{"id":"https://openalex.org/W1591151241","doi":null,"title":"Regulation of caspase expression and apoptosis by adenomatous polyposis coli.","display_name":"Regulation of caspase expression and apoptosis by adenomatous polyposis coli.","publication_year":2003,"publication_date":"2003-08-01","ids":{"openalex":"https://openalex.org/W1591151241","mag":"1591151241","pmid":"https://pubmed.ncbi.nlm.nih.gov/12907606"},"language":"en","primary_location":{"id":"pmid:12907606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12907606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075473281","display_name":"Tingan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingan Chen","raw_affiliation_strings":["Department of Interdisciplinary Oncology and Surgery, University of South Florida, Tampa, FL 33612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Interdisciplinary Oncology and Surgery, University of South Florida, Tampa, FL 33612, USA","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042472677","display_name":"Ivana V. Yang","orcid":"https://orcid.org/0000-0002-1018-489X","observed_orcids":["https://orcid.org/0000-0002-1018-489X"]},"institutions":[{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivana Yang","raw_affiliation_strings":["J. Craig Venter Institute|"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Craig Venter Institute|","institution_ids":["https://openalex.org/I1301553790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109072560","display_name":"Rosalyn Irby","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosalyn Irby","raw_affiliation_strings":["Department of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053572690","display_name":"Kenneth H. Shain","orcid":"https://orcid.org/0000-0003-4178-8888","observed_orcids":["https://orcid.org/0000-0003-4178-8888"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth H Shain","raw_affiliation_strings":["University of South FLorida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South FLorida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025430347","display_name":"Hong\u2010Gang Wang","orcid":"https://orcid.org/0000-0003-0551-0571","observed_orcids":["https://orcid.org/0000-0003-0551-0571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Gang Wang","raw_affiliation_strings":["Department of Pediatrics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084245470","display_name":"John F Quackenbush","orcid":"https://orcid.org/0000-0002-2702-5879","observed_orcids":["https://orcid.org/0000-0002-2702-5879","https://orcid.org/0009-0005-2193-1829"]},"institutions":[{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Quackenbush","raw_affiliation_strings":["J. Craig Venter Institute|"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"J. Craig Venter Institute|","institution_ids":["https://openalex.org/I1301553790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076324164","display_name":"Domenico Coppola","orcid":"https://orcid.org/0000-0001-9090-1205","observed_orcids":["https://orcid.org/0000-0001-9090-1205","https://orcid.org/0009-0008-3540-2014"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Domenico Coppola","raw_affiliation_strings":["University of South FLorida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South FLorida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023217981","display_name":"Jin Quan Cheng","orcid":"https://orcid.org/0000-0003-1473-7807","observed_orcids":["https://orcid.org/0000-0003-1473-7807"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Q Cheng","raw_affiliation_strings":["University of South FLorida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South FLorida","institution_ids":["https://openalex.org/I2613432"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113849367","display_name":"Timothy Joseph Yeatman","orcid":"https://orcid.org/0000-0002-7487-0784","observed_orcids":["https://orcid.org/0000-0002-7487-0784"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J Yeatman","raw_affiliation_strings":["University of South FLorida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of South FLorida","institution_ids":["https://openalex.org/I2613432"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.9671,"has_fulltext":false,"cited_by_count":94,"citation_normalized_percentile":{"value":0.94896271,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"63","issue":"15","first_page":"4368","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.6753000020980835,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.2964000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenomatous-polyposis-coli","display_name":"adenomatous polyposis coli","score":0.9950000047683716},{"id":"https://openalex.org/keywords/caspase-expression","display_name":"caspase expression","score":0.9070000052452087},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8510000109672546},{"id":"https://openalex.org/keywords/apcmin-mice","display_name":"ApcMin/+ mice","score":0.6600000262260437},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.7459999918937683},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9259999990463257},{"id":"https://openalex.org/keywords/caspase-7","display_name":"caspase-7","score":1.0},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":1.0},{"id":"https://openalex.org/keywords/intestinal-epithelial-cell-differentiation","display_name":"intestinal epithelial