{"id":"https://openalex.org/W15921592","doi":null,"title":"Genes outside The Hla Region affecting Susceptibility to Type 1 Diabetes - The Role of Iddm2 and Iddm9 in the Finnish Population","display_name":"Genes outside The Hla Region affecting Susceptibility to Type 1 Diabetes - The Role of Iddm2 and Iddm9 in the Finnish Population","publication_year":2008,"publication_date":"2008-02-14","ids":{"openalex":"https://openalex.org/W15921592","mag":"15921592"},"language":"en","primary_location":{"id":"pmh:oai:utupub.fi:11111/26143","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/26143","pdf_url":"https://www.utupub.fi/bitstreams/273b790e-89df-4a1c-98eb-bd5ee341f230/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/33720","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.utupub.fi/bitstreams/273b790e-89df-4a1c-98eb-bd5ee341f230/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023154153","display_name":"Antti\u2010Pekka Laine","orcid":"https://orcid.org/0000-0003-4962-2882","observed_orcids":["https://orcid.org/0000-0003-4962-2882"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Antti\u2010Pekka Laine","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4962-2882","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023154153"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hla-region","display_name":"HLA region","score":0.7540000081062317},{"id":"https://openalex.org/keywords/finnish-population","display_name":"Finnish population","score":0.5559999942779541},{"id":"https://openalex.org/keywords/multiplex-families","display_name":"multiplex families","score":0.8960000276565552},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5370000004768372},{"id":"https://openalex.org/keywords/hla-dqa1","display_name":"HLA-DQA1","score":0.4860000014305115},{"id":"https://openalex.org/keywords/hla-dqb1","display_name":"HLA-DQB1","score":0.7329999804496765},{"id":"https://openalex.org/keywords/hla-drb1","display_name":"HLA-DRB1","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hla-drb3","display_name":"HLA-DRB3","score":0.7139999866485596},{"id":"https://openalex.org/keywords/hla-drb4","display_name":"HLA-DRB4","score":0.7860000133514404},{"id":"https://openalex.org/keywords/hla-drb5","display_name":"HLA-DRB5","score":0.8759999871253967},{"id":"https://openalex.org/keywords/hla-dqa2","display_name":"HLA-DQA2","score":0.6230000257492065},{"id":"https://openalex.org/keywords/hla-dqb2","display_name":"HLA-DQB2","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hla-drb1-03-01","display_name":"HLA-DRB1*0301","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5139300227165222},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5049121975898743},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.49590691924095154},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.45213571190834045},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4111041724681854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2717326879501343},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26749187707901},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.26650696992874146},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.2404569685459137},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.07489445805549622},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:utupub.fi:11111/26143","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/26143","pdf_url":"https://www.utupub.fi/bitstreams/273b790e-89df-4a1c-98eb-bd5ee341f230/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/33720","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.utupub.fi:10024/33720","doi":null,"is_oa":true,"landing_page_url":"http://www.utupub.fi/handle/10024/33720","pdf_url":"http://www.utupub.fi/handle/10024/33720","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},{"id":"pmh:oai:www.doria.fi:10024/33720","doi":null,"is_oa":false,"landing_page_url":"http://www.doria.fi/handle/10024/33720","pdf_url":null,"source":{"id":"https://openalex.org/S4377196760","display_name":"Doria (University of Helsinki)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I133731052","host_organization_name":"University of Helsinki","host_organization_lineage":["https://openalex.org/I133731052"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral dissertation (article-based)"},{"id":"mag:15921592","doi":null,"is_oa":false,"landing_page_url":"https://www.utupub.fi/handle/10024/33720","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utupub.fi:11111/26143","doi":null,"is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/11111/26143","pdf_url":"https://www.utupub.fi/bitstreams/273b790e-89df-4a1c-98eb-bd5ee341f230/download","source":{"id":"https://openalex.org/S4306402470","display_name":"UTUPub (University of Turku)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I155660961","host_organization_name":"University of Turku","host_organization_lineage":["https://openalex.org/I155660961"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.utupub.fi/handle/10024/33720","raw_type":"fi=Artikkeliv\u00e4it\u00f6skirja|en=Doctoral dissertation (article-based)|"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323313","display_name":"Turun Yliopisto","ror":"https://ror.org/05vghhr25"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W15921592.pdf","grobid_xml":"https://content.openalex.org/works/W15921592.