{"id":"https://openalex.org/W1593976080","doi":null,"title":"Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins.","display_name":"Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins.","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W1593976080","mag":"1593976080","pmid":"https://pubmed.ncbi.nlm.nih.gov/11006244","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1851917"},"language":"en","primary_location":{"id":"pmid:11006244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11006244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1851917","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108360577","display_name":"Jeong-Hyeon Sohn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H Sohn","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081736910","display_name":"Henry J. Kaplan","orcid":"https://orcid.org/0000-0003-1799-5692","observed_orcids":["https://orcid.org/0000-0003-1799-5692"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H J Kaplan","raw_affiliation_strings":["From the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis; and the","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041376802","display_name":"Hye-Jung Suk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H J Suk","raw_affiliation_strings":["From the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis; and the","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065261686","display_name":"Puran S. Bora","orcid":"https://orcid.org/0000-0003-4781-1217","observed_orcids":["https://orcid.org/0000-0003-4781-1217"]},"institutions":[{"id":"https://openalex.org/I2802034949","display_name":"Saint Louis University Hospital","ror":"https://ror.org/01v49sd11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801580383","https://openalex.org/I2802034949"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P S Bora","raw_affiliation_strings":["Department of Medicine, Division of Cardiology, St. Louis University Medical Center, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, St. Louis University Medical Center, Missouri","institution_ids":["https://openalex.org/I2802034949","https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108250563","display_name":"Nalini S. Bora","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N S Bora","raw_affiliation_strings":["From the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis; and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis; and the","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3571,"has_fulltext":false,"cited_by_count":142,"citation_normalized_percentile":{"value":0.78826748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"41","issue":"11","first_page":"3492","last_page":"502"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.07940000295639038,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.8349999785423279},{"id":"https://openalex.org/keywords/complement-regulatory-proteins","display_name":"complement regulatory proteins","score":0.984000027179718},{"id":"https://openalex.org/keywords/eye","display_name":"eye","score":0.5669999718666077},{"id":"https://openalex.org/keywords/anterior-uveitis","display_name":"anterior uveitis","score":0.8450000286102295},{"id":"https://openalex.org/keywords/crry","display_name":"Crry","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cd59","display_name":"CD59","score":0.9710000157356262},{"id":"https://openalex.org/keywords/membrane-cofactor-protein","display_name":"membrane cofactor protein","score":0.8989999890327454},{"id":"https://openalex.org/keywords/membrane-attack-complex","display_name":"membrane attack complex","score":0.7639999985694885},{"id":"https://openalex.org/keywords/c3-activation","display_name":"C3 activation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/zymosan","display_name":"zymosan","score":0.8330000042915344},{"id":"https://openalex.org/keywords/alternative-complement-pathway","display_name":"alternative complement pathway","score":0.7440000176429749},{"id":"https://openalex.org/keywords/immune-privilege","display_name":"immune privilege","score":0.6259999871253967},{"id":"https://openalex.org/keywords/aqueous-humor","display_name":"aqueous humor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cobra-venom-factor","display_name":"cobra venom factor","score":0.8259999752044678},{"id":"https://openalex.org/keywords/lewis-rats","display_name":"Lewis rats","score":0.7360000014305115},{"id":"https://openalex.org/keywords/ocular-immunology","display_name":"ocular immunology","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C184404459","wikidata":"https://www.wikidata.org/wiki/Q5009828","display_name":"CD59","level":4,"score":0.7589648365974426},{"id":"https://openalex.org/C8487232","wikidata":"https://www.wikidata.org/wiki/Q5248822","display_name":"Decay-accelerating