{"id":"https://openalex.org/W15931925","doi":"https://doi.org/10.1096/fasebj.21.5.a588","title":"Serotonin Modifies Actin Cytoskeleton In Human Intestinal Epithelial Cells via Involvement of PKC\u03b1","display_name":"Serotonin Modifies Actin Cytoskeleton In Human Intestinal Epithelial Cells via Involvement of PKC\u03b1","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W15931925","doi":"https://doi.org/10.1096/fasebj.21.5.a588","mag":"15931925"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a588","doi":"https://doi.org/10.1096/fasebj.21.5.a588","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a588","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002264441","display_name":"Ravinder K. Gill","orcid":"https://orcid.org/0000-0002-5337-2567","observed_orcids":["https://orcid.org/0000-0002-5337-2567"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ravinder Gill","raw_affiliation_strings":["Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080210254","display_name":"Jerrold R. Turner","orcid":"https://orcid.org/0000-0003-0627-9455","observed_orcids":["https://orcid.org/0000-0003-0627-9455"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerrold Turner","raw_affiliation_strings":["Univ. of Chicago 5841 S Maryland Ave Chicago IL 60637","Univ. of Chicago, 5841 S Maryland Ave, Chicago, IL, 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Chicago 5841 S Maryland Ave Chicago IL 60637","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Univ. of Chicago, 5841 S Maryland Ave, Chicago, IL, 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067027209","display_name":"Seema Saksena","orcid":"https://orcid.org/0000-0002-2166-6317","observed_orcids":["https://orcid.org/0000-0002-2166-6317"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seema Saksena","raw_affiliation_strings":["Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045604140","display_name":"Waddah A. Alrefai","orcid":"https://orcid.org/0000-0002-3961-5438","observed_orcids":["https://orcid.org/0000-0002-3961-5438"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Waddah Alrefai","raw_affiliation_strings":["Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053353445","display_name":"Fadi Annaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fadi Annaba","raw_affiliation_strings":["Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078342564","display_name":"Nitika Pant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitika Pant","raw_affiliation_strings":["Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113704386","display_name":"Krishnamurthy Ramaswamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishnamurthy Ramaswamy","raw_affiliation_strings":["JBVAMC 820 S Damen Ave Chicago IL 60612","Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","JBVAMC, 820 S Damen Ave, Chicago, IL, 60612","Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JBVAMC 820 S Damen Ave Chicago IL 60612","institution_ids":[]},{"raw_affiliation_string":"Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"JBVAMC, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":[]},{"raw_affiliation_string":"Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016617625","display_name":"Pradeep Kumar Dudeja","orcid":"https://orcid.org/0000-0003-2252-7703","observed_orcids":["https://orcid.org/0000-0003-2252-7703"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pradeep Dudeja","raw_affiliation_strings":["JBVAMC 820 S Damen Ave Chicago IL 60612","Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","JBVAMC, 820 S Damen Ave, Chicago, IL, 60612","Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"JBVAMC 820 S Damen Ave Chicago IL 60612","institution_ids":[]},{"raw_affiliation_string":"Univ. of Illinois at Chicago 820 S Damen Ave Chicago IL 60612","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"JBVAMC, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":[]},{"raw_affiliation_string":"Univ. of Illinois at Chicago, 820 S Damen Ave, Chicago, IL, 60612","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.00162914,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.7544000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.16030000150203705,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":1.0},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9559999704360962},{"id":"https://openalex.org/keywords/protein-kinase-c-alpha","display_name":"protein kinase C alpha","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nhe3","display_name":"NHE3","score":0.8510000109672546},{"id":"https://openalex.org/keywords/intestinal-epithelial-cells","display_name":"intestinal epithelial cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/5-ht4-receptor","display_name":"5-HT4 