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W136910319","https://openalex.org/W154663569","https://openalex.org/W342493743","https://openalex.org/W1499143852","https://openalex.org/W1499666021","https://openalex.org/W1519521580","https://openalex.org/W1528955459","https://openalex.org/W1543868019","https://openalex.org/W1603787155","https://openalex.org/W1620880263","https://openalex.org/W1629057897","https://openalex.org/W1963682324","https://openalex.org/W1970548308","https://openalex.org/W1970897847","https://openalex.org/W1971772103","https://openalex.org/W1975854306","https://openalex.org/W1976741643","https://openalex.org/W1977873497","https://openalex.org/W1980515070","https://openalex.org/W1983974380","https://openalex.org/W1985960725","https://openalex.org/W1987677365","https://openalex.org/W1988573538","https://openalex.org/W1990139289","https://openalex.org/W1990472926","https://openalex.org/W1990678679","https://openalex.org/W1994402720","https://openalex.org/W2001295992","https://openalex.org/W2002422078","https://openalex.org/W2003431429","https://openalex.org/W2003720880","https://openalex.org/W2004956511","https://openalex.org/W2005722435","https://openalex.org/W2005935256","https://openalex.org/W2008539299","https://openalex.org/W2008865088","https://openalex.org/W2010148594","https://openalex.org/W2011108094","https://openalex.org/W2013869066","https://openalex.org/W2014077667","https://openalex.org/W2015941944","https://openalex.org/W2017695531","https://openalex.org/W2019199233","https://openalex.org/W2019972832","https://openalex.org/W2020414379","https://openalex.org/W2022902540","https://openalex.org/W2023334953","https://openalex.org/W2026767467","https://openalex.org/W2028222510","https://openalex.org/W2028702466","https://openalex.org/W2030979593","https://openalex.org/W2031539362","https://openalex.org/W2031597554","https://openalex.org/W2034957838","https://openalex.org/W2036048737","https://openalex.org/W2036993603","https://openalex.org/W2037487383","https://openalex.org/W2045090480","https://openalex.org/W2046225888","https://openalex.org/W2046383867","https://openalex.org/W2049447247","https://openalex.org/W2057159752","https://openalex.org/W2059704957","https://openalex.org/W2061819326","https://openalex.org/W2061860446","https://openalex.org/W2063392958","https://openalex.org/W2067630127","https://openalex.org/W2067942096","https://openalex.org/W2068387198","https://openalex.org/W2070972996","https://openalex.org/W2072038834","https://openalex.org/W2072652145","https://openalex.org/W2079078071","https://openalex.org/W2079490247","https://openalex.org/W2087265576","https://openalex.org/W2087704501","https://openalex.org/W2090713986","https://openalex.org/W2092865149","https://openalex.org/W2093592442","https://openalex.org/W2097575675","https://openalex.org/W2098219907","https://openalex.org/W2100960647","https://openalex.org/W2101899025","https://openalex.org/W2107871825","https://openalex.org/W2116599892","https://openalex.org/W2118094114","https://openalex.org/W2118225901","https://openalex.org/W2118545358","https://openalex.org/W2120329743","https://openalex.org/W2122505319","https://openalex.org/W2126278946","https://openalex.org/W2130445686","https://openalex.org/W2131691281","https://openalex.org/W2131889332","https://openalex.org/W2132216352","https://openalex.org/W2132284589","https://openalex.org/W2134303810","https://openalex.org/W2134783591","https://openalex.org/W2135167801","https://openalex.org/W2137221262","https://openalex.org/W2137299974","https://openalex.org/W2141616651","https://openalex.org/W2142155452","https://openalex.org/W2144789687","https://openalex.org/W2144870508","https://openalex.org/W2147109875","https://openalex.org/W2147351691","https://openalex.org/W2149291412","https://openalex.org/W2150138957","https://openalex.org/W2152461165","https://openalex.org/W2155766648","https://openalex.org/W2156862610","https://openalex.org/W2156989422","https://openalex.org/W2157118336","https://openalex.org/W2160609383","https