323285032","https://openalex.org/W2027852533","https://openalex.org/W1543980776","https://openalex.org/W4323034953"],"abstract_inverted_index":{"On":[0],"circulating":[1],"platelets,":[2],"the":[3,29,41,48,64,77,84,89,108,113,123,132,143,151,155,170,190,211,216,223,229,236,244,254,264,279,283,295],"integrin":[4,42,93,109,284,296,320],"fibrinogen":[5],"receptor":[6,51],"&alphaIIb&beta3":[7,14,23,78,117,267,324],"favors":[8],"inactive":[9,92,144],"conformations.":[10],"Platelets":[11],"rapidly":[12],"activate":[13],"to":[15,40,69,96,140,154,162,177,202,220,281,325],"bind":[16,101,282],"fibrinogen,":[17],"mediating":[18],"a":[19,147,312],"platelet":[20],"clot.":[21],"Resting":[22],"is":[24,120,160,248],"stabilized":[25],"by":[26,107],"interactions":[27,164],"between":[28,165,213,266,292,319],"&alphaIIb":[30,139],"and":[31,38,50,86,91,103,112,172,179,215,268,271,294],"&beta3":[32,124,141,168,182,217],"transmembrane":[33],"domains.":[34],"Binding":[35],"of":[36,47,60,88,138,228,238],"talin-1":[37,102,178,214,239],"kindlin-3":[39,104,195,270,275],"cytoplasmic":[43,94,118,183,218,285],"domain":[44,95,119,184,219,286],"stabilizes":[45],"separation":[46],"TMs":[49],"activation.":[52],"Src":[53],"family":[54],"kinases":[55],"are":[56,74,105],"needed":[57],"for":[58,240],"transmission":[59],"extracellular":[61],"signals":[62,73],"into":[63],"cell.":[65],"We":[66,208,258],"have":[67],"sought":[68],"better":[70],"understand":[71],"how":[72,98,222,316],"transmitted":[75],"across":[76],"TM":[79],"domain.":[80],"First":[81],"we":[82,310],"characterized":[83],"structure":[85],"dynamics":[87],"active":[90],"determine":[97,221],"motifs":[99],"that":[100,149,193,243,301],"affected":[106],"activation":[110,328],"state":[111,145],"membrane":[114,156,171,224,233,280],"environment.":[115],"The":[116,135,181,232,290],"disorded,":[121],"while":[122],"subunit":[125],"contains":[126],"two":[127],"&alpha-helices,":[128],"which":[129],"interact":[130,203],"with":[131,169,175,204,287],"phospholipid":[133],"bilayer.":[134],"close":[136],"proximity":[137],"in":[142,167],"induces":[146],"kink":[148,159],"projects":[150],"&beta-chain":[152],"parallel":[153],"surface.":[157],"This":[158],"likely":[161],"stabilize":[163],"helices":[166],"possibly":[173],"compete":[174],"binding":[176,196,206],"kindlin-3.":[180],"becomes":[185],"increasingly":[186],"dynamic":[187],"further":[188],"from":[189],"membrane,":[191],"suggesting":[192,300],"distal":[194],"residues":[197],"should":[198],"be":[199],"more":[200,251],"accessible":[201],"their":[205],"partners.":[207],"also":[209,259],"studied":[210],"interaction":[212,265,291],"environment":[225],"affects":[226],"formation":[227],"talin-1/&beta3":[230],"complex.":[231],"significantly":[234,250],"increases":[235],"affinity":[237],"&beta3,":[241],"but":[242],"ternary":[245],"integrin/talin-1/membrane":[246],"complex":[247,256],"not":[249,277],"stable":[252],"than":[253],"talin-1/membrane":[255],"alone.":[257],"performed":[260],"preliminary":[261],"experiments":[262],"characterizing":[263],"both":[269],"c-Src.":[272],"Unlike":[273],"talin-1,":[274],"does":[276],"require":[278,304],"high":[288],"affinity.":[289],"c-Src":[293],"was":[297],"extremely":[298],"weak":[299],"it":[302],"might":[303,322],"colocalization":[305],"through":[306],"other":[307],"interactions.":[308],"Finally,":[309],"developed":[311],"simplified":[313],"model":[314],"showing":[315],"thermodynamic":[317],"coupling":[318],"subunits":[321],"allow":[323],"adopt":[326],"multiple":[327],"states.":[329]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}