{"id":"https://openalex.org/W1593557340","doi":"https://doi.org/10.1126/science.277.5333.1788","title":"Creating Isoprenoid Diversity","display_name":"Creating Isoprenoid Diversity","publication_year":1997,"publication_date":"1997-09-19","ids":{"openalex":"https://openalex.org/W1593557340","doi":"https://doi.org/10.1126/science.277.5333.1788","mag":"1593557340","pmid":"https://pubmed.ncbi.nlm.nih.gov/9324768"},"language":"en","primary_location":{"id":"doi:10.1126/science.277.5333.1788","doi":"https://doi.org/10.1126/science.277.5333.1788","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.277.5333.1788","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103456216","display_name":"James C. Sacchettini","orcid":"https://orcid.org/0000-0001-5767-2367","observed_orcids":["https://orcid.org/0000-0001-5767-2367"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James C. Sacchettini","raw_affiliation_strings":["J. C. Sacchettini is in the Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843-2128, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. C. Sacchettini is in the Department of Biochemistry and Biophysics, Texas A & M University, College Station, TX 77843-2128, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036710196","display_name":"C. Dale Poulter","orcid":"https://orcid.org/0000-0001-7682-3095","observed_orcids":["https://orcid.org/0000-0001-7682-3095"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Dale Poulter","raw_affiliation_strings":["C. D. Poulter is in the Department of Chemistry, University of Utah, Salt Lake City, UT 84112-0858, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. D. Poulter is in the Department of Chemistry, University of Utah, Salt Lake City, UT 84112-0858, USA","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0371,"has_fulltext":false,"cited_by_count":553,"citation_normalized_percentile":{"value":0.9228356,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"277","issue":"5333","first_page":"1788","last_page":"1789"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.9819999933242798},{"id":"https://openalex.org/keywords/isoprenoid-biosynthesis","display_name":"isoprenoid biosynthesis","score":0.9470000267028809},{"id":"https://openalex.org/keywords/cyclase","display_name":"cyclase","score":0.6489999890327454},{"id":"https://openalex.org/keywords/enzyme-structure","display_name":"enzyme structure","score":0.7289999723434448},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"stereochemistry","score":0.5400000214576721},{"id":"https://openalex.org/keywords/stereochemical-diversity","display_name":"stereochemical diversity","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C206103511","wikidata":"https://www.wikidata.org/wiki/Q426694","display_name":"Terpenoid","level":2,"score":0.8291139006614685},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.46728214621543884},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.4570392072200775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42781010270118713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40359923243522644},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40044915676116943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28540074825286865},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.18151569366455078},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.11465737223625183},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.07186746597290039},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.06897145509719849}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002338","descriptor_name":"Carotenoids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003500","descriptor_name":"Cyclization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007535","descriptor_name":"Isomerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007535","descriptor_name":"Isomerases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013261","descriptor_name":"Sterols","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014166","descriptor_name":"Transferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019751","descriptor_name":"Intramolecular Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019753","descriptor_name":"Intramolecular Lyases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019883","descriptor_name":"Alkyl and Aryl Transferases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051228","descriptor_name":"Geranyltranstransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.277.5333.1788","doi":"https://doi.org/10.1126/science.277.5333.1788","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.277.5333.1788","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:9324768","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9324768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Comment"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2036948758","https://openalex.org/W2056400844","https://openalex.org/W2074105121","https://openalex.org/W6636723008"],"related_works":["https://openalex.org/W4247064645","https://openalex.org/W2062743073","https://openalex.org/W2046652484","https://openalex.org/W1989750374","https://openalex.org/W6910169034","https://openalex.org/W4406592056","https://openalex.org/W2176603852","https://openalex.org/W7098292402","https://openalex.org/W7073997294","https://openalex.org/W7100112903"],"abstract_inverted_index":{"Living":[0],"things":[1],"use":[2],"isoprenoids":[3],"as":[4],"pigments,":[5],"hormones,":[6],"molecular":[7],"signals,":[8],"and":[9,29],"pheromones.":[10],"The":[11],"many":[12],"variations":[13],"of":[14,36,38,60,67],"isoprenoid":[15,68],"are":[16],"generated":[17],"by":[18],"versatile":[19],"enzymes":[20],"that":[21],"synthesize":[22],"multiple":[23],"products.":[24],"In":[25],"their":[26],"Perspective,":[27],"Sacchettini":[28],"Poulter":[30],"discuss":[31],"what":[32],"the":[33,65],"new":[34],"structures":[35],"three":[37],"these":[39],"cyclases,":[40],"reported":[41],"on":[42],"pages\n":[43],"1811,\n":[47],"1815,":[51],"and\n":[52],"1820\n":[56],"this":[61],"issue,":[62],"reveal":[63],"about":[64],"mechanisms":[66],"formation.":[69]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}