{"id":"https://openalex.org/W1591763200","doi":null,"title":"Role of notch-delta signalling in cell fate determination during cutaneous epithelial differentiation","display_name":"Role of notch-delta signalling in cell fate determination during cutaneous epithelial differentiation","publication_year":2011,"publication_date":"2011-07-31","ids":{"openalex":"https://openalex.org/W1591763200","mag":"1591763200"},"language":"en","primary_location":{"id":"pmh:oai:https://orca.cardiff.ac.uk:35300","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/35300/1/2012AlShuailiMPhil.pdf","pdf_url":"https://orca.cardiff.ac.uk/35300/1/2012AlShuailiMPhil.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://orca.cardiff.ac.uk/35300/1/2012AlShuailiMPhil.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026892529","display_name":"Al Shuaili","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Al Shuaili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043464019","display_name":"Altaf Mohammed","orcid":"https://orcid.org/0000-0003-1058-6909","observed_orcids":["https://orcid.org/0000-0003-1058-6909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Altaf Mohammed","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1058-6909","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.847000002861023},{"id":"https://openalex.org/keywords/delta-like-ligands","display_name":"Delta-like ligands","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dll1","display_name":"DLL1","score":0.6660000085830688},{"id":"https://openalex.org/keywords/dll3","display_name":"DLL3","score":0.9020000100135803},{"id":"https://openalex.org/keywords/delta-like-ligand-4","display_name":"DLL4","score":1.0},{"id":"https://openalex.org/keywords/jagged-ligands","display_name":"Jagged ligands","score":0.8500000238418579},{"id":"https://openalex.org/keywords/jag1","display_name":"JAG1","score":0.984000027179718},{"id":"https://openalex.org/keywords/jagged2","display_name":"Jagged2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/epidermal-differentiation","display_name":"epidermal differentiation","score":0.9380000233650208},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.8859999775886536},{"id":"https://openalex.org/keywords/calcium-induced-differentiation","display_name":"calcium-induced differentiation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"cell fate determination","score":0.6230000257492065},{"id":"https://openalex.org/keywords/skin-development","display_name":"skin development","score":0.4129999876022339},{"id":"https://openalex.org/keywords/skin-diseases","display_name":"skin diseases","score":0.5299999713897705},{"id":"https://openalex.org/keywords/epidermal-stem-cells","display_name":"epidermal stem cells","score":0.3930000066757202}],"concepts":[{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.9536013603210449},{"id":"https://openalex.org/C202769670","wikidata":"https://www.wikidata.org/wiki/Q4045508","display_name":"Notch proteins","level":4,"score":0.8579959869384766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7455906867980957},{"id":"https://openalex.org/C2779156968","wikidata":"https://www.wikidata.org/wiki/Q17141495","display_name":"Hairless","level":2,"score":0.640163004398346},{"id":"https://openalex.org/C2778668844","wikidata":"https://www.wikidata.org/wiki/Q18251749","display_name":"JAG1","level":4,"score":0.6388431787490845},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5895580649375916},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.5460363626480103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4891860783100128},{"id":"https://openalex.org/C65114990","wikidata":"https://www.wikidata.org/wiki/Q5745269","display_name":"Hes3 signaling axis","level":4,"score":0.48284751176834106},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4123808741569519},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3836703896522522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2619556784629822},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1922762095928192},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.1831027865409851}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:https://orca.cardiff.ac.uk:35300","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/35300/1/2012AlShuailiMPhil.pdf","pdf_url":"https://orca.cardiff.ac.uk/35300/1/2012AlShuailiMPhil.