{"id":"https://openalex.org/W1592736602","doi":"https://doi.org/10.1111/j.1365-2036.2011.04925.x","title":"Efficacy and tolerability of methotrexate therapy for refractory Crohn\u2019s disease: a large single\u2010centre experience","display_name":"Efficacy and tolerability of methotrexate therapy for refractory Crohn\u2019s disease: a large single\u2010centre experience","publication_year":2011,"publication_date":"2011-11-24","ids":{"openalex":"https://openalex.org/W1592736602","doi":"https://doi.org/10.1111/j.1365-2036.2011.04925.x","mag":"1592736602","pmid":"https://pubmed.ncbi.nlm.nih.gov/22112005"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2036.2011.04925.x","doi":"https://doi.org/10.1111/j.1365-2036.2011.04925.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2036.2011.04925.x","pdf_url":null,"source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology & Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113081448","display_name":"Nicole C Suares","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"N. C. Suares","raw_affiliation_strings":["Leeds Gastroenterology Institute, Leeds General Infirmary, UK","Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK.\u2028"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute, Leeds General Infirmary, UK","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK.\u2028","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018921019","display_name":"Peter John Hamlin","orcid":"https://orcid.org/0000-0001-8080-1358","observed_orcids":["https://orcid.org/0000-0001-8080-1358"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"P. J. Hamlin","raw_affiliation_strings":["Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078066112","display_name":"Dan Greer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. P. Greer","raw_affiliation_strings":["Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Warren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Warren","raw_affiliation_strings":["Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060861593","display_name":"Tanya Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Clark","raw_affiliation_strings":["Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK","institution_ids":["https://openalex.org/I1295121038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044392782","display_name":"Alexander Charles Ford","orcid":"https://orcid.org/0000-0001-6371-4359","observed_orcids":["https://orcid.org/0000-0001-6371-4359"]},"institutions":[{"id":"https://openalex.org/I1295121038","display_name":"Leeds General Infirmary","ror":"https://ror.org/04hrjej96","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1295121038","https://openalex.org/I2799390153"]},{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"A. C. Ford","raw_affiliation_strings":["Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK","Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Gastroenterology Institute, Leeds General Infirmary, Leeds, UK","institution_ids":["https://openalex.org/I1295121038"]},{"raw_affiliation_string":"Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044392782"],"corresponding_institution_ids":["https://openalex.org/I1295121038","https://openalex.org/I130828816"],"apc_list":{"value":5250,"currency":"USD","value_usd":5250},"apc_paid":null,"fwci":2.9491,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89787773,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"35","issue":"2","first_page":"284","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.9599999785423279},{"id":"https://openalex.org/keywords/refractory-crohn-s-disease","display_name":"refractory Crohn's disease","score":0.9049999713897705},{"id":"https://openalex.org/keywords/thiopurine-intolerance","display_name":"thiopurine intolerance","score":0.9919999837875366},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.7070000171661377},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5649999976158142},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6940000057220459},{"id":"https://openalex.org/keywords/predictors-of-treatment-response","display_name":"predictors of treatment response","score":0.7559999823570251},{"id":"https://openalex.org/keywords/family-planning","display_name":"family planning","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9359521269798279},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.8007193803787231},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7075085043907166},{"id":"https://openalex.org/C2778375690","wikidata":"https://www.wikidata.org/wiki/Q7814214","display_name":"Tolerability","level":3,"score":0.6694093346595764},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.6535686254501343},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5898963212966919},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.581702470779419},{"id":"https://openalex.org/C70917649","wikidata":"https://www.wikidata.org/wiki/Q94307","display_name":"Thiopurine methyltransferase","level":4,"score":0.516093909740448},{"id":"https://openalex.org/C2778283404","wikidata":"https://www.wikidata.org/wiki/Q6736822","display_name":"Maintenance therapy","level":3,"score":0.45089083909988403},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.44423559308052063},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.438895583152771},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.41450974345207214},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.3953056037425995},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3931392729282379},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3861183226108551},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3414607048034668},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2447769045829773},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2036.2011.04925.x","doi":"https://doi.org/10.1111/j.1365-2036.2011.04925.