{"id":"https://openalex.org/W1594957439","doi":"https://doi.org/10.21236/ada297167","title":"Mouse Models of the Neu Ligand Interaction with its Receptor in Mammary Gland Tumorigenesis and Development.","display_name":"Mouse Models of the Neu Ligand Interaction with its Receptor in Mammary Gland Tumorigenesis and Development.","publication_year":1995,"publication_date":"1995-06-23","ids":{"openalex":"https://openalex.org/W1594957439","doi":"https://doi.org/10.21236/ada297167","mag":"1594957439"},"language":"en","primary_location":{"id":"doi:10.21236/ada297167","doi":"https://doi.org/10.21236/ada297167","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada297167","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070752173","display_name":"Philip Leder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip Leder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055855883","display_name":"Ian M. Krane","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian Krane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.12630000710487366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neu-differentiation-factor","display_name":"neu differentiation factor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mammary-gland-development","display_name":"mammary gland development","score":0.828000009059906},{"id":"https://openalex.org/keywords/mammary-adenocarcinoma","display_name":"mammary adenocarcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.6019999980926514},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7789999842643738},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.6299999952316284},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6704574227333069},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.6500004529953003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4822736084461212},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.47364914417266846},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45243364572525024},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4219767451286316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42127281427383423},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4144141674041748},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36048752069473267},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20289257168769836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18509668111801147},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1840164065361023},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.09119001030921936}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21236/ada297167","doi":"https://doi.org/10.21236/ada297167","is_oa":false,"landing_page_url":"http://doi.org/10.21236/ada297167","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1597245211","https://openalex.org/W1529081594","https://openalex.org/W2408681326","https://openalex.org/W2079816467","https://openalex.org/W2117237148","https://openalex.org/W1483414363","https://openalex.org/W2025187161","https://openalex.org/W2070638372","https://openalex.org/W2016761620","https://openalex.org/W2161111319"],"abstract_inverted_index":{"Abstract":[0],":":[1],"To":[2],"test":[3],"if":[4],"Neu":[5],"differentiation":[6],"factor":[7],"(NDF),":[8],"an":[9,74],"activator":[10],"of":[11,54,66,81,98,123,126,144,159],"the":[12,20,33,55,69,82,112,132,145],"c-neu":[13,83,113,133],"gene,":[14],"is":[15,88,93,135],"proliferative":[16,64],"or":[17],"differentiative":[18],"in":[19,32,41,68,85,95,120],"mammary":[21,34,39,56,70],"gland,":[22],"we":[23],"have":[24,50,102],"generated":[25],"a":[26,42,63,96],"transgenic":[27],"mouse":[28],"line":[29],"overexpressing":[30],"NDF":[31,67],"epithelium.":[35],"These":[36],"mice":[37],"develop":[38,45,148],"adenocarcinomas":[40],"stochastic":[43],"fashion,":[44],"Harderian":[46],"gland":[47,71],"hyperplasia":[48],"and":[49,72,106],"subtle":[51],"developmental":[52],"abnormalities":[53],"gland.":[57],"Together,":[58],"these":[59,127],"data":[60],"point":[61],"to":[62,110,115,137,149],"effect":[65,76],"possibly":[73],"inhibitory":[75],"on":[77],"apoptosis.":[78],"The":[79],"role":[80,119],"proto-oncogene":[84],"normal":[86],"development":[87],"unclear,":[89],"though":[90],"its":[91,117],"expression":[92],"seen":[94],"variety":[97],"fetal":[99],"tissues.":[100],"We":[101],"used":[103],"homologous":[104],"recombination":[105],"gene":[107,114,134,147],"targeting":[108],"strategies":[109],"disrupt":[111],"understand":[116],"potential":[118],"development.":[121,138],"Analysis":[122],"several":[124],"generations":[125],"animals":[128,140],"has":[129],"revealed":[130],"that":[131],"vital":[136],"No":[139],"carrying":[141],"two":[142],"copies":[143],"mutated":[146],"term.":[150],"Homozygous":[151],"mutants":[152],"do":[153],"not":[154],"live":[155],"past":[156],"day":[157],"10":[158],"gestation.":[160]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
