{"id":"https://openalex.org/W159124181","doi":null,"title":"Prediction of Alzheimer\u2019s disease in subjects with Mild Cognitive Impairment using biomarkers","display_name":"Prediction of Alzheimer\u2019s disease in subjects with Mild Cognitive Impairment using biomarkers","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W159124181","mag":"159124181"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:dcbb28a3-1d3e-4965-9673-2cf76f9381f9","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1845269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084055939","display_name":"Peder Buchhave","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Buchhave, Peder","raw_affiliation_strings":["Clinical Memory Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Memory Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5084055939"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9269999861717224},{"id":"https://openalex.org/keywords/prodromal-alzheimer-s-disease","display_name":"prodromal Alzheimer's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.9459999799728394},{"id":"https://openalex.org/keywords/phosphorylated-tau","display_name":"phosphorylated tau","score":0.8320000171661377},{"id":"https://openalex.org/keywords/total-tau","display_name":"total tau","score":0.9829999804496765},{"id":"https://openalex.org/keywords/amyloid-beta-1-42","display_name":"amyloid-beta 42","score":0.8870000243186951},{"id":"https://openalex.org/keywords/soluble-tnf-receptor-1","display_name":"soluble TNF receptor 1","score":0.6869999766349792},{"id":"https://openalex.org/keywords/soluble-tnf-receptor-2","display_name":"soluble TNF receptor 2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/soluble-cd40","display_name":"soluble CD40","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.925000011920929},{"id":"https://openalex.org/keywords/dementia-progression","display_name":"dementia progression","score":0.503000020980835},{"id":"https://openalex.org/keywords/early-diagnosis","display_name":"early diagnosis","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.7960089445114136},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6158414483070374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5758635997772217},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.549210250377655},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5345256924629211},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5089237689971924},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.49471399188041687},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.47485804557800293},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.42776787281036377},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4269790053367615},{"id":"https://openalex.org/C2780066322","wikidata":"https://www.wikidata.org/wiki/Q719444","display_name":"Lumbar puncture","level":3,"score":0.422377347946167},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3817915916442871},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3703412413597107},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:lup.lub.lu.se:dcbb28a3-1d3e-4965-9673-2cf76f9381f9","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/1845269","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2921640499","https://openalex.org/W2161737267","https://openalex.org/W1987911931","https://openalex.org/W4389411839","https://openalex.org/W2085767421","https://openalex.org/W1975103375","https://openalex.org/W3100080537","https://openalex.org/W2146788881","https://openalex.org/W1969006299","https://openalex.org/W2060446879"],"abstract_inverted_index":{"Background:":[0],"Alzheimer\u2019s":[1],"disease":[2,23],"(AD)":[3],"is":[4,274],"the":[5,22,29,48,113,133,145,175,198,253,286,296],"most":[6],"common":[7],"cause":[8],"of":[9,16,67,115,148,160,197,236,278,289,298],"dementia.":[10,33,157,190,219,233,263],"In":[11],"order":[12],"to":[13,218,262],"have":[14,31,41,282],"effect":[15],"future":[17],"disease-modifying":[18],"therapies":[19],"for":[20,47,75,101,118],"AD,":[21,43],"must":[24],"be":[25],"identified":[26],"early,":[27],"before":[28,216,260],"patients":[30,35,59,80,153,170,186,230,255,290],"developed":[32,155,188],"Many":[34],"with":[36,60,62,81,88,166,171,231,256,270,291],"Mild":[37],"Cognitive":[38],"Impairment":[39],"(MCI)":[40],"prodromal":[42,77,172,271],"but":[44],"other":[45],"causes":[46],"syndrome":[49],"are":[50],"common.":[51],"No":[52],"diagnostic":[53,287],"method":[54],"can":[55,267],"identify":[56,169,268],"AD":[57,78,156,189,232,257,299],"in":[58,69,79,229,242,248,252],"MCI":[61,89,254],"sufficient":[63],"accuracy.":[64],"Aim:":[65],"Evaluation":[66],"biomarkers":[68,140,266],"cerebrospinal":[70],"fluid":[71],"(CSF)":[72],"and":[73,90,109,124,132,163,193,222,239,244,246],"plasma":[74,245,249],"identifying":[76],"MCI.":[82],"Settings:":[83],"At":[84],"baseline":[85,98],"137":[86],"subjects":[87,269],"successful":[91],"lumbar":[92],"puncture":[93],"were":[94,136,205,211,224,250],"included.":[95],"CSF":[96,243,265],"from":[97,183],"was":[99,178],"analyzed":[100],"phosphorylated":[102],"tau":[103,106],"(P-tau),":[104],"total":[105],"(T-":[107],"tau)":[108],"amyloid\u03b21-42":[110],"(A\u03b242).":[111],"Furthermore,":[112],"levels":[114,159,210,235],"soluble":[116,129],"receptors":[117],"Tumor":[119],"Necrosis":[120],"Factor-\u03b1":[121],"(sTNFR)":[122],"1":[123,238],"2,":[125],"as":[126,128,293,295],"well":[127,294],"CD40":[130,134],"(sCD40)":[131],"ligand":[135],"analyzed.":[137],"The":[138,158,191,208,234],"latter":[139],"reflect":[141],"inflammation.":[142],"Results:":[143],"After":[144,174],"first":[146],"follow-up":[147,177,204],"around":[149,206],"5":[150,258],"years,":[151],"57":[152],"had":[154,187],"T-tau,":[161],"P-tau":[162,200],"A\u03b242":[164,209,223],"could":[165],"high":[167],"accuracy":[168],"AD.":[173,272,279],"second":[176],"finished,":[179],"approximately":[180],"9":[181],"years":[182,215,259],"baseline,":[184],"72":[185],"positive":[192],"negative":[194],"predictive":[195],"values":[196],"A\u03b242/":[199],"ratio":[201],"after":[202],"this":[203],"90%.":[207],"pathological":[212],"already":[213],"10":[214],"progression":[217,261],"Moreover,":[220],"Tau":[221],"quite":[225],"stable":[226],"over":[227],"time":[228],"TNFR":[237],"2":[240],"both":[241],"sCD40":[247],"elevated":[251],"Conclusion:":[264],"Inflammation":[273],"an":[275,283],"early":[276],"feature":[277],"These":[280],"results":[281],"impact":[284],"on":[285],"work-up":[288],"MCI,":[292],"development":[297],"therapies.":[300]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}