{"id":"https://openalex.org/W1594628130","doi":null,"title":"Flavonoids as Modulators of Amyloid Precursor Protein Metabolism and Alzheimer Disease Pathology","display_name":"Flavonoids as Modulators of Amyloid Precursor Protein Metabolism and Alzheimer Disease Pathology","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1594628130","mag":"1594628130"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-1472","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/473","pdf_url":"https://digitalcommons.usf.edu/etd/473","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.usf.edu/etd/473","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054797910","display_name":"Kavon P. Rezai-Zadeh","orcid":"https://orcid.org/0000-0002-8822-3641","observed_orcids":["https://orcid.org/0000-0002-8822-3641"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kavon Rezai\u2010Zadeh","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8822-3641","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5054797910"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8759999871253967},{"id":"https://openalex.org/keywords/amyloid-precursor-protein","display_name":"amyloid precursor protein","score":0.7979999780654907},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.8899999856948853},{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.8930000066757202},{"id":"https://openalex.org/keywords/green-tea-catechins","display_name":"green tea catechins","score":0.8960000276565552},{"id":"https://openalex.org/keywords/luteolin","display_name":"luteolin","score":0.9599999785423279},{"id":"https://openalex.org/keywords/chrysin","display_name":"chrysin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7919999957084656},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"amyloidosis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/adam10","display_name":"ADAM10","score":0.906000018119812},{"id":"https://openalex.org/keywords/gamma-secretase","display_name":"gamma-secretase","score":0.8870000243186951},{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.8790000081062317},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.949999988079071},{"id":"https://openalex.org/keywords/neurodegenerative-disease-prevention","display_name":"neurodegenerative disease prevention","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5207576751708984},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5094552636146545},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5042160749435425},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5014679431915283},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.43318140506744385},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.428308367729187},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42623668909072876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.384097158908844},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.372982382774353},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3205553889274597}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:digitalcommons.usf.edu:etd-1472","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/473","pdf_url":"https://digitalcommons.usf.edu/etd/473","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},{"id":"pmh:oai:scholarcommons.usf.edu:etd-1472","doi":null,"is_oa":true,"landing_page_url":"https://scholarcommons.usf.edu/etd/473","pdf_url":"https://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=1472&context=etd","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Graduate Theses and Dissertations","raw_type":"text"},{"id":"mag:1594628130","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.usf.edu/cgi/viewcontent.cgi?article=1472&context=etd","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:digitalcommons.usf.edu:etd-1472","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.usf.edu/etd/473","pdf_url":"https://digitalcommons.usf.edu/etd/473","source":{"id":"https://openalex.org/S4377196272","display_name":"Digital Commons - University of South Florida (University of South Florida)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2613432","host_organization_name":"University of South Florida","host_organization_lineage":["https://openalex.org/I2613432"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"USF Tampa Graduate Theses and