{"id":"https://openalex.org/W1592374233","doi":null,"title":"Activation of the novel PDGFS by plasminogen activators in tumorigenesis","display_name":"Activation of the novel PDGFS by plasminogen activators in tumorigenesis","publication_year":2010,"publication_date":"2010-04-30","ids":{"openalex":"https://openalex.org/W1592374233","mag":"1592374233"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26908951","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Activation_of_the_novel_PDGFS_by_plasminogen_activators_in_tumorigenesis/26908951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/38406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001231097","display_name":"Monika Ehnman","orcid":"https://orcid.org/0000-0003-0468-2531","observed_orcids":["https://orcid.org/0000-0003-0468-2531"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Monika Ehnman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0468-2531","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5001231097"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.5503000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.18520000576972961,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.040699999779462814,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pdgf-cc","display_name":"PDGF-CC","score":0.9990000128746033},{"id":"https://openalex.org/keywords/plasminogen-activator","display_name":"plasminogen activator","score":0.9589999914169312},{"id":"https://openalex.org/keywords/proteolytic-activation","display_name":"proteolytic activation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cub-domain","display_name":"CUB domain","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.625},{"id":"https://openalex.org/keywords/pdgfrbeta","display_name":"PDGFR\u03b2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9259999990463257},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7260000109672546},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.4059999883174896},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.4449999928474426}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5062636137008667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4258003830909729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40835580229759216},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35815614461898804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3338817358016968},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32986021041870117},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2384057641029358},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19289857149124146}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26908951","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Activation_of_the_novel_PDGFS_by_plasminogen_activators_in_tumorigenesis/26908951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/38406","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38406","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1592374233","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/38406/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/38406","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/38406","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W64884126","https://openalex.org/W1500453306","https://openalex.org/W1554167856","https://openalex.org/W1964822816","https://openalex.org/W1980325398","https://openalex.org/W1990794205","https://openalex.org/W2025529909","https://openalex.org/W2107908226","https://openalex.org/W2161021883","https://openalex.org/W2169304723"],"related_works":["https://openalex.org/W1838315390","https://openalex.org/W2137732774","https://openalex.org/W1483090589","https://openalex.org/W1998846962","https://openalex.org/W2012460154","https://openalex.org/W7096455892","https://openalex.org/W2034470062","https://openalex.org/W2165700649","https://openalex.org/W2063373381","https://openalex.org/W4255219836"],"abstract_inverted_index":{"Members":[0],"of":[1,12,176,214,236,261,280,293,330,399,418,428,445,479,507,536],"the":[2,25,54,97,141,145,168,173,177,192,215,234,237,241,273,278,281,291,313,377,400,477,508],"platelet-derived":[3,447,510],"growth":[4,385,448,511],"factor":[5,449],"(PDGF)":[6],"family":[7],"are":[8,78,129,304],"mitogens":[9],"for":[10,96,395,416,443,482],"cells":[11],"a":[13,264,412],"mesenchymal":[14],"origin":[15],"and":[16,23,51,64,71,90,105,111,120,127,147,152,197,220,244,286,302,340,368,373,405,424,516,534],"have":[17,186,226,325],"important":[18],"functions":[19],"both":[20,300,421],"during":[21],"development":[22,50],"in":[24,29,44,59,136,227,284,308,312,350,357,403,422,425,520],"adult.":[26],"Their":[27],"role":[28,175,222,279,398],"developmental":[30],"processes":[31],"has":[32,73],"been":[33,74],"extensively":[34],"investigated":[35],"by":[36,80,451],"methodical":[37],"targeted":[38],"gene":[39],"inactivations,":[40],"revealing":[41],"critical":[42],"involvement":[43],"microvascular":[45],"pericyte":[46],"recruitment,":[47],"neural":[48],"crest":[49],"alveogenesis.":[52],"In":[53,138,202,272,352],"adult,":[55],