{"id":"https://openalex.org/W1591316404","doi":"https://doi.org/10.4049/jimmunol.173.3.2050","title":"Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome","display_name":"Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W1591316404","doi":"https://doi.org/10.4049/jimmunol.173.3.2050","mag":"1591316404","pmid":"https://pubmed.ncbi.nlm.nih.gov/15265940"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.173.3.2050","doi":"https://doi.org/10.4049/jimmunol.173.3.2050","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.3.2050","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018521931","display_name":"Gerhard Carl Hildebrandt","orcid":"https://orcid.org/0000-0003-0478-3340","observed_orcids":["https://orcid.org/0000-0003-0478-3340","https://orcid.org/0000-0001-7811-6888"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerhard C Hildebrandt","raw_affiliation_strings":["Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111704414","display_name":"Leigh A. Corrion","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leigh A Corrion","raw_affiliation_strings":["Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","*Department of Pediatrics, Blood and Marrow Transplantation Program, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"*Department of Pediatrics, Blood and Marrow Transplantation Program, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004037599","display_name":"Krystyna M. Olkiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krystyna M Olkiewicz","raw_affiliation_strings":["Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","*Department of Pediatrics, Blood and Marrow Transplantation Program, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"*Department of Pediatrics, Blood and Marrow Transplantation Program, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113749473","display_name":"Bao Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bao Lu","raw_affiliation_strings":["Perlmutter Laboratory, Children\u2019s Hospital, and Harvard Medical School , Boston, MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Perlmutter Laboratory, Children\u2019s Hospital, and Harvard Medical School , Boston, MA 02115","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014360240","display_name":"Kathleen P. Lowler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen Lowler","raw_affiliation_strings":["Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","*Department of Pediatrics, Blood and Marrow Transplantation Program, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"*Department of Pediatrics, Blood and Marrow Transplantation Program, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039620347","display_name":"Ulrich A. Duffner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich A Duffner","raw_affiliation_strings":["Klinik IV Paediatrische Haematologie und Onkologie, Medizinische Universitaetsklinik Freiburg , Freiburg ,","\u00a7 Klinik IV Paediatrische Haematologie und Onkologie, Medizinische Universitaetsklinik Freiburg, Freiburg, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik IV Paediatrische Haematologie und Onkologie, Medizinische Universitaetsklinik Freiburg , Freiburg ,","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"\u00a7 Klinik IV Paediatrische Haematologie und Onkologie, Medizinische Universitaetsklinik Freiburg, Freiburg, Germany;","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023482526","display_name":"Bethany B. Moore","orcid":"https://orcid.org/0000-0003-3051-745X","observed_orcids":["https://orcid.org/0000-0003-3051-745X","https://orcid.org/0000-0002-2104-7292"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bethany B Moore","raw_affiliation_strings":["Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan , Ann Arbor, MI 48109"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan , Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110206614","display_name":"William A. Kuziel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William A Kuziel","raw_affiliation_strings":["Section of Molecular Genetics and Microbiology, University of Texas , Austin, TX 78712","\u00b6 Section of Molecular Genetics and Microbiology, University of Texas, Austin, TX 78712; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Molecular Genetics and Microbiology, University of Texas , Austin, TX 78712","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"\u00b6 Section of Molecular Genetics and Microbiology, University of Texas, Austin, TX 78712; and","institution_ids":["https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322216","display_name":"Chen Liu","orcid":"https://orcid.org/0009-0003-0430-6146","observed_orcids":["https://orcid.org/0009-0003-0430-6146","https://orcid.org/0009-0008-6552-1719"]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Liu","raw_affiliation_strings":["\u2225 Department of Pathology, University of Florida School of Medicine, Gainesville, FL 32610"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2225 Department of Pathology, University of Florida School of Medicine, Gainesville, FL 32610","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040158605","display_name":"Kenneth R. Cooke","orcid":"https://orcid.org/0000-0002-0275-6931","observed_orcids":["https://orcid.org/0000-0002-0275-6931"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth R Cooke","raw_affiliation_strings":["Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","*Department