{"id":"https://openalex.org/W1592937239","doi":null,"title":"EJ/ras neoplastic transformation of simian virus 40-immortalized human uroepithelial cells: a rare event.","display_name":"EJ/ras neoplastic transformation of simian virus 40-immortalized human uroepithelial cells: a rare event.","publication_year":1990,"publication_date":"1990-08-01","ids":{"openalex":"https://openalex.org/W1592937239","mag":"1592937239","pmid":"https://pubmed.ncbi.nlm.nih.gov/2164447"},"language":"en","primary_location":{"id":"pmid:2164447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2164447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112580387","display_name":"Brian J. Christian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B J Christian","raw_affiliation_strings":["Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison 53792"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Oncology, University of Wisconsin Clinical Cancer Center, Madison 53792","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111365848","display_name":"Chinghai H. Kao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C H Kao","raw_affiliation_strings":["University of Wisconsin \u2013,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin \u2013,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113500299","display_name":"Shi Qi Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Q Wu","raw_affiliation_strings":["University of Wisconsin \u2013,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin \u2013,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111770505","display_name":"Lorraine F. Meisner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L F Meisner","raw_affiliation_strings":["University of Wisconsin \u2013,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin \u2013,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109874549","display_name":"Catherine A. Reznikoff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C A Reznikoff","raw_affiliation_strings":["University of Wisconsin \u2013,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wisconsin \u2013,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5655,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.89916857,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"50","issue":"15","first_page":"4779","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.7211999893188477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.4790000021457672},{"id":"https://openalex.org/keywords/oncogenic-transformation","display_name":"oncogenic transformation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/simian-virus-40","display_name":"simian virus 40","score":0.7699999809265137},{"id":"https://openalex.org/keywords/urothelial-cells","display_name":"urothelial cells","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tumorigenicity","display_name":"tumorigenicity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neomycin-resistance","display_name":"neomycin resistance","score":0.515999972820282},{"id":"https://openalex.org/keywords/nude-mouse-xenograft","display_name":"nude mouse xenograft","score":0.675000011920929},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.756995439529419},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.6644325256347656},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6421656012535095},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6389939188957214},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6093177795410156},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5085779428482056},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.48583123087882996},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4584774971008301},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.43524059653282166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4221726059913635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1527400016784668}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011905","descriptor_name":"Genes, ras","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013539","descriptor_name":"Simian virus 40","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015689","descriptor_name":"Oncogene Protein p21(ras)","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2164447","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2164447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:1592937239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2164447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5199999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5483413752","display_name":"NEW