{"id":"https://openalex.org/W1593083333","doi":null,"title":"Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation.","display_name":"Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation.","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W1593083333","mag":"1593083333","pmid":"https://pubmed.ncbi.nlm.nih.gov/9403710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858361"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:1533018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858361","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032335251","display_name":"Mara Riminucci","orcid":"https://orcid.org/0000-0002-8643-9211","observed_orcids":["https://orcid.org/0000-0002-8643-9211"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Riminucci","raw_affiliation_strings":["Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Craniofacial and Skeletal Diseases Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108400573","display_name":"Larry W. Fisher","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L W Fisher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049683780","display_name":"Andrew Shenker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Shenker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111658095","display_name":"Allen M. Spiegel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A M Spiegel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"P Bianco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Bianco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5027181492","display_name":"Pamela Gehron Robey","orcid":"https://orcid.org/0000-0002-5316-5576","observed_orcids":["https://orcid.org/0000-0002-5316-5576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Gehron Robey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":11.1197,"has_fulltext":false,"cited_by_count":228,"citation_normalized_percentile":{"value":0.98653867,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"151","issue":"6","first_page":"1587","last_page":"600"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrous-dysplasia","display_name":"fibrous dysplasia","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mccune-albright-syndrome","display_name":"McCune-Albright syndrome","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gs-protein","display_name":"Gs protein","score":0.9350000023841858},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.75},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.796999990940094},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5490000247955322},{"id":"https://openalex.org/keywords/versican","display_name":"versican","score":0.777999997138977},{"id":"https://openalex.org/keywords/sparc","display_name":"SPARC","score":0.9950000047683716},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bone-sialoprotein","display_name":"bone sialoprotein","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.6800000071525574},{"id":"https://openalex.org/keywords/bone-matrix","display_name":"bone matrix","score":0.5289999842643738},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2781362533","wikidata":"https://www.wikidata.org/wiki/Q1410864","display_name":"Fibrous dysplasia","level":2,"score":0.7982239723205566},{"id":"https://openalex.org/C2781460891","wikidata":"https://www.wikidata.org/wiki/Q422360","display_name":"Osteonectin","level":5,"score":0.7576290965080261},{"id":"https://openalex.org/C2776432469","wikidata":"https://www.wikidata.org/wiki/Q14907671","display_name":"Bone sialoprotein","level":5,"score":0.6336725950241089},{"id":"https://openalex.org/C159470946","wikidata":"https://www.wikidata.org/wiki/Q14888030","display_name":"Versican","level":4,"score":0.5912485122680664},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.5589087009429932},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5130590200424194},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.46358299255371094},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.4436969459056854},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4402523338794708},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.4294971525669098},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.3964170217514038},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37772446870803833},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3300299644470215},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3289450705051422},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.26181888580322266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22805708646774292},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20416459441184998},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.16839194297790527},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12683048844337463},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11727878451347351},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.07980605959892273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07583498954772949},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003994","descriptor_name":"Bucladesine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005359","descriptor_name":"Fibrous Dysplasia, Polyostotic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005359","descriptor_name":"Fibrous Dysplasia, Polyostotic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015513","descriptor_name":"Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015676","descriptor_name":"Osteonectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017403","descriptor_name":"In Situ Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019205","descriptor_name":"GTP-Binding Protein alpha