{"id":"https://openalex.org/W1591545172","doi":"https://doi.org/10.4049/jimmunol.134.6.4184","title":"Characterization of the human newborn response to herpesvirus antigen.","display_name":"Characterization of the human newborn response to herpesvirus antigen.","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W1591545172","doi":"https://doi.org/10.4049/jimmunol.134.6.4184","mag":"1591545172","pmid":"https://pubmed.ncbi.nlm.nih.gov/2580908"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.134.6.4184","doi":"https://doi.org/10.4049/jimmunol.134.6.4184","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.134.6.4184","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054064597","display_name":"Barbara A. Chilmonczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019586173","display_name":"National Jewish Health","ror":"https://ror.org/016z2bp30","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019586173"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B A Chilmonczyk","raw_affiliation_strings":["National Jewish Hospital and Research Center, National Asthma Center , Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Jewish Hospital and Research Center, National Asthma Center , Denver, CO","institution_ids":["https://openalex.org/I3019586173"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051264386","display_name":"Myron J. Levin","orcid":"https://orcid.org/0000-0002-7468-106X","observed_orcids":["https://orcid.org/0000-0002-7468-106X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M J Levin","raw_affiliation_strings":["University of Colorado School of Medicine, Departments of Pediatrics , Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado School of Medicine, Departments of Pediatrics , Denver, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089079386","display_name":"R McDuffy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R McDuffy","raw_affiliation_strings":["University of Colorado School of Medicine, Departments of Pediatrics , Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado School of Medicine, Departments of Pediatrics , Denver, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047782310","display_name":"Anthony R Hayward","orcid":"https://orcid.org/0000-0003-3123-2894","observed_orcids":["https://orcid.org/0000-0003-3123-2894"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A R Hayward","raw_affiliation_strings":["University of Colorado School of Medicine, Departments of Pediatrics , Denver, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado School of Medicine, Departments of Pediatrics , Denver, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":2.857,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.89850567,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"134","issue":"6","first_page":"4184","last_page":"4188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.12770000100135803,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neonatal-immunity","display_name":"neonatal immunity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":1.0},{"id":"https://openalex.org/keywords/varicella-zoster-virus","display_name":"varicella-zoster virus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hla-restriction","display_name":"HLA restriction","score":0.7379999756813049},{"id":"https://openalex.org/keywords/t4-lymphocytes","display_name":"T4 lymphocytes","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6694943904876709},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.6418175101280212},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.638150691986084},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5905460715293884},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5670103430747986},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.545717716217041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5117635726928711},{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.4736389219760895},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43837612867355347},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.4382718801498413},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43498462438583374},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4269225299358368},{"id":"https://openalex.org/C3017875465","wikidata":"https://www.wikidata.org/wiki/Q189146","display_name":"Cellular immunity","level":3,"score":0.4202568531036377},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.3953211307525635},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.19986027479171753},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.095971018075943},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.134.6.4184","doi":"https://doi.org/10.4049/jimmunol.134.6.4184","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.134.6.4184","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:2580908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2580908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6291545850","display_name":null,"funder_award_id":"HDI3733","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1597573846","https://openalex.org/W7099707351","https://openalex.org/W1021309891","https://openalex.org/W1986853600","https://openalex.org/W2116603221","https://openalex.org/W2060843008","https://openalex.org/W1780716402","https://openalex.org/W2026864807","https://openalex.org/W2415896803","https://openalex.org/W2079861744"],"abstract_inverted_index":{"An":[0],"investigation":[1],"was":[2],"made":[3],"into":[4],"the":[5,28,31,44,79,109,132,235],"human":[6,139],"newborn":[7,74,121,211,236],"cellular":[8],"response":[9,77],"to":[10,24,34,85,125,148,170,181,185,193,200,206,230],"herpes":[11],"simplex":[12],"virus":[13,22],"type":[14],"1":[15],"(HSV),":[16],"cytomegalovirus":[17],"(CMV),":[18],"and":[19,196,227,244],"varicella":[20],"zoster":[21],"(VZV)":[23],"understand":[25],"more":[26],"about":[27],"nature":[29],"of":[30,48,78,116,162,179,214],"neonate's":[32],"susceptibility":[33],"overwhelming":[35],"infection":[36,233],"by":[37,73,90],"these":[38],"viruses.":[39],"Newborn":[40],"mononuclear":[41],"cells":[42],"sustained":[43],"proliferation":[45],"in":[46,92,100,120,138,141,158,187,225,239],"culture":[47,103],"maternal":[49,80,94],"(i.e.,":[50],"haplotype-matched)":[51],"T":[52,81,95,134,220],"cell":[53,82,96,135,153,176,221],"blasts":[54,83,97],"with":[55],"specificity":[56],"for":[57,69],"HSV,":[58],"CMV,":[59],"or":[60],"VZV":[61],"(p":[62],"less":[63],"than":[64,156],"0.05).":[65],"This":[66],"is":[67,217,223],"evidence":[68],"intact":[70],"antigen-processing":[71],"capability":[72],"monocytes.":[75],"The":[76,183],"appeared":[84],"be":[86],"HLA-haplotype-restricted":[87],"as":[88],"suggested":[89],"experiments":[91],"which":[93],"were":[98,146],"limited":[99],"number.":[101],"Our":[102],"conditions":[104],"elicited":[105],"responses":[106],"predominantly":[107],"from":[108,204],"T4+":[110,118],"lymphocyte":[111],"subset.":[112],"A":[113],"low":[114,224],"frequency":[115,137,154,177],"herpesvirus-specific":[117,151],"lymphocytes":[119],"blood":[122],"might":[123],"contribute":[124],"deficient":[126],"viral":[127],"immunity,":[128],"so":[129],"we":[130],"evaluated":[131],"virus-specific":[133],"responding":[136],"newborns":[140],"limiting":[142],"dilution":[143],"cultures.":[144],"We":[145,208],"unable":[147],"find":[149],"a":[150,173],"responder":[152,175],"greater":[155],"1:1,400,000":[157],"nonimmune":[159],"newborns.":[160],"Three":[161],"seven":[163],"adults":[164,243],"who":[165],"had":[166,172],"no":[167],"serum":[168],"antibody":[169],"CMV":[171,174],"(RCF)":[178],"1:100,000":[180],"1:200,000.":[182],"RCF":[184,222,241],"HSV":[186,231],"immune":[188],"children,":[189],"ages":[190,198],"18":[191],"mo":[192],"12":[194],"yr,":[195,202],"adults,":[197],"13":[199],"80":[201],"ranged":[203],"1:14,000":[205],"1:18,000.":[207],"conclude":[209],"that":[210,219,228],"monocyte":[212],"processing":[213],"herpesvirus":[215],"antigen":[216],"intact,":[218],"neonates,":[226],"immunity":[229],"after":[232],"outside":[234],"period":[237],"results":[238],"comparable":[240],"between":[242],"children.":[245]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}