Dissertations","raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1594628130.pdf","grobid_xml":"https://content.openalex.org/works/W1594628130.grobid-xml"},"referenced_works_count":202,"referenced_works":["https://openalex.org/W11956919","https://openalex.org/W106625362","https://openalex.org/W149130878","https://openalex.org/W170509155","https://openalex.org/W188237391","https://openalex.org/W1510308646","https://openalex.org/W1523062737","https://openalex.org/W1526919466","https://openalex.org/W1544910072","https://openalex.org/W1555938246","https://openalex.org/W1563012525","https://openalex.org/W1567624342","https://openalex.org/W1572812739","https://openalex.org/W1577397450","https://openalex.org/W1577751913","https://openalex.org/W1605023308","https://openalex.org/W1655404681","https://openalex.org/W1706681742","https://openalex.org/W1754645121","https://openalex.org/W1807257653","https://openalex.org/W1841050729","https://openalex.org/W1928020405","https://openalex.org/W1964314802","https://openalex.org/W1964454256","https://openalex.org/W1965640630","https://openalex.org/W1969427905","https://openalex.org/W1970988215","https://openalex.org/W1972992370","https://openalex.org/W1974187431","https://openalex.org/W1975877815","https://openalex.org/W1977177481","https://openalex.org/W1978101203","https://openalex.org/W1979240613","https://openalex.org/W1980749733","https://openalex.org/W1981331199","https://openalex.org/W1981570625","https://openalex.org/W1982866117","https://openalex.org/W1982947429","https://openalex.org/W1983668432","https://openalex.org/W1984924722","https://openalex.org/W1986537744","https://openalex.org/W1987452659","https://openalex.org/W1988022242","https://openalex.org/W1988999387","https://openalex.org/W1989530212","https://openalex.org/W1992779539","https://openalex.org/W1993722622","https://openalex.org/W1994232621","https://openalex.org/W1995947967","https://openalex.org/W1996388135","https://openalex.org/W1996511362","https://openalex.org/W1996795806","https://openalex.org/W1996917933","https://openalex.org/W1996995902","https://openalex.org/W1997466535","https://openalex.org/W2000075444","https://openalex.org/W2001210466","https://openalex.org/W2001391027","https://openalex.org/W2001870435","https://openalex.org/W2002659179","https://openalex.org/W2003153226","https://openalex.org/W2004524375","https://openalex.org/W2008354106","https://openalex.org/W2008750119","https://openalex.org/W2011539716","https://openalex.org/W2011619359","https://openalex.org/W2011928284","https://openalex.org/W2012862746","https://openalex.org/W2014535402","https://openalex.org/W2015328082","https://openalex.org/W2018455181","https://openalex.org/W2021148680","https://openalex.org/W2021181758","https://openalex.org/W2021751402","https://openalex.org/W2022055086","https://openalex.org/W2024538027","https://openalex.org/W2027103305","https://openalex.org/W2028091371","https://openalex.org/W2028394765","https://openalex.org/W2028846933","https://openalex.org/W2029017865","https://openalex.org/W2029352103","https://openalex.org/W2029427029","https://openalex.org/W2030641075","https://openalex.org/W2031740592","https://openalex.org/W2032920422","https://openalex.org/W2033847972","https://openalex.org/W2033974751","https://openalex.org/W2035283365","https://openalex.org/W2036094153","https://openalex.org/W2036504274","https://openalex.org/W2036670646","https://openalex.org/W2039550162","https://openalex.org/W2039755830","https://openalex.org/W2040252771","https://openalex.org/W2040721710","https://openalex.org/W2041088774","https://openalex.org/W2042750183","https://openalex.org/W2043661712","https://openalex.org/W2044460323","https://openalex.org/W2044558869","https://openalex.org/W2045861063","https://openalex.org/W2046496042","https://openalex.org/W2046766517","https://openalex.org/W2046798812","https://openalex.org/W2046847750","https://openalex.org/W2046969224","https://openalex.org/W2048146741","https://openalex.org/W2049451196","https://openalex.org/W2050697792","https://openalex.org/W2052380265","https://openalex.org/W2052384271","https://openalex.org/W2053152816","https://openalex.org/W2053328915","https://openalex.org/W2053658936","https://openalex.org/W2053665966","https://openalex.org/W2053791137","https://openalex.org/W2056181922","https://openalex.org/W2058723245","https://openalex.org/W2060935518","https://openalex.org/W2061459919","https://openalex.org/W2062649816","https://openalex.org/W2064363789","https://openalex.org/W2066116456","https://openalex.org/W2066501874","https://openalex.org/W2068137765","https://openalex.org/W2069390160","https://openalex.org/W2069584842","https://openalex.org/W2070815033","https://openalex.org/W2070847811","https://openalex.org/W2072985152","https://openalex.org/W2073012903","https://openalex.org/W2073292164","https://openalex.org/W2076237242","https://openalex.org/W2076246785","https://openalex.org/W2078646014","https://openalex.org/W2081182167","https://openalex.org/W2084972185","https://openalex.org/W2087074879","https://openalex.org/W2088501796","https://openalex.org/W2090097368","https://openalex.org/W2090650498","https://openalex.org/W2092698227","https://openalex.org/W2092800106","https://openalex.org/W2096410114","https://openalex.org/W2097563901","https://openalex.org/W2097820520","https://openalex.org/W2099370040","https://openalex.org/W2102582