{"id":"https://openalex.org/W159165204","doi":null,"title":"Mathematical modeling of chemical signals in inflammatory pathways","display_name":"Mathematical modeling of chemical signals in inflammatory pathways","publication_year":2011,"publication_date":"2011-09-29","ids":{"openalex":"https://openalex.org/W159165204","mag":"159165204"},"language":"en","primary_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9133","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9133/1/Price_Thesis_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/9133/1/Price_Thesis_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://d-scholarship.pitt.edu/9133/1/Price_Thesis_2011.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006173542","display_name":"Ian Price","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ian Price","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006173542"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.57669997215271,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.08789999783039093,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.08470000326633453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7129999995231628},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6579999923706055},{"id":"https://openalex.org/keywords/chemical-communication","display_name":"chemical communication","score":0.734000027179718},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"influenza A virus","score":0.7480000257492065},{"id":"https://openalex.org/keywords/immune-response-modeling","display_name":"immune response modeling","score":0.7839999794960022},{"id":"https://openalex.org/keywords/parameter-estimation","display_name":"parameter estimation","score":0.503000020980835},{"id":"https://openalex.org/keywords/model-calibration","display_name":"model calibration","score":0.7070000171661377},{"id":"https://openalex.org/keywords/metropolis-hastings-algorithm","display_name":"Metropolis-Hastings algorithm","score":0.8659999966621399},{"id":"https://openalex.org/keywords/multi-objective-optimization","display_name":"multi-objective optimization","score":0.7990000247955322},{"id":"https://openalex.org/keywords/mosquito-immunity","display_name":"mosquito immunity","score":0.824999988079071},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9409999847412109},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pathogen-clearance","display_name":"pathogen clearance","score":0.6019999980926514},{"id":"https://openalex.org/keywords/tissue-damage","display_name":"tissue damage","score":0.875}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.728187084197998},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.6382262110710144},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6020215749740601},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5472608804702759},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47404003143310547},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.4551600515842438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44267603754997253},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43828386068344116},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4038391411304474},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39660096168518066},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35585689544677734},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20751085877418518},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:d-scholarship.pitt.edu:9133","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9133/1/Price_Thesis_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/9133/1/Price_Thesis_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"mag:159165204","doi":null,"is_oa":false,"landing_page_url":"http://d-scholarship.pitt.edu/9133/1/Price_Thesis_2011.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:d-scholarship.pitt.edu:9133","doi":null,"is_oa":true,"landing_page_url":"https://d-scholarship.pitt.edu/9133/1/Price_Thesis_2011.pdf","pdf_url":"http://d-scholarship.pitt.edu/9133/1/Price_Thesis_2011.pdf","source":{"id":"https://openalex.org/S4306402372","display_name":"D-Scholarship@Pitt (University of Pittsburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170201317","host_organization_name":"University of Pittsburgh","host_organization_lineage":["https://openalex.org/I170201317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W159165204.pdf","grobid_xml":"https://content.openalex.org/works/W159165204.