{"id":"https://openalex.org/W1591032267","doi":"https://doi.org/10.1016/s0021-9258(19)41061-2","title":"Hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site","display_name":"Hemoglobin Abruzzo (beta143 (H21) His replaced by Arg). Consequences of altering the 2,3-diphosphoglycerate binding site","publication_year":1975,"publication_date":"1975-08-01","ids":{"openalex":"https://openalex.org/W1591032267","doi":"https://doi.org/10.1016/s0021-9258(19)41061-2","mag":"1591032267","pmid":"https://pubmed.ncbi.nlm.nih.gov/239943"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)41061-2","doi":"https://doi.org/10.1016/s0021-9258(19)41061-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)41061-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)41061-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060269662","display_name":"Celia Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"C Bonaventura","raw_affiliation_strings":["$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107412810","display_name":"Joseph Bonaventura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"J Bonaventura","raw_affiliation_strings":["$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002157417","display_name":"Gino Amiconi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"G Amiconi","raw_affiliation_strings":["$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013317750","display_name":"L Tentori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"L Tentori","raw_affiliation_strings":["$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090015641","display_name":"Maurizio Brunori","orcid":"https://orcid.org/0000-0002-7795-1635","observed_orcids":["https://orcid.org/0000-0002-7795-1635"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"M Brunori","raw_affiliation_strings":["$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073641797","display_name":"Eraldo Antonini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"E Antonini","raw_affiliation_strings":["$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"$ Present address, Duke University Marine Laboratory, Beau-fort, North Carolina 28516","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"From the Consiglio Nazionale delle Richerche Centre of Molecular Biology, Institutes of Biochemistry and Chemistry, Faculty of ibfedicine, University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.3446,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91700611,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"250","issue":"16","first_page":"6273","last_page":"6277"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-variants","display_name":"hemoglobin variants","score":0.675000011920929},{"id":"https://openalex.org/keywords/beta-globin","display_name":"beta-globin","score":0.6499999761581421},{"id":"https://openalex.org/keywords/bohr-effect","display_name":"Bohr effect","score":0.699999988079071},{"id":"https://openalex.org/keywords/oxygen-affinity","display_name":"oxygen affinity","score":0.8309999704360962},{"id":"https://openalex.org/keywords/heme-heme-interaction","display_name":"heme-heme interaction","score":0.9369999766349792},{"id":"https://openalex.org/keywords/subunit-dissociation","display_name":"subunit dissociation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/co-binding","display_name":"carbon monoxide binding","score":0.6449999809265137},{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"allosteric regulation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.6909999847412109},{"id":"https://openalex.org/keywords/organic-phosphates","display_name":"organic phosphates","score":0.6600000262260437},{"id":"https://openalex.org/keywords/oxygen-dissociation-kinetics","display_name":"oxygen dissociation kinetics","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C77562769","wikidata":"https://www.wikidata.org/wiki/Q890877","display_name":"Bohr effect","level":4,"score":0.8636326789855957},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.8318095207214355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7675992250442505},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.6286293864250183},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.617700457572937},{"id":"https://openalex.org/C2778460671","wikidata":"https://www.wikidata.org/wiki/Q485277","display_name":"Histidine","level":3,"score":0.5838747620582581},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.5390529036521912},{"id":"https://openalex.org/C2777393523","wikidata":"https://www.wikidata.org/wiki/Q50008082","display_name":"Hemoglobin