factor","level":4,"score":0.6740661859512329},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6656022071838379},{"id":"https://openalex.org/C79196540","wikidata":"https://www.wikidata.org/wiki/Q14905298","display_name":"Complement membrane attack complex","level":4,"score":0.6570615172386169},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.588074803352356},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5596320033073425},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5231829285621643},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.5225205421447754},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.46334442496299744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4605405032634735},{"id":"https://openalex.org/C2778870864","wikidata":"https://www.wikidata.org/wiki/Q3083725","display_name":"Zymosan","level":3,"score":0.4379195272922516},{"id":"https://openalex.org/C2777346216","wikidata":"https://www.wikidata.org/wiki/Q1479494","display_name":"Paroxysmal nocturnal hemoglobinuria","level":2,"score":0.42265334725379944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36585575342178345},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34138649702072144},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23569458723068237},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003167","descriptor_name":"Complement Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011951","descriptor_name":"Receptors, Complement","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011951","descriptor_name":"Receptors, Complement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014606","descriptor_name":"Uveitis, Anterior","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014606","descriptor_name":"Uveitis, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014606","descriptor_name":"Uveitis, Anterior","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015054","descriptor_name":"Zymosan","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015941","descriptor_name":"Complement Hemolytic Activity Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018957","descriptor_name":"CD59 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018957","descriptor_name":"CD59 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018958","descriptor_name":"CD55 Antigens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018958","descriptor_name":"CD55 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051916","descriptor_name":"Membrane Cofactor Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:11006244","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11006244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1851917","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1851917","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.318.1988","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.318.1988","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.iovs.org/content/41/11/3492.full.pdf","raw_type":"text"},{"id":"mag:1593976080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11006244","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1851917","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1851917","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3153079640","display_name":"Core Grant for Vision Research","funder_award_id":"P30EY002687","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8057114933","display_name":"ETIOPATHOGENESIS OF UVEITIS","funder_award_id":"R01EY009730","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8619890116","display_name":"IN VIVO IMAGING IN AUTOIMMUNE UVEITIS","funder_award_id":"R01EY013094","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G8809336194","display_name":"EAAU--ANTIGEN STRUCTURE AND THERAPY","funder_award_id":"R01EY010543","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W8374004","https://openalex.org/W23073772","https://openalex.org/W56842853","https://openalex.org/W77072218","https://openalex.org/W102151282","https://openalex.org/W128686398","https://openalex.org/W143427596","https://openalex.org/W175199685","https://openalex.org/W179508987","https://openalex.org/W190980893","https://openalex.org/W205838380","https://openalex.org/W265055649","https://openalex.org/W1500833770","https://openalex.org/W1536005089","https://openalex.org/W1537414502","https://openalex.org/W1538060285","https://openalex.org/W1539043079","https://openalex.org/W1555889999","https://openalex.org/W1585826239","https://openalex.org/W1839131783","https://openalex.org/W1922947289","https://openalex.org/W1969008225","https://openalex.org/W1970405266","https://openalex.org/W1974963696","https://openalex.org/W1979228328","https://openalex.org/W1979236750","https://openalex.org/W1983099386","https://openalex.org/W1993057071","https://openalex.org/W2003096299","https://openalex.org/W2