{"id":"https://openalex.org/W1592992185","doi":"https://doi.org/10.1128/jvi.66.10.5937-5948.1992","title":"Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaques","display_name":"Alterations in potential sites for glycosylation predominate during evolution of the simian immunodeficiency virus envelope gene in macaques","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W1592992185","doi":"https://doi.org/10.1128/jvi.66.10.5937-5948.1992","mag":"1592992185","pmid":"https://pubmed.ncbi.nlm.nih.gov/1527847","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/241471"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.66.10.5937-5948.1992","doi":"https://doi.org/10.1128/jvi.66.10.5937-5948.1992","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.66.10.5937-5948.1992","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/241471","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075328638","display_name":"Julie M. Overbaugh","orcid":"https://orcid.org/0000-0002-0239-9444","observed_orcids":["https://orcid.org/0000-0002-0239-9444"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Overbaugh","raw_affiliation_strings":["Department of Microbiology, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041860582","display_name":"Lyle M. Rudensey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L M Rudensey","raw_affiliation_strings":["Department of Microbiology, University of Washington, Seattle 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, University of Washington, Seattle 98195","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":2.2293,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.8729038,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"66","issue":"10","first_page":"5937","last_page":"5948"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simian-immunodeficiency-virus","display_name":"simian immunodeficiency virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/v4-region","display_name":"V4 region","score":0.9900000095367432},{"id":"https://openalex.org/keywords/v3-region","display_name":"V3 region","score":0.9229999780654907},{"id":"https://openalex.org/keywords/amino-acid-variation","display_name":"amino acid sequence variation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/simian-aids","display_name":"simian AIDS","score":0.6970000267028809},{"id":"https://openalex.org/keywords/macaque","display_name":"macaque","score":0.45500001311302185},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.6510000228881836},{"id":"https://openalex.org/keywords/envelope-protein","display_name":"envelope protein","score":0.4230000078678131},{"id":"https://openalex.org/keywords/serine-and-threonine-residues","display_name":"serine and threonine residues","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9084731340408325},{"id":"https://openalex.org/C2777995582","wikidata":"https://www.wikidata.org/wiki/Q1890246","display_name":"Simian immunodeficiency virus","level":3,"score":0.8635824918746948},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6627655625343323},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6261623501777649},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.6121640801429749},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5900139808654785},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5743994116783142},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5552030205726624},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.4940081238746643},{"id":"https://openalex.org/C2776488936","wikidata":"https://www.wikidata.org/wiki/Q5452918","display_name":"Simian","level":3,"score":0.48173025250434875},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.4128206968307495},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.18661606311798096}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008254","descriptor_name":"Macaca nemestrina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012689","descriptor_name":"Sequence Homology, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015686","descriptor_name":"Gene Products, env","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jvi.66.10.5937-5948.1992","doi":"https://doi.org/10.1128/jvi.66.10.5937-5948.1992","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.66.10.5937-5948.1992","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1313099","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/241471","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:241471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/241471","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:1527847","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1527847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1313099","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/241471","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G169531593","display_name":null,"funder_award_id":"AI26503","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6952987319","display_name":"National