MODEL OF HUMAN BLADDER CANCER PATHOGENESIS","funder_award_id":"2r01ca029525-17a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2020895277","https://openalex.org/W2159162740","https://openalex.org/W2067139623","https://openalex.org/W2140566800","https://openalex.org/W1525023012","https://openalex.org/W1515940763","https://openalex.org/W7095441567","https://openalex.org/W2132010690","https://openalex.org/W1495863746","https://openalex.org/W1532248313"],"abstract_inverted_index":{"To":[0],"determine":[1],"if":[2],"expression":[3,353],"of":[4,68,79,89,98,177,180,186,231,247,255,320,339,354,367],"mutant":[5,125,218,248,356],"p21":[6,74,100,126,257,310],"ras":[7,70,75,99,130,138,144,249,258,300,325,357],"could":[8],"convert":[9],"Simian":[10],"Virus":[11],"40-immortalized":[12],"human":[13],"uroepithelial":[14],"cell":[15],"line":[16],"(SV-HUC)":[17],"to":[18,107,194,280],"tumorigenicity,":[19],"SV-HUC":[20,63],"cells":[21,340,345],"were":[22,44,54,156],"transfected":[23],"with":[24,32,109,122],"pSV2-neo":[25],"(a":[26],"neomycin-resistant":[27],"gene)":[28],"or":[29,281],"PREJ/ras":[30],"(c-HA-ras-1":[31],"the":[33,103,187,252,261,284,295,315,318],"12th":[34],"codon":[35],"mutation":[36],"and":[37,50,86,105,114,153,163,206,307,343],"neo).":[38],"Seven":[39],"independent":[40],"G418-resistant":[41],"clones":[42,53,59,82,91,104,121,155,182,189,243,263,275,316],"(A----G)":[43],"isolated":[45],"from":[46,294],"each":[47,171],"group":[48],"(SV-HUC/ras":[49],"SV-HUC/neo).":[51],"SV-HUC/ras":[52,81,188,262,274],"morphologically":[55],"altered,":[56],"while":[57],"SV-HUC/neo":[58,150,181],"retained":[60],"a":[61,348],"typical":[62],"epithelial":[64],"morphology.":[65],"Electrophoretic":[66],"analysis":[67],"immunoprecipitated":[69],"proteins":[71],"detected":[72,147],"altered":[73,143,256],"protein":[76,145,259,277,326,358],"in":[77,87,111,134,148,229,239,314,324,332,341,361],"four":[78,168,198,230,232],"seven":[80,90],"at":[83,92,160,165,190,196,224,289,317],"passage":[84,110,338],"(P)2":[85],"five":[88],"P12":[93,166],"posttransfection.":[94],"The":[95],"relative":[96,253],"levels":[97,132,246,254,278],"differed":[101],"among":[102,260],"appeared":[106],"increase":[108],"culture.":[112],"RNA":[113,131,305],"DNA":[115],"dot":[116],"blot":[117],"analyses":[118],"showed":[119],"that":[120],"more":[123,308],"abundant":[124,217,309,355],"also":[127],"had":[128,244,276,347],"higher":[129,282,299,304],"and,":[133],"one":[135,209],"case,":[136],"increased":[137],"gene":[139,301],"copy":[140,302],"number.":[141],"No":[142],"was":[146,183,220,312,359],"any":[149],"clones.":[151],"ras-":[152],"neo-transfected":[154],"tested":[157],"for":[158,364],"tumorigenicity":[159],"P2":[161,191],"posttransfection":[162],"again":[164],"by":[167],"s.c.":[169],"inoculations":[170,179],"into":[172],"athymic":[173],"nude":[174],"mice.":[175],"None":[176,185],"56":[178],"tumorigenic.":[184],"gave":[192],"rise":[193],"tumors":[195,228],"all":[197],"injection":[199],"sites.":[200],"However,":[201,251,352],"two":[202],"ras-transfected":[203],"clones,":[204],"SV-HUC/ras-B":[205],"SV-HUC/ras-F,":[207],"produced":[208,216,227],"tumor":[210,296,330],"each.":[211],"One":[212],"clone,":[213],"SV-HUC/ras-D":[214],"which":[215],"p21,":[219],"negative":[221],"when":[222,234],"inoculated":[223],"P2,":[225],"but":[226],"sites":[233],"reinoculated":[235],"after":[236],"ten":[237],"passages":[238],"vitro.":[240],"All":[241],"tumorigenic":[242,269,286],"detectable":[245],"p21.":[250],"did":[264],"not":[265,360],"directly":[266],"predict":[267],"their":[268],"potential,":[270],"as":[271,334,336],"several":[272],"nontumorigenic":[273],"equal":[279],"than":[283,311],"most":[285],"clone":[287],"(SV-HUC/ras-D":[288],"P12).":[290],"Cell":[291],"lines":[292],"established":[293],"explants":[297],"exhibited":[298],"numbers,":[303],"levels,":[306],"seen":[313],"time":[319],"inoculation.":[321],"Therefore,":[322],"increases":[323],"abundance":[327],"occurred":[328],"during":[329,337],"formation":[331],"vivo,":[333],"well":[335],"culture,":[342],"such":[344],"apparently":[346],"selective":[349],"growth":[350],"advantage.":[351],"itself":[362],"sufficient":[363],"neoplastic":[365],"transformation":[366],"SV-HUC.(ABSTRACT":[368],"TRUNCATED":[369],"AT":[370],"400":[371],"WORDS)":[372]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
