{"id":"https://openalex.org/W15926193","doi":"https://doi.org/10.4049/jimmunol.184.supp.132.15","title":"Expression and regulation of Toso, a new Fc receptor for IgM, during B cell development (132.15)","display_name":"Expression and regulation of Toso, a new Fc receptor for IgM, during B cell development (132.15)","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W15926193","doi":"https://doi.org/10.4049/jimmunol.184.supp.132.15","mag":"15926193"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.184.supp.132.15","doi":"https://doi.org/10.4049/jimmunol.184.supp.132.15","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.132.15","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076397278","display_name":"Seung\u2010Chul Choi","orcid":"https://orcid.org/0000-0001-6230-9087","observed_orcids":["https://orcid.org/0000-0001-6230-9087"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seung-Chul Choi","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH , Rockville, MD","1Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH , Rockville, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"1Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059216527","display_name":"Sriram Narayanan","orcid":"https://orcid.org/0000-0002-6484-2800","observed_orcids":["https://orcid.org/0000-0002-6484-2800"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriram Narayanan","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH , Rockville, MD","1Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH , Rockville, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"1Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038195681","display_name":"Konrad Krzewski","orcid":"https://orcid.org/0000-0002-9473-953X","observed_orcids":["https://orcid.org/0000-0002-9473-953X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Konrad Krzewski","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH , Rockville, MD","1Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH , Rockville, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"1Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061418519","display_name":"Francisco Borrego","orcid":"https://orcid.org/0000-0002-3105-981X","observed_orcids":["https://orcid.org/0000-0002-3105-981X"]},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francisco Borrego","raw_affiliation_strings":["Laboratory of Molecular and Developmental Biology, DMA/CDER/FDA , Bethesda, MD","2Laboratory of Molecular and Developmental Biology, DMA/CDER/FDA, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular and Developmental Biology, DMA/CDER/FDA , Bethesda, MD","institution_ids":["https://openalex.org/I1320320070"]},{"raw_affiliation_string":"2Laboratory of Molecular and Developmental Biology, DMA/CDER/FDA, Bethesda, MD","institution_ids":["https://openalex.org/I1320320070"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105466343","display_name":"John E. Coligan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Coligan","raw_affiliation_strings":["Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH , Rockville, MD","1Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH , Rockville, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"raw_affiliation_string":"1Receptor Cell Biology Section, Laboratory of Immunogenetics, NIAID, NIH, Rockville, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"184","issue":"Supplement_1","first_page":"132.15","last_page":"132.15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.6104000210762024,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.3792000114917755,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toso","display_name":"TOSO","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fcmur","display_name":"Fc\u03bcR","score":0.8140000104904175},{"id":"https://openalex.org/keywords/fc-receptors","display_name":"Fc receptors","score":0.6959999799728394},{"id":"https://openalex.org/keywords/igm","display_name":"IgM","score":0.8349999785423279},{"id":"https://openalex.org/keywords/b-cell-development","display_name":"B cell development","score":0.9980000257492065},{"id":"https://openalex.org/keywords/b-cell-differentiation","display_name":"B cell differentiation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/lipopolysaccharide-stimulation","display_name":"lipopolysaccharide stimulation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/anti-cd40-antibody","display_name":"anti-CD40 antibody","score":0.8930000066757202},{"id":"https://openalex.org/keywords/anti-igm","display_name":"anti-IgM","score":0.949999988079071},{"id":"https://openalex.org/keywords/bone-marrow-b-cells","display_name":"bone marrow B cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/splenic-b-cells","display_name":"splenic B cells","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.6312973499298096},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6211341023445129},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.602705717086792},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.5930056571960449},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5652031302452087},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.547904908657074},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5207421779632568},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.48127979040145874},{"id":"https://openalex.org/C189976730","wikidata":"https://www.wikidata.org/wiki/Q3493700","display_name":"Splenocyte","level":3,"score":0.465749591588974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46184179186820984},{"id":"https://openalex.org/C200180986","wikidata":"https://www.wikidata.org/wiki/Q3269473","display_name":"Naive B cell","level":5,"score":0.4523979425430298},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4304150342941284},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.4147787094116211},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38211217522621155},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35655999183654785},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2917625904083252},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.280122846364975},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.24791628122329712},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12001857161521912},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10286355018615723},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.10139462351799011},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05864003300666809}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.184.supp.132.15","doi":"https://doi.org/10.4049/jimmunol.184.supp.132.15","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.184.supp.132.15","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1654923970","https://openalex.org/W2133345063","https://openalex.org/W2279109496","https://openalex.org/W2580655888","https://openalex.org/W2154499883","https://openalex.org/W2131309445","https://openalex.org/W2131100307","https://openalex.org/W2026614008","https://openalex.org/W2127198215","https://openalex.org/W3017510544"],"abstract_inverted_index":{"Abstract":[0],"Fc":[1],"receptors":[2],"(FcRs)":[3],"are":[4,167],"key":[5],"regulators":[6],"of":[7,50,58,71,121,155],"the":[8,48,56,140,169],"immune":[9],"response.":[10],"A":[11],"receptor":[12],"specific":[13],"for":[14],"IgM":[15],"(Fc\u03bcR)":[16],"has":[17,44],"been":[18],"recently":[19],"identified":[20],"and":[21,36,90,143,148,161,178],"shown":[22],"to":[23],"be":[24],"predominately":[25],"expressed":[26],"on":[27,75,83,105],"human":[28],"B":[29,76,107,116,127,136,150,163,175],"cells.":[30,108,128,164],"Fc\u03bcR,":[31],"known":[32],"previously":[33],"as":[34,37],"TOSO":[35],"Fas":[38],"apoptosis":[39],"inhibitory":[40],"molecule":[41],"3":[42],"(Faim3),":[43],"no":[45],"role":[46,170],"in":[47,60,139,174],"inhibition":[49],"Fas-mediated":[51],"apoptosis.":[52],"We":[53,66,109],"have":[54,110,118],"examined":[55],"expression":[57,74,82,101,124,134],"Fc\u03bcR":[59,72,80,99,122,132,156,172],"mouse":[61],"splenocytes":[62],"by":[63],"real-time":[64],"PCR.":[65],"found":[67,112,145],"significantly":[68],"higher":[69],"levels":[70,120,154],"mRNA":[73,81,100,123,133,157],"cells":[77,117,151],"compared":[78,158],"with":[79,94,159],"T":[84],"cells,":[85,87],"NK":[86],"granulocytes,":[88],"macrophages":[89],"monocytes.":[91],"After":[92],"stimulation":[93],"LPS,":[95],"anti-CD40":[96],"or":[97],"anti-IgM,":[98],"was":[102],"dramatically":[103],"down-regulated":[104],"splenic":[106,126],"also":[111],"that":[113,146,171],"bone":[114,141],"marrow":[115,142],"lower":[119],"than":[125],"Furthermore,":[129],"we":[130,144,166],"analyzed":[131],"during":[135],"cell":[137,176],"development":[138,177],"immature":[147],"mature":[149],"express":[152],"high":[153],"pro-":[160],"pre-":[162],"Currently,":[165],"investigating":[168],"plays":[173],"signaling.":[179]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2016-06-24T00:00:00"}