{"id":"https://openalex.org/W1594624075","doi":null,"title":"Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats","display_name":"Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats","publication_year":2008,"publication_date":"2008-09-15","ids":{"openalex":"https://openalex.org/W1594624075","mag":"1594624075"},"language":"en","primary_location":{"id":"mag:1594624075","doi":null,"is_oa":false,"landing_page_url":"http://www.ijarnp.org/index.php/ijarnp/article/view/65","pdf_url":null,"source":{"id":"https://openalex.org/S2764815085","display_name":"International journal of applied research in natural products","issn_l":"1940-6223","issn":["1940-6223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International journal of applied research in natural products","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111687564","display_name":"AA Adeneye","orcid":"https://orcid.org/0000-0002-1314-6282","observed_orcids":["https://orcid.org/0000-0002-1314-6282"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AA Adeneye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027848641","display_name":"Joseph Abayomi Olagunju","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JA Olagunju","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057827717","display_name":"Simiat Olanike Elias","orcid":"https://orcid.org/0000-0001-6403-3854","observed_orcids":["https://orcid.org/0000-0001-6403-3854"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simiat Olanike Elias","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6403-3854","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036957982","display_name":"Dami Olatunbosun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dami Olatunbosun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087242451","display_name":"A O Mustafa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A O Mustafa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015380873","display_name":"O I Adeshile","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O I Adeshile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023060059","display_name":"A O Ashaolu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A O Ashaolu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081496913","display_name":"T A Laoye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T A Laoye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034568993","display_name":"A O Bamigboye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A O Bamigboye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019171086","display_name":"Azeez Omoniyi Adeoye","orcid":"https://orcid.org/0000-0002-8206-052X","observed_orcids":["https://orcid.org/0000-0002-8206-052X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Azeez Omoniyi Adeoye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0796643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1","issue":"3","first_page":"29","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12657","display_name":"Phytochemistry Medicinal Plant Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/harungana-madagascariensis","display_name":"Harungana madagascariensis","score":0.996999979019165},{"id":"https://openalex.org/keywords/acetaminophen-induced-hepatotoxicity","display_name":"acetaminophen hepatotoxicity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8489999771118164},{"id":"https://openalex.org/keywords/aqueous-root-extract","display_name":"aqueous root extract","score":0.9369999766349792},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.48899999260902405},{"id":"https://openalex.org/keywords/conjugated-bilirubin","display_name":"direct bilirubin","score":0.8849999904632568},{"id":"https://openalex.org/keywords/total-bilirubin","display_name":"total bilirubin","score":0.7839999794960022},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hepatocellular-necrosis","display_name":"liver necrosis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.6259999871253967},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.3240000009536743},{"id":"https://openalex.org/keywords/folk-medicine","display_name":"folk