009028704","https://openalex.org/W2014153887","https://openalex.org/W2021131879","https://openalex.org/W2030471723","https://openalex.org/W2034060724","https://openalex.org/W2059250207","https://openalex.org/W2087184100","https://openalex.org/W2093300360","https://openalex.org/W2104223335","https://openalex.org/W2105575614","https://openalex.org/W2116100746","https://openalex.org/W2117689741","https://openalex.org/W2128635872","https://openalex.org/W2139370490","https://openalex.org/W2155571650","https://openalex.org/W2157388487","https://openalex.org/W2157619027","https://openalex.org/W2161062368","https://openalex.org/W2245215591","https://openalex.org/W2268795693","https://openalex.org/W2323555293","https://openalex.org/W2398742409","https://openalex.org/W2403602962"],"related_works":["https://openalex.org/W1502922948","https://openalex.org/W77072218","https://openalex.org/W8374004","https://openalex.org/W2062889513","https://openalex.org/W7098198011","https://openalex.org/W2003985640","https://openalex.org/W2064577212","https://openalex.org/W2313331495","https://openalex.org/W2793528954","https://openalex.org/W2100969164"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"explore":[2],"the":[3,6,17,28,71,80,84,182,208,233,278,312,323],"role":[4,141],"of":[5,21,30,43,52,70,74,83,86,99,125,142,153,184,215,239,268,280,288],"complement":[7,10,31,53,75,143,222,273,313,332],"system":[8,76,144,314],"and":[9,48,60,167,189,196,212,228,241,326],"regulatory":[11,32,223,333],"proteins":[12],"in":[13,111,145,194,207,232,246,255,322],"an":[14,112],"immune-privileged":[15],"organ,":[16],"eye.":[18,236],"METHODS:":[19],"Eyes":[20],"normal":[22,195,209,234,247,324],"Lewis":[23,87,256],"rats":[24,257],"were":[25,90,178,230,243],"analyzed":[26],"for":[27],"expression":[29],"proteins,":[33,224],"membrane":[34,41,185],"cofactor":[35],"protein":[36],"(MCP),":[37],"decay-acceleration":[38],"factor":[39,158],"(DAF),":[40],"inhibitor":[42],"reactive":[44],"lysis":[45],"(MIRL,":[46],"CD59),":[47],"cell":[49],"surface":[50],"regulator":[51],"(Crry),":[54],"using":[55],"immunohistochemistry,":[56],"Western":[57,175],"blot":[58,176],"analysis,":[59],"reverse":[61],"transcription-polymerase":[62],"chain":[63],"reaction":[64],"(RT-PCR).":[65],"Zymosan,":[66],"a":[67,260,319],"known":[68],"activator":[69],"alternative":[72],"pathway":[73],"was":[77,148,205],"injected":[78,92,258],"into":[79],"anterior":[81,118,219,252,281],"chamber":[82],"eye":[85,325],"rats.":[88],"Animals":[89],"also":[91,244],"intracamerally":[93],"with":[94,174,259,265],"5":[95,123],"microl":[96,124],"(25":[97,131,134,138],"microg)":[98],"neutralizing":[100,261],"monoclonal":[101],"antibody":[102,116,163],"(mAb)":[103],"against":[104,263],"rat":[105,198,210,235,248],"Crry":[106,240],"(5I2)":[107],"or":[108,136,301],"CD59":[109,242,290],"(6D1)":[110],"attempt":[113],"to":[114,180],"develop":[115],"induced":[117,217],"uveitis;":[119],"control":[120],"animals":[121],"received":[122],"sterile":[126],"phosphate-buffered":[127],"saline":[128],"(PBS),":[129],"OX-18":[130],"microg),":[132,135],"G-16-510E3":[133],"MOPC-21":[137,302],"microg).":[139],"The":[140,221,308],"antibody-induced":[146],"uveitis":[147,253,282],"explored":[149],"by":[150,275,283,330],"intraperitoneal":[151],"injection":[152,214,287],"35":[154],"U":[155],"cobra":[156],"venom":[157],"(CVF),":[159],"24":[160],"hours":[161],"before":[162],"injection.":[164],"Immunohistochemical":[165],"staining":[166],"sodium":[168],"dodecyl":[169],"sulfate-polyacrylamide":[170],"gel":[171],"electrophoresis":[172],"(SDS-PAGE)":[173],"analysis":[177],"used":[179],"detect":[181],"presence":[183],"attack":[186],"complex":[187],"(MAC)":[188],"C3":[190,269],"activation":[191,202],"products,":[192],"respectively,":[193],"antibody-injected":[197],"eyes.":[199],"RESULTS:":[200],"Complement":[201],"product":[203],"MAC":[204],"present":[206],"eye,":[211],"intraocular":[213,331],"zymosan":[216],"severe":[218],"uveitis.":[220],"MCP,":[225],"DAF,":[226],"CD59,":[227],"Crry,":[229,264],"identified":[231],"Soluble":[237],"forms":[238],"detected":[245],"aqueous":[249],"humor.":[250],"Severe":[251],"developed":[254],"mAb":[262],"increased":[266],"formation":[267],"split":[270],"products.":[271],"Systemic":[272],"depletion":[274],"CVF":[276],"prevented":[277],"induction":[279],"anti-Crry":[284],"mAb.":[285],"Intracameral":[286],"anti-rat":[289,292,298],"(6D1),":[291],"MHC":[293],"class":[294],"I":[295],"antigen":[296],"(OX-18),":[297],"Ig":[299],"(G-16-510E3),":[300],"caused":[303],"no":[304],"inflammatory":[305],"reaction.":[306],"CONCLUSIONS:":[307],"results":[309],"suggest":[310],"that":[311],"is":[315,327],"continuously":[316],"active":[317],"at":[318],"low":[320],"level":[321],"tightly":[328],"regulated":[329],"proteins.":[334]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}