532","https://openalex.org/W2103247095","https://openalex.org/W2104973990","https://openalex.org/W2106274713","https://openalex.org/W2108285073","https://openalex.org/W2108302157","https://openalex.org/W2108649886","https://openalex.org/W2111050644","https://openalex.org/W2111314225","https://openalex.org/W2113686815","https://openalex.org/W2114655589","https://openalex.org/W2116784956","https://openalex.org/W2122872164","https://openalex.org/W2124578903","https://openalex.org/W2126800086","https://openalex.org/W2129250495","https://openalex.org/W2131059456","https://openalex.org/W2132810311","https://openalex.org/W2133488570","https://openalex.org/W2134873827","https://openalex.org/W2134979720","https://openalex.org/W2136210930","https://openalex.org/W2137119117","https://openalex.org/W2141978185","https://openalex.org/W2142806233","https://openalex.org/W2144483204","https://openalex.org/W2144631174","https://openalex.org/W2144868623","https://openalex.org/W2144937345","https://openalex.org/W2145395978","https://openalex.org/W2146610745","https://openalex.org/W2147029696","https://openalex.org/W2147177629","https://openalex.org/W2147958725","https://openalex.org/W2149818957","https://openalex.org/W2150802333","https://openalex.org/W2150970420","https://openalex.org/W2153767421","https://openalex.org/W2154430571","https://openalex.org/W2154508412","https://openalex.org/W2155863144","https://openalex.org/W2157359173","https://openalex.org/W2158240118","https://openalex.org/W2159879659","https://openalex.org/W2162815565","https://openalex.org/W2166405876","https://openalex.org/W2167607663","https://openalex.org/W2169152986","https://openalex.org/W2170714849","https://openalex.org/W2171330197","https://openalex.org/W2179699524","https://openalex.org/W2415617158","https://openalex.org/W4300007302","https://openalex.org/W4321429567"],"related_works":["https://openalex.org/W186576522","https://openalex.org/W3011017201","https://openalex.org/W4293399717","https://openalex.org/W3037747036","https://openalex.org/W2026564199","https://openalex.org/W4311004257","https://openalex.org/W6939459744","https://openalex.org/W2950473171","https://openalex.org/W2154508412","https://openalex.org/W4294741436"],"abstract_inverted_index":{"Alzheimer":[0],"disease":[1],"(AD)":[2],"is":[3,26],"a":[4,39,54],"progressive":[5],"neurodegenerative":[6,57],"disorder":[7],"pathologically":[8],"characterized":[9],"by":[10],"deposition":[11],"of":[12,28,41,53,56,66,70,88,124,168,185],"\u00df-amyloid":[13],"(A\u00df)":[14],"peptides":[15],"as":[16,149],"plaques":[17],"in":[18,82,106,109,144,147],"the":[19,29,49,64,125,190],"brain.":[20],"Central":[21],"to":[22,78,195,200],"this":[23],"AD":[24,196],"pathology":[25],"mismetabolism":[27],"amyloid":[30],"precursor":[31],"protein":[32],"(APP).":[33],"Recent":[34],"studies":[35,60],"suggest":[36],"that":[37,92,153,192],"flavonoids,":[38,71],"class":[40],"secondary":[42],"plant":[43],"metabolites,":[44],"may":[45,198],"be":[46,201],"useful":[47],"for":[48,177],"prevention":[50],"and":[51,76,102,108,132,140,146,203],"treatment":[52],"variety":[55],"diseases.":[58],"The":[59],"detailed":[61],"herein,":[62],"investigate":[63],"ability":[65],"two":[67],"such":[68],"classes":[69],"green":[72,93],"tea":[73,94],"derived":[74,95],"catechins":[75],"5,7-dihydroxyflavones,":[77,135],"modulate":[79],"APP":[80,85,120,158],"metabolism":[81],"\"Swedish\"":[83],"mutant":[84],"(APPsw)":[86],"models":[87],"AD.":[89,186],"Studies":[90],"showed":[91],"(-)-epigallocatechin-3-gallate":[96],"(EGCG)":[97],"effectively":[98,136],"reduced":[99,137],"A\u00df":[100,138],"generation":[101,139],"resultant":[103,141],"amyloidosis":[104,142],"both":[105,143],"vitro":[107,145],"vivo.":[110],"In":[111],"concert":[112],"with":[113],"these":[114,169],"findings,":[115],"EGCG":[116],"markedly":[117],"promoted":[118],"non-amyloidogenic":[119],"proteolysis":[121,159],"via":[122,160],"activation":[123],"putative":[126],"a-secretase,":[127],"a-disintegrin-and-metalloprotease-10":[128],"(ADAM10).":[129],"Furthermore,":[130],"luteolin":[131,154],"various":[133],"related":[134],"vivo,":[148],"well.":[150],"Data":[151],"revealed":[152,174],"decreased":[155],"amyloidogenic":[156],"\u03b3-secretase":[157],"presenilin-1":[161],"(PS1)":[162],"carboxyl-terminal":[163],"fragment":[164],"(CTF)":[165],"phosphorylation.":[166],"Elucidation":[167],"flavonoids'":[170],"cellular/molecular":[171],"mechanisms":[172],"also":[173],"their":[175],"potential":[176],"opposing":[178],"neurofibrillary":[179],"tangle":[180],"(NFT)":[181],"pathology,":[182],"another":[183],"hallmark":[184],"These":[187],"data":[188],"raise":[189],"possibility":[191],"flavonoid":[193],"administration":[194],"patients":[197],"prove":[199],"viable":[202],"effective":[204],"prophylactic":[205],"strategy.":[206]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}