"an":[56,320,327,383,396],"active":[57,384,397],"participation":[58],"tissue":[60,452],"homeostasis,":[61],"wound":[62],"healing":[63],"human":[65],"diseases":[66],"such":[67],"as":[68,251],"oncogenesis,":[69],"atherosclerosis":[70],"fibrosis":[72],"substantiated.":[75],"Cellular":[76],"effects":[77],"exerted":[79],"five":[81],"homo-":[82],"or":[83],"heterodimeric":[84],"ligands":[85],"(PDGF-AA,":[86],"-BB,":[87],"-AB,":[88],"-CC":[89],"-DD)":[91],"with":[92,269],"individual":[93],"binding":[94],"affinities":[95],"two":[98,142,231],"structurally":[99],"related":[100],"receptor":[101,109],"tyrosine":[102],"kinases,":[103],"PDGFRalpha":[104],"PDGFRbeta.":[106],"Binding":[107],"induces":[108],"dimerization":[110],"transphosphorylation,":[112],"thereby":[113],"initiating":[114],"intracellular":[115],"signaling":[116],"events.":[117],"Both":[118],"PDGF-AA":[119],"PDGF-CC":[121,151,301,372],"signal":[122],"via":[123,134],"PDGFRalpha,":[124],"while":[125],"PDGF-BB":[126],"PDGF-DD":[128,262,303,339,537],"believed":[130],"to":[131,140,187,196,209,250],"act":[132],"preferentially":[133],"PDGFRbeta":[135],"vivo.":[137,228,351,426],"contrast":[139],"classical":[143],"PDGFs,":[144],"novel":[146,216,242,282,401,509],"less":[148],"characterized":[149],"members,":[150],"PDGF-DD,":[153],"contain":[154],"N-terminal":[155],"complement":[156],"subcomponents":[157],"C1r/C1s,":[158],"urchin":[159],"EGF-like":[160],"protein,":[161],"bone":[162],"morphogenic":[163],"protein-1":[164],"(CUB)":[165],"domains":[166,179],"within":[167],"fulllength":[169],"protein.":[170],"So":[171],"far,":[172],"functional":[174],"CUB":[178],"is":[180,218],"not":[181,380],"fully":[182],"understood,":[183],"but":[184,387],"they":[185],"be":[188,411],"proteolytically":[189,369],"removed":[190],"before":[191],"factors":[193,512],"can":[194,364,410],"bind":[195],"activate":[198],"their":[199,245,348],"cognate":[200],"receptors.":[201],"this":[203,223,309,358],"thesis,":[204],"we":[205,276,316,324,392],"used":[206],"different":[207],"approaches":[208],"investigate":[210],"how":[211],"proteolytic":[212,247,259,378],"activation":[213,260,379,444,506],"PDGFs":[217,243,283,402],"regulated":[219],"what":[221],"process":[224],"may":[225],"The":[229],"first":[230],"studies":[232,345],"describe":[233],"characterization":[235,535],"biochemical":[238],"interactions":[239,268],"between":[240],"specific":[246],"enzymes":[248],"referred":[249],"plasminogen":[252,294,362,453],"activators.":[253,295],"Experimental":[254],"evidence":[255,394],"also":[256],"suggests":[257],"that":[258,299,361,376,407],"reveals":[263],"retention":[265],"motif":[266],"mediating":[267],"pericellular":[270],"components.":[271],"third":[274],"study,":[275,315],"elucidate":[277],"rhabdomyosarcoma":[285,404],"unravel":[287],"regulatory":[288],"mechanisms":[289],"controlling":[290],"expression":[292],"Our":[296],"data":[297,318],"suggest":[298,406],"promising":[305],"therapeutic":[306],"targets":[307],"disease.":[310],"Therefore,":[311],"fourth":[314],"summarize":[317],"from":[319],"ongoing":[321],"project":[322],"where":[323],"initiated":[326],"extensive":[328],"production":[329],"monoclonal":[331,408,538],"antibodies":[332,336,409],"targeting":[333],"PDGF-DD.":[334,374],"Generated":[335],"recognize":[337],"full-length":[338],"possess":[341],"neutralizing":[342],"activity.":[343],"Future":[344],"will":[346],"enlighten":[347],"efficacy":[349],"summary,":[353],"our":[354],"findings":[355],"presented":[356],"thesis":[359],"show":[360],"activators":[363],"directly":[365],"interact":[366],"with,":[367],"process,":[370],"latent":[371,446],"Weshow":[375],"only":[381],"generates":[382],"factor,":[386],"alsocontrols":[388],"its":[389],"bioavailability.":[390],"Furthermore,":[391],"present":[393],"useful":[413],"molecular":[414],"tool":[415],"neutralization":[417],"PDGF":[419],"activity":[420],"vitro":[423],"List":[427],"scientific":[429],"papers":[430],"I.":[431],"Fredriksson":[432,466],"L,":[433,467],"Ehnman":[434,462,490,524],"M,":[435,463,491,525],"Fieber":[436],"C,":[437],"Eriksson":[438,470,502,530],"U":[439,471,503,531],"(2005).":[440],"\"Structural":[441],"requirements":[442],"CC":[450],"activator.\"":[454],"J":[455],"Biol":[456],"Chem.":[457],"280(29):":[458],"26856-62.":[459],"https://pubmed.ncbi.nlm.nih.gov/15911618":[460],"II.":[461],"Li":[464,526],"H,":[465,527,529],"Pietras":[468,500],"K,":[469,501],"(2009).":[472],"\"The":[473],"uPA/uPAR":[474],"system":[475],"regulates":[476,513],"bioavailability":[478],"PDGF-DD:":[480],"implications":[481],"tumour":[483],"growth.\"":[484],"Oncogene.":[485],"28(4):":[486],"534-44.":[487],"https://pubmed.ncbi.nlm.nih.gov/18997817":[488],"III.":[489],"Missiaglia":[492],"E,":[493,495],"Folestad":[494],"Delattre":[496],"O,":[497],"Shipley":[498],"J,":[499],"(2010).":[504,532],"\"Proteolytic":[505],"tumor":[514],"progression":[515],"extracellular":[517],"matrix":[518],"remodeling":[519],"rhabdomyosarcoma.\"":[521],"[Manuscript]":[522,540],"IV.":[523],"Gladh":[528],"\"Development":[533],"antibodies.\"":[539]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}