{"id":"https://openalex.org/W1591789003","doi":"https://doi.org/10.1111/j.1474-9728.2004.00134.x","title":"Cellular lifespan and senescence signaling in embryonic stem cells","display_name":"Cellular lifespan and senescence signaling in embryonic stem cells","publication_year":2004,"publication_date":"2004-11-01","ids":{"openalex":"https://openalex.org/W1591789003","doi":"https://doi.org/10.1111/j.1474-9728.2004.00134.x","mag":"1591789003","pmid":"https://pubmed.ncbi.nlm.nih.gov/15569350"},"language":"en","primary_location":{"id":"doi:10.1111/j.1474-9728.2004.00134.x","doi":"https://doi.org/10.1111/j.1474-9728.2004.00134.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9728.2004.00134.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9728.2004.00134.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9728.2004.00134.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112153888","display_name":"Takumi Miura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Takumi Miura","raw_affiliation_strings":["Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA","Stem Cell Biology Unit and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Biology Unit, Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Stem Cell Biology Unit and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083040475","display_name":"Mark P. Mattson","orcid":"https://orcid.org/0000-0002-9816-4155","observed_orcids":["https://orcid.org/0000-0002-9816-4155","https://orcid.org/0009-0000-5542-5565"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. Mattson","raw_affiliation_strings":["Cellular and Molecular Neurosciences Section, Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA","Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Neurosciences Section, Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD 21224, USA","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111365293","display_name":"Mahendra S. Rao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mahendra S. Rao","raw_affiliation_strings":["Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA","Stem Cell Biology Unit and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Stem Cell Biology Unit and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111365293"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.5095,"has_fulltext":true,"cited_by_count":103,"citation_normalized_percentile":{"value":0.43161634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"3","issue":"6","first_page":"333","last_page":"343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9449999928474426},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cellular-lifespan","display_name":"cellular lifespan","score":0.7879999876022339},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.968999981880188},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8849999904632568},{"id":"https://openalex.org/keywords/rb-pathway","display_name":"Rb pathway","score":0.8669999837875366},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9470000267028809},{"id":"https://openalex.org/keywords/insulin-like-growth-factor","display_name":"insulin-like growth factor","score":0.8640000224113464},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/cell-immortalization","display_name":"cell immortalization","score":0.550000011920929}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.8808379769325256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8785015344619751},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.8215088844299316},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7926276326179504},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.7882117033004761},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7680677175521851},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6624589562416077},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5152516961097717},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4258999526500702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32031863927841187},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.12399914860725403},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09411567449569702}],"mesh":[{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1474-9728.2004.00134.x","doi":"https://doi.org/10.1111/j.1474-9728.2004.00134.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9728.2004.00134.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9728.2004.00134.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmid:15569350","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15569350","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1474-9728.2004.00134.x","doi":"https://doi.org/10.1111/j.1474-9728.2004.00134.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1474-9728.2004.00134.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1474-9728.2004.00134.x","source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1591789003.pdf","grobid_xml":"https://content.openalex.org/works/W1591789003.grobid-xml"},"referenced_works_count":128,"referenced_works":["https://openalex.org/W75894761","https://openalex.org/W98533868","https://openalex.org/W134790102","https://openalex.org/W1482850909","https://openalex.org/W1486595217","https://openalex.org/W1507319558","https://openalex.org/W1513261706","https://openalex.org/W1520658182","https://openalex.org/W1531643369","https://openalex.org/W1532405552","https://openalex.org/W1541877559","https://openalex.org/W1547608553","https://openalex.org/W1549402393","https://openalex.org/W1594827217","https://openalex.org/W1599568627","https://openalex.org/W1632349675","https://openalex.org/W1639582946","