of Pediatrics, Blood and Marrow Transplantation Program, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Blood and Marrow Transplantation Program, University of Michigan , Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"*Department of Pediatrics, Blood and Marrow Transplantation Program, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.7978,"has_fulltext":false,"cited_by_count":98,"citation_normalized_percentile":{"value":0.95530476,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"173","issue":"3","first_page":"2050","last_page":"2059"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pneumonia-syndrome","display_name":"idiopathic pneumonia syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cxcr3","display_name":"CXCR3","score":0.9089999794960022},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.8820000290870667},{"id":"https://openalex.org/keywords/cxcl10","display_name":"CXCL10","score":0.9940000176429749},{"id":"https://openalex.org/keywords/allogeneic-stem-cell-transplantation","display_name":"allogeneic stem cell transplantation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.6389999985694885},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.9340000152587891},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/chemokine-neutralization","display_name":"chemokine neutralization","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C25532541","wikidata":"https://www.wikidata.org/wiki/Q655541","display_name":"CXCR3","level":5,"score":0.8181519508361816},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5814210176467896},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.5512198805809021},{"id":"https://openalex.org/C2781448352","wikidata":"https://www.wikidata.org/wiki/Q1637912","display_name":"Lung transplantation","level":3,"score":0.5455323457717896},{"id":"https://openalex.org/C5858377","wikidata":"https://www.wikidata.org/wiki/Q986112","display_name":"CXCL10","level":4,"score":0.539559006690979},{"id":"https://openalex.org/C17502307","wikidata":"https://www.wikidata.org/wiki/Q411999","display_name":"CXCL9","level":5,"score":0.520668625831604},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5024509429931641},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4903690814971924},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.48160240054130554},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4196656048297882},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41220131516456604},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4014279246330261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3325428068637848},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.3197697401046753},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22923481464385986},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2096908688545227},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.10010519623756409}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003433","descriptor_name":"Crosses, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013154","descriptor_name":"Spleen","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019743","descriptor_name":"Chemokines, CXC","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054357","descriptor_name":"Chemokine CXCL10","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054367","descriptor_name":"Receptors, CXCR3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054370","descriptor_name":"Chemokine CXCL9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.173.3.2050","doi":"https://doi.org/10.4049/jimmunol.173.3.2050","is_oa":false,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.3.2050","pdf_url":null,"source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15265940","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15265940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2542997258","display_name":"MECHANISMS OF IPS AFTER ALLOGENEIC BMT","funder_award_id":"R01HL055162","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3190915014","display_name":null,"funder_award_id":"R01 HL072258-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3637178087","display_name":"Mechanisms of Leukocyte Recruitment During IPS After BMT","funder_award_id":"7r01hl072258-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5320032215","display_name":null,"funder_award_id":"R01 HL55162-05","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000888561","display_name":"Advancing Child Health Through Cellular and Molecular Biology","funder_award_id":"K12HD028820","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":85,"referenced_works":["https://openalex.org/W40112356","https://openalex.org/W1491831527","https://openalex.org/W1500954694","https://openalex.org/W1505315838","https://openalex.org/W1544331058","https://openalex.org/W1544569979","https://openalex.org/W1558253890","https://openalex.org/W1592858281","https://openalex.org/W1594111463","https://openalex.org/W1602460865","https://openalex.org/W1648537547","https://openalex.org/W1648671938","https://openalex.org/W1881316889","https://openalex.org/W1887472438","https://openalex.org/W1920557811","https://openalex.org/W1964616348","https://openalex.org/W1964649749","https://openalex.org/W1973953825","https://openalex.org/W1974005261","https://openalex.org/W1974210099","https://openalex.org/W1976161748","https://openalex.org/W1978015875","https://