receptor","score":1.0},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.7870000004768372},{"id":"https://openalex.org/keywords/microvilli","display_name":"microvilli","score":0.824999988079071},{"id":"https://openalex.org/keywords/actin-polymerization","display_name":"actin polymerization","score":0.8930000066757202},{"id":"https://openalex.org/keywords/calcium-signaling","display_name":"calcium signaling","score":0.7200000286102295},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.7179999947547913},{"id":"https://openalex.org/keywords/intestinal-ion-transport","display_name":"intestinal ion transport","score":0.5210000276565552}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7651669383049011},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7565515041351318},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5892296433448792},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5564906597137451},{"id":"https://openalex.org/C2781099445","wikidata":"https://www.wikidata.org/wiki/Q4121060","display_name":"Stress fiber","level":4,"score":0.5088870525360107},{"id":"https://openalex.org/C3620293","wikidata":"https://www.wikidata.org/wiki/Q14908027","display_name":"Actin remodeling","level":5,"score":0.49277594685554504},{"id":"https://openalex.org/C189040839","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Microfilament","level":4,"score":0.48504704236984253},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.45664095878601074},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4402908682823181},{"id":"https://openalex.org/C71829478","wikidata":"https://www.wikidata.org/wiki/Q901305","display_name":"Immunoprecipitation","level":3,"score":0.41721653938293457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3845128118991852},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.311439573764801},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.195794016122818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1454605758190155},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a588","doi":"https://doi.org/10.1096/fasebj.21.5.a588","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a588","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7300000190734863,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1972800124","https://openalex.org/W2013319375","https://openalex.org/W2084279650","https://openalex.org/W2035500168","https://openalex.org/W2018054062","https://openalex.org/W2075196569","https://openalex.org/W2055604806","https://openalex.org/W2235829819","https://openalex.org/W2336211917","https://openalex.org/W2015176407"],"abstract_inverted_index":{"Serotonin":[0],"(5\u2010HT)":[1],"inhibits":[2,25],"intestinal":[3,42],"Na+/H+":[4],"exchanger":[5],"3":[6],"(NHE3)":[7],"activity":[8],"by":[9,118],"mechanisms":[10],"not":[11],"fully":[12],"understood":[13],"Since,":[14],"NHE3":[15,26,161],"function":[16],"requires":[17],"an":[18,155],"intact":[19],"cytoskeleton,":[20],"we":[21],"hypothesized":[22],"that":[23,47,76,127,138],"5\u2010HT":[24,48,77,107,128],"via":[27,143],"the":[28,53,104],"actin":[29,70,85,95,140],"cytoskeleton.":[30],"Electron":[31],"microscopy":[32,73],"(EM),":[33],"immunofluorescence":[34],"and":[35,67,99,112,120,147,149],"immunoprecipitation":[36],"were":[37],"employed":[38],"utilizing":[39],"polarized":[40],"Caco\u20102":[41],"cell":[43],"monolayers.":[44],"EM":[45],"showed":[46,126],"(0.1":[49],"\u03bcM,":[50],"1h)":[51],"caused":[52],"apical":[54],"membrane":[55],"to":[56],"assume":[57],"a":[58],"convex":[59],"dome":[60],"shape":[61],"with":[62,88,133],"cells":[63],"displaying":[64],"shorter":[65],"microvilli":[66],"prominent":[68],"cortical":[69],"filaments.":[71],"Fluorescence":[72],"studies":[74,125],"demonstrated":[75],"induced":[78],"basal":[79],"stress":[80,110],"fiber":[81],"assembly.":[82],"This":[83],"morphological":[84],"reorganization":[86],"correlated":[87],"20":[89],"\u00b1":[90],"1.5%":[91],"(P<0.05)":[92],"increases":[93],"in":[94,108,158],"polymerization.":[96],"Both":[97],"5\u2010HT3":[98],"5\u2010HT4":[100],"receptor":[101,145],"agonists":[102],"mimicked":[103],"effects":[105],"of":[106,131,160],"inducing":[109],"fibers":[111],"this":[113],"induction":[114],"was":[115],"partially":[116],"prevented":[117],"BAPTA\u2010AM":[119],"PKC\u03b1":[121,132,150],"inhibition":[122,159],"(Go6976).":[123],"Immunoprecipitation":[124],"decreased":[129],"association":[130],"actin.":[134],"These":[135],"results":[136],"suggested":[137],"5\u2010HT\u2010induced":[139],"cytoskeletal":[141],"re\u2010organization":[142],"5\u2010HT3/4":[144],"subtypes":[146],"Ca2+":[148],"dependent":[151],"pathways":[152],"might":[153],"play":[154],"important":[156],"role":[157],"activity.":[162]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2016-06-24T00:00:00"}