differentiation","score":0.703000009059906},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.7393351197242737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6731169819831848},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.655217707157135},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.628017783164978},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6162199974060059},{"id":"https://openalex.org/C155863897","wikidata":"https://www.wikidata.org/wiki/Q14913269","display_name":"Caspase 2","level":5,"score":0.5807161927223206},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.48026514053344727},{"id":"https://openalex.org/C1186008","wikidata":"https://www.wikidata.org/wiki/Q17855945","display_name":"Caspase 10","level":5,"score":0.4663250744342804},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4599764347076416},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45166611671447754},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.41224798560142517},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39877885580062866},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3842424750328064},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.28131771087646484},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2810707688331604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25319409370422363},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2112073302268982}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D025601","descriptor_name":"Adenomatous Polyposis Coli Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12907606","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12907606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.6977","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.6977","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://compbio.dfci.harvard.edu/pubs/Caspases.pdf","raw_type":"text"},{"id":"mag:1591151241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12907606","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W93601381","https://openalex.org/W1554815317","https://openalex.org/W1589643407","https://openalex.org/W1609607086","https://openalex.org/W1966121721","https://openalex.org/W1971225070","https://openalex.org/W1975740413","https://openalex.org/W1978276004","https://openalex.org/W1991588439","https://openalex.org/W2002404925","https://openalex.org/W2007530728","https://openalex.org/W2024954553","https://openalex.org/W2053666128","https://openalex.org/W2076035242","https://openalex.org/W2093392246","https://openalex.org/W2099388441","https://openalex.org/W2104143846","https://openalex.org/W2131320300","https://openalex.org/W2132686612","https://openalex.org/W2133879302","https://openalex.org/W2140940373","https://openalex.org/W2149022033","https://openalex.org/W2153206163","https://openalex.org/W2155476683","https://openalex.org/W2157405979","https://openalex.org/W2163149540","https://openalex.org/W2167109216","https://openalex.org/W2167962847","https://openalex.org/W2168714182","https://openalex.org/W2171996338","https://openalex.org/W2324524545"],"related_works":["https://openalex.org/W7099232573","https://openalex.org/W2060998383","https://openalex.org/W2039661491","https://openalex.org/W2144066537","https://openalex.org/W141799699","https://openalex.org/W2128096299","https://openalex.org/W7027313467","https://openalex.org/W2150695642","https://openalex.org/W184300614","https://openalex.org/W2063197030"],"abstract_inverted_index":{"The":[0],"adenomatous":[1],"polyposis":[2],"coli":[3],"(APC)":[4],"gene,":[5],"a":[6,21,77,103,118],"member":[7],"of":[8,23,29,48,67,72,80,95,109,123,152,179,182,187],"the":[9,30,92,106,175,180,185,200],"WNT":[10],"pathway,":[11],"has":[12],"been":[13],"shown":[14],"to":[15,20,40,51,83,90,134,147],"assign":[16],"intestinal":[17],"epithelial":[18],"cells":[19],"program":[22],"proliferation":[24],"or":[25],"differentiation":[26,42],"through":[27],"regulation":[28,186],"beta-catenin/TCF-4":[31],"complex.":[32],"Wild-type":[33],"APC,":[34,49],"in":[35,105,120,128,140,145,199],"certain":[36],"cellular":[37],"contexts,":[38],"appears":[39],"induce":[41,70],"and":[43,54,113,126,150,190],"apoptosis,":[44],"although":[45],"mutant":[46,65],"forms":[47,66],"known":[50,133],"produce":[52],"polyps":[53],"ultimately":[55],"cancers,":[56],"may":[57],"suppress":[58],"these":[59],"events.":[60],"Here,":[61],"we":[62,101],"show":[63],"that":[64,177],"APC":[68,136,183],"can":[69],"repression":[71],"select":[73],"terminal":[74],"caspases":[75,111],"as":[76],"potential":[78],"means":[79],"attenuating":[81],"responses":[82],"apoptotic":[84,156,192],"stimuli.":[85],"Using":[86],"gene":[87],"expression":[88,108,197],"profiling":[89],"interrogate":[91],"intact":[93],"intestines":[94],"Apc(+/min)":[96],"mice":[97],"harboring":[98],"numerous":[99],"polyps,":[100],"identified":[102,117],"reduction":[104,119,139],"mRNA":[107],"both":[110],"3":[112],"7.":[114],"We":[115],"additionally":[116],"protein":[121,142,168],"levels":[122,143,154,198],"caspase-3,":[124],"caspase-7,":[125],"caspase-9":[127],"human":[129],"colon":[130],"cancer":[131],"specimens":[132],"harbor":[135],"mutations.":[137],"A":[138],"caspase":[141,153,167,188],"resulted":[144],"resistance":[146],"apoptotic-inducing":[148],"agents":[149],"restoration":[151],"reinstated":[155],"capacities.":[157],"Consistent":[158],"with":[159],"Wnt":[160],"pathway":[161],"involvement,":[162],"dominant":[163],"negative":[164],"TCF/LEF":[165],"induced":[166],"expression.":[169],"These":[170],"data":[171],"provide":[172],"support":[173],"for":[174],"hypothesis":[176],"one":[178],"functions":[181],"is":[184],"activity":[189],"other":[191],"proteins":[193],"by":[194],"controlling":[195],"their":[196],"cell.":[201]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