openalex.org/W1981818329","https://openalex.org/W1988019016","https://openalex.org/W1990482372","https://openalex.org/W1992613163","https://openalex.org/W1997185418","https://openalex.org/W1997491414","https://openalex.org/W1998605540","https://openalex.org/W2001483781","https://openalex.org/W2001636475","https://openalex.org/W2003980550","https://openalex.org/W2008780066","https://openalex.org/W2012153513","https://openalex.org/W2016581990","https://openalex.org/W2019948813","https://openalex.org/W2021764775","https://openalex.org/W2025430232","https://openalex.org/W2025930905","https://openalex.org/W2026429785","https://openalex.org/W2036196845","https://openalex.org/W2044510555","https://openalex.org/W2046773769","https://openalex.org/W2047863254","https://openalex.org/W2048228223","https://openalex.org/W2048526870","https://openalex.org/W2055254092","https://openalex.org/W2059901653","https://openalex.org/W2064411005","https://openalex.org/W2066720913","https://openalex.org/W2067564880","https://openalex.org/W2071871975","https://openalex.org/W2075303797","https://openalex.org/W2080138855","https://openalex.org/W2081596482","https://openalex.org/W2082362404","https://openalex.org/W2087268029","https://openalex.org/W2089105141","https://openalex.org/W2091184113","https://openalex.org/W2097236298","https://openalex.org/W2107452215","https://openalex.org/W2107996874","https://openalex.org/W2115289037","https://openalex.org/W2115700507","https://openalex.org/W2119299530","https://openalex.org/W2120056104","https://openalex.org/W2127086092","https://openalex.org/W2127908593","https://openalex.org/W2133586702","https://openalex.org/W2137636472","https://openalex.org/W2139213208","https://openalex.org/W2147519354","https://openalex.org/W2153869022","https://openalex.org/W2155940448","https://openalex.org/W2159520551","https://openalex.org/W2160915452","https://openalex.org/W2166734438","https://openalex.org/W2256215671","https://openalex.org/W2317145780","https://openalex.org/W2323692764","https://openalex.org/W2405893856","https://openalex.org/W2411714135","https://openalex.org/W2413882691","https://openalex.org/W2417395376","https://openalex.org/W3166209807"],"related_works":["https://openalex.org/W2075630479","https://openalex.org/W2109653742","https://openalex.org/W2032273043","https://openalex.org/W2130741213","https://openalex.org/W2980390115","https://openalex.org/W7127315517","https://openalex.org/W2059292686","https://openalex.org/W1970864665","https://openalex.org/W2050158941","https://openalex.org/W2058641049"],"abstract_inverted_index":{"Idiopathic":[0],"pneumonia":[1],"syndrome":[2],"(IPS)":[3],"is":[4,48,53],"a":[5,49,83,98,199],"frequently":[6],"fatal":[7],"complication":[8],"after":[9,228],"allogeneic":[10],"stem":[11],"cell":[12,59,86,223],"transplantation":[13],"(allo-SCT)":[14],"that":[15,52,122,207,248],"responds":[16],"poorly":[17],"to":[18,44,107,220,225],"standard":[19],"immunosuppressive":[20],"therapy.":[21],"The":[22,157],"pathophysiology":[23],"of":[24,29,40,64,85,111,118,136,148,161,170,236],"IPS":[25,171],"involves":[26],"the":[27,38,45,62,109,116,132,146,155,168,226,234],"secretion":[28],"inflammatory":[30],"cytokines":[31],"including":[32],"IFN-gamma":[33,71,89],"and":[34,61,73,124,143,176,211,216],"TNF-alpha":[35],"along":[36],"with":[37,94,140,145,173],"recruitment":[39,224],"donor":[41,151,221],"T":[42,58,152,222],"cells":[43,153],"lung.":[46,156],"CXCR3":[47,112,210],"chemokine":[50],"receptor":[51],"expressed":[54],"on":[55,233],"activated":[56],"Th1/Tc1":[57],"subsets":[60],"expression":[63],"its":[65,212],"ligands":[66,184,214],"CXCL9":[67],"(monokine":[68],"induced":[69,81],"by":[70,88],"(Mig))":[72],"CXCL10":[74],"(IFN-gamma-inducible":[75],"protein":[76,126],"10":[77],"(IP-10))":[78],"can":[79],"be":[80],"in":[82,92,115,131,158,198,202,242,250],"variety":[84],"types":[87],"alone":[90],"or":[91,164,244],"combination":[93],"TNF-alpha.":[95],"We":[96,120],"used":[97],"lethally":[99],"irradiated":[100],"murine":[101],"SCT":[102,194],"model":[103],"(B6":[104],"-->":[105],"bm1)":[106],"evaluate":[108],"role":[110],"receptor:ligand":[113],"interactions":[114,208,238],"development":[117],"IPS.":[119,203],"found":[121],"Mig":[123,163,215],"IP-10":[125,165,217],"levels":[127],"were":[128,185],"significantly":[129,166,218],"elevated":[130],"bronchoalveolar":[133],"lavage":[134],"fluid":[135],"allo-SCT":[137],"recipients":[138],"compared":[139,172],"syngeneic":[141],"controls":[142],"correlated":[144],"infiltration":[147],"IFN-gamma-secreting":[149],"CXCR3(+)":[150],"into":[154],"vivo":[159],"neutralization":[160],"either":[162],"reduced":[167],"severity":[169],"control-treated":[174],"animals,":[175],"an":[177],"additive":[178],"effect":[179],"was":[180],"observed":[181],"when":[182],"both":[183],"blocked":[186],"simultaneously.":[187],"Complementary":[188],"experiments":[189],"using":[190],"CXCR3(-/-)":[191],"mice":[192],"as":[193],"donors":[195],"also":[196],"resulted":[197],"significant":[200],"decrease":[201],"These":[204],"data":[205],"demonstrate":[206],"involving":[209],"primary":[213],"contribute":[219],"lung":[227,246],"allo-SCT.":[229],"Therefore,":[230],"approaches":[231],"focusing":[232],"abrogation":[235],"these":[237],"may":[239],"prove":[240],"successful":[241],"preventing":[243],"treating":[245],"injury":[247],"occurs":[249],"this":[251],"setting.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}