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:uilis.unsyiah.ac.id:30423","doi":null,"is_oa":true,"landing_page_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30423","pdf_url":"http://uilis.unsyiah.ac.id/opentheses/items/show/30423","source":{"id":"https://openalex.org/S4377196378","display_name":"UPT. Syiah Kuala University Library (Syiah Kuala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187494767","host_organization_name":"Universitas Syiah Kuala","host_organization_lineage":["https://openalex.org/I187494767"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:1591763200","doi":null,"is_oa":false,"landing_page_url":"http://orca.cf.ac.uk/id/eprint/35300","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:https://orca.cardiff.ac.uk:35300","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/35300/1/2012AlShuailiMPhil.pdf","pdf_url":"https://orca.cardiff.ac.uk/35300/1/2012AlShuailiMPhil.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1591763200.pdf","grobid_xml":"https://content.openalex.org/works/W1591763200.grobid-xml"},"referenced_works_count":82,"referenced_works":["https://openalex.org/W64962480","https://openalex.org/W178736140","https://openalex.org/W1560488482","https://openalex.org/W1564421323","https://openalex.org/W1964273402","https://openalex.org/W1968343429","https://openalex.org/W1968956851","https://openalex.org/W1971814935","https://openalex.org/W1971895815","https://openalex.org/W1972518538","https://openalex.org/W1972690430","https://openalex.org/W1975718597","https://openalex.org/W1976134177","https://openalex.org/W1977962361","https://openalex.org/W1978968660","https://openalex.org/W1979812265","https://openalex.org/W1981053128","https://openalex.org/W1982793777","https://openalex.org/W1985657116","https://openalex.org/W1990803574","https://openalex.org/W1991506501","https://openalex.org/W1993363599","https://openalex.org/W1995004385","https://openalex.org/W1997801717","https://openalex.org/W2000720929","https://openalex.org/W2000783625","https://openalex.org/W2006107567","https://openalex.org/W2011842366","https://openalex.org/W2013096956","https://openalex.org/W2029107946","https://openalex.org/W2029675195","https://openalex.org/W2030360356","https://openalex.org/W2031531828","https://openalex.org/W2036189250","https://openalex.org/W2050753752","https://openalex.org/W2054623554","https://openalex.org/W2054828183","https://openalex.org/W2056629908","https://openalex.org/W2070640889","https://openalex.org/W2073638852","https://openalex.org/W2079809508","https://openalex.org/W2082289095","https://openalex.org/W2082726234","https://openalex.org/W2085021251","https://openalex.org/W2086677653","https://openalex.org/W2086943447","https://openalex.org/W2088969512","https://openalex.org/W2091022798","https://openalex.org/W2099059205","https://openalex.org/W2102767758","https://openalex.org/W2103546044","https://openalex.org/W2104058491","https://openalex.org/W2105455857","https://openalex.org/W2109380828","https://openalex.org/W2110521270","https://openalex.org/W2112549882","https://openalex.org/W2114213130","https://openalex.org/W2119483052","https://openalex.org/W2126879560","https://openalex.org/W2127508599","https://openalex.org/W2127700562","https://openalex.org/W2132650229","https://openalex.org/W2133885516","https://openalex.org/W2133943800","https://openalex.org/W2138818809","https://openalex.org/W2140255023","https://openalex.org/W2140382887","https://openalex.org/W2140836243","https://openalex.org/W2141243765","https://openalex.org/W2148459495","https://openalex.org/W2148529881","https://openalex.org/W2153111026","https://openalex.org/W2153558905","https://openalex.org/W2156891963","https://openalex.org/W2156930945","https://openalex.org/W2158986010","https://openalex.org/W2165684064","https://openalex.org/W2166724005","https://openalex.org/W2168211018","https://openalex.org/W2169671179","https://openalex.org/W2169851453","https://openalex.org/W2286913336"],"related_works":["https://openalex.org/W2060399286","https://openalex.org/W187623996","https://openalex.org/W2070095742","https://openalex.org/W3086418713","https://openalex.org/W2016514944","https://openalex.org/W4285174858","https://openalex.org/W2320865101","https://openalex.org/W2963723259","https://openalex.org/W4366088168","https://openalex.org/W1968956851"],"abstract_inverted_index":{"The":[0,15,89,127,208],"notch":[1,54,73,93,114,191,219,254,271,292,394,445],"signalling":[2,30,50,65,192,255,272,293,528],"pathway":[3,17],"is":[4,66,197],"essential":[5],"for":[6,364,443],"the":[7,40,96,113,119,130,174,216,267,297,304,535],"development":[8],"and":[9,24,56,60,69,83,99,132,138,145,166,222,283,285,330,335,344,366,372,375,403,430,448,454,464,466,474,492,499,504,517,531],"growth":[10,282],"of":[11,176,210,218,260,270,299,303,327,353,484,489,537],"all":[12,433],"mammalian":[13],"cells.":[14,338],"canonical":[16],"works":[18],"by":[19,173,407],"cell":[20,22,36,97,120,251,274,281],"to":[21,107,140,160,205,214,265,418,476],"communication":[23],"influences":[25],"gene":[26,421],"expression":[27,217,326,340,357,368,382,485],"directly.":[28],