{"id":"https://openalex.org/W1594375673","doi":"https://doi.org/10.4049/jimmunol.177.6.4203","title":"Increased Frequencies of Cochlin-Specific T Cells in Patients with Autoimmune Sensorineural Hearing Loss","display_name":"Increased Frequencies of Cochlin-Specific T Cells in Patients with Autoimmune Sensorineural Hearing Loss","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W1594375673","doi":"https://doi.org/10.4049/jimmunol.177.6.4203","mag":"1594375673","pmid":"https://pubmed.ncbi.nlm.nih.gov/16951386"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.177.6.4203","doi":"https://doi.org/10.4049/jimmunol.177.6.4203","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.177.6.4203","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/177/6/4203/1222989/zim01806004203.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/177/6/4203/1222989/zim01806004203.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067403724","display_name":"Moo-Jin Baek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moo-Jin Baek","raw_affiliation_strings":["Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","Head and Neck Institute, Cleveland Clinic , Cleveland, OH 44195","*Department of Immunology, Lerner Research Institute,","\u2020Head and Neck Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Head and Neck Institute, Cleveland Clinic , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"*Department of Immunology, Lerner Research Institute,","institution_ids":["https://openalex.org/I4405287411"]},{"raw_affiliation_string":"\u2020Head and Neck Institute, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112479218","display_name":"Hyun-Min Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyun-Min Park","raw_affiliation_strings":["Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","Head and Neck Institute, Cleveland Clinic , Cleveland, OH 44195","*Department of Immunology, Lerner Research Institute,","\u2020Head and Neck Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"Head and Neck Institute, Cleveland Clinic , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"*Department of Immunology, Lerner Research Institute,","institution_ids":["https://openalex.org/I4405287411"]},{"raw_affiliation_string":"\u2020Head and Neck Institute, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087616048","display_name":"Justin M. Johnson","orcid":"https://orcid.org/0000-0003-4344-9863","observed_orcids":["https://orcid.org/0000-0003-4344-9863"]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin M Johnson","raw_affiliation_strings":["Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","*Department of Immunology, Lerner Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"*Department of Immunology, Lerner Research Institute,","institution_ids":["https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026426427","display_name":"Cengiz Zubeyir Altuntas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102607778","display_name":"Cleveland State University","ror":"https://ror.org/002tx1f22","country_code":"US","type":"education","lineage":["https://openalex.org/I102607778"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cengiz Z Altuntas","raw_affiliation_strings":["Department of Biology, Cleveland State University , Cleveland, OH 44115","Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","*Department of Immunology, Lerner Research Institute,","\u00a7Department of Biology, Cleveland State University, Cleveland, OH 44115; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Cleveland State University , Cleveland, OH 44115","institution_ids":["https://openalex.org/I102607778"]},{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"*Department of Immunology, Lerner Research Institute,","institution_ids":["https://openalex.org/I4405287411"]},{"raw_affiliation_string":"\u00a7Department of Biology, Cleveland State University, Cleveland, OH 44115; and","institution_ids":["https://openalex.org/I102607778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004236987","display_name":"Dan Jane\u2010wit","orcid":"https://orcid.org/0000-0001-7115-0362","observed_orcids":["https://orcid.org/0000-0001-7115-0362"]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Jane-wit","raw_affiliation_strings":["Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","*Department of Immunology, Lerner Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"*Department of Immunology, Lerner Research Institute,","institution_ids":["https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031174923","display_name":"Ritika Jaini","orcid":"https://orcid.org/0000-0002-4580-8789","observed_orcids":["https://orcid.org/0000-0002-4580-8789"]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ritika Jaini","raw_affiliation_strings":["Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","*Department of Immunology, Lerner Research Institute,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"*Department of Immunology, Lerner Research Institute,","institution_ids":["https://openalex.org/I4405287411"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043584787","display_name":"Clementino Arturo Solares","orcid":"https://orcid.org/0000-0002-2794-5034","observed_orcids":["https://orcid.org/0000-0002-2794-5034"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Arturo Solares","raw_affiliation_strings":["Head and Neck Institute, Cleveland Clinic , Cleveland, OH 44195","\u2020Head and Neck Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Institute, Cleveland Clinic , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"\u2020Head and Neck Institute, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023705866","display_name":"Dawn Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn M Thomas","raw_affiliation_strings":["Allogen Laboratories, Cleveland Clinic , Cleveland, OH 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allogen Laboratories, Cleveland Clinic , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112178719","display_name":"Edward J. Ball","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J Ball","raw_affiliation_strings":["Allogen Laboratories, Cleveland Clinic , Cleveland, OH 44195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Allogen Laboratories, Cleveland Clinic , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108915366","display_name":"Nahid G. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nahid G Robertson","raw_affiliation_strings":["\u00b6Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082045576","display_name":"Cynthia Casson Morton","orcid":"https://orcid.org/0000-0003-2198-6756","observed_orcids":["https://orcid.org/0000-0003-2198-6756"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia C Morton","raw_affiliation_strings":["\u00b6Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6Department of Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037200015","display_name":"Gordon B. Hughes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B Hughes","raw_affiliation_strings":["Head and Neck Institute, Cleveland Clinic , Cleveland, OH 44195","\u2020Head and Neck Institute, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Head and Neck Institute, Cleveland Clinic , Cleveland, OH 44195","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"\u2020Head and Neck Institute, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044282307","display_name":"Vincent K. Tuohy","orcid":"https://orcid.org/0000-0003-1026-8521","observed_orcids":["https://orcid.org/0000-0003-1026-8521"]},"institutions":[{"id":"https://openalex.org/I102607778","display_name":"Cleveland State University","ror":"https://ror.org/002tx1f22","country_code":"US","type":"education","lineage":["https://openalex.org/I102607778"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I4405287411","display_name":"Cleveland Clinic Research","ror":"https://ror.org/053229s83","country_code":"US","type":"facility","lineage":["https://openalex.org/I1316902750","https://openalex.org/I4405287411"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent K Tuohy","raw_affiliation_strings":["Department of Biology, Cleveland State University , Cleveland, OH 44115","Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","*Department of Immunology, Lerner Research Institute,","\u00a7Department of Biology, Cleveland State University, Cleveland, OH 44115; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Cleveland State University , Cleveland, OH 44115","institution_ids":["https://openalex.org/I102607778"]},{"raw_affiliation_string":"Department of Immunology, Lerner Research Institute , Cleveland, OH 44195","institution_ids":["https://openalex.org/I36373038","https://openalex.org/I4405287411"]},{"raw_affiliation_string":"*Department of Immunology, Lerner Research Institute,","institution_ids":["https://openalex.org/I4405287411"]},{"raw_affiliation_string":"\u00a7Department of Biology, Cleveland State University, Cleveland, OH 44115; and","institution_ids":["https://openalex.org/I102607778"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5031174923"],"corresponding_institution_ids":["https://openalex.org/I36373038","https://openalex.org/I4405287411"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":3.1301,"has_fulltext":true,"cited_by_count":101,"citation_normalized_percentile":{"value":0.89434343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"177","issue":"6","first_page":"4203","last_page":"4210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders","score":0.9218999743461609,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":0.07580000162124634,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-sensorineural-hearing-loss","display_name":"autoimmune sensorineural hearing loss","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cochlin","display_name":"cochlin","score":0.9729999899864197},{"id":"https://openalex.org/keywords/t-cell-autoreactivity","display_name":"T cell autoreactivity","score":0.8420000076293945},{"id":"https://openalex.org/keywords/inner-ear-autoimmunity","display_name":"inner ear autoimmunity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7580000162124634},{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/serum-autoantibodies","display_name":"serum autoantibodies","score":0.7919999957084656},{"id":"https://openalex.org/keywords/sudden-hearing-loss","display_name":"sudden hearing loss","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7154513597488403},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.6116554141044617},{"id":"https://openalex.org/C2780607864","wikidata":"https://www.wikidata.org/wiki/Q928697","display_name":"Sensorineural hearing loss","level":3,"score":0.5223946571350098},{"id":"https://openalex.org/C2778500370","wikidata":"https://www.wikidata.org/wiki/Q212344","display_name":"Inner ear","level":2,"score":0.5166245102882385},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5062931776046753},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.49997997283935547},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.4862467050552368},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4792609214782715},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47341567277908325},{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.4212713837623596},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.41511625051498413},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.4130121171474457},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2530590891838074},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.20133599638938904},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.18951815366744995},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.06461653113365173}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006319","descriptor_name":"Hearing Loss, Sensorineural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018984","descriptor_name":"Epitopes, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4049/jimmunol.177.6.4203","doi":"https://doi.org/10.4049/jimmunol.177.6.4203","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.177.6.4203","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/177/6/4203/1222989/zim01806004203.