Subunits, Gs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019205","descriptor_name":"GTP-Binding Protein alpha Subunits, Gs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:1533018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:9403710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9403710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1858361","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1858361/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma1.it:11573/103373","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/103373","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:1593083333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9403710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1533018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1858361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W26493126","https://openalex.org/W239911627","https://openalex.org/W1475713056","https://openalex.org/W1491876144","https://openalex.org/W1499047562","https://openalex.org/W1570147293","https://openalex.org/W1576215194","https://openalex.org/W1965836520","https://openalex.org/W1966073197","https://openalex.org/W1967092942","https://openalex.org/W1970360897","https://openalex.org/W1972526384","https://openalex.org/W1977556078","https://openalex.org/W1992660305","https://openalex.org/W1994768570","https://openalex.org/W2008634935","https://openalex.org/W2016136435","https://openalex.org/W2016910756","https://openalex.org/W2025308185","https://openalex.org/W2040195944","https://openalex.org/W2040337853","https://openalex.org/W2042444320","https://openalex.org/W2045171889","https://openalex.org/W2048169623","https://openalex.org/W2051300777","https://openalex.org/W2088943140","https://openalex.org/W2109218792","https://openalex.org/W2123358515","https://openalex.org/W2127599101","https://openalex.org/W2141877739","https://openalex.org/W2337777109","https://openalex.org/W2433500836","https://openalex.org/W4290363200"],"related_works":["https://openalex.org/W1977556078","https://openalex.org/W239911627","https://openalex.org/W2255711579","https://openalex.org/W2475962588","https://openalex.org/W2943678774","https://openalex.org/W2334263069","https://openalex.org/W2090891308","https://openalex.org/W2329768928","https://openalex.org/W7100048006","https://openalex.org/W2063159496"],"abstract_inverted_index":{"In":[0],"addition":[1],"to":[2,29,46,93,222,241,257,305],"caf\u00e9-au-lait":[3],"pigmentation":[4],"patterns":[5],"and":[6,65,81,97,163,206,208,215,299],"hyperendocrinopathies,":[7],"fibrous":[8,51,106,112,194,243],"dysplasia":[9,52,195,244],"of":[10,23,31,50,61,78,89,101,111,123,126,131,148,175,190,226,245,250,260,276,292],"bone":[11,54,137,192,198,216,246,264,307],"is":[12,84,103,219,309],"a":[13,197,248,271,286,302],"major":[14],"finding":[15],"in":[16,37,53,71,105,121,160,170,193,201,210,220,231,252,282,294,311],"the":[17,24,43,47,117,135,145,173,186,211,223,239,253,258,283,290,295],"McCune-Albright":[18,40],"syndrome.":[19],"Activating":[20],"missense":[21],"mutations":[22,293],"Gs":[25,79,277,296],"alpha":[26,80,278,297],"gene":[27,298],"leading":[28,45],"overactivity":[30],"adenylyl":[32],"cyclase":[33],"have":[34],"been":[35,57],"identified":[36],"patients":[38],"with":[39,128,165,185],"syndrome,":[41],"but":[42,150],"mechanism":[44],"specific":[48,62],"development":[49],"has":[55],"not":[56],"elucidated.":[58],"By":[59],"means":[60],"peptide":[63],"antisera":[64],"reverse":[66],"transcriptase":[67],"polymerase":[68],"chain":[69],"reaction":[70],"situ":[72],"hybridization,":[73],"we":[74],"show":[75],"that":[76,98,116,270],"expression":[77,102],"its":[82],"mRNA":[83],"critically":[85],"up-regulated":[86],"during":[87],"maturation":[88],"precursor":[90],"osteogenic":[91,181,254,284],"cells":[92,96,127,154,251,281],"normal":[94,232],"osteoblast":[95],"this":[99,312],"pattern":[100],"retained":[104],"dysplasia.":[107],"A":[108],"functional":[109],"characterization":[110],"dysplastic":[113],"tissues":[114],"revealed":[115],"fibrotic":[118,142],"areas":[119,143],"consist,":[120],"fact,":[122],"an":[124],"excess":[125,176,261],"phenotypic":[129],"features":[130],"pre-osteogenic":[132],"cells,":[133],"whereas":[134],"lesional":[136,191],"formed":[138],"de":[139,187,233],"novo":[140,188,234],"within":[141],"represents":[144],"biosynthetic":[146],"output":[147],"mature":[149],"abnormal":[151],"osteoblasts.":[152],"These":[153],"are":[155],"noted":[156],"for":[157,289],"peculiar":[158],"changes":[159],"cell":[161,265],"shape":[162],"interaction":[164],"matrix,":[166],"which":[167,218],"were":[168],"mimicked":[169],"vitro":[171],"by":[172],"effects":[174,259,291],"exogenous":[177],"cAMP":[178,262],"on":[179,263],"human":[180],"cells.":[182],"Osteoblasts":[183],"involved":[184],"deposition":[189],"produce":[196],"matrix":[199],"enriched":[200],"certain":[202],"anti-adhesion":[203],"molecules":[204,213],"(versican":[205],"osteonectin),":[207],"poor":[209],"pro-adhesive":[212],"osteopontin":[214],"sialoprotein,":[217],"contrast":[221],"high":[224],"levels":[225,279],"these":[227],"two":[228],"proteins":[229],"found":[230],"bone.":[235],"Our":[236],"data":[237],"indicate":[238],"need":[240],"reinterpret":[242],"as":[247,304],"disease":[249],"lineage,":[255],"related":[256],"function.":[266],"They":[267],"further":[268],"suggest":[269],"critical,":[272],"physiological,":[273],"maturation-related":[274],"regulation":[275],"makes":[280],"lineage":[285],"natural":[287],"target":[288],"may":[300],"provide":[301],"clue":[303],"why":[306],"itself":[308],"affected":[310],"somatic,":[313],"mutation-dependent":[314],"disease.":[315]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}