://openalex.org/W2163155417","https://openalex.org/W2163331597","https://openalex.org/W2165052240","https://openalex.org/W2174210280","https://openalex.org/W2323207956","https://openalex.org/W2332910275","https://openalex.org/W2403319411","https://openalex.org/W2526749570","https://openalex.org/W2582777050","https://openalex.org/W3044574244"],"related_works":["https://openalex.org/W2095676441","https://openalex.org/W1994676898","https://openalex.org/W2092706398","https://openalex.org/W256931825","https://openalex.org/W2093682762","https://openalex.org/W2155309219","https://openalex.org/W154663569","https://openalex.org/W2466967196","https://openalex.org/W2033101511","https://openalex.org/W2148354866"],"abstract_inverted_index":{"Tyypin":[0],"1":[1,28,65,161,237],"diabeteksen":[2,162,238],"perinn\u00f6llinen":[3],"alttius":[4],"Suomessa":[5],"-":[6],"HLA-alueen":[7,31,60,85,116],"ulkopuolisten":[8,32],"alttiuslokusten":[9],"IDDM2":[10],"ja":[11,46,76,148],"IDDM9":[12],"rooli":[13],"taudin":[14],"periytymisess\u00e4":[15],"HLA-alue,":[16],"joka":[17],"sijaitsee":[18,158],"kromosomissa":[19],"6p21.3,":[20],"vastaa":[21],"noin":[22],"puolesta":[23],"perinn\u00f6llisest\u00e4":[24],"alttiudesta":[25],"sairastua":[26],"tyypin":[27,64,160,236],"diabetekseen.":[29],"My\u00f6s":[30,190],"lokusten":[33],"on":[34,41,53,206],"todettu":[35,54],"liittyv\u00e4n":[36,55],"sairausalttiuteen.":[37,56],"N\u00e4ist\u00e4":[38],"kolmen":[39],"lokuksen":[40],"varmistettu":[42],"olevan":[43],"todellisia":[44],"alttiuslokuksia":[45],"lis\u00e4ksi":[47],"useiden":[48],"muiden,":[49],"viel\u00e4":[50],"varmistamattomien":[51],"lokusten,":[52],"T\u00e4ss\u00e4":[57],"tutkimuksessa":[58],"12:n":[59],"ulkopuolisen":[61],"alttiuslokuksen":[62],"kytkent\u00e4":[63,75,124,146],"diabetekseen":[66],"tutkittiin":[67],"k\u00e4ytt\u00e4en":[68],"107:aa":[69],"suomalaista":[70],"multiplex-perhett\u00e4.":[71],"Jatkotutkimuksessa":[72],"analysoitiin":[73],"IDDM9-alueen":[74,126,142],"assosiaatio":[77,150],"sairauteen":[78],"laajennetuissa":[79],"perhemateriaaleissa":[80],"sek\u00e4":[81,219],"IDDM2-alueen":[82,91,173,222,230],"mahdollinen":[83],"interaktio":[84],"kanssa":[86],"sairauden":[87],"muodostumisessa.":[88],"Lis\u00e4ksi":[89],"suoritettiin":[90],"suojaavien":[92],"haplotyyppien":[93,98,223,231],"alatyypitys":[94],"tarkoituksena":[95],"tutkia":[96],"eri":[97],"k\u00e4ytt\u00f6kelpoisuutta":[99],"sairastumisriskin":[100],"tarkempaa":[101],"ennustamista":[102],"varten.":[103],"Ensimm\u00e4isess\u00e4":[104],"kytkent\u00e4tutkimuksessa":[105],"ei":[106,131],"l\u00f6ytynyt":[107],"koko":[108],"genomin":[109],"tasolla":[110],"merkitsev\u00e4\u00e4":[111,194],"tai":[112,134,181],"viitteellist\u00e4":[113],"kytkent\u00e4\u00e4":[114],"tutkituista":[115],"ulkopuolisista":[117],"lokuksista.":[118],"Voimakkain":[119],"havaittu":[120,144],"nimellisen":[121],"merkitsevyyden":[122],"tavoittava":[123],"n\u00e4htiin":[125],"markkerilla":[127],"D3S3576":[128],"(MLS=1.05).":[129],"Tutkimuksessa":[130],"kyetty":[132],"varmistamaan":[133],"sulkemaan":[135],"pois":[136],"aiempia":[137],"kytkent\u00e4havaintoja":[138],"tutkituilla":[139],"lokuksilla,":[140],"mutta":[141],"jatkotutkimuksessa":[143],"voimakas":[145],"(MLS=3.4)":[147],"merkitsev\u00e4":[149],"(TDT":[151],"p=0.0002)":[152],"viittaa":[153],"vahvasti":[154],"siihen,":[155],"ett\u00e4":[156,201,221],"3q21-alueella":[157],"todellinen":[159],"alttiusgeeni,":[163],"jolloin":[164],"alueen":[165],"kattava":[166],"assosiaatiotutkimus":[167],"olisi":[168],"perusteltu":[169],"jatkotoimenpide.":[170],"Sairauteen":[171],"altistava":[172],"MspI-2221":[174],"genotyyppi":[175],"CC":[176],"oli":[177],"nimellisesti":[178],"yleisempi":[179],"matalan":[180],"kohtalaisen":[182],"HLA-sairastumisriskin":[183],"diabeetikoilla,":[184],"verrattuna":[185],"korkean":[186],"HLA-riskin":[187],"potilaisiin":[188],"(p=0.05).":[189],"genotyyppijakauman":[191],"vertailu":[192],"osoitti":[193],"eroa":[195],"ryhmien":[196],"v\u00e4lill\u00e4":[197,224],"(p=0.01).":[198],"VNTR-haplotyyppitutkimus":[199],"osoitti,":[200],"IIIA/IIIA-homotsygootin":[202],"sairaudelta":[203],"suojaava":[204],"vaikutus":[205],"merkitsev\u00e4sti":[207],"voimakkaampi":[208],"kuin":[209],"muiden":[210],"luokka":[211],"III:n":[212],"genotyypeill\u00e4.":[213],"N\u00e4m\u00e4":[214],"tulokset":[215],"viittaavat":[216],"IDDM2-HLA":[217],"-vuorovaikutukseen":[218],"siihen":[220],"esiintyy":[225],"etiologista":[226],"heterogeniaa.":[227],"T\u00e4m\u00e4n":[228],"johdosta":[229],"tarkempi":[232],"m\u00e4\u00e4ritt\u00e4minen":[233],"voisi":[234],"tehostaa":[235],"riskiarviointia.":[239]},"counts_by_year":[],"updated_date":"2026-10-18T09:31:52.927876","created_date":"2016-06-24T00:00:00"}