A","level":3,"score":0.4886811077594757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4815395474433899},{"id":"https://openalex.org/C166014724","wikidata":"https://www.wikidata.org/wiki/Q337217","display_name":"Cooperativity","level":2,"score":0.47045981884002686},{"id":"https://openalex.org/C2909111029","wikidata":"https://www.wikidata.org/wiki/Q5279760","display_name":"Diphosphoglycerate","level":3,"score":0.4404098093509674},{"id":"https://openalex.org/C127503593","wikidata":"https://www.wikidata.org/wiki/Q7115970","display_name":"Oxygen\u2013haemoglobin dissociation curve","level":3,"score":0.3707612156867981},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.32602769136428833},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.15156614780426025},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14633402228355408},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1034296452999115},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0899764895439148}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001120","descriptor_name":"Arginine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004163","descriptor_name":"Diphosphoglyceric Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006455","descriptor_name":"Hemoglobins, Abnormal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(19)41061-2","doi":"https://doi.org/10.1016/s0021-9258(19)41061-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)41061-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:239943","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/239943","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)41061-2","doi":"https://doi.org/10.1016/s0021-9258(19)41061-2","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)41061-2","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1456466086","https://openalex.org/W1495666670","https://openalex.org/W1508323399","https://openalex.org/W1524166106","https://openalex.org/W1543771189","https://openalex.org/W1550638451","https://openalex.org/W1555912259","https://openalex.org/W1622780310","https://openalex.org/W1919505456","https://openalex.org/W1971123108","https://openalex.org/W2001334824","https://openalex.org/W2005436544","https://openalex.org/W2013862948","https://openalex.org/W2014630872","https://openalex.org/W2025747003","https://openalex.org/W2055603817","https://openalex.org/W2071463158","https://openalex.org/W2071686464","https://openalex.org/W2073266875","https://openalex.org/W2077864524","https://openalex.org/W2084356408","https://openalex.org/W2107188627","https://openalex.org/W2115250484","https://openalex.org/W2272748618"],"related_works":["https://openalex.org/W1580885984","https://openalex.org/W1521226608","https://openalex.org/W2080312893","https://openalex.org/W1604356881","https://openalex.org/W2037543287","https://openalex.org/W2043043469","https://openalex.org/W7099750113","https://openalex.org/W2062822590","https://openalex.org/W2088516173","https://openalex.org/W2052020205"],"abstract_inverted_index":{"Hemoglobin":[0],"Abruzzo":[1,125,157],"is":[2,69,84,158,171],"an":[3],"abnormal":[4],"human":[5],"hemoglobin":[6,62,76,124,133,156,172],"with":[7,140],"a":[8,11,78],"substitution":[9,120],"at":[10,121],"residue":[12],"known":[13],"to":[14,98,118,127,161],"be":[15,96,128],"involved":[16],"in":[17,32,66,74],"the":[18,33,45,54,89,99,104,108,116,152,162],"binding":[19],"of":[20,35,61,81,88,92,103,151,165],"2,3-diphosphoglyceric":[21],"acid.":[22],"It":[23],"has":[24],"increased":[25],"oxygen":[26,55,82,101],"affinity":[27,56,102],"and":[28,48,77,167],"reduced":[29],"heme-heme":[30,49],"interaction":[31,50,139],"absence":[34],"organic":[36,141,166],"or":[37,142],"inorganic":[38,42,67,143,168],"phosphate":[39,43,68],"cofactors.":[40],"In":[41,149],"buffers":[44],"Bohr":[46],"effect":[47],"are":[51,112],"normal,":[52],"but":[53],"remains":[57],"higher":[58],"than":[59,73,132,170],"that":[60,138],"A.":[63,134,173],"CO":[64],"combination":[65],"more":[70,130,159],"strongly":[71],"autocatalytic":[72],"normal":[75],"slower":[79],"rate":[80],"dissociation":[83],"observed.":[85],"Although":[86],"many":[87],"functional":[90,153],"differences":[91],"this":[93],"variant":[94],"may":[95],"attributed":[97],"high":[100],"mutant":[105],"beta":[106],"chains,":[107],"interactions":[109],"between":[110],"subunits":[111],"also":[113],"affected":[114],"by":[115],"histidine":[117],"arginine":[119],"beta143.":[122],"Stripped":[123],"appears":[126],"significantly":[129],"dissociated":[131],"Kinetic":[135],"studies":[136],"indicate":[137],"phosphates":[144],"decreases":[145],"its":[146],"subunit":[147],"dissociation.":[148],"all":[150],"properties":[154],"examined,":[155],"sensitive":[160],"allosteric":[163],"influence":[164],"anions":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