medicine","score":0.41600000858306885},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2778722691","wikidata":"https://www.wikidata.org/wiki/Q57055","display_name":"Acetaminophen","level":2,"score":0.8643441200256348},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.6076497435569763},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5810196399688721},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.5803545713424683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.501903772354126},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49481791257858276},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45443931221961975},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4336458146572113},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.42907679080963135},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38663387298583984},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3763170838356018},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13334715366363525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12689277529716492}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1594624075","doi":null,"is_oa":false,"landing_page_url":"http://www.ijarnp.org/index.php/ijarnp/article/view/65","pdf_url":null,"source":{"id":"https://openalex.org/S2764815085","display_name":"International journal of applied research in natural products","issn_l":"1940-6223","issn":["1940-6223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"International journal of applied research in natural products","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058037503","https://openalex.org/W4238152714","https://openalex.org/W4385271680","https://openalex.org/W4285351471","https://openalex.org/W2157795406","https://openalex.org/W2042898044","https://openalex.org/W1600857098","https://openalex.org/W2782248695","https://openalex.org/W2895096526","https://openalex.org/W4205106075"],"abstract_inverted_index":{"Summary:":[0],"In":[2,257,305],"this":[3,209,258],"study,":[4,259],"the":[5,14,29,73,98,123,133,146,155,163,179,202,205,212,216,219,241,260,264,278,293,297,306,313,317],"protective":[6,261],"effects":[7,131,262],"of":[8,13,18,87,90,101,113,182,194,208,215,221,240,244,263,268,292,296,312,325],"100":[9,109],"\u2013":[10],"500":[11,111],"mg/kg/day":[12],"aqueous":[15,265],"root":[16,266],"extract":[17,164,217,267,299,318],"Harungana":[20,115,270],"madagascariensis":[21,116,271],"Lam.":[23],"ex":[24],"Poir":[25],"were":[26,198,273],"evaluated":[27],"on":[28],"average":[30],"body":[31],"weight,":[32,35],"relative":[33],"liver-body":[34],"serum":[36,99,124,156,180],"alanine":[37],"(ALT)":[38],"and":[39,48,69,75,104,158,184,254,275,280,310],"aspartate":[40],"aminotransferases":[41],"(AST),":[42],"alkaline":[43],"phosphatase":[44],"(ALP),":[45],"total":[46,54,66],"(TB)":[47],"conjugated":[49],"bilirubin":[50],"(CB),":[51],"triglycerides":[52],"(TG),":[53],"cholesterol":[55,57],"(TC),":[56],"fractions":[58],"(HDL-c,":[59],"LDL-c,":[60],"VLDL-c),":[61],"fasting":[62],"blood":[63],"glucose":[64],"(FBG),":[65],"protein":[67],"(TP)":[68],"albumin":[70],"(ALB)":[71],"in":[72,97,122,132,145,154,178,186,218,246,277,300,333],"acute":[74,84,279],"repeated":[76,281],"dose":[77,187,282],"acetaminophen":[78,91,127,168,245,283,302,335],"hepatotoxic":[79,284],"rats.":[80,285],"Results":[81],"showed":[82],"that":[83,137],"intraperitoneal":[85],"injection":[86],"800":[88],"mg/kg":[89,112],"induced":[92,169],"significant":[93,142,150,176],"(p":[94,119],"0.05)":[95,120],"alterations":[96,121],"levels":[100,181],"lipids,":[102],"TB":[103,157,183],"CB.":[105,159],"However,":[106],"pretreatments":[107,161],"with":[108,141,162,249],"-":[110],"significantly":[118,165,172],"lipids.":[125],"Repeated":[126],"hepatotoxicity":[128,234,336],"caused":[129],"similar":[130],"measured":[134],"parameters":[135],"except":[136],"it":[138],"was":[139],"associated":[140,191],"(p<0.001)":[143,166],"reduction":[144],"FBG":[147],"while":[148,171],"inducing":[149],"(p<0.05,":[151,173],"p<0.001)":[152],"increases":[153],"Oral":[160],"enhanced":[167],"hypoglycemia":[170],"p<0.01)":[174],"attenuating":[175],"elevations":[177],"CB,":[185],"related":[188,303],"fashion.":[189],"The":[190,286],"histopathologic":[192],"features":[193],"moderate-to-severe":[195],"hepatic":[196],"necrosis":[197],"also":[199],"attenuated":[200],"by":[201],"extract.":[203],"Thus,":[204],"overall":[206],"results":[207],"study":[210],"confirm":[211],"folkloric":[213],"use":[214,243],"treatment":[220],"drug-induced":[222],"hepatotoxicity.":[223,304],"Industrial":[230],"relevance":[231],":":[232],"Acetaminophen":[233],"remains":[235],"a":[236],"major":[237],"intolerable":[238],"side-effect":[239],"clinical":[242],"all":[247],"age-groups,":[248],"limited":[250],"available":[251],"conventional":[252],"therapeutic":[253,294,327],"chemoprophylactic":[255],"options.":[256],"investigated":[274],"confirmed":[276],"results,":[287],"thus":[288],"obtained,":[289],"are":[290],"indicative":[291],"potentials":[295],"plant":[298],"combating":[301,334],"near":[307],"future,":[308],"isolation":[309],"discovery":[311],"lead":[314],"compound(s)":[315],"from":[316],"could":[319,330],"pave":[320],"way":[321],"to":[322],"subsequent":[323],"development":[324],"effective":[326],"drug":[328],"which":[329],"be":[331],"useful":[332]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}