Primate Research Center","funder_award_id":"P51RR000166","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000868680","display_name":"University of Washington/Fred Hutch Center for AIDS Research","funder_award_id":"P30AI027757","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1489355333","https://openalex.org/W1518023932","https://openalex.org/W1575011634","https://openalex.org/W1585442973","https://openalex.org/W1629496165","https://openalex.org/W1739595091","https://openalex.org/W1768734130","https://openalex.org/W1933773138","https://openalex.org/W1955516651","https://openalex.org/W1962508276","https://openalex.org/W1966551225","https://openalex.org/W1980259340","https://openalex.org/W1982701792","https://openalex.org/W1988356694","https://openalex.org/W1993398279","https://openalex.org/W2000309384","https://openalex.org/W2002432452","https://openalex.org/W2012097474","https://openalex.org/W2020948366","https://openalex.org/W2021984449","https://openalex.org/W2024451651","https://openalex.org/W2035658978","https://openalex.org/W2040410548","https://openalex.org/W2048499136","https://openalex.org/W2053667638","https://openalex.org/W2062229947","https://openalex.org/W2078069915","https://openalex.org/W2079122481","https://openalex.org/W2083479623","https://openalex.org/W2086725873","https://openalex.org/W2090507582","https://openalex.org/W2103488145","https://openalex.org/W2110917275","https://openalex.org/W2114279162","https://openalex.org/W2121849883","https://openalex.org/W2150956237","https://openalex.org/W2157644226","https://openalex.org/W2159872710","https://openalex.org/W2161039922","https://openalex.org/W2162772698","https://openalex.org/W2337484707","https://openalex.org/W2414469960","https://openalex.org/W4233721986","https://openalex.org/W4246686612","https://openalex.org/W4298399578"],"related_works":["https://openalex.org/W1489355333","https://openalex.org/W7100782556","https://openalex.org/W2152281378","https://openalex.org/W2000251212","https://openalex.org/W1981440953","https://openalex.org/W1494195177","https://openalex.org/W2117786107","https://openalex.org/W2124175534","https://openalex.org/W2123660365","https://openalex.org/W2170586960"],"abstract_inverted_index":{"Genetic":[0],"diversity":[1],"is":[2,24,28,54,72],"a":[3,73,81,216],"hallmark":[4],"of":[5,15,22,83,94,118,146,172,191,218],"the":[6,13,20,29,91,115,125,134,144,173,192,212],"human":[7],"immunodeficiency":[8,50],"virus":[9,51,100],"(HIV)":[10],"genome,":[11],"but":[12],"role":[14],"distinct":[16],"HIV":[17,35],"variants":[18,194],"in":[19,34,39,48,57,114,133,152,157,178,211],"development":[21],"AIDS":[23,79,142,200],"unclear.":[25],"Envelope":[26],"(env)":[27],"most":[30],"highly":[31],"variable":[32],"gene":[33],"as":[36,38,78,215],"well":[37],"other":[40],"retroviruses.":[41],"We":[42],"have":[43],"previously":[44],"demonstrated":[45],"that":[46,76,154,195,203],"variation":[47],"simian":[49,66],"(SIV)":[52],"env":[53,86,213],"primarily":[55],"localized":[56],"two":[58],"regions":[59],"(V1":[60],"and":[61,159,162,180,208],"V4)":[62],"during":[63,197],"progression":[64,198],"to":[65,199],"AIDS.":[67],"To":[68],"determine":[69],"whether":[70],"there":[71],"common":[74,175,189],"genotype":[75],"evolves":[77],"develops,":[80],"total":[82],"160":[84],"SIV":[85,193],"genes":[87],"isolated":[88],"directly":[89],"from":[90,137],"tissue":[92],"DNAs":[93],"four":[95,139],"macaques":[96],"infected":[97],"with":[98,165],"cloned":[99],"were":[101,108],"compared.":[102],"Common":[103],"amino":[104,127],"acid":[105,128],"sequence":[106,151,176],"changes":[107,177,210],"identified":[109],"within":[110],"V1,":[111],"V4,":[112],"and,":[113],"late":[116],"stages":[117],"disease,":[119],"near":[120],"V3.":[121],"At":[122],"several":[123],"positions,":[124],"same":[126],"change":[129],"was":[130,155],"seen":[131],"frequently":[132],"variant":[135],"genomes":[136],"all":[138],"animals.":[140],"As":[141],"developed,":[143],"majority":[145],"viruses":[147],"evolved":[148],"an":[149],"extended":[150],"V1":[153,179],"rich":[156],"serine":[158],"threonine":[160],"residues":[161],"shared":[163],"similarity":[164],"proteins":[166],"modified":[167],"by":[168],"O-linked":[169],"glycosylation.":[170,187],"Several":[171],"predominant":[174],"V4":[181],"created":[182],"new":[183],"sites":[184],"for":[185,206],"N-linked":[186],"Thus,":[188],"features":[190],"evolve":[196],"are":[201],"motifs":[202],"potentially":[204],"allow":[205],"structural":[207],"functional":[209],"protein":[214],"result":[217],"carbohydrate":[219],"addition.":[220]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