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W339353406","https://openalex.org/W1501778305","https://openalex.org/W1532188080","https://openalex.org/W1538314991","https://openalex.org/W1549251788","https://openalex.org/W1558813989","https://openalex.org/W1596321532","https://openalex.org/W1597944220","https://openalex.org/W1963149902","https://openalex.org/W1982242405","https://openalex.org/W1986589631","https://openalex.org/W1992282800","https://openalex.org/W1998855065","https://openalex.org/W2000614107","https://openalex.org/W2003652884","https://openalex.org/W2004877269","https://openalex.org/W2006683926","https://openalex.org/W2011409010","https://openalex.org/W2014337138","https://openalex.org/W2018600164","https://openalex.org/W2023447635","https://openalex.org/W2026407589","https://openalex.org/W2040876125","https://openalex.org/W2041422216","https://openalex.org/W2042295185","https://openalex.org/W2046923162","https://openalex.org/W2047420973","https://openalex.org/W2051001095","https://openalex.org/W2054519334","https://openalex.org/W2060982649","https://openalex.org/W2065317320","https://openalex.org/W2069142066","https://openalex.org/W2069711056","https://openalex.org/W2073234751","https://openalex.org/W2085237060","https://openalex.org/W2086550332","https://openalex.org/W2094268929","https://openalex.org/W2094354431","https://openalex.org/W2104145923","https://openalex.org/W2104918497","https://openalex.org/W2106535354","https://openalex.org/W2109977701","https://openalex.org/W2127240692","https://openalex.org/W2127260736","https://openalex.org/W2134573759","https://openalex.org/W2141133391","https://openalex.org/W2143576416","https://openalex.org/W2146766088","https://openalex.org/W2153190303","https://openalex.org/W2156661166","https://openalex.org/W2158868985","https://openalex.org/W2160988127","https://openalex.org/W2161074777","https://openalex.org/W2161830466","https://openalex.org/W2166751342","https://openalex.org/W2167017590","https://openalex.org/W2168297851","https://openalex.org/W2168573378","https://openalex.org/W2171405797","https://openalex.org/W2336871225","https://openalex.org/W2612743911","https://openalex.org/W4388364567"],"related_works":["https://openalex.org/W2225073576","https://openalex.org/W2070102965","https://openalex.org/W2064571548","https://openalex.org/W630322457","https://openalex.org/W3036102133","https://openalex.org/W4388435430","https://openalex.org/W7096162606","https://openalex.org/W1573734451","https://openalex.org/W2743738384","https://openalex.org/W1755252075"],"abstract_inverted_index":{"Mechanistic,":[0],"autonomous,":[1],"ordinary":[2],"differential":[3],"equations":[4],"represent":[5,26],"a":[6,27,51,134,198],"powerful":[7],"way":[8],"to":[9,29,87,113,132,139,149,182,204,233],"crystalize":[10],"and":[11,20,42,59,64,93,138,164,170,185,211,224],"reproduce":[12],"the":[13,30,46,69,78,111,115,127,162,176,189],"dynamics":[14],"of":[15,22,32,48,71,80,99,129,166,178,191,201,230],"complex,":[16],"nonlinear":[17,52,199,252],"interactions.":[18],"Design":[19],"calibration":[21],"these":[23,74,130,173],"models,":[24],"however,":[25,107],"challenge":[28],"construction":[31],"fully":[33],"validated":[34],"models.":[35,254],"Various":[36],"parameter":[37],"techniques":[38],"are":[39,124],"employed,":[40],"evaluated":[41],"improved":[43],"upon":[44],"for":[45,155,221,251],"purpose":[47],"fitting":[49,244],"in":[50,147,188],"setting.":[53],"Cells":[54],"communicate":[55],"with":[56,208],"other":[57],"cells":[58,81],"their":[60],"environment":[61],"by":[62],"producing":[63],"receiving":[65],"chemical":[66],"signals.":[67],"In":[68],"context":[70,177],"pathogen":[72,100],"response,":[73],"signals":[75,184,187],"regulate":[76],"how":[77],"collective":[79],"reacts.":[82],"One":[83],"such":[84],"undifferentiated":[85],"response":[86,157,181,203,232],"signal":[88],"is":[89,95,195,217,239],"known":[90],"as":[91,102,104,146,236],"inflammation,":[92],"it":[94,108],"an":[96],"important":[97],"mediator":[98],"clearance":[101],"well":[103],"tissue":[105,117,179],"healing;":[106],"also":[109,240],"has":[110],"potential":[112],"damage":[114],"surrounding":[116],"when":[118],"regulatory":[119],"mechanisms":[120,128,174],"break":[121],"down.":[122],"Models":[123],"built":[125],"using":[126,245],"interactions":[131],"produce":[133],"high":[135],"level":[136,180],"effect,":[137],"predict":[140],"what":[141],"measures":[142],"can":[143],"be":[144],"taken,":[145],"influenza,":[148],"prevent":[150],"dysregulation.":[151],"The":[152,215],"models":[153],"developed":[154],"inflammatory":[156],"first":[158],"take":[159],"into":[160,175,197],"consideration":[161],"production":[163],"reception":[165],"immune":[167,202,237],"factors,":[168],"cytokines,":[169],"then":[171],"put":[172],"external":[183],"internal":[186],"form":[190],"system":[192],"damage.":[193],"This":[194],"incorporated":[196],"model":[200,216,229,243],"Influenza":[205],"A":[206,228],"Virus,":[207],"innate,":[209],"adaptive,":[210],"humoral":[212],"immunity":[213],"components.":[214],"calibrated":[218],"against":[219],"data":[220],"both":[222],"sublethal":[223],"lethal":[225],"initial":[226],"dosages.":[227],"mosquito":[231],"exogenous":[234],"cytokine":[235],"stimulation":[238],"explored.":[241],"Successful":[242],"Metropolis-Hastings":[246],"methods":[247],"yields":[248],"multi-objective":[249],"results":[250],"deterministic":[253]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}