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:16951386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16951386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/0f33ed62-18ac-4505-b2a7-754a82b62aaa","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/0f33ed62-18ac-4505-b2a7-754a82b62aaa","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Baek, M-J, Park, H-M, Johnson, J M, Altuntas, C Z, Jane-Wit, D, Jaini, R, Solares, C A, Thomas, D M, Ball, E J, Robertson, N G, Morton, C C, Hughes, G B & Tuohy, V K 2006, 'Increased frequencies of cochlin-specific T cells in patients with autoimmune sensorineural hearing loss', Journal of immunology (Baltimore, Md. : 1950), vol. 177, no. 6, pp. 4203-10.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.177.6.4203","doi":"https://doi.org/10.4049/jimmunol.177.6.4203","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.177.6.4203","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/177/6/4203/1222989/zim01806004203.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2281745726","display_name":"DISEASE MECHANISMS IN ASNHL AND ITS MOUSE MODEL","funder_award_id":"R01DC006422","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G3402894398","display_name":"Cloning Genes Involved in Hearing","funder_award_id":"R01DC003402","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1594375673.pdf","grobid_xml":"https://content.openalex.org/works/W1594375673.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1561460904","https://openalex.org/W1572893611","https://openalex.org/W1969438779","https://openalex.org/W1970567936","https://openalex.org/W1971449558","https://openalex.org/W1980242141","https://openalex.org/W1991823448","https://openalex.org/W1999443534","https://openalex.org/W2001536146","https://openalex.org/W2012739814","https://openalex.org/W2014217048","https://openalex.org/W2018878430","https://openalex.org/W2028824062","https://openalex.org/W2028861905","https://openalex.org/W2028863216","https://openalex.org/W2049272185","https://openalex.org/W2057303596","https://openalex.org/W2059593508","https://openalex.org/W2081897939","https://openalex.org/W2102786337","https://openalex.org/W2111188295","https://openalex.org/W2122134062","https://openalex.org/W2125268482","https://openalex.org/W2128792546","https://openalex.org/W2130852318","https://openalex.org/W2134744337","https://openalex.org/W2139129545","https://openalex.org/W2140031588","https://openalex.org/W2144450343","https://openalex.org/W2145920349","https://openalex.org/W2149539861","https://openalex.org/W2159885007","https://openalex.org/W2162457391","https://openalex.org/W2176915983","https://openalex.org/W2405354205","https://openalex.org/W2431817686"],"related_works":["https://openalex.org/W2122134062","https://openalex.org/W2162457391","https://openalex.org/W2407269323","https://openalex.org/W1985517403","https://openalex.org/W4236464994","https://openalex.org/W2075637013","https://openalex.org/W4406021261","https://openalex.org/W2093767203","https://openalex.org/W2008408916","https://openalex.org/W196854437"],"abstract_inverted_index":{"Autoimmune":[0],"sensorineural":[1],"hearing":[2,12,53,129,141,185],"loss":[3,13,142],"(ASNHL)":[4],"is":[5,154],"the":[6,86,155],"most":[7,87],"common":[8],"cause":[9],"of":[10,30,65],"sudden":[11],"in":[14,24,39,80,167],"adults.":[15],"Although":[16],"autoimmune":[17,180],"etiopathogenic":[18],"events":[19],"have":[20,35,61],"long":[21],"been":[22,37],"suspected":[23],"ASNHL,":[25],"inner":[26,89,164,181],"ear-specific":[27,165],"Ags":[28],"capable":[29],"targeting":[31],"T":[32,67,102,113,159],"cell":[33,160],"autoreactivity":[34],"not":[36],"identified":[38],"ASNHL.":[40],"In":[41,92],"this":[42],"study,":[43],"we":[44],"show":[45,158],"by":[46],"ELISPOT":[47],"analysis":[48],"that":[49],"compared":[50,125],"with":[51,126,137],"normal":[52,128],"age-":[54,130],"and":[55,100,131,135,170,184],"sex-matched":[56,132],"control":[57,133],"subjects,":[58],"ASNHL":[59,115,168],"patients":[60,106,116,136],"significantly":[62,119],"higher":[63],"frequencies":[64],"circulating":[66],"cells":[68,103],"producing":[69],"either":[70],"IFN-gamma":[71],"(p":[72,77,143],"=":[73,78],"0.0001)":[74],"or":[75],"IL-5":[76],"0.03)":[79],"response":[81],"to":[82,111,157,162],"recombinant":[83],"human":[84],"cochlin,":[85],"abundant":[88],"ear":[90,182],"protein.":[91],"some":[93],"patients,":[94,169],"cochlin":[95,108,172],"responsiveness":[96,109,161],"involved":[97],"both":[98,127],"CD4+":[99],"CD8+":[101,112],"whereas":[104],"other":[105],"showed":[107,118],"confined":[110],"cells.":[114],"also":[117],"elevated":[120],"cochlin-specific":[121],"serum":[122],"Ab":[123],"titers":[124],"subjects":[134],"noise-":[138],"and/or":[139],"age-related":[140],"<":[144],"0.05":[145],"at":[146],"all":[147],"dilutions":[148],"tested":[149],"through":[150],"1/2048).":[151],"Our":[152],"study":[153],"first":[156],"an":[163],"protein":[166],"implicates":[171],"as":[173],"a":[174],"prominent":[175],"target":[176],"Ag":[177],"for":[178],"mediating":[179],"inflammation":[183],"loss.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}