"Notch":[29,149],"plays":[31],"an":[32,177],"important":[33],"role":[34,269],"in":[35,39,45,63,193,199,229,236,244,273,296,312,332,369,393,400,487,495,509,540],"differentiation":[37,228,262,399,539],"processes":[38],"embryo":[41],"as":[42,44,241,243,432],"well":[43,242],"adult":[46,200,319],"tissues.":[47],"In":[48],"Drosophila,":[49],"requires":[51],"a":[52,92,103,134,161,249,419],"single":[53],"receptor":[55,94,122],"two":[57,84,444,467],"ligands":[58,79,86,221,308,451],"(delta":[59],"serrate).":[61],"However,":[62],"mammals":[64],"more":[67],"complex":[68,135],"there":[70,376],"are":[71],"four":[72],"receptors":[74,150,446],"(NOTCH1-4),":[75],"three":[76,450],"delta":[77,307],"like":[78],"(DLL1,":[80,452],"DLL3,":[81],"DLL4)":[82],"jagged":[85],"(JAG1,":[87],"JAG2).":[88],"interaction":[90],"between":[91],"at":[95,257],"surface":[98,121],"its":[100],"ligand":[101,183,395],"on":[102,190,306,318,325],"neighbouring":[104],"cell,":[105],"leads":[106],"sequential":[108],"proteolytic":[109],"cleavages":[110],"which":[111],"release":[112],"intracellular":[115],"domain":[116],"(NICD)":[117],"from":[118],"(Estrach":[123],"et":[124],"al.,":[125],"2008).":[126],"NICD":[128],"enters":[129],"nucleus":[131],"forms":[133],"with":[136,203,315,397,521],"CSL":[137],"Mastermind":[139],"activate":[141],"target":[142,224],"genes":[143,225,458,469],"(HES":[144],"HEY":[146],"family":[147],"members).":[148],"have":[151,186],"modified":[152],"EGF-like":[153],"repeats":[154],"where":[155],"fucose":[156,169],"has":[157,309],"been":[158,187,310],"added":[159],"serine":[162],"or":[163,181,355],"threonine":[164],"residue":[165],"this":[167,211],"O-linked":[168],"can":[170],"be":[171,416],"elongated":[172],"action":[175],"enzyme":[178],"(fringe),":[179],"enhancing":[180],"blocking":[182],"binding.":[184],"There":[185],"extensive":[188],"studies":[189],"embryos":[194],"but":[195,349,512],"less":[196],"known":[198],"tissues,":[201],"especially":[202],"regard":[204],"non-canonical":[206],"pathways.":[207],"aim":[209],"project":[212],"was":[213,233,341,358,361,377,524],"examine":[215],"receptors,":[220],"specific":[223],"during":[226,277,385],"epidermal":[227],"human":[230,237,333,370,423,425,500,541],"skin.":[231,320],"This":[232,480],"examined":[234],"both":[235,496],"epidermis":[238,334,371],"(in":[239],"vivo)":[240],"culture":[245],"models":[246],"using":[247],"HaCaT,":[248],"keratinocyte":[250,261],"line.":[252],"Examining":[253],"activity":[256],"different":[258],"stages":[259],"could":[263,414],"help":[264],"understand":[266],"precise":[268],"fate":[275],"determination":[276],"normal":[278],"cutaneous":[279],"epithelial":[280],"development,":[284],"may":[286,533],"indicate":[287],"what":[288],"role,":[289],"if":[290],"any":[291],"might":[294,383],"play":[295],"pathology":[298],"skin":[300],"disease.":[301],"Most":[302],"work":[305,317],"done":[311],"embryonic":[313],"tissues":[314],"little":[316,508],"Thus,":[321,440],"our":[322],"approach":[323],"focused":[324],"DLL1,":[328],"DLL3":[329,354],"DLL4":[331,356],"cultured":[336,373],"HaCaT":[337,401,497,510],"DLL1":[339,505],"confirmed":[342],"(mRNA":[343],"protein":[345],"level":[346],"including":[347],"sequence)":[348],"no":[350],"convincing":[351],"evidence":[352],"found.":[359],"Evidence":[360],"also":[362,525],"obtained":[363],"JAG1":[365,453,532],"JAG2":[367,516],"cells,":[374],"some":[378],"indication":[379],"that":[380,527],"differential":[381],"occur":[384],"terminal":[386,538],"differentiation.":[387,522],"RT-PCR":[388],"results":[389],"indicated":[390],"possible":[391],"changes":[392],"levels":[396,413,486,519],"calcium-induced":[398],"cells":[402,498,511],"these":[404],"were":[405,436,472],"quantitated":[406],"real":[408],"time":[409],"PCR":[410],"(qPCR).":[411],"Expression":[412],"not":[415,437],"normalised":[417],"housekeeping":[420],"(\u03b2-Actin,":[422],"ARP,":[424],"TF2H,":[426],"GRP58,":[427],"B2H,":[428],"RPL13":[429],"TBP)":[431],"those":[434],"tested":[435],"stable":[438],"enough.":[439],"cDNA":[441],"probes":[442],"(N1":[447],"N3),":[449],"JAG2),":[455],"six":[456],"responsive":[457],"(HES1,":[459],"HES5,":[460],"HES7,":[461],"HEY1,":[462],"HEY2":[463],"HEYL)":[465],"keratin":[468],"(KRT14,":[470],"KRT10)":[471],"cloned":[473],"used":[475],"construct":[477],"standard":[478],"curves.":[479],"allowed":[481],"quantitative":[482],"estimation":[483],"terms":[488],"copy":[490],"number":[491],"fold":[493],"change":[494],"epidermis.":[501],"K14,":[502],"Notch1":[503],"changed":[506],"very":[507],"K10,":[513],"Notch3,":[514],"JAG1,":[515],"HES1":[518],"increased":[520],"It":[523],"concluded":[526],"via":[529],"Notch3":[530],"influence":[534],"progress":[536],"keratinocytes.":[542]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