https://openalex.org/W1666383155","https://openalex.org/W1857253598","https://openalex.org/W1881393103","https://openalex.org/W1929283771","https://openalex.org/W1963550744","https://openalex.org/W1969044026","https://openalex.org/W1969255091","https://openalex.org/W1973199982","https://openalex.org/W1973718738","https://openalex.org/W1975489321","https://openalex.org/W1977055737","https://openalex.org/W1977292721","https://openalex.org/W1979913537","https://openalex.org/W1983673827","https://openalex.org/W1984374449","https://openalex.org/W1985910710","https://openalex.org/W1987055178","https://openalex.org/W1989627660","https://openalex.org/W1993864973","https://openalex.org/W1998590751","https://openalex.org/W2000971601","https://openalex.org/W2001775703","https://openalex.org/W2002585385","https://openalex.org/W2002761352","https://openalex.org/W2003137016","https://openalex.org/W2004314923","https://openalex.org/W2007249806","https://openalex.org/W2008355658","https://openalex.org/W2008550494","https://openalex.org/W2009002616","https://openalex.org/W2014073178","https://openalex.org/W2018369441","https://openalex.org/W2020329784","https://openalex.org/W2024022955","https://openalex.org/W2026637815","https://openalex.org/W2026856852","https://openalex.org/W2028320710","https://openalex.org/W2028361915","https://openalex.org/W2032407757","https://openalex.org/W2034277114","https://openalex.org/W2036385196","https://openalex.org/W2037520011","https://openalex.org/W2038421379","https://openalex.org/W2039709545","https://openalex.org/W2043204829","https://openalex.org/W2045388302","https://openalex.org/W2048861528","https://openalex.org/W2049842278","https://openalex.org/W2052244692","https://openalex.org/W2054447845","https://openalex.org/W2055755257","https://openalex.org/W2056022475","https://openalex.org/W2056089399","https://openalex.org/W2056707698","https://openalex.org/W2057092384","https://openalex.org/W2058197513","https://openalex.org/W2062997697","https://openalex.org/W2072744580","https://openalex.org/W2075084906","https://openalex.org/W2076396921","https://openalex.org/W2076534093","https://openalex.org/W2077180087","https://openalex.org/W2079977894","https://openalex.org/W2081327669","https://openalex.org/W2081742266","https://openalex.org/W2083763893","https://openalex.org/W2086943348","https://openalex.org/W2086992094","https://openalex.org/W2087011288","https://openalex.org/W2087404852","https://openalex.org/W2088740611","https://openalex.org/W2090547063","https://openalex.org/W2093308617","https://openalex.org/W2098810873","https://openalex.org/W2099724117","https://openalex.org/W2103413641","https://openalex.org/W2103725178","https://openalex.org/W2105871477","https://openalex.org/W2105896701","https://openalex.org/W2106996266","https://openalex.org/W2110419228","https://openalex.org/W2111125738","https://openalex.org/W2113168077","https://openalex.org/W2113280225","https://openalex.org/W2117912210","https://openalex.org/W2121444961","https://openalex.org/W2123105653","https://openalex.org/W2125547572","https://openalex.org/W2126679757","https://openalex.org/W2140884727","https://openalex.org/W2147114673","https://openalex.org/W2148050967","https://openalex.org/W2148599090","https://openalex.org/W2148969043","https://openalex.org/W2150932906","https://openalex.org/W2153358400","https://openalex.org/W2154938844","https://openalex.org/W2155062057","https://openalex.org/W2156555850","https://openalex.org/W2159505514","https://openalex.org/W2167887541","https://openalex.org/W2170578522","https://openalex.org/W2171317581","https://openalex.org/W2316434439","https://openalex.org/W2324248025","https://openalex.org/W2325068802","https://openalex.org/W2395959362","https://openalex.org/W3028308266","https://openalex.org/W4210247538","https://openalex.org/W4253503843","https://openalex.org/W6603045130"],"related_works":["https://openalex.org/W1991258129","https://openalex.org/W2020180197","https://openalex.org/W1573460510","https://openalex.org/W2038329703","https://openalex.org/W2082331160","https://openalex.org/W2055858985","https://openalex.org/W2538269543","https://openalex.org/W2223448752","https://openalex.org/W2052244692","https://openalex.org/W2614825120"],"abstract_inverted_index":{"Most":[0],"mammalian":[1],"cells":[2,35,101,106],"when":[3],"placed":[4],"in":[5,31,63,97],"culture":[6],"will":[7],"undergo":[8],"a":[9],"limited":[10,42],"number":[11],"of":[12],"cell":[13,84],"divisions":[14],"before":[15],"entering":[16],"an":[17],"unresponsive":[18],"non-proliferating":[19],"state":[20],"termed":[21],"senescence.":[22],"However,":[23],"several":[24],"pathways":[25,58,96,111],"that":[26,79,104],"are":[27,107,112],"activated":[28],"singly":[29],"or":[30],"concert":[32],"can":[33],"allow":[34],"to":[36,50,60,65,94],"bypass":[37],"senescence":[38,62],"at":[39],"least":[40],"for":[41],"periods.":[43],"These":[44],"include":[45],"the":[46,54,74],"telomerase":[47],"pathway":[48,78],"required":[49,59],"maintain":[51],"telomere":[52,68],"ends,":[53],"p53":[55],"and":[56,70,73,83,102],"Rb":[57],"direct":[61],"response":[64],"DNA":[66],"damage,":[67],"shortening":[69],"mitogenic":[71],"signals,":[72],"insulin-like":[75],"growth":[76],"factor--Akt":[77],"may":[80],"regulate":[81],"lifespan":[82],"proliferation.":[85],"In":[86],"this":[87],"review,":[88],"we":[89],"summarize":[90],"recent":[91],"findings":[92],"related":[93],"these":[95,110],"embryonic":[98],"stem":[99],"(ES)":[100],"suggest":[103],"ES":[105],"immortal":[108],"because":[109],"tightly":[113],"regulated.":[114]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