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2036.2011.04925.x","pdf_url":null,"source":{"id":"https://openalex.org/S158079644","display_name":"Alimentary Pharmacology & Therapeutics","issn_l":"0269-2813","issn":["0269-2813","1365-2036"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary Pharmacology & Therapeutics","raw_type":"journal-article"},{"id":"pmid:22112005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22112005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alimentary pharmacology & therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W94987321","https://openalex.org/W129429327","https://openalex.org/W1871949656","https://openalex.org/W1980441215","https://openalex.org/W1980692490","https://openalex.org/W1991810959","https://openalex.org/W2003106549","https://openalex.org/W2009025779","https://openalex.org/W2025343624","https://openalex.org/W2028349643","https://openalex.org/W2039421900","https://openalex.org/W2041005766","https://openalex.org/W2050437475","https://openalex.org/W2055335630","https://openalex.org/W2055879151","https://openalex.org/W2061421106","https://openalex.org/W2069009549","https://openalex.org/W2126807394","https://openalex.org/W2127664523","https://openalex.org/W2135029469","https://openalex.org/W2137775651","https://openalex.org/W2154117979","https://openalex.org/W2154875222","https://openalex.org/W2159143303","https://openalex.org/W2167152940","https://openalex.org/W2169932963","https://openalex.org/W2171341132","https://openalex.org/W2188248802","https://openalex.org/W2323383014","https://openalex.org/W2326745462","https://openalex.org/W2402287310","https://openalex.org/W4211172424"],"related_works":["https://openalex.org/W2583940155","https://openalex.org/W2002301077","https://openalex.org/W3136103483","https://openalex.org/W4240145299","https://openalex.org/W2039421900","https://openalex.org/W2061421106","https://openalex.org/W2055335630","https://openalex.org/W4210402399","https://openalex.org/W2321626447","https://openalex.org/W1984988228"],"abstract_inverted_index":{"BACKGROUND:":[0],"Randomised":[1],"controlled":[2],"trials":[3],"demonstrate":[4],"that":[5,208],"methotrexate":[6,40,67,73,128,209],"is":[7,210,231],"effective":[8,211],"in":[9,41,157,166,200,212,217,234],"inducing":[10],"remission":[11],"and":[12,79,98,111,131],"preventing":[13],"relapse":[14],"of":[15,39,44,49,86,135,174,189,214],"Crohn's":[16,218],"disease":[17,99,219],"(CD)":[18],"as":[19],"a":[20,42],"first-line":[21],"immunosuppressant,":[22],"but":[23],"efficacy":[24,38,230],"data":[25,206],"after":[26],"failure":[27],"with,":[28],"or":[29,55,103,145,191,224],"intolerance":[30],"to,":[31,54],"thiopurines":[32],"are":[33,225],"limited.":[34],"AIMS:":[35],"To":[36],"report":[37],"cohort":[43],"refractory":[45],"CD":[46],"patients,":[47,119],"most":[48],"whom":[50,136],"had":[51,143],"not":[52,232],"responded":[53],"were":[56,62,91,107,146,195],"intolerant":[57,147,226],"of,":[58,148,227],"thiopurines.":[59,149,228],"METHODS:":[60],"Data":[61],"collected":[63],"for":[64,68,183],"patients":[65,126,142,170,178,220],"receiving":[66],"active":[69],"CD.":[70],"Response":[71,150],"to":[72,151],"induction":[74],"therapy":[75,152],"at":[76,83,122,153,171],"4":[77,154],"months,":[78],"sustained":[80,104,162,192,233],"clinical":[81,105,163,193],"benefit":[82,164,194],"last":[84,172],"point":[85,173],"follow-up":[87],"with":[88],"maintenance":[89],"therapy,":[90],"assessed":[92],"via":[93],"physician's":[94],"global":[95],"assessment.":[96],"Demographic":[97],"factors":[100],"predicting":[101],"response,":[102],"benefit,":[106],"examined":[108],"by":[109],"univariate":[110],"multivariate":[112],"analysis.":[113],"RESULTS:":[114],"Sixty-six":[115],"[38":[116],"(54%)":[117],"female":[118],"mean":[120],"age":[121],"diagnosis":[123],"29.4":[124],"years]":[125],"received":[127,137],"between":[129],"2001":[130],"2010,":[132],"61":[133],"(92%)":[134],"the":[138,181,235],"drug":[139,182],"parenterally.":[140],"Sixty":[141],"failed,":[144,223],"months":[155],"occurred":[156,165,199],"54":[158],"(82%)":[159],"patients.":[160,203],"However,":[161,229],"only":[167],"19":[168],"(29%)":[169],"follow-up,":[175],"including":[176],"six":[177],"who":[179,221],"discontinued":[180],"family":[184],"planning":[185],"reasons.":[186],"No":[187],"predictors":[188],"response":[190,216],"identified.":[196],"Adverse":[197],"events":[198],"20":[201],"(30%)":[202],"CONCLUSIONS:":[204],"These":[205],"suggest":[207],"terms":[213],"initial":[215],"have":[222],"long":[236],"term.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}