{"id":"https://openalex.org/W1594448858","doi":"https://doi.org/10.4049/jimmunol.147.8.2455","title":"Antigen-specific inhibition of ongoing murine IgE responses. II. Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis","display_name":"Antigen-specific inhibition of ongoing murine IgE responses. II. Inhibition of IgE responses induced by treatment with glutaraldehyde-modified allergens is paralleled by reciprocal increases in IgG2a synthesis","publication_year":1991,"publication_date":"1991-10-01","ids":{"openalex":"https://openalex.org/W1594448858","doi":"https://doi.org/10.4049/jimmunol.147.8.2455","mag":"1594448858","pmid":"https://pubmed.ncbi.nlm.nih.gov/1717560"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.147.8.2455","doi":"https://doi.org/10.4049/jimmunol.147.8.2455","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.147.8.2455","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072841776","display_name":"Kent T. HayGlass","orcid":"https://orcid.org/0000-0002-4621-7737","observed_orcids":["https://orcid.org/0000-0002-4621-7737"]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"K T Hayglass","raw_affiliation_strings":["Department of Immunology, University of Manitoba , Winnipeg,","Department of Immunology, University of Manitoba, Winnipeg, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Manitoba , Winnipeg,","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Department of Immunology, University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070070906","display_name":"William P. Stefura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"W P Stefura","raw_affiliation_strings":["Department of Immunology, University of Manitoba , Winnipeg,","Department of Immunology, University of Manitoba, Winnipeg, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Manitoba , Winnipeg,","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"Department of Immunology, University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I46247651"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.3891,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.6521217,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"147","issue":"8","first_page":"2455","last_page":"2460"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.1469999998807907,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.040800001472234726,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ige-response","display_name":"IgE response","score":0.890999972820282},{"id":"https://openalex.org/keywords/igg2a","display_name":"IgG2a","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ovalbumin","display_name":"ovalbumin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/allergen-modification","display_name":"allergen modification","score":0.5770000219345093},{"id":"https://openalex.org/keywords/t-cell-dependent-antibody-response","display_name":"T cell-dependent antibody response","score":0.8090000152587891},{"id":"https://openalex.org/keywords/c57bl-6-mice","display_name":"C57BL/6 mice","score":0.8029999732971191},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.7140290141105652},{"id":"https://openalex.org/C141105273","wikidata":"https://www.wikidata.org/wiki/Q79455","display_name":"Immunoglobulin E","level":3,"score":0.7035377025604248},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.547767162322998},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.457528680562973},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44603610038757324},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4400821924209595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32253265380859375},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2307044267654419},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.04124933481216431}],"mesh":[{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000485","descriptor_name":"Allergens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005976","descriptor_name":"Glutaral","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007073","descriptor_name":"Immunoglobulin E","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.147.8.2455","doi":"https://doi.org/10.4049/jimmunol.147.8.2455","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.147.8.2455","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:1717560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1717560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W323722602","https://openalex.org/W62569982","https://openalex.org/W2041291976","https://openalex.org/W2094880227","https://openalex.org/W2168621633","https://openalex.org/W2056878140","https://openalex.org/W802116501","https://openalex.org/W1967854031","https://openalex.org/W7098262442","https://openalex.org/W1614077485"],"abstract_inverted_index":{"Administration":[0],"of":[1,11,29,41,50,58,84,95],"high":[2],"m.w.":[3],"glutaraldehyde-polymerized":[4],"OVA":[5],"(termed":[6],"OVA-POL)":[7],"before":[8],"OVA-[A1(OH)3]":[9],"immunization":[10],"C57BL/6":[12],"mice":[13,97],"markedly":[14],"impairs":[15],"their":[16],"capacity":[17,94],"to":[18,98],"generate":[19,99],"OVA-specific":[20],"IgE":[21,52,62,86,101,130],"responses,":[22],"while":[23],"simultaneously":[24],"resulting":[25],"in":[26,47,54,90,129],"striking":[27],"enhancement":[28],"Ag-specific":[30,85],"IgG2a":[31,88,132],"responses.":[32],"We":[33],"demonstrate":[34],"here":[35],"that":[36,64],"treatment":[37,68,123],"with":[38,69,115,124],"this":[39],"class":[40],"chemically":[42],"modified":[43,125],"allergen":[44],"also":[45],"results":[46],"pronounced":[48],"inhibition":[49],"ongoing":[51],"responses":[53,63,89,102],"vivo.":[55,91],"The":[56],"abrogation":[57],"well":[59],"established":[60],"murine":[61],"is":[65,72,76],"elicited":[66],"after":[67],"OVA-POL":[70],"(i)":[71],"potent":[73],"(97%),":[74],"(ii)":[75],"long":[77],"lived,":[78],"and":[79,87,111,131,137],"(iii)":[80],"reflects":[81],"reciprocal":[82],"regulation":[83],"Moreover,":[92],"the":[93],"OVA-POL-treated":[96],"secondary":[100],"remains":[103],"strongly":[104],"decreased":[105],"for":[106],"at":[107],"least":[108],"260":[109],"days":[110],"six":[112],"subsequent":[113],"immunizations":[114],"native":[116],"allergen,":[117],"despite":[118],"there":[119],"being":[120],"no":[121],"further":[122],"allergen.":[126],"These":[127],"changes":[128],"responsiveness":[133],"are":[134],"Ag":[135],"specific":[136],"T":[138],"